Professor James De Voss
Professor

James De Voss

Email: 
Phone: 
+61 7 336 54622

Background

James De Voss received a B. Sc (Hons) in Chemistry and a University Medal from the University of Queensland in 1984. He was a Royal Commission for the Exhibition of 1851 scholar at Cambridge University, where he worked on the biosynthesis of Vitamin B12 with Prof. Sir Alan Battersby. A postdoctoral fellowship, again from the Royal Commission for the Exhibition of 1851, allowed him to work with Prof. Craig Townsend at Johns Hopkins University on the mechanism of DNA cleavage caused by the enediyne antibiotic calicheamicin. He was then introduced to the cytochromes P450 by Prof. Paul Ortiz de Montellano with whom he worked while at the University of California, San Francisco. Since returning to the University of Queensland to take up an academic appointment, initially as a Senior lecturer and subsequently as a Reader and then a Professor, he has continued his interest in problems at the interface of chemistry and biology and currently works with a range of bacterial, insect and mammalian P450s, as well as on the biogenesis of insect pheromones and phytochemistry of herbal medicines.

Availability

Professor James De Voss is:
Available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy, University of Cambridge

Search Professor James De Voss’s works on UQ eSpace

252 works between 1985 and 2025
All (252) Journal Article (196) Book Chapter (5) Conference Publication (50) Other Outputs (1)

221 - 240 of 252 works

2000

Journal Article

Expression, purification, and characterization of biol: A carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis

Stok, J. and De Voss, J. J. (2000). Expression, purification, and characterization of biol: A carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis. Archives of Biochemistry And Biophysics, 384 (2), 351-360. doi: 10.1006/abbi.2000.2067

Expression, purification, and characterization of biol: A carbon-carbon bond cleaving cytochrome P450 involved in biotin biosynthesis in Bacillus subtilis

2000

Conference Publication

Oxidation of indole by human cytochrome P450 enzymes

Guengerich, F. P., Cai, H., Notley, L., De Voss, J. J. and Gillam, E. M. J. (2000). Oxidation of indole by human cytochrome P450 enzymes. Joint meeting ASBMB/ASPET 2000, Boston, MA, USA, 4 - 8 June, 2000. BETHESDA: The Federation of American Societies for Experimental Biology.

Oxidation of indole by human cytochrome P450 enzymes

2000

Journal Article

Oxidation of Indole by Cytochrome P450 Enzymes

Gillam, E. M. J., Notley, L. M., Cai, H. L., De Voss, J. J. and Guengerich, F. P. (2000). Oxidation of Indole by Cytochrome P450 Enzymes. Biochemistry, 39 (45), 13817-13824. doi: 10.1021/bi001229u

Oxidation of Indole by Cytochrome P450 Enzymes

2000

Conference Publication

A carbon-carbon bond cleaving enzyme involved in biotin biosynthesis

Stok, J., Cryle, M. J. and De Voss, J. J. (2000). A carbon-carbon bond cleaving enzyme involved in biotin biosynthesis. BICS III, Brisbane, 30 November, 2000. Australia: Royal Australian Chemical Institute.

A carbon-carbon bond cleaving enzyme involved in biotin biosynthesis

1999

Journal Article

Iron acquisition and metabolism by mycobacteria

De Voss, James J., Rutter, Kerry, Schroeder, Benjamin G. and Barry, Clifton E. (1999). Iron acquisition and metabolism by mycobacteria. Journal of Bacteriology, 181 (15), 4443-4451. doi: 10.1128/jb.181.15.4443-4451.1999

Iron acquisition and metabolism by mycobacteria

1999

Conference Publication

Investigation into the biosynthesis of the major sex pheromone from B.cacuminata and B. cucumis

Stok, J., De Voss, J. J. and Kitching, W. (1999). Investigation into the biosynthesis of the major sex pheromone from B.cacuminata and B. cucumis. 1st Asia-Pacific Conference on Chemical Ecology, Shanghai, China, 1 -4 November 1999. Shanghai, China: Chinese Academy of Science.

Investigation into the biosynthesis of the major sex pheromone from B.cacuminata and B. cucumis

1999

Journal Article

Formation of indigo by recombinant mammalian cytochrome P450

Gillam, E. M. J., Aguinaldo, A. M. A., Notley, L. M., Kim, D., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., DeVoss, J. J. and Guengerich, F. P. (1999). Formation of indigo by recombinant mammalian cytochrome P450. Biochemical and Biophysical Research Communications, 265 (2), 469-472. doi: 10.1006/bbrc.1999.1702

Formation of indigo by recombinant mammalian cytochrome P450

1998

Journal Article

Biogenesis of sex pheromones in the female olive fruit-fly

Hungerford, Natasha L., Mazomenos, Basilis E., Konstantopoulou, Maria A., Krokos, Fragoulis D., Haniotakis, George E., Hubener, Achim, Fletcher, Mary T., Moore, Christopher J., DeVoss, James J. and Kitching, William (1998). Biogenesis of sex pheromones in the female olive fruit-fly. Chemical Communications, 29 (8), 863-864. doi: 10.1039/a800691a

Biogenesis of sex pheromones in the female olive fruit-fly

1997

Journal Article

Bioactivation of Phenytoin by Human Cytochrome P450: Characterization of the Mechanism and Targets of Covalent Adduct Formation

Munns, Andrew J., De Voss, James J., Hooper, Wayne D., Dickinson, Ronald G. and Gillam, Elizabeth M. J. (1997). Bioactivation of Phenytoin by Human Cytochrome P450: Characterization of the Mechanism and Targets of Covalent Adduct Formation. Chemical Research In Toxicology, 10 (9), 1049-1058. doi: 10.1021/tx9700836

Bioactivation of Phenytoin by Human Cytochrome P450: Characterization of the Mechanism and Targets of Covalent Adduct Formation

1997

Journal Article

The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease

Rutenber, Earl E., De Voss, James J., Hoffman, Lucas, Stroud, Robert M., Lee, Kwan H., Alvarez, Juan, McPhee, Fiona, Craik, Charles and Ortiz De Montellano, Paul R. (1997). The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease. Bioorganic and Medicinal Chemistry, 5 (7), 1311-1320. doi: 10.1016/S0968-0896(97)00078-3

The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease

1997

Journal Article

Substrate docking algorithms and prediction of the substrate specificity of cytochrome P450(cam) and its L244A mutant

De Voss, James J., Sibbesen, Ole, Zhang, Zhoupeng and Ortiz De Montellano, Paul R. (1997). Substrate docking algorithms and prediction of the substrate specificity of cytochrome P450(cam) and its L244A mutant. Journal of the American Chemical Society, 119 (24), 5489-5498. doi: 10.1021/ja970349v

Substrate docking algorithms and prediction of the substrate specificity of cytochrome P450(cam) and its L244A mutant

1997

Journal Article

Synthetic studies relevant to biosynthetic research on vitamin B12. Part 12. Modification of the periphery of chlorins and isobacteriochlorins

De Voss, James J., Leeper, Finian J. and Battersby, Alan R. (1997). Synthetic studies relevant to biosynthetic research on vitamin B12. Part 12. Modification of the periphery of chlorins and isobacteriochlorins. Journal of the Chemical Society - Perkin Transactions 1 (8), 1105-1116. doi: 10.1039/a607852d

Synthetic studies relevant to biosynthetic research on vitamin B12. Part 12. Modification of the periphery of chlorins and isobacteriochlorins

1997

Conference Publication

Purification and characterisation of P450

De Voss, J. J. and Stok, J. E. (1997). Purification and characterisation of P450. 1997 Faseb Summer Research Conference On Amyloid, Copper Mountain, Colorado, 13-18 July, 1997. Bethesda, MD: Federation of American Societies for Experimental Biology.

Purification and characterisation of P450

1997

Journal Article

Purification and characterisation of P450Biol

De Voss J.J. and Stok J.E. (1997). Purification and characterisation of P450Biol. FASEB Journal, 11 (9)

Purification and characterisation of P450Biol

1996

Journal Article

Putidaredoxin reductase-putidaredoxin-cytochrome P450(cam) triple fusion protein. Construction of a self-sufficient Escherichia coli catalytic system

Sibbesen, Ole, De Voss, James J. and Ortiz de Montellano, Paul R. (1996). Putidaredoxin reductase-putidaredoxin-cytochrome P450(cam) triple fusion protein. Construction of a self-sufficient Escherichia coli catalytic system. Journal of Biological Chemistry, 271 (37), 22462-22469. doi: 10.1074/jbc.271.37.22462

Putidaredoxin reductase-putidaredoxin-cytochrome P450(cam) triple fusion protein. Construction of a self-sufficient Escherichia coli catalytic system

1996

Journal Article

Irreversible inhibition of the HIV-1 protease: Targeting alkylating agents to the catalytic aspartate groups

Yu, Z., Caldera, P., McPhee, F., De Voss, J. J., Jones, P. R., Burlingame, A. L., Kuntz, I. D., Craik, C. S. and Ortiz De Montellano, P. R. (1996). Irreversible inhibition of the HIV-1 protease: Targeting alkylating agents to the catalytic aspartate groups. Journal of the American Chemical Society, 118 (25), 5846-5856. doi: 10.1021/ja954069w

Irreversible inhibition of the HIV-1 protease: Targeting alkylating agents to the catalytic aspartate groups

1996

Journal Article

Substrate docking algorithms and the predicition of substrate specificity

De Voss, James J. and Ortiz De Montellano, Paul R. (1996). Substrate docking algorithms and the predicition of substrate specificity. Methods in Enzymology, 272, 336-347.

Substrate docking algorithms and the predicition of substrate specificity

1995

Journal Article

Enhanced secretion of glycocholic acid in a specially adapted cell line is associated with overexpression of apparently novel ATP-binding cassette proteins

Brown Jr., R. S., Lomri, N., De Voss, J., Rahmaoui, C. M., Xie, M. H., Hua, T., Lidofsky, S. D. and Scharschmidt, B. F. (1995). Enhanced secretion of glycocholic acid in a specially adapted cell line is associated with overexpression of apparently novel ATP-binding cassette proteins. Proceedings of the National Academy of Sciences of the United States of America, 92 (12), 5421-5425. doi: 10.1073/pnas.92.12.5421

Enhanced secretion of glycocholic acid in a specially adapted cell line is associated with overexpression of apparently novel ATP-binding cassette proteins

1995

Journal Article

Computer-Assisted, Structure-Based Prediction of Substrates for Cytochrome P450cam

De Voss, James J. and Ortiz de Montellano, Paul R. (1995). Computer-Assisted, Structure-Based Prediction of Substrates for Cytochrome P450cam. Journal of the American Chemical Society, 117 (14), 4185-4186. doi: 10.1021/ja00119a041

Computer-Assisted, Structure-Based Prediction of Substrates for Cytochrome P450cam

1994

Journal Article

Nonpeptide HIV Protease Inhibitors. Differential Introduction of Alkylamino Groups into the Two Aryl Rings of Haloperidol

Lee, Kwan Hee, McPhee, Fiona, DeVoss, James J., Craik, Charles S. and de Montellano, Paul R. Ortiz (1994). Nonpeptide HIV Protease Inhibitors. Differential Introduction of Alkylamino Groups into the Two Aryl Rings of Haloperidol. Journal of Organic Chemistry, 59 (21), 6194-6199. doi: 10.1021/jo00100a021

Nonpeptide HIV Protease Inhibitors. Differential Introduction of Alkylamino Groups into the Two Aryl Rings of Haloperidol

Current funding

  • 2024 - 2027
    New biocatalysts for selective chemical oxidations under extreme conditions (ARC Discovery Project administered by The University of Adelaide)
    University of Adelaide
    Open grant

Past funding

  • 2021 - 2024
    Mycobacterial Cholesterol Degradation: A Unique Metabolic Weakness?
    ARC Discovery Projects
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Enabling at Traditional Australian Medicinal Plants Agribusiness (CRCNA project administered by Integria Healthcare Pty Ltd)
    CRC for Developing Northern Australia
    Open grant
  • 2018 - 2019
    Gas chromatography: Separating inseparables, identifying unidentifiables (ARC LIEF grant administered by Monash University)
    Monash University
    Open grant
  • 2017 - 2019
    Development of a bio-enabled synthesis for the glycopeptide antibiotics (ARC Discovery Project administered by Monash University)
    Monash University
    Open grant
  • 2016 - 2017
    Bio-actives: Value-adding to industrial hemp production
    UQ Collaboration and Industry Engagement Fund - FirstLink
    Open grant
  • 2015
    Separation of Terpenes
    UniQuest Pty Ltd
    Open grant
  • 2015 - 2016
    Online, virtual and adaptive learning environments: improving the journey through large first year chemistry courses
    Technology-Enhanced Learning Grants
    Open grant
  • 2014 - 2015
    Identification of Dopamine Receptor Agonists from Chaste Tree Berry
    UniQuest Pty Ltd
    Open grant
  • 2014 - 2017
    Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines
    ARC Linkage Projects
    Open grant
  • 2014 - 2016
    Understanding the mechanism of two important cytochrome P450 catalysed reactions: dehydrogenation and C-C cleavage
    ARC Discovery Projects
    Open grant
  • 2013 - 2014
    Can understanding antibiotic biogenesis allow construction of chemotherapeutics?
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2013 - 2015
    Understanding the structural basis for catalysis and substrate specificity in non-heme diiron medium-chain alkane hydroxylases (ARC Discovery Project administered by Monash University)
    Monash University
    Open grant
  • 2011 - 2013
    A NEW CHEMOTHERAPEUTIC TARGET FROM LEISHMANIA SPP. UNDERSTANDING AND INHIBITING CYP61LD, A STEROL C22 DESATURASE
    ARC Discovery Projects
    Open grant
  • 2010 - 2011
    Biotransformation of Cholesterol into Commercially Important Steroidal Saponins Present in Herbal Medicines
    UQ FirstLink Scheme
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2010
    Cytochrome P450 libraries for Lead Optimisation in Drug Discovery
    UQ FirstLink Scheme
    Open grant
  • 2009 - 2011
    Putting smells into context: Using in vivo technologies to understand plant-insect odour signalling.
    ARC Discovery Projects
    Open grant
  • 2008 - 2009
    Analytical and preparative enantioselective chromatography
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2008 - 2010
    Understanding and Inhibiting P450 CYP24, a target for cancer chemotherapeutics
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    An X-Ray Diffraction Facility for Molecular Structure Determination
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2007
    Understanding and Inhibiting P450 CYP24, a target for cancer chemotherapuetics.
    UQ External Support Enabling Grant
    Open grant
  • 2006
    A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2008
    Biocatalysts mined from cytochrome P450 Libraries: an innovative tool for accelerating drug development
    ARC Linkage Projects
    Open grant
  • 2004 - 2005
    Molecular Breeding Of Biocatalysts Mined From Cytochrome P450 Libraries: An Innovative Tool for Accelerating Drug Development
    UQ FirstLink Scheme
    Open grant
  • 2004 - 2007
    What is in therapeutically prescribed herbal medicines? Phytochemical characterisation of steroidal saponins from two popular nutraceuticals, False Unicorn and Tribulus terrestris.
    ARC Linkage Projects
    Open grant
  • 2004 - 2006
    Disruption of Sex Pheromone Biosynthesis: A Novel Control Method for Pestiferous Fruit Flies
    ARC Discovery Projects
    Open grant
  • 2004
    The Insect-Plant Chemical Ecology Network (IPCEN)
    ARC Seed Funding for Research Networks
    Open grant
  • 2003
    Unprecedented Alkaloid Hybrids that Selectively Modulate Various Cancers and the Central Nervous System
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2005
    Structural chacterization of active constituents in plant extracts with potential for the control of ovine lice and parasitic worms
    ARC Linkage Projects
    Open grant
  • 2002 - 2004
    Molecular breeding of cytochrome P450 enzymes
    ARC Discovery Projects
    Open grant
  • 2001 - 2003
    The Biosynthesis of Mycobactin T, a Virulence Factor from Mycobacterium Tuberculosis
    NHMRC Project Grant
    Open grant
  • 1998
    Characterisation of Biol, a Carbon Carbon Bond Cleaving P450
    ARC Australian Research Council (Small grants)
    Open grant
  • 1998 - 2000
    Fruit-fly sex pheromones: biosynthesis and enzymology
    ARC Australian Research Council (Large grants)
    Open grant
  • 1998 - 2000
    Polyketide synthases from marine molluscs
    ARC Australian Research Council (Large grants)
    Open grant
  • 1997
    Conversion of P450cn into P450 cam: a prelude to engineering biodegradative pathways
    ARC Australian Research Council (Small grants)
    Open grant
  • 1996
    Cloning, expression and characterisation of two novel proteins involved in biotin biosynthesis
    University of Queensland New Staff Research Grant
    Open grant
  • 1996 - 1998
    Pyochelin: a siderophore and virulence factor from pathogenic pseudomonads
    NHMRC Project Grant
    Open grant

Availability

Professor James De Voss is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Structure Elucidation in Pursuit of Bioactive Compounds

    Principal Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Bioactive Phytochemicals from Australian Native Plants used as Ingienous medicines

    Principal Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Microbial manufacturing of plant saponin-inspired vaccine adjuvants

    Principal Advisor

    Other advisors: Professor Craig Williams

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Synthesis of peptide antibiotic constituents for elucidation of their biosyntheses and II) Characterization of bacterial cytochromes P450

    Principal Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Exploiting plant biosynthesis to produce vaccine adjuvants

    Associate Advisor

    Other advisors: Dr Birgitta Ebert

  • Doctor Philosophy

    Isolation and identification of natural products from Australian Native Medicinal Plants

    Associate Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Engineering Saccharomyces cerevisiae for triterpenoid production

    Associate Advisor

    Other advisors: Dr Birgitta Ebert

  • Doctor Philosophy

    Stingless bee enzymes for biotransformation of cane sugar to a low GI sugar

    Associate Advisor

    Other advisors: Emerita Professor Mary Fletcher, Dr Loan Nguyen, Dr Natasha Hungerford

  • Doctor Philosophy

    Synthesis of novel probes and inhibitors of carbohydrate-binding proteins

    Associate Advisor

    Other advisors: Professor Vito Ferro

  • Doctor Philosophy

    Isolation and identification of natural products from Australian Native Medicinal Plants

    Associate Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Identification of the Structure and bioavailability of bioactive compounds from Australian native plants.

    Associate Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Stingless bee enzymes for biotransformation of cane sugar to a low GI sugar

    Associate Advisor

    Other advisors: Emerita Professor Mary Fletcher, Dr Loan Nguyen, Dr Natasha Hungerford

Completed supervision

Enquiries

Contact Professor James De Voss directly for media enquiries about:

  • Bio-organic chemistry
  • Biosynthesis of natural products
  • Chemistry - organic
  • Enzymes - P450
  • Enzymology
  • Herbs - bioactives
  • Natural products - chemistry of
  • Organic chemistry
  • P450 enzymes

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