Dr Zyta M Ziora
Dr

Zyta M Ziora

Email: 
Phone: 
+61 7 334 62202

Background

Dr Zyta Ziora received PhD (Wroclaw University of Science & Technology, Poland) in chemistry and has wide range of experience in development of antimalarial therapeutics (the University of Montpellier, France), antibacterial agents, enzyme inhibitors and drug candidates against Alzheimer disease (Kyoto Pharmaceutical University, Japan). Her research time is currently dedicated mainly to projects devoted to the modification of existing antibiotics, and complexing them with additional antimicrobial agents, like metal ions, to produce more potent alternatives and by this to overcome the drug resistance of superbugs. She is also working on alternative to antibiotics nature-derived compounds with antimicrobial and anticancer potency, such poliphenolic derivatives to control tyrosinase function.

Availability

Dr Zyta M Ziora is:
Available for supervision

Fields of research

Medicinal and biomolecular chemistry Organic chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Doctor of Philosophy, Wroclaw University of Technology

Research interests

  • Researcher and Lecturer in Biotechnology & Molecular Biology Programs

    Modification of existing antibiotics – complexing with metal ions Alternative to antibiotics – nature-derived compounds with antimicrobial and anticancer potency Tyrosinase inhibition – potential treatment for skin bacterial infections and melanoma prevention

Research impacts

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Search Professor Zyta M Ziora’s works on UQ eSpace

110 works between 1999 and 2025
All (110) Journal Article (96) Conference Publication (5) Book Chapter (9)

81 - 100 of 110 works

2012

Journal Article

Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes

Zaman, Mehfuz, Abdel-Aal, Abu-Baker M., Fujita, Yoshio, Ziora, Zyta M., Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2012). Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes. Journal of Medicinal Chemistry, 55 (19), 8515-8523. doi: 10.1021/jm301074n

Structure-activity relationship for the development of a self-adjuvanting mucosally active lipopeptide vaccine against Streptococcus pyogenes

2012

Journal Article

Lipoamino acids as major components of absorption promoters in drug delivery

Ziora, Zyta M., Blaskovich, Mark A., Toth, Istvan and Cooper, Matthew A. (2012). Lipoamino acids as major components of absorption promoters in drug delivery. Current Topics in Medicinal Chemistry, 12 (14), 1562-1580. doi: 10.2174/156802612802652448

Lipoamino acids as major components of absorption promoters in drug delivery

2012

Journal Article

ChemInform Abstract: Medicinal Chemistry of α-Hydroxy-β-amino Acids

Ziora, Zyta, Skwarczynski, Mariusz and Kiso, Yoshiaki (2012). ChemInform Abstract: Medicinal Chemistry of α-Hydroxy-β-amino Acids. ChemInform, 43 (25), no-no. doi: 10.1002/chin.201225259

ChemInform Abstract: Medicinal Chemistry of α-Hydroxy-β-amino Acids

2012

Journal Article

Lipopeptides for the fragment-based pharmaceutics design

Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2012). Lipopeptides for the fragment-based pharmaceutics design. International Journal of Organic Chemistry, 2 (01), 75-81. doi: 10.4236/ijoc.2012.21013

Lipopeptides for the fragment-based pharmaceutics design

2012

Conference Publication

Nanoparticles-based peptide subunit vaccines against group A Streptococcus

Skwarczynski, M., Fuaad, A. A. H. A., Zaman, M., Jia, Z., Kowapradit, J., Rustanti, L., Ziora, Z. M., Monteiro, M. L. J., Batzloff, M. R., Goodc, M. F. and Toth, I. (2012). Nanoparticles-based peptide subunit vaccines against group A Streptococcus. 32nd European Peptide Symposium, Athens, Greece, 2-7 September 2012. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2448

Nanoparticles-based peptide subunit vaccines against group A Streptococcus

2012

Conference Publication

New glycopeptidic antibiotics to combat multidrug resistant pathogens

Gong, Y., Muldoon, C. A., Premraj, R., Ziora, Z. M., Bradford, T. A., Cheng, M., Ramu, S., Huang, J. X., Kavanagh, A., Pelingon, R., Lee, J. C., Wong, K., Butler, M. S., Blaskovich, M. A. and Cooper, M. A. (2012). New glycopeptidic antibiotics to combat multidrug resistant pathogens. 32nd European Peptide Symposium, Athens, Greece, 2-7 September 2012. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2449

New glycopeptidic antibiotics to combat multidrug resistant pathogens

2011

Journal Article

Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery

Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2011). Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery. Carbohydrate Research, 346 (12), 1439-1444. doi: 10.1016/j.carres.2011.03.019

Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery

2011

Journal Article

Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers

Lin, I-Chun, Liang, Mingtao, Liu, Tzu-Yu, Ziora, Zyta M., Monteiro, Michael J. and Toth, Istvan (2011). Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers. Biomacromolecules, 12 (4), 1339-1348. doi: 10.1021/bm200116z

Interaction of densely polymer-coated gold nanoparticles with epithelial Caco-2 monolayers

2011

Journal Article

Group A streptococcal vaccine candidates based on the conserved conformational epitope from M protein

Skwarczynski, Mariusz, Ahmad Fuaad, Abdullah A. H., Rustanti, Lina, Ziora, Zyta M., Aqil, Mohammed, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2011). Group A streptococcal vaccine candidates based on the conserved conformational epitope from M protein. Drug Delivery Letters, 1 (1), 2-8. doi: 10.2174/2210304X11101010002

Group A streptococcal vaccine candidates based on the conserved conformational epitope from M protein

2011

Book Chapter

Medicinal chemistry of a-hydroxy-b-amino acids

Ziora, Zyta, Skwarczynski, Mariusz and Kiso, Yoshiaki (2011). Medicinal chemistry of a-hydroxy-b-amino acids. Amino Acids, Peptides and Proteins in Organic Chemistry: Volume 4 - Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis. (pp. 189-234) edited by Andrew B. Hughes. Weinheim, Germany: Wiley-VCH. doi: 10.1002/9783527631827.ch6

Medicinal chemistry of a-hydroxy-b-amino acids

2010

Journal Article

ChemInform Abstract: Reactions of N-Phthalylamino Acid Chlorides with Trialkyl Phosphites

Ziora, Zyta, Maly, Alina, Lejczak, Barbara, Kafarski, Pawel, Holband, Jolanta and Wojcik, Grazyna (2010). ChemInform Abstract: Reactions of N-Phthalylamino Acid Chlorides with Trialkyl Phosphites. ChemInform, 31 (28), 1-1. doi: 10.1002/chin.200028203

ChemInform Abstract: Reactions of N-Phthalylamino Acid Chlorides with Trialkyl Phosphites

2010

Journal Article

Tetrapeptides, as small-sized peptidic inhibitors; Synthesis and their inhibitory activity against BACE1

Kakizawa, Taeko, Hidaka, Koushi, Hamada, Daisuke, Yamaguchi, Ryoji, Uemura, Tsuyoshi, Kitamura, Hitomi, Tagad, Harichandra D., Hamada, Takashi, Ziora, Zyta, Hamada, Yoshio, Kimura, Tooru and Kiso, Yoshiaki (2010). Tetrapeptides, as small-sized peptidic inhibitors; Synthesis and their inhibitory activity against BACE1. Journal of Peptide Science, 16 (6), 257-262. doi: 10.1002/psc.1238

Tetrapeptides, as small-sized peptidic inhibitors; Synthesis and their inhibitory activity against BACE1

2010

Journal Article

In vitro and in vivo evaluation of positively charged liposaccharide derivatives as oral absorption enhancers for the delivery of anionic drugs

Bergeon, Julie A., Ziora, Zyta M., Abdelrahim, Adel S., Pernevi, Niklas, Moss, Anne R. and Toth, Istvan (2010). In vitro and in vivo evaluation of positively charged liposaccharide derivatives as oral absorption enhancers for the delivery of anionic drugs. Journal of Pharmaceutical Sciences, 99 (5), 2333-2342. doi: 10.1002/jps.21999

In vitro and in vivo evaluation of positively charged liposaccharide derivatives as oral absorption enhancers for the delivery of anionic drugs

2010

Journal Article

Thymine, adenine and lipoamino acid based gene delivery systems

Skwarczynski, Mariusz, Ziora, Zyta M., Coles, Daniel J., Lin, I-Chun and Toth, Istvan (2010). Thymine, adenine and lipoamino acid based gene delivery systems. Chemical Communications, 46 (18), 3140-3142. doi: 10.1039/b924371b

Thymine, adenine and lipoamino acid based gene delivery systems

2009

Journal Article

Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery

Abdelrahim, Adel. S., Ziora, Zyta M., Bergeon, Julie A., Moss, Anne R. and Toth, Istvan (2009). Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery. Tetrahedron, 65 (45), 9436-9442. doi: 10.1016/j.tet.2009.08.072

Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery

2009

Journal Article

Amidoalkylation of Phosphorus Trichloride with Acetamide and Alkyl Oxocycloalkanecarboxylates

Ziora, Zyta and Kafarski, Pawel (2009). Amidoalkylation of Phosphorus Trichloride with Acetamide and Alkyl Oxocycloalkanecarboxylates. Phosphorus, Sulfur, and Silicon and the Related Elements, 184 (4), 1047-1053. doi: 10.1080/10426500902737356

Amidoalkylation of Phosphorus Trichloride with Acetamide and Alkyl Oxocycloalkanecarboxylates

2007

Journal Article

Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines

Calas, Michele, Outtara, Mahama, Piquet, Giles, Ziora, Zyta, Bordat, Y., Ancelin, Marie L., Escale, Roger and Vial, Henri (2007). Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines. Journal of Medicinal Chemistry, 50 (25), 6307-6315. doi: 10.1021/jm0704752

Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines

2007

Journal Article

Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes

Nagahama, Masahiro, Otsuka, Akiko, Oda, Masataka, Singh, Rajesh K., Ziora, Zyta M., Imagawa, Hiroshi, Nishizawa, Mugio and Sakurai, Jun (2007). Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1768 (11), 2940-2945. doi: 10.1016/j.bbamem.2007.08.016

Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes

2007

Journal Article

Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4(phenylthio)butyric acid

Ziora, Zyta, Kasai, Soko, Hidaka, Koushi, Nagamine, Ayaka, Kimura, Tooru, Hayashi, Yoshio and Kiso, Yoshiaki (2007). Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4(phenylthio)butyric acid. Bioorganic and Medicinal Chemistry Letters, 17 (6), 1629-1633. doi: 10.1016/j.bmcl.2006.12.097

Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4(phenylthio)butyric acid

2006

Journal Article

beta-Secretase inhibitors: Modification at the P-4 position and improvement of inhibitory activity in cultured cells

Hamada, Yoshio, Igawa, Naoto, Ikari, Hayato, Ziora, Zyta, Nguyen, Jeffrey-Tri, Yamani, Abdellah, Hidaka, Koushi, Kimura, Tooru, Saito, Kazuki, Hayashi, Yoshio, Ebina, Maiko, Ishiura, Shoichi and Kiso, Yoshiaki (2006). beta-Secretase inhibitors: Modification at the P-4 position and improvement of inhibitory activity in cultured cells. Bioorganic and Medicinal Chemistry Letters, 16 (16), 4354-4359. doi: 10.1016/j.bmcl.2006.05.046

beta-Secretase inhibitors: Modification at the P-4 position and improvement of inhibitory activity in cultured cells

Current funding

  • 2023 - 2028
    ARC Training Centre for Environmental and Agricultural Solutions to Antimicrobial Resistance (ARC CEA-StAR)
    ARC Industrial Transformation Training Centres
    Open grant

Past funding

  • 2017 - 2018
    Natureceuticals from post-production wine extracts
    Innovation Connections
    Open grant

Availability

Dr Zyta M Ziora is:
Available for supervision

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Available projects

Supervision history

Current supervision

Completed supervision

Enquiries

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