
Overview
Background
I am a molecular virologist and postdoctoral research fellow in Prof. Alexander Khromykh's laboratory, specialising in virus evolution, virus bioinformatics, and reverse genetics.
My research journey began with a Bachelor of Science, First Class Honours in Molecular Biology from The University of Queensland (2015). I then pursued my PhD (2016-2021) at UQ's School of Biology under Prof. Sassan Asgari, where I analysed the virome and microbiome of Aedes aegypti and Aedes albopictus mosquitoes, focusing on their interactions with Wolbachia pipientis infections.
Since 2021, I have been a postdoctoral researcher in Prof. Alexander Khromykh's RNA Virology lab. Here, I contributed to developing the SARS-CoV-2 circular polymerase extension reaction (CPER) reverse-genetics methodology. As a physical containment 3 (PC3) researcher, I examine the virological properties of Flaviviruses and SARS-CoV-2 viruses under stringent PC3 conditions. Recently, with support from Therapeutic Innovation Australia and the Australian Infectious Diseases Research Centre, I have been utilising the Kunjin virus replicon system as a versatile and durable self-replicating RNA platform for vaccine and protein replacement therapy.
Beyond my virology work, I actively provide bioinformatics and phylogenetics support within UQ and internationally. Let's connect if you’re interested in collaborating on differential gene and ncRNA expression analysis, ATAC-sequencing, ancestral state prediction, virus discovery, or microbiome analyses.
I am also on the organising committee of MicroSeq (2023-2024), an Australasian Microbiology conference focused on microbial sequencing promoting PhD students and early career researchers. Additionally, I am an incoming Ex Officio member of the Australian Society for Microbiology (ASM) Queensland branch.
Availability
- Dr Rhys Parry is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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Development of self-replicating RNA vaccines and therapeutics.
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Flavivirus evolution and diversity.
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Interferon-antagonistic activities of amino acid residues in the West Nile virus capsid protein identified by deep mutational scanning.
Research impacts
As a COVID-19 scientist, I am actively combating misinformation about COVID-19 research through academic channels and providing expert analysis to independent journalism organisations engaged in Fact-Checking. Some examples include COVID-19 vaccine misinformation examined by the Australian Associated Press and Health Feedback, an organisation contracted by Facebook to verify misinformation.
Works
Search Professor Rhys Parry’s works on UQ eSpace
2023
Journal Article
Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery
Edwards, Mark R., Forbes, Gordon, Walker, Neil, Morton, Dion G., Mythen, Monty G., Murray, Dave, Anderson, Iain, Mihaylova, Borislava, Thomson, Ann, Taylor, Matt, Hollyman, Marianne, Phillips, Rachel, Young, Keith, Kahan, Brennan C., Pearse, Rupert M., Grocott, Michael P. W., Skubala, Alexandra, Tapley, Patrick, Kellett, Suzanne, Bolger, Clare, Burnish, Rachel, Collings, Nikki, Cumpstey, Andrew, Wong, Hannah, Rehnberg, Vic, Lees, Jessica, Salmon, Karen, Wee, Naomi, Harrison, Sarah ... Brennan, Christopher (2023). Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery. Trials, 24 (1) 313, 1-16. doi: 10.1186/s13063-023-07275-3
2023
Journal Article
Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”
Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. Journal of Virology, 97 (5), e0045123. doi: 10.1128/jvi.00451-23
2023
Journal Article
Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”
Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mSphere, 8 (3), e0016523. doi: 10.1128/msphere.00165-23
2023
Journal Article
Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”
Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mBio, 14 (3), e0081523. doi: 10.1128/mbio.00815-23
2023
Journal Article
Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”
Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”. Journal of Virology, 97 (5). doi: 10.1128/jvi.00451-23
2023
Journal Article
GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection
Foo, Cheng Xiang, Bartlett, Stacey, Chew, Keng Yih, Ngo, Minh Dao, Bielefeldt-Ohmann, Helle, Jayakody Arachchige, Buddhika, Matthews, Benjamin, Reed, Sarah, Wang, Ran, Smith, Christian, Sweet, Matthew J., Burr, Lucy, Bisht, Kavita, Shatunova, Svetlana, Sinclair, Jane E., Parry, Rhys, Yang, Yuanhao, Lévesque, Jean-Pierre, Khromykh, Alexander, Rosenkilde, Mette Marie, Short, Kirsty R. and Ronacher, Katharina (2023). GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection. European Respiratory Journal, 61 (3) 2201306, 1-15. doi: 10.1183/13993003.01306-2022
2023
Journal Article
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0
2022
Journal Article
The Troublesome Ticks research protocol: developing a comprehensive, multidiscipline research plan for investigating human tick-associated diseasein Australia
Barbosa, Amanda D., Long, Michelle, Lee, Wenna, Austen, Jill M., Cunneen, Mike, Ratchford, Andrew, Burns, Brian, Kumarasinghe, Prasad, Ben-Othman, Rym, Kollmann, Tobias R., Stewart, Cameron R., Beaman, Miles, Parry, Rhys, Hall, Roy, Tabor, Ala, O’Donovan, Justine, Faddy, Helen M., Collins, Marjorie, Cheng, Allen C., Stenos, John, Graves, Stephen, Oskam, Charlotte L., Ryan, Una M. and Irwin, Peter J. (2022). The Troublesome Ticks research protocol: developing a comprehensive, multidiscipline research plan for investigating human tick-associated diseasein Australia. Pathogens, 11 (11) 1290, 1-26. doi: 10.3390/pathogens11111290
2022
Journal Article
Comparative analysis of genome-encoded viral sequences reveals the evolutionary history of flavivirids (family Flaviviridae)
Bamford, Connor G. G., de Souza, William M., Parry, Rhys and Gifford, Robert J. (2022). Comparative analysis of genome-encoded viral sequences reveals the evolutionary history of flavivirids (family Flaviviridae). Virus Evolution, 8 (2) veac085, veac085. doi: 10.1093/ve/veac085
2022
Journal Article
Reporter flaviviruses as tools to demonstrate homologous and heterologous superinfection exclusion
Torres, Francisco J., Parry, Rhys, Hugo, Leon E., Slonchak, Andrii, Newton, Natalee D., Vet, Laura J., Modhiran, Naphak, Pullinger, Brody, Wang, Xiaohui, Potter, James, Winterford, Clay, Hobson-Peters, Jody, Hall, Roy A. and Khromykh, Alexander A. (2022). Reporter flaviviruses as tools to demonstrate homologous and heterologous superinfection exclusion. Viruses, 14 (7) 1501, 1501. doi: 10.3390/v14071501
2022
Journal Article
Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study
Kouli, O., Murray, V., Bhatia, S., Cambridge, W. A., Kawka, M., Shafi, S., Knight, S. R., Kamarajah, S. K., McLean, K. A., Glasbey, J. C., Khaw, R. A., Ahmed, W., Akhbari, M., Baker, D., Borakati, A., Mills, E., Thavayogan, R., Yasin, I., Raubenheimer, K., Ridley, W., Sarrami, M., Zhang, G., Egoroff, N., Pockney, P., Richards, T., Bhangu, A., Creagh-Brown, B., Edwards, M., Harrison, E. M. ... Wischhusen, S. (2022). Evaluation of prognostic risk models for postoperative pulmonary complications in adult patients undergoing major abdominal surgery: a systematic review and international external validation cohort study. The Lancet Digital Health, 4 (7), e520-e531. doi: 10.1016/S2589-7500(22)00069-3
2022
Journal Article
Structural analysis of 3’UTRs in insect flaviviruses reveals novel determinants of sfRNA biogenesis and provides new insights into flavivirus evolution
Slonchak, Andrii, Parry, Rhys, Pullinger, Brody, Sng, Julian D. J., Wang, Xiaohui, Buck, Teresa F., Torres, Francisco J., Harrison, Jessica J., Colmant, Agathe M. G., Hobson-Peters, Jody, Hall, Roy A., Tuplin, Andrew and Khromykh, Alexander A. (2022). Structural analysis of 3’UTRs in insect flaviviruses reveals novel determinants of sfRNA biogenesis and provides new insights into flavivirus evolution. Nature Communications, 13 (1) 1279, 1-16. doi: 10.1038/s41467-022-28977-3
2022
Journal Article
Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs
Gestuveo, Rommel J., Parry, Rhys, Dickson, Laura B., Lequime, Sebastian, Sreenu, Vattipally B., Arnold, Matthew J., Khromykh, Alexander A., Schnettler, Esther, Lambrechts, Louis, Varjak, Margus and Kohl, Alain (2022). Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs. PLOS Pathogens, 18 (1) e1010202, 1-29. doi: 10.1371/journal.ppat.1010202
2021
Journal Article
Persistent Spodoptera frugiperda rhabdovirus infection in Sf9 cells is not restricted by Wolbachia wMelPop-CLA and wAlbB strains and is targeted by the RNAi machinery
Parry, Rhys, de Malmanche, Henry and Asgari, Sassan (2021). Persistent Spodoptera frugiperda rhabdovirus infection in Sf9 cells is not restricted by Wolbachia wMelPop-CLA and wAlbB strains and is targeted by the RNAi machinery. Virology, 563, 82-87. doi: 10.1016/j.virol.2021.08.013
2021
Other Outputs
Endosymbionts and viromes: interplays between Wolbachia pipientis and the virome of Aedes mosquitoes
Parry, Rhys (2021). Endosymbionts and viromes: interplays between Wolbachia pipientis and the virome of Aedes mosquitoes. PhD Thesis, School of Biological Sciences, The University of Queensland. doi: 10.14264/abcdf38
2021
Journal Article
No evidence of SARS-CoV-2 reverse transcription and integration as the origin of chimeric transcripts in patient tissues
Parry, Rhys, Gifford, Robert J., Lytras, Spyros, Ray, Stuart C. and Coin, Lachlan J. M. (2021). No evidence of SARS-CoV-2 reverse transcription and integration as the origin of chimeric transcripts in patient tissues. Proceedings of the National Academy of Sciences, 118 (33) e2109066118, e2109066118. doi: 10.1073/pnas.2109066118
2021
Journal Article
Uncovering the worldwide diversity and evolution of the virome of the mosquitoes Aedes aegypti and Aedes albopictus
Parry, Rhys, James, Maddie E. and Asgari, Sassan (2021). Uncovering the worldwide diversity and evolution of the virome of the mosquitoes Aedes aegypti and Aedes albopictus. Microorganisms, 9 (8) 1653, 1653. doi: 10.3390/microorganisms9081653
2021
Journal Article
A 1958 isolate of Kedougou Virus (KEDV) from Ndumu, South Africa, expands the geographic and temporal range of KEDV in Africa
Jansen van Vuren, Petrus , Parry, Rhys, Khromykh, Alexander A. and Paweska, Janusz T. (2021). A 1958 isolate of Kedougou Virus (KEDV) from Ndumu, South Africa, expands the geographic and temporal range of KEDV in Africa. Viruses, 13 (7) 1368, 1368. doi: 10.3390/v13071368
2021
Journal Article
Human blood microRNA hsa-miR-21-5p induces vitellogenin in the mosquito Aedes aegypti
Perdomo, Hugo D., Hussain, Mazhar, Parry, Rhys, Etebari, Kayvan, Hedges, Lauren M., Zhang, Guangmei, Schulz, Benjamin L. and Asgari, Sassan (2021). Human blood microRNA hsa-miR-21-5p induces vitellogenin in the mosquito Aedes aegypti. Communications Biology, 4 (1) 856, 856. doi: 10.1038/s42003-021-02385-7
2021
Journal Article
A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses
Amarilla, Alberto A., Sng, Julian D. J., Parry, Rhys, Deerain, Joshua M., Potter, James R., Setoh, Yin Xiang, Rawle, Daniel J., Le, Thuy T., Modhiran, Naphak, Wang, Xiaohui, Peng, Nias Y. G., Torres, Francisco J., Pyke, Alyssa, Harrison, Jessica J., Freney, Morgan E., Liang, Benjamin, McMillan, Christopher L. D., Cheung, Stacey T. M., Guevara, Darwin J Da Costa, Hardy, Joshua M., Bettington, Mark, Muller, David A., Coulibaly, Fasséli, Moore, Frederick, Hall, Roy A., Young, Paul R., Mackenzie, Jason M., Hobson-Peters, Jody, Suhrbier, Andreas ... Khromykh, Alexander A. (2021). A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses. Nature Communications, 12 (1) 3431, 3431. doi: 10.1038/s41467-021-23779-5
Funding
Current funding
Supervision
Availability
- Dr Rhys Parry is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
Survey of farmers¿ perceptions of gastrointestinal parasites and investigation of prevalence, impact, and control of these parasites on sub-tropical dairy cattle
Associate Advisor
Other advisors: Dr Ben Wood, Professor Ricardo Soares Magalhaes, Dr Shahab Ranjbar Nezhad Isfahani, Dr Swaid Abdullah
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Doctor Philosophy
Predicting and preparing for the unfolding evolution of SARS-CoV-2
Associate Advisor
Other advisors: Professor Alexander Khromykh
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Doctor Philosophy
Survey of farmers¿ perceptions of gastrointestinal parasites and investigation of prevalence, impact, and control of these parasites on sub-tropical dairy cattle
Associate Advisor
Other advisors: Dr Ben Wood, Professor Ricardo Soares Magalhaes, Dr Shahab Ranjbar Nezhad Isfahani, Dr Swaid Abdullah
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Doctor Philosophy
Predicting and preparing for the unfolding evolution of SARS-CoV-2
Associate Advisor
Other advisors: Professor Alexander Khromykh
Media
Enquiries
Contact Dr Rhys Parry directly for media enquiries about:
- SARS-CoV-2
- Virology
- Virus evolution
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