
Overview
Background
James De Voss received a B. Sc (Hons) in Chemistry and a University Medal from the University of Queensland in 1984. He was a Royal Commission for the Exhibition of 1851 scholar at Cambridge University, where he worked on the biosynthesis of Vitamin B12 with Prof. Sir Alan Battersby. A postdoctoral fellowship, again from the Royal Commission for the Exhibition of 1851, allowed him to work with Prof. Craig Townsend at Johns Hopkins University on the mechanism of DNA cleavage caused by the enediyne antibiotic calicheamicin. He was then introduced to the cytochromes P450 by Prof. Paul Ortiz de Montellano with whom he worked while at the University of California, San Francisco. Since returning to the University of Queensland to take up an academic appointment, initially as a Senior lecturer and subsequently as a Reader and then a Professor, he has continued his interest in problems at the interface of chemistry and biology and currently works with a range of bacterial, insect and mammalian P450s, as well as on the biogenesis of insect pheromones and phytochemistry of herbal medicines.
Availability
- Professor James De Voss is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy, University of Cambridge
Works
Search Professor James De Voss’s works on UQ eSpace
2018
Journal Article
Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675)
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161
2018
Journal Article
Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris catalyzes heteroatom dealkylations, sulfoxidation, and amide and cyclic hemiacetal formation
Coleman, Tom, Wong, Siew Hoon, Podgorski, Matthew N., Bruning, John B., De Voss, James J. and Bell, Stephen G. (2018). Cytochrome P450 CYP199A4 from Rhodopseudomonas palustris catalyzes heteroatom dealkylations, sulfoxidation, and amide and cyclic hemiacetal formation. ACS Catalysis, 8 (7), 5915-5927. doi: 10.1021/acscatal.8b00909
2018
Journal Article
Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism
Greule, Anja, Stok, Jeanette E., De Voss, James J. and Cryle, Max J. (2018). Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism. Natural Product Reports, 35 (8), 757-791. doi: 10.1039/c7np00063d
2018
Conference Publication
Identifying the pyrrolizidine alkaloid LC-MS/MS profile of Blue heliotrope (Heliotropium amplexicaule)
Matheus Carpinelli de Jesus, Natasha Hungerford, Steve Carter, Shalona Anuj, Joanne Blanchfield, James De Voss and Mary Fletcher (2018). Identifying the pyrrolizidine alkaloid LC-MS/MS profile of Blue heliotrope (Heliotropium amplexicaule). QMSS 2018 – 3rd Queensland Mass Spectrometry Symposium, QUT, Brisbane, 6-7 December 2018.
2018
Conference Publication
Pyrrolizidine alkaloids in Blue Heliotrope (Heliotropium amplexicaule) in Australia
Carpinelli de Jesus, M., Hungerford, N. L., Carter, S. J., Anuj, S. R., De Voss, J. J., Blanchfield, J. T. and Fletcher, M. T. (2018). Pyrrolizidine alkaloids in Blue Heliotrope (Heliotropium amplexicaule) in Australia. 10th International Symposium of Poisonous Plants (ISOPP10), St George, Utah, United States, 16-20 September 2018.
2017
Journal Article
Metabolomics and genomics combine to unravel the pathway for the presence of fragrance in rice
Daygon, Venea Dara, Calingacion, Mariafe, Forster, Louise C., De Voss, James J., Schwartz, Brett D., Ovenden, Ben, Alonso, David E., McCouch, Susan R., Garson, Mary J. and Fitzgerald, Melissa A. (2017). Metabolomics and genomics combine to unravel the pathway for the presence of fragrance in rice. Scientific Reports, 7 (1) 8767, 8767. doi: 10.1038/s41598-017-07693-9
2017
Conference Publication
P450 catalysed dehydrogenation
Wong, Siew Hoon, Bell, Stephen G. and De Voss, James J. (2017). P450 catalysed dehydrogenation. Berlin, Germany: Walter de Gruyter GmbH. doi: 10.1515/pac-2016-1216
2017
Journal Article
Stable isotope dilution assay (SIDA) and HS-SPME-GCMS quantification of key aroma volatiles for fruit and sap of Australian mango cultivars
San, Anh T., Joyce, Daryl C., Hofman, Peter J., Macnish, Andrew J., Webb, Richard I., Matovic, Nicolas J., Williams, Craig M., De Voss, James J., Wong, Siew H. and Smyth, Heather E. (2017). Stable isotope dilution assay (SIDA) and HS-SPME-GCMS quantification of key aroma volatiles for fruit and sap of Australian mango cultivars. Food Chemistry, 221, 613-619. doi: 10.1016/j.foodchem.2016.11.130
2017
Book Chapter
CW and pulse EPR of cytochrome P450 to determine structure and function
Harbort, Joshua S., De Voss, James J., Stok, Jeanette E., Bell, Stephen G. and Harmer, Jeffrey R. (2017). CW and pulse EPR of cytochrome P450 to determine structure and function. Future directions in metalloprotein and metalloenzyme research. (pp. 103-142) edited by Graeme Hanson and Lawrence Berliner. New York, United States: Springer. doi: 10.1007/978-3-319-59100-1_5
2016
Journal Article
Modification of an enzyme biocatalyst for the efficient and selective oxidative demethylation of para-substituted benzene derivatives
Chao, Rebecca R., Lau, Ian C. -K., De Voss, James J. and Bell, Stephen G. (2016). Modification of an enzyme biocatalyst for the efficient and selective oxidative demethylation of para-substituted benzene derivatives. ChemCatChem, 8 (23), 3626-3635. doi: 10.1002/cctc.201600951
2016
Journal Article
Thermo-alkaline treatment as a practical degradation strategy to reduce indospicine contamination in camel meat
Tan, Eddie T. T., Yong, Ken W. L., Wong, Siew-Hoon, D'Arcy, Bruce R., Al Jassim, Rafat, De Voss, James J. and Fletcher, Mary T. (2016). Thermo-alkaline treatment as a practical degradation strategy to reduce indospicine contamination in camel meat. Journal of Agricultural And Food Chemistry, 64 (44), 8447-8453. doi: 10.1021/acs.jafc.6b03499
2016
Journal Article
The efficient and selective catalytic oxidation of para-substituted cinnamic acid derivatives by the cytochrome P450 monooxygenase, CYP199A4
Chao, Rebecca R., De Voss, James J. and Bell, Stephen G. (2016). The efficient and selective catalytic oxidation of para-substituted cinnamic acid derivatives by the cytochrome P450 monooxygenase, CYP199A4. Rsc Advances, 6 (60), 55286-55297. doi: 10.1039/c6ra11025h
2016
Journal Article
The importance of the benzoic acid carboxylate moiety for substrate recognition by CYP199A4 from Rhodopseudomonas palustris HaA2
Coleman, Tom, Chao, Rebecca R., de Voss, James J. and Bell, Stephen G. (2016). The importance of the benzoic acid carboxylate moiety for substrate recognition by CYP199A4 from Rhodopseudomonas palustris HaA2. Biochimica et Biophysica Acta, 1864 (6), 667-675. doi: 10.1016/j.bbapap.2016.03.006
2016
Journal Article
In vivo and in vitro hydroxylation of cineole and camphor by cytochromes P450CYP101A1, CYP101B1 and N242A CYP176A1
Stok, Jeanette E., Hall, Emma A., Stone, Isobella S. J, Noble, Margaret C., Wong, Siew Hoon, Bell, Stephen G. and De Voss, James J. (2016). In vivo and in vitro hydroxylation of cineole and camphor by cytochromes P450CYP101A1, CYP101B1 and N242A CYP176A1. Journal of Molecular Catalysis B: Enzymatic, 128, 52-64. doi: 10.1016/j.molcatb.2016.03.004
2016
Journal Article
Cholesterol analogs with degradation-resistant alkyl side chains are effective Mycobacterium tuberculosis growth inhibitors
Frank, Daniel J., Zhao, Yan, Wong, Siew Hoon, Basudhar, Debashree, De Voss, James J. and De Montellano, Paul R. Ortiz (2016). Cholesterol analogs with degradation-resistant alkyl side chains are effective Mycobacterium tuberculosis growth inhibitors. Journal of Biological Chemistry, 291 (14), 7325-7333. doi: 10.1074/jbc.M115.708172
2016
Journal Article
Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Frontispiece: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere. Angewandte Chemie International Edition, 55 (11), 8359-8359. doi: 10.1002/anie.201681161
2016
Journal Article
Direct observation of an oxepin from a bacterial cytochrome P450-catalyzed oxidation
Stok, Jeanette E., Chow, Sharon, Krenske, Elizabeth H., Farfan Soto, Clementina, Matyas, Csongor, Poirier, Raymond A., Williams, Craig M. and De Voss, James J. (2016). Direct observation of an oxepin from a bacterial cytochrome P450-catalyzed oxidation. Chemistry: A European Journal, 22 (13), 4408-4412. doi: 10.1002/chem.201600246
2016
Journal Article
Validating Eaton's hypothesis: cubane as a benzene bioisostere
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2016). Validating Eaton's hypothesis: cubane as a benzene bioisostere. Angewandte Chemie (International Edition), 55 (11), 3580-3585. doi: 10.1002/anie.201510675
2016
Journal Article
Synthesis of L-Indospicine, [5,5,6-2H3 ]- L-Indospicine and L-Norindospicine
Lang, Cheng-Shan, Wong, Siew-Hoon, Chow, Sharon, Challinor, Victoria L., Yong, Ken W. L., Fletcher, Mary T., Arthur, Dionne M., Ng, Jack C. and De Voss, James J. (2016). Synthesis of L-Indospicine, [5,5,6-2H3 ]- L-Indospicine and L-Norindospicine. Organic and Biomolecular Chemistry, 14 (28), 6826-6832. doi: 10.1039/C6OB01187J
2016
Conference Publication
Establishing compositional guidelines for flavonoids and saponins in Gynostemma pentaphyllum
Leach, D., Ahmed, I., De Voss, J. and Wohlmuth, H. (2016). Establishing compositional guidelines for flavonoids and saponins in Gynostemma pentaphyllum. 9th Joint Meeting of AFERP, ASP, GA, JSP, PSE and SIF, Copenhagen Denmark, 24 - 27 July 2016. Stuttgart, Germany: Georg Thieme Verlag. doi: 10.1055/s-0036-1597033
Funding
Current funding
Past funding
Supervision
Availability
- Professor James De Voss is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Microbial manufacturing of plant saponin-inspired vaccine adjuvants
Principal Advisor
Other advisors: Professor Craig Williams
-
Doctor Philosophy
Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications
Principal Advisor
-
Doctor Philosophy
Synthesis of peptide antibiotic constituents for elucidation of their biosyntheses and II) Characterization of bacterial cytochromes P450
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
Doctor Philosophy
Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications
Principal Advisor
-
Doctor Philosophy
Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications
Principal Advisor
-
Doctor Philosophy
Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications
Principal Advisor
-
Doctor Philosophy
Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications
Principal Advisor
-
Doctor Philosophy
Bioactive Phytochemicals from Australian Native Plants used as Ingienous medicines
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
Doctor Philosophy
Identification of the Structure and bioavailability of bioactive compounds from Australian native plants.
Associate Advisor
Other advisors: Professor Joanne Blanchfield
-
Doctor Philosophy
Stingless bee enzymes for biotransformation of cane sugar to a low GI sugar
Associate Advisor
Other advisors: Emerita Professor Mary Fletcher, Dr Loan Nguyen, Dr Natasha Hungerford
-
Doctor Philosophy
Synthesis of novel probes and inhibitors of carbohydrate-binding proteins
Associate Advisor
Other advisors: Professor Vito Ferro
-
Doctor Philosophy
Engineering Saccharomyces cerevisiae for triterpenoid production
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Stingless bee enzymes for biotransformation of cane sugar to a low GI sugar
Associate Advisor
Other advisors: Emerita Professor Mary Fletcher, Dr Loan Nguyen, Dr Natasha Hungerford
-
Doctor Philosophy
Isolation and identification of natural products from Australian Native Medicinal Plants
Associate Advisor
Other advisors: Professor Joanne Blanchfield
-
Doctor Philosophy
Exploiting plant biosynthesis to produce vaccine adjuvants
Associate Advisor
Other advisors: Dr Birgitta Ebert
-
Doctor Philosophy
Isolation and identification of natural products from Australian Native Medicinal Plants
Associate Advisor
Other advisors: Professor Joanne Blanchfield
Completed supervision
-
2024
Doctor Philosophy
I) Synthesis of peptide antibiotic constituents for elucidation of their biosyntheses and II) Characterization of bacterial cytochromes P450
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2023
Doctor Philosophy
Isolation and Characterization of Bioactive Australian Natural Products
Principal Advisor
-
2023
Doctor Philosophy
Synthesis for the exploration and exploitation of Cytochrome P450 enzymes
Principal Advisor
Other advisors: Professor Craig Williams
-
2023
Doctor Philosophy
Characterisation of Bacterial Cytochromes P450
Principal Advisor
Other advisors: Professor Paul Bernhardt
-
2021
Doctor Philosophy
Synthesis of cholesterol derivatives for exploration of cytochromes P450 from Dioscorea transversa and inhibition of Mycobacterium tuberculosis
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2021
Doctor Philosophy
Biosynthesis of Steroidal Saponins
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2020
Doctor Philosophy
Synthesis of Mechanistic Probes for Cytochrome P450 Catalysed Desaturation
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2019
Doctor Philosophy
Phytochemistry of Gynostemma pentaphyllum (Thunb.) Makino
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2016
Doctor Philosophy
Unusual cytochrome P450-catalysed reactions: synthesis of small molecule probes
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2014
Doctor Philosophy
CYP710C1: Mechanism and Design of Inhibitors
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2013
Doctor Philosophy
Steroidal Saponins from Medicinal Herbs
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2012
Doctor Philosophy
Cytochrome P450-catalysed oxidations: Biosynthetic and mechanistic studies
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2009
Doctor Philosophy
Cytochrome P450cin: An Investigation into the Substrate-Based Determinants of Reactivity
Principal Advisor
-
2008
Doctor Philosophy
Chemical Characterisation of Novel Metabolites from Bioactive Herbs
Principal Advisor
-
2008
Doctor Philosophy
Cytochrome P450cin: Chemistry and Biochemistry
Principal Advisor
Other advisors: Professor Paul Bernhardt
-
2007
Doctor Philosophy
TOTAL SYNTHESIS OF PROPOSED ACTIVE CONSTITUENTS IN ECHINACEA. SP. AND CHAMALERIUM LEUTEUM
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2006
Doctor Philosophy
FATTY ACID METABOLISM BY CYTOCHROMES P450
Principal Advisor
-
2005
Doctor Philosophy
SYNTHESIS AND BIOSYNTHESIS OF INSECT DERIVED SPIROACETAL PHEROMONES
Principal Advisor
-
2005
Doctor Philosophy
MEDTHOD DEVELOPMENT FOR THE SYNTHESIS OF SOME HETEROCYCLIC NATURAL PRODUCTS
Principal Advisor
-
2003
Doctor Philosophy
CYROCHROME P450cin
Principal Advisor
-
Doctor Philosophy
BACTROCERA TRYONI VOLATILES: SPIROACETAL STRUCTURE, SYNTHESIS AND BIOSYNTHESIS
Principal Advisor
-
2024
Doctor Philosophy
Characterising the structure, bioactivity and bioavailability of active compounds from complex herbal extracts
Associate Advisor
Other advisors: Professor Joanne Blanchfield
-
2024
Doctor Philosophy
Developing Chemical Building Blocks for Medicinal Chemistry and Microelectronic Applications
Associate Advisor
Other advisors: Professor Craig Williams
-
2024
Doctor Philosophy
Theoretical and experimental investigations into the mechanisms of Cytochromes P450
Associate Advisor
Other advisors: Professor Elizabeth Krenske
-
2021
Doctor Philosophy
Phytochemical characterisation of Australian medicinal plants: Doctrina veteris et novi
Associate Advisor
Other advisors: Professor Joanne Blanchfield
-
2020
Doctor Philosophy
Insights into the Chemical Composition and Ecology of Nudibranchs of the Genus Goniobranchus
Associate Advisor
Other advisors: Associate Professor Karen Cheney
-
2020
Doctor Philosophy
Development and Characterisation of Cytochrome P450 Support Systems
Associate Advisor
Other advisors: Professor Elizabeth Gillam
-
2020
Doctor Philosophy
Electron Paramagnetic Resonance Spectroscopy: A Toolbox for Characterising Molecular Structure and Function in Metal-Centred Catalysts
Associate Advisor
Other advisors: Associate Professor Jeffrey Harmer
-
2016
Doctor Philosophy
Physical and chemical interactions between bile pigments and polyaromatic mutagens
Associate Advisor
Other advisors: Professor Joanne Blanchfield
-
2016
Doctor Philosophy
Synthesis of C-2 Functionalized L-Iduronic Acid Derivatives as Potential Pharmacological Chaperones for MPS II (Hunter Syndrome)
Associate Advisor
Other advisors: Professor Vito Ferro
-
2012
Doctor Philosophy
Chemical Investigation of Marine Invertebrates from South East Queensland: Secondary Metabolites from Nudibranchs and Sponges
Associate Advisor
-
2012
Doctor Philosophy
Stable High Level Expression of Heterologous Gene Clusters Encoding Antitumour Antibiotics in Escherichia coli K12
Associate Advisor
Other advisors: Emeritus Professor John Fuerst, Emeritus Professor John Pemberton
-
2012
Doctor Philosophy
Total synthesis of (-)-neovibsanin G and (-)-14-epi-neovibsanin G and synthetic studies towards other related caged neovibsanins
Associate Advisor
Other advisors: Professor Craig Williams
-
2012
Doctor Philosophy
Directed evolution of enzymes of cytochrome P450 catalysis: Evolving CYP1A, CYP2D and P450 reductase
Associate Advisor
Other advisors: Professor Elizabeth Gillam
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2011
Doctor Philosophy
Towards the Total Synthesis of 5ß-Hydroxy-Cis-Dehydrocrotonin And Development of Novel Methodology in the Synthesis of Cis-Vinylstannanes and Cis-Vinylpinacolboronates.
Associate Advisor
Other advisors: Professor Craig Williams
-
2008
Doctor Philosophy
2-Iodoxybenzoic acid: Acidity investigations and the total synthesis of 5,14-bis-epi-spirovibsanin A
Associate Advisor
Other advisors: Professor Craig Williams
-
2007
Doctor Philosophy
REDOX PROPERTIES AND MEMBRANE LOCALIZATION OF HUMAN RECOMBINANT CYTOCHROME P450 SYSTEMS
Associate Advisor
Other advisors: Professor Elizabeth Gillam, Professor Paul Bernhardt
-
2005
Doctor Philosophy
MOLECULAR BREEDING OF CYTOCHROME P450s FOR INDIGOID PIGMENT PRODUCTION
Associate Advisor
Other advisors: Professor Elizabeth Gillam
-
2002
Doctor Philosophy
STRUCTURAL CHARACTERISATION OF INTRACELLULAR COPPER TRANSPORTING PROTEINS
Associate Advisor
Media
Enquiries
Contact Professor James De Voss directly for media enquiries about:
- Bio-organic chemistry
- Biosynthesis of natural products
- Chemistry - organic
- Enzymes - P450
- Enzymology
- Herbs - bioactives
- Natural products - chemistry of
- Organic chemistry
- P450 enzymes
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