Dr

Naphak Modhiran

Email: 
Phone: 
+61 7 336 52485

Availability

Dr Naphak Modhiran is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Naphak Modhiran’s works on UQ eSpace

65 works between 2010 and 2024
All (65) Journal Article (62) Book Chapter (1) Conference Publication (1) Other Outputs (1)

1 - 20 of 65 works

2024

Journal Article

A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge

Harrison, Jessica J., Nguyen, Wilson, Morgan, Mahali S., Tang, Bing, Habarugira, Gervais, de Malmanche, Henry, Freney, Morgan E., Modhiran, Naphak, Watterson, Daniel, Cox, Abigail L., Yan, Kexin, Yuen, Nicholas K. Y., Bowman, Dylan H., Kirkland, Peter D., Bielefeldt-Ohmann, Helle, Suhrbier, Andreas, Hall, Roy A., Rawle, Daniel J. and Hobson-Peters, Jody (2024). A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge. npj Vaccines, 9 (1) 134, 134. doi: 10.1038/s41541-024-00903-2

A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge

2024

Journal Article

Equal Maintenance of Anti-SARS-CoV-2 Antibody Levels Induced by Heterologous and Homologous Regimens of the BNT162b2, ChAdOx1, CoronaVac and Ad26.COV2.S Vaccines: A Longitudinal Study Up to the 4th Dose of Booster

do Nascimento, Tatiana A., Nogami, Patricia Y., de Oliveira, Camille F., Neto, Walter F. F., da Silva, Carla P., Ribeiro, Ana Claudia S., de Sousa, Alana W., Freitas, Maria N. O., Chiang, Jannifer O., Silva, Franko A., das Chagas, Liliane L., Carvalho, Valéria L., Azevedo, Raimunda S. S., Vasconcelos, Pedro F. C., Costa, Igor B., Costa, Iran B., Barbagelata, Luana S., das Chagas Junior, Wanderley D., da Penha Junior, Edvaldo T., Soares, Luana S., Viana, Giselle M. R., Amarilla, Alberto A., Modhiran, Naphak, Watterson, Daniel, Casseb, Lívia M. N., Martins, Lívia C. and Henriques, Daniele F. (2024). Equal Maintenance of Anti-SARS-CoV-2 Antibody Levels Induced by Heterologous and Homologous Regimens of the BNT162b2, ChAdOx1, CoronaVac and Ad26.COV2.S Vaccines: A Longitudinal Study Up to the 4th Dose of Booster. Vaccines, 12 (7) 792, 792. doi: 10.3390/vaccines12070792

Equal Maintenance of Anti-SARS-CoV-2 Antibody Levels Induced by Heterologous and Homologous Regimens of the BNT162b2, ChAdOx1, CoronaVac and Ad26.COV2.S Vaccines: A Longitudinal Study Up to the 4th Dose of Booster

2024

Journal Article

Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2

Chhabra, Mohit, Shanthamurthy, Chethan D., Kumar, Nanjudaswamy Vijendra, Mardhekar, Sandhya, Vishweshwara, Sharath S., Wimmer, Norbert, Modhiran, Naphak, Watterson, Daniel, Amarilla, Alberto A., Cha, Jonathan S., Beckett, James R., De Voss, James J., Kayal, Yasmin, Vlodavsky, Israel, Dorsett, Lauren R., Smith, Raymond A. A., Gandhi, Neha S., Kikkeri, Raghavendra and Ferro, Vito (2024). Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2. Journal of Medicinal Chemistry, 67 (14), 11885-11916. doi: 10.1021/acs.jmedchem.4c00487

Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2

2024

Journal Article

Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne Viruses

Nahain, Abdullah Al, Li, Jinlin, Modhiran, Naphak, Watterson, Daniel, Li, Jin-ping, Ignjatovic, Vera, Monagle, Paul, Tsanaktsidis, John, Vamvounis, George and Ferro, Vito (2024). Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne Viruses. ACS Applied Bio Materials, 7 (5), 2862-2871. doi: 10.1021/acsabm.3c01223

Antiviral Activities of Heparan Sulfate Mimetic RAFT Polymers Against Mosquito-borne Viruses

2024

Journal Article

Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein

McMillan, Christopher L. D., Wijesundara, Danushka K., Choo, Jovin J. Y., Amarilla, Alberto A., Modhiran, Naphak, Fernando, Germain J. P., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R. and Muller, David A. (2024). Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein. Journal of General Virology, 105 (1) ARTN 001947, 1-6. doi: 10.1099/jgv.0.001947

Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein

2023

Journal Article

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant

Pegg, Cassandra L., Modhiran, Naphak, Parry, Rhys H., Liang, Benjamin, Amarilla, Alberto A., Khromykh, Alexander A., Burr, Lucy, Young, Paul R., Chappell, Keith, Schulz, Benjamin L. and Watterson, Daniel (2023). The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant. Glycobiology, 34 (2) cwad097, 1-13. doi: 10.1093/glycob/cwad097

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant

2023

Journal Article

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Aguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 3 (12), 1561-1575. doi: 10.1038/s43587-023-00519-6

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

2023

Journal Article

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Amarilla, Alberto A., Modhiran, Naphak, Liang, Benjamin, Li, Zheyi, Wijesundara, Danushka K., Lackenby, Julia A., Griffin, Paul, Bennet, Jillian K., Hensen, Luca, Zhang, Wuji, Nguyen, Thi H.O., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Kedzierska, Katherine, Ranasinghe, Charani, Subbarao, Kanta, Watterson, Daniel, Young, Paul R. and Munro, Trent P. (2023). Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial. eBioMedicine, 97 104842. doi: 10.1016/j.ebiom.2023.104842

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial

2023

Journal Article

Kinetics of severe dengue virus infection and development of gut pathology in mice

Pliego Zamora, Adriana, Kim, Jaehyeon, Vajjhala, Parimala R., Thygesen, Sara J., Watterson, Daniel, Modhiran, Naphak, Bielefeldt-Ohmann, Helle and Stacey, Katryn J. (2023). Kinetics of severe dengue virus infection and development of gut pathology in mice. Journal of Virology, 97 (11) ARTN e0125123, e0125123. doi: 10.1128/jvi.01251-23

Kinetics of severe dengue virus infection and development of gut pathology in mice

2023

Journal Article

Cubane and cyclooctatetraene pirfenidones – synthesis and biological evaluation

Liu, Yizhou, Wen Liang, Benjamin Jian, Modhiran, Naphak, Savage, G. Paul, Watterson, Daniel and Williams, Craig M. (2023). Cubane and cyclooctatetraene pirfenidones – synthesis and biological evaluation. Asian Journal of Organic Chemistry, 12 (8) e202300238, 1-7. doi: 10.1002/ajoc.202300238

Cubane and cyclooctatetraene pirfenidones – synthesis and biological evaluation

2023

Journal Article

A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants

Modhiran, Naphak, Lauer, Simon Malte, Amarilla, Alberto A., Hewins, Peter, Lopes van den Broek, Sara Irene, Low, Yu Shang, Thakur, Nazia, Liang, Benjamin, Nieto, Guillermo Valenzuela, Jung, James, Paramitha, Devina, Isaacs, Ariel, Sng, Julian D. J., Song, David, Jørgensen, Jesper Tranekjær, Cheuquemilla, Yorka, Bürger, Jörg, Andersen, Ida Vang, Himelreichs, Johanna, Jara, Ronald, MacLoughlin, Ronan, Miranda-Chacon, Zaray, Chana-Cuevas, Pedro, Kramer, Vasko, Spahn, Christian M. T., Mielke, Thorsten, Khromykh, Alexander A., Munro, Trent, Jones, Martina L. ... Watterson, Daniel (2023). A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants. iScience, 26 (7) 107085, 107085. doi: 10.1016/j.isci.2023.107085

A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants

2023

Journal Article

Structure and antigenicity of divergent Henipavirus fusion glycoproteins

Isaacs, Ariel, Low, Yu Shang, Macauslane, Kyle L., Seitanidou, Joy, Pegg, Cassandra L., Cheung, Stacey T. M., Liang, Benjamin, Scott, Connor A. P., Landsberg, Michael J., Schulz, Benjamin L., Chappell, Keith J., Modhiran, Naphak and Watterson, Daniel (2023). Structure and antigenicity of divergent Henipavirus fusion glycoproteins. Nature Communications, 14 (1) 3577, 1-10. doi: 10.1038/s41467-023-39278-8

Structure and antigenicity of divergent Henipavirus fusion glycoproteins

2023

Journal Article

Inactivation of SARS‐CoV ‐2 infectivity in platelet concentrates or plasma following treatment with ultraviolet C light or with methylene blue combined with visible light

Hobson‐Peters, Jody, Amarilla, Alberto A., Rustanti, Lina, Marks, Denese C., Roulis, Eileen, Khromykh, Alexander A., Modhiran, Naphak, Watterson, Daniel, Reichenberg, Stefan, Tolksdorf, Frank, Sumian, Chryslain, Seltsam, Axel, Gravemann, Ute and Faddy, Helen M. (2023). Inactivation of SARS‐CoV ‐2 infectivity in platelet concentrates or plasma following treatment with ultraviolet C light or with methylene blue combined with visible light. Transfusion, 63 (2), 288-293. doi: 10.1111/trf.17238

Inactivation of SARS‐CoV ‐2 infectivity in platelet concentrates or plasma following treatment with ultraviolet C light or with methylene blue combined with visible light

2023

Journal Article

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

2022

Journal Article

Monoclonal antibodies specific for SARS-CoV-2 spike protein suitable for multiple applications for current variants of concern

Morgan, Mahali S., Yan, Kexin, Le, Thuy T., Johnston, Ryan A., Amarilla, Alberto A., Muller, David A., McMillan, Christopher L. D., Modhiran, Naphak, Watterson, Daniel, Potter, James R., Sng, Julian D. J., Lor, Mary, Paramitha, Devina, Isaacs, Ariel, Khromykh, Alexander A., Hall, Roy A., Suhrbier, Andreas, Rawle, Daniel J. and Hobson-Peters, Jody (2022). Monoclonal antibodies specific for SARS-CoV-2 spike protein suitable for multiple applications for current variants of concern. Viruses, 15 (1) 139, 1-18. doi: 10.3390/v15010139

Monoclonal antibodies specific for SARS-CoV-2 spike protein suitable for multiple applications for current variants of concern

2022

Journal Article

Development and evaluation of an 18F-labeled nanobody to target SARS-CoV-2's spike protein

Lopes van den Broek, Sara, García-Vázquez, Rocío, Andersen, Ida Vang, Valenzuela-Nieto, Guillermo, Shalgunov, Vladimir, Battisti, Umberto M., Schwefel, David, Modhiran, Naphak, Kramer, Vasko, Cheuquemilla, Yorka, Jara, Ronald, Salinas-Varas, Constanza, Amarilla, Alberto A., Watterson, Daniel, Rojas-Fernandez, Alejandro and Herth, Matthias M. (2022). Development and evaluation of an 18F-labeled nanobody to target SARS-CoV-2's spike protein. Frontiers in Nuclear Medicine, 2 1033697. doi: 10.3389/fnume.2022.1033697

Development and evaluation of an 18F-labeled nanobody to target SARS-CoV-2's spike protein

2022

Conference Publication

Democratising large scale instrument-based science through e-Infrastructure

Abramson, David, Barkauskas, Deborah S., Carroll, Jake, Condon, Nicholas D, Modhiran, Naphak, Nguyen, Hoang, Springfield, James, Watterson, Daniel and Jin, Chao (2022). Democratising large scale instrument-based science through e-Infrastructure. IEEE 18th International Conference on E-Science (E-Science), Salt Lake City, UT USA, 10-14 October 2022. New York, NY USA: Institute of Electrical and Electronics Engineers. doi: 10.1109/escience55777.2022.00033

Democratising large scale instrument-based science through e-Infrastructure

2022

Journal Article

A platform technology for generating subunit vaccines against diverse viral pathogens

Young, Andrew, Isaacs, Ariel, Scott, Connor A. P., Modhiran, Naphak, McMillan, Christopher L. D., Cheung, Stacey T. M., Barr, Jennifer, Marsh, Glenn, Thakur, Nazia, Bailey, Dalan, Li, Kenneth S. M., Luk, Hayes K. H., Kok, Kin-Hang, Lau, Susanna K. P., Woo, Patrick C. Y., Furuyama, Wakako, Marzi, Andrea, Young, Paul R., Chappell, Keith J. and Watterson, Daniel (2022). A platform technology for generating subunit vaccines against diverse viral pathogens. Frontiers in Immunology, 13 963023, 1-16. doi: 10.3389/fimmu.2022.963023

A platform technology for generating subunit vaccines against diverse viral pathogens

2022

Journal Article

Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern

McMillan, Christopher L.D., Amarilla, Alberto A., Modhiran, Naphak, Choo, Jovin J.Y., Azuar, Armira, Honeyman, Kate E., Khromykh, Alexander A., Young, Paul R., Watterson, Daniel and Muller, David A. (2022). Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern. Vaccine, 40 (34), 4929-4932. doi: 10.1016/j.vaccine.2022.07.013

Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern

2022

Journal Article

SARS-CoV-2 triggers complement activation through interactions with heparan sulfate

Lo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413

SARS-CoV-2 triggers complement activation through interactions with heparan sulfate

Current funding

  • 2023 - 2025
    Broad-spectrum vaccine design for flaviviruses and henipaviruses
    NHMRC MRFF EMCR - Early to Mid-Career Researchers
    Open grant
  • 2023 - 2026
    Structurally informed vaccines and therapies to resist and counter JEV emergence
    NHMRC IDEAS Grants
    Open grant
  • 2022 - 2025
    Revealing bat antibody recognition mechanism against bat-borne viruses
    ARC Discovery Early Career Researcher Award
    Open grant
  • 2022 - 2024
    How the synergy between flavivirus protein and noncoding RNA defeats antiviral response
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2021 - 2022
    Molecular Clamp Stabilised HTLV-1 Envelope Glycoprotein for Vaccination and Immunotherapy
    Australian Centre for HIV and Hepatitis Virology Research (ACH2)
    Open grant
  • 2020 - 2021
    Development of Hepatitis C (HCV) chimeric viruses for structural and vaccine application
    UQ Early Career Researcher
    Open grant
  • 2019 - 2022
    Intestinal barrier integrity in dengue virus infection
    NHMRC Project Grant
    Open grant
  • 2019 - 2022
    Structural insights into the function and antigenicity of the flavivirus NS1 protein
    NHMRC Project Grant
    Open grant

Availability

Dr Naphak Modhiran is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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