Dr Johannes Zuegg
Dr

Johannes Zuegg

Email: 
Phone: 
+61 7 334 62994

Availability

Dr Johannes Zuegg is:
Available for supervision

Fields of research

Bacteriology Basic pharmacology Bioinformatics and computational biology Biological Sciences Biomedical and Clinical Sciences Chemical Sciences Infectious agents Information and Computing Sciences Medicinal and biomolecular chemistry Microbiology Molecular targets Oncology and carcinogenesis Organic chemistry Pharmacology and pharmaceutical sciences Protein trafficking Receptors and membrane biology Structural biology (incl. macromolecular modelling)

Qualifications

  • Doctor of Philosophy of Chemistry and Biochemistry, Technische Universität Graz

Search Professor Johannes Zuegg’s works on UQ eSpace

79 works between 1991 and 2025
All (79) Journal Article (69) Conference Publication (2) Other Outputs (8)

41 - 60 of 79 works

2017

Journal Article

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017). Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 e21221. doi: 10.7554/eLife.21221

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

2016

Journal Article

Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides

Edwards, Ingrid A., Elliott, Alysha G., Kavanagh, Angela M., Zuegg, Johannes, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides. ACS Infectious Diseases, 2 (6), 442-450. doi: 10.1021/acsinfecdis.6b00045

Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides

2016

Journal Article

Targeting bacterial cell wall peptidoglycan synthesis by inhibition of glycosyltransferase activity

Mesleh, Michael F., Rajaratnam, Premraj, Conrad, Mary, Chandrasekaran, Vasu, Liu, Christopher M., Pandya, Bhaumik A., Hwang, You Seok, Rye, Peter T., Muldoon, Craig, Becker, Bernd, Zuegg, Johannes, Meutermans, Wim and Moy, Terence I. (2016). Targeting bacterial cell wall peptidoglycan synthesis by inhibition of glycosyltransferase activity. Chemical Biology and Drug Design, 87 (2), 190-199. doi: 10.1111/cbdd.12662

Targeting bacterial cell wall peptidoglycan synthesis by inhibition of glycosyltransferase activity

2015

Journal Article

Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites

Jarrad, Angie M., Karoli, Tomislav, Anjan, Debnath, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A. and Cooper, Matthew A. (2015). Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. European Journal of Medicinal Chemistry, 101 7946, 96-102. doi: 10.1016/j.ejmech.2015.06.019

Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites

2015

Journal Article

Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity

Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Le Thanh, Giang, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh, Demon, Dieter, Meyer, Evelyne, Meutermans, Wim and Cooper, Matthew A. (2015). Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6 (1) 7719, 1-11. doi: 10.1038/ncomms8719

Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity

2015

Journal Article

Helping chemists discover new antibiotics

Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G. and Cooper, Matthew (2015). Helping chemists discover new antibiotics. ACS Infectious Diseases, 1 (7), 285-287. doi: 10.1021/acsinfecdis.5b00044

Helping chemists discover new antibiotics

2015

Journal Article

Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach

Bajaj, Megha, Mamidyala, Sreeman K., Zuegg, Johannes, Begg, Stephanie L., Ween, Miranda P., Luo, Zhenyao, Huang, Johnny Xiao, McEwan, Alastair G., Kobe, Bostjan, Paton, James C., McDevitt, Christopher A. and Cooper, Matthew A. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10 (6), 1511-1520. doi: 10.1021/cb501032x

Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach

2015

Journal Article

Neue Strukturen für Antibiotika gesucht

Zuegg, Johannes (2015). Neue Strukturen für Antibiotika gesucht. Nachrichten aus der Chemie, 63 (11), 1101-1103. doi: 10.1002/nadc.201590371

Neue Strukturen für Antibiotika gesucht

2014

Journal Article

An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants

Phetsang, Wanida, Blaskovich, Mark A. T., Butler, Mark S., Huang, Johnny Xiao, Zuegg, Johannes, Mamidyala, Sreeman K., Ramu, Soumya, Kavanagh, Angela M. and Cooper, Matthew A. (2014). An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants. Bioorganic and Medicinal Chemistry, 22 (16), 4490-4498. doi: 10.1016/j.bmc.2014.05.054

An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants

2014

Journal Article

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

Couñago, Rafael M., Ween, Miranda P., Begg, Stephanie L., Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L., Cooper, Matthew A., McEwan, Alastair G., Paton, James C., Kobe, Bostjan and McDevitt, Christopher A. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10 (1), 35-41. doi: 10.1038/nCHeMBIO.1382

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

2013

Journal Article

Vancomycin: ligand recognition, dimerization and super-complex formation

Jia, ZhiGuang, O'Mara, Megan L., Zuegg, Johannes, Cooper, Matthew A. and Mark, Alan E. (2013). Vancomycin: ligand recognition, dimerization and super-complex formation. FEBS Journal, 280 (5), 1294-1307. doi: 10.1111/febs.12121

Vancomycin: ligand recognition, dimerization and super-complex formation

2013

Journal Article

Erratum: The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II (Biophysical Journal (2011) 101 (2684-2692))

Jia, Z. G., O'Mara, M. L., Zuegg, J., Matthew Cooper and Mark, Alan (2013). Erratum: The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II (Biophysical Journal (2011) 101 (2684-2692)). Biophysical Journal, 104 (2), 516-516. doi: 10.1016/j.bpj.2012.12.031

Erratum: The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II (Biophysical Journal (2011) 101 (2684-2692))

2012

Journal Article

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: effect on opioid activity and biodistribution

Novoa, Alexandre, Van Dorpe, Sylvia, Wynendaele, Evelien, Spetea, Mariana, Bracke, Nathalie, Stalmans, Sofie, Betti, Cecilia, Chung, Nga N., Lemieux, Carole, Zuegg, Johannes, Cooper, Matthew A., Tourwe, Dirk, De Spiegeleer, Bart, Schiller, Peter W. and Ballet, Steven (2012). Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: effect on opioid activity and biodistribution. Journal of Medicinal Chemistry, 55 (22), 9549-9561. doi: 10.1021/jm3008079

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: effect on opioid activity and biodistribution

2012

Journal Article

Identification of antitubercular benzothiazinone compounds by ligand-based design

Karoli, Tomislav, Becker, Bernd, Zuegg, Johannes, Moellmann, Ute, Ramu, Soumya, Huang, Johnny X. and Cooper, Matthew A. (2012). Identification of antitubercular benzothiazinone compounds by ligand-based design. Journal of Medicinal Chemistry, 55 (17), 7940-7944. doi: 10.1021/jm3008882

Identification of antitubercular benzothiazinone compounds by ligand-based design

2012

Journal Article

Drug-likeness and increased hydrophobicity of commercially available compound libraries for drug screening

Zuegg, Johannes and Cooper, Matthew A. (2012). Drug-likeness and increased hydrophobicity of commercially available compound libraries for drug screening. Current Topics in Medicinal Chemistry, 12 (14), 1500-1513. doi: 10.2174/156802612802652466

Drug-likeness and increased hydrophobicity of commercially available compound libraries for drug screening

2012

Journal Article

Structure aided design of chimeric antibiotics

Karoli, Tomislav, Mamidyala, Sreeman K., Zuegg, Johannes, Fry, Scott R., Tee, Ernest H. L., Bradford, Tanya A., Madala, Praveen K., Huang, Johnny X., Ramu, Soumya, Butler, Mark S. and Cooper, Matthew A. (2012). Structure aided design of chimeric antibiotics. Bioorganic & Medicinal Chemistry Letters, 22 (7), 2428-2433. doi: 10.1016/j.bmcl.2012.02.019

Structure aided design of chimeric antibiotics

2011

Journal Article

The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II

Jia, ZhiGuang, O'Mara, Megan L., Zuegg, Johannes, Cooper, Matthew A. and Mark, Alan E. (2011). The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II. Biophysical Journal, 101 (11), 2684-2692. doi: 10.1016/j.bpj.2011.10.047

The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II

2011

Conference Publication

Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin and maculatin

Chia, C. S. Brian, Gong, Yujing, Bowie, John H., Zuegg, Johannes and Cooper, Matthew A. (2011). Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin and maculatin. New York, NY, U.S.A.: John Wiley & Sons. doi: 10.1002/bip.21438

Membrane binding and perturbation studies of the antimicrobial peptides caerin, citropin and maculatin

2010

Journal Article

Biological diversity from a structurally diverse library: Systematically scanning conformational space using a pyranose scaffold

Abbenante, Giovanni, Becker, Bernd, Blanc, Sebastien, Clark, Chris, Condie, Glenn, Fraser, Graeme, Grathwohl, Matthias, Halliday, Judy, Henderson, Senka, Lam, Ann, Liu, Ligong, Mann, Maretta, Muldoon, Craig, Pearson, Andrew, Premraj, Rajaratnam, Ramsdale, Tracie, Rossetti, Tony, Schafer, Karl, Le Thanh, Giang, Tometzki, Gerald, Vari, Frank, Verquin, Geraldine, Waanders, Jennifer, West, Michael, Wimmer, Norbert, Yau, Annika, Zuegg, Johannes and Meutermans, Wim (2010). Biological diversity from a structurally diverse library: Systematically scanning conformational space using a pyranose scaffold. Journal of Medicinal Chemistry, 53 (15), 5576-5586. doi: 10.1021/jm1002777

Biological diversity from a structurally diverse library: Systematically scanning conformational space using a pyranose scaffold

2010

Journal Article

A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds

Thanh, Giang Le, Abbenante, Giovanni, Adamson, George, Becker, Bernd, Clark, Chris, Condie, Glenn, Falzun, Tania, Grathwohl, Matthias, Gupta, Praveer, Hanson, Michael, Huynh, Ngoc, Katavic, Peter, Kuipers, Krystle, Lam, Ann, Liu, Ligong, Mann, Maretta, Mason, Jeff, McKeveney, Declan, Muldoon, Craig, Pearson, Andrew, Rajaratnam, Premraj, Ryan, Sarah, Tometzki, Gerry, Verquin, Geraldine, Waanders, Jennifer, West, Michael, Wilcox, Neil, Wimmer, Norbert, Yau, Annika ... Meutermans, Wim (2010). A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds. Journal of Organic Chemistry, 75 (1), 197-203. doi: 10.1021/jo9021919

A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds

Past funding

  • 2023
    CSIRO Library Screening
    CSIRO
    Open grant
  • 2022
    CSIRO Library Screening
    CSIRO
    Open grant
  • 2021 - 2024
    Predictive Models to Design and Develop New Antibiotics Derived from the Community for Open Antimicrobial Drug Discovery
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2020
    Antibacterial Potentiation Screening 1. Master Research Services Agreement - Statement of Work no.3
    Global Antibiotic Research & Development Partnership Foundation
    Open grant
  • 2019
    Antibacterial Potentiation Screening 1. Master Research Services Agreement - Statement of Work no.2
    Global Antibiotic Research & Development Partnership Foundation
    Open grant
  • 2019
    Antibacterial Screening 1. Master Research Services Agreement - Statement of Work no.1
    Global Antibiotic Research & Development Partnership Foundation
    Open grant
  • 2013 - 2015
    Potent antibiotics against drug-resistant Tuberculosis
    NHMRC Development Grant
    Open grant

Availability

Dr Johannes Zuegg is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Development of computational models to discover new antibiotics against Gram-negative bacteria. (Note: online component of Onawole's application lists his Master's thesis title instead of this project)

    Principal Advisor

    Other advisors: Professor Mark Blaskovich

  • Doctor Philosophy

    How does cannabidiol kill bacteria?

    Principal Advisor

    Other advisors: Professor Mark Blaskovich

  • Master Philosophy

    The antibacterial mechanism of action of cannabidiol

    Associate Advisor

    Other advisors: Professor Mark Blaskovich

  • Doctor Philosophy

    Antibiotic potentiators as an alternative therapeutic option for the treatment of extensively drug-resistant Gram-negative infections.

    Associate Advisor

    Other advisors: Professor Mark Blaskovich

Completed supervision

Enquiries

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