Overview
Background
Dr Rash completed his Honours (1996) and PhD (2001) on the pharmacological activity of spider venoms at the Department of Pharmacology, Monash University in the group of Professor Wayne Hodgson. After 18 months as an Assistant Lecturer at Monash Pharmacology, he was awarded an INSERM/NH&MRC Post-doctoral Fellowship to work in the group of Prof. Michel Lazdunski at the Institute of Molecular and Cellular Pharmacology in Antibes, France. It was here that he became involved in discovery and characterisation of venom peptides that act on acid-sensing ion channels, voltage-gated sodium channels and other pain related channels. Upon returning to Australia to the Institute for Molecular Bioscience (The University of Queensland), he established an ASIC research program and was awarded an NH&MRC project grant as CIA to investigate the molecular basis of the interaction of PcTx1 and APETx2 with ASIC1a and ASIC3 respectively. Dr Rash was appointed as senior lecturer in Pharmacology in the School of Biomedical Sciences in early 2016 where he continues his research on identifying novel bioactive peptides from animal venoms, unravelling the molecular basis for their specific channel interactions and their use as research tools and potential therapeutic lead molecules.
Availability
- Dr Lachlan Rash is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, Monash University
- Doctor of Philosophy, Monash University
Works
Search Professor Lachlan Rash’s works on UQ eSpace
2000
Journal Article
Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata)
Rash, LD, King, RG and Hodgson, WC (2000). Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata). Toxicon, 38 (8), 1111-1127. doi: 10.1016/S0041-0101(99)00226-3
1998
Journal Article
Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi)
Rash, LD, King, RG and Hodgson, WC (1998). Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi). Toxicon, 36 (2), 367-375. doi: 10.1016/S0041-0101(97)00072-X
Funding
Current funding
Supervision
Availability
- Dr Lachlan Rash is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Novel Venom Peptides targeting Acid Sensing Ion Channels: Insights into their role in the Pathophysiology of a model of Multiple Sclerosis
Principal Advisor
Other advisors: Dr Neville Butcher, Dr Nemat Khan
-
Doctor Philosophy
Understanding the role acid-sensing ion channels in disease progression and pain associated with neuroinflammatory conditions.
Principal Advisor
Other advisors: Emeritus Professor Maree Smith, Dr Neville Butcher, Dr Nemat Khan
-
Doctor Philosophy
The ASIC thumb domain as a channel proxy for identification of drug leads for the treatment of ischemic conditions
Associate Advisor
Other advisors: Professor Mehdi Mobli
Completed supervision
-
2023
Doctor Philosophy
Characterisation of venom-derived peptides that target acid-sensing ion channels
Principal Advisor
Other advisors: Professor Irina Vetter, Professor Mehdi Mobli
-
2019
Doctor Philosophy
Discovery and modulation of acid-sensing ion channel modulating venom peptides
Principal Advisor
Other advisors: Professor Glenn King
-
2023
Doctor Philosophy
Structural study of the ASIC thumb domain (ATD) in isolation by solution-state NMR spectroscopy
Associate Advisor
Other advisors: Professor Mehdi Mobli
-
2022
Doctor Philosophy
Centipede venom: Modulation, functional neuro-anatomy and evolutionary origin of the venom gland
Associate Advisor
-
2017
Doctor Philosophy
Peptide modulators of ASIC1a: a putative drug target for the treatment of stroke
Associate Advisor
Other advisors: Professor Glenn King
-
2017
Doctor Philosophy
Biotechnological applications of spider venom peptides
Associate Advisor
Other advisors: Professor Glenn King
-
2014
Doctor Philosophy
Discovery and characterization of NaV modulatory venom peptides
Associate Advisor
Other advisors: Professor Irina Vetter
-
2013
Doctor Philosophy
Characterising the molecular basis of the interaction between the putative drug target ASIC1a and pi-TRTX-Pc1a
Associate Advisor
Other advisors: Professor Glenn King
-
2013
Doctor Philosophy
Dissecting the interaction between the sea anemone toxin APETx2 and its analgesic target, acid-sensing ion channel 3
Associate Advisor
Other advisors: Professor Glenn King
Media
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