Professor James De Voss
Professor

James De Voss

Email: 
Phone: 
+61 7 336 54622

Background

James De Voss received a B. Sc (Hons) in Chemistry and a University Medal from the University of Queensland in 1984. He was a Royal Commission for the Exhibition of 1851 scholar at Cambridge University, where he worked on the biosynthesis of Vitamin B12 with Prof. Sir Alan Battersby. A postdoctoral fellowship, again from the Royal Commission for the Exhibition of 1851, allowed him to work with Prof. Craig Townsend at Johns Hopkins University on the mechanism of DNA cleavage caused by the enediyne antibiotic calicheamicin. He was then introduced to the cytochromes P450 by Prof. Paul Ortiz de Montellano with whom he worked while at the University of California, San Francisco. Since returning to the University of Queensland to take up an academic appointment, initially as a Senior lecturer and subsequently as a Reader and then a Professor, he has continued his interest in problems at the interface of chemistry and biology and currently works with a range of bacterial, insect and mammalian P450s, as well as on the biogenesis of insect pheromones and phytochemistry of herbal medicines.

Availability

Professor James De Voss is:
Available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy, University of Cambridge

Search Professor James De Voss’s works on UQ eSpace

252 works between 1985 and 2025
All (252) Journal Article (196) Book Chapter (5) Conference Publication (50) Other Outputs (1)

141 - 160 of 252 works

2008

Journal Article

The role of the conserved threonine in P450BM3 oxygen activation: Substrate-determined hydroxylation activity of the Thr268Ala mutant

Cryle, Max J. and De Voss, James J. (2008). The role of the conserved threonine in P450BM3 oxygen activation: Substrate-determined hydroxylation activity of the Thr268Ala mutant. ChemBioChem, 9 (2), 261-266. doi: 10.1002/cbic.200700537

The role of the conserved threonine in P450BM3 oxygen activation: Substrate-determined hydroxylation activity of the Thr268Ala mutant

2007

Journal Article

Complete 1H and 13C assignments of the four major saponins from Dioscorea villosa (wild yam)

Hayes, Patricia Y., Lambert, Lynette K., Lehmann, Reg, Penman, Kerry, Kitching, William and De Voss, James J. (2007). Complete 1H and 13C assignments of the four major saponins from Dioscorea villosa (wild yam). Magnetic Resonance in Chemistry, 45 (11), 1001-1005. doi: 10.1002/mrc.2071

Complete 1H and 13C assignments of the four major saponins from Dioscorea villosa (wild yam)

2007

Journal Article

A shuffled CYP1A library shows both structural integrity and functional diversity

Johnston, Wayne A., Huang, Weiliang, De Voss, James J., Hayes, Martin A. and Gillam, Elizabeth M.J. (2007). A shuffled CYP1A library shows both structural integrity and functional diversity. Drug Metabolism And Disposition, 35 (12), 2177-2185. doi: 10.1124/dmd.107.017939

A shuffled CYP1A library shows both structural integrity and functional diversity

2007

Journal Article

A shuffled CYP2C library with a high degree of structural integrity and functional versatility

Huang, Weiliang, Johnston, Wayne A., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2007). A shuffled CYP2C library with a high degree of structural integrity and functional versatility. Archives of Biochemistry And Biophysics, 467 (2), 193-205. doi: 10.1016/j.abb.2007.08.023

A shuffled CYP2C library with a high degree of structural integrity and functional versatility

2007

Journal Article

Functional expression and characterization of cytochrome P450 52A21 from Candida albicans

Kim, Donghak, Cryle, Max J., De Voss, James J. and de Montellano, Paul R. Ortiz (2007). Functional expression and characterization of cytochrome P450 52A21 from Candida albicans. Archives of Biochemistry And Biophysics, 464 (2), 213-220. doi: 10.1016/j.abb.2007.02.032

Functional expression and characterization of cytochrome P450 52A21 from Candida albicans

2007

Journal Article

Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC: application to the analysis of fatty acid oxidation by a P450(BM3) mutant

Cryle, Max J. and De Voss, James J. (2007). Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC: application to the analysis of fatty acid oxidation by a P450(BM3) mutant. Tetrahedron: Asymmetry, 18 (4), 547-551. doi: 10.1016/j.tetasy.2007.01.034

Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC: application to the analysis of fatty acid oxidation by a P450(BM3) mutant

2007

Journal Article

Synthesis and absolute configuration of a constitutionally-new [5.6] spiroacetal from B. tryoni (Queensland fruit fly)

Booth, Yvonne K., Hayes, Patricia Y., Moore, Christopher J., Lambert, Lynette K., Kitching, William and De Voss, James J. (2007). Synthesis and absolute configuration of a constitutionally-new [5.6] spiroacetal from B. tryoni (Queensland fruit fly). Organic & Biomolecular Chemistry, 5 (7), 1111-1117. doi: 10.1039/b701833a

Synthesis and absolute configuration of a constitutionally-new [5.6] spiroacetal from B. tryoni (Queensland fruit fly)

2007

Journal Article

Extending the diversity of cytochrome P450 enzymes by DNA family shuffling

Rosic, Nedeljka N., Huang, Weiliang, Johnston, Wayne A., DeVoss, James J. and Gillam, Elizabeth M.J. (2007). Extending the diversity of cytochrome P450 enzymes by DNA family shuffling. Gene, 395 (1-2), 40-48. doi: 10.1016/j.gene.2007.01.031

Extending the diversity of cytochrome P450 enzymes by DNA family shuffling

2007

Book Chapter

Carbon-Carbon Bond Cleavage by P450 Systems

De Voss, J. and Cryle, M. (2007). Carbon-Carbon Bond Cleavage by P450 Systems. The Ubiquitous Roles of Cytochrome P450 Proteins: Metal Ions in Life Sciences, Volume 3. (pp. 397-435) edited by A. Sigel, H. Sigel and R. Sigel. United Kingdom: Wiley & Sons. doi: 10.1002/9780470028155.ch13

Carbon-Carbon Bond Cleavage by P450 Systems

2007

Journal Article

Stereoselective synthesis, natural occurrence and CB2 receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp.

Matovic, N., Matthias, A., Gertsch, J., Raduner, S., Bone, K. M., Lehmann, R. P. and DeVoss, J. J. (2007). Stereoselective synthesis, natural occurrence and CB2 receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp.. Organic & Biomolecular Chemistry, 5 (1), 169-174. doi: 10.1039/b615487e

Stereoselective synthesis, natural occurrence and CB2 receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp.

2007

Journal Article

The stereochemistry of fatty acid hydroxylation by cytochrome P450(BM3)

Cryle, Max J., Matovic, Nick J. and De Voss, James J. (2007). The stereochemistry of fatty acid hydroxylation by cytochrome P450(BM3). Tetrahedron Letters, 48 (1), 133-136. doi: 10.1016/j.tetlet.2006.10.136

The stereochemistry of fatty acid hydroxylation by cytochrome P450(BM3)

2007

Conference Publication

NMR studies found that a commercially supplied standard reference purported to be Withanolide D was instead Withanolide

Penman, K., Bone, K.M., Hayes, P.C., De Voss, J., Agarwal, A., Murali, B, Mundkinajeddu, D., Mayachari, A., Shenoy, R. and Lehmann, R. P. (2007). NMR studies found that a commercially supplied standard reference purported to be Withanolide D was instead Withanolide. 55th International Congress & Annual Meeting of the Society for Medicinal Plant Research, Karl Franzens University, Graz, Austria, 2-6 September, 2007. Stuttgart, Germany: Thieme.

NMR studies found that a commercially supplied standard reference purported to be Withanolide D was instead Withanolide

2006

Journal Article

Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome P450s?

Cryle, Max J. and De Voss, James J. (2006). Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome P450s?. Angewandte Chemie International Edition, 45 (48), 8221-8223. doi: 10.1002/anie.200603411

Is the ferric hydroperoxy species responsible for sulfur oxidation in cytochrome P450s?

2006

Conference Publication

Biodiversity and Natural Products - IUPAC International Conference (ICOB-5 & ISCNP-25) - 23-28 July 2006, Kyoto, Japan

De Voss, J. (2006). Biodiversity and Natural Products - IUPAC International Conference (ICOB-5 & ISCNP-25) - 23-28 July 2006, Kyoto, Japan. London: Current Drugs.

Biodiversity and Natural Products - IUPAC International Conference (ICOB-5 & ISCNP-25) - 23-28 July 2006, Kyoto, Japan

2006

Journal Article

Bilberry adulteration using the food dye amaranth

Penman, K. G., Halstead, C. W., Matthias, A., De Voss, J. J., Stuthe, J. M. U., Bone, K. M. and Lehmann, R. P. (2006). Bilberry adulteration using the food dye amaranth. Journal of Agricultural and Food Chemistry, 54 (19), 7378-7382. doi: 10.1021/jf061387d

Bilberry adulteration using the food dye amaranth

2006

Conference Publication

Chemical constituents of Chamaelirium luteum

Stuthe, J. M., Lambert, L. K., Lehmann, R P, Kitching, W and De Voss, J J (2006). Chemical constituents of Chamaelirium luteum. ANZMAG, Murramarang, NSW, 13-16 Feb, 2006.

Chemical constituents of Chamaelirium luteum

2006

Journal Article

Structural revision of shatavarins I and IV, the major components from the roots of Asparagus racemosus

Hayes, P. Y., Jahidin, A. H., Lehmann, R., Penman, K., Kitching, W. and De Voss, J. J. (2006). Structural revision of shatavarins I and IV, the major components from the roots of Asparagus racemosus. Tetrahedron Letters, 47 (39), 6965-6969. doi: 10.1016/j.tetlet.2006.07.121

Structural revision of shatavarins I and IV, the major components from the roots of Asparagus racemosus

2006

Journal Article

Asparinins, asparosides, curillins, curillosides and shavatarins: structural clarification with the isolation of shatavarin V, a new steroidal saponin from the root of Asparagus racemosus

Hayes, P. Y., Jahidin, A. H., Lehmann, R., Penman, K., Kitching, W. and De Voss, J. J. (2006). Asparinins, asparosides, curillins, curillosides and shavatarins: structural clarification with the isolation of shatavarin V, a new steroidal saponin from the root of Asparagus racemosus. Tetrahedron Letters, 47 (-), 8683-8687. doi: 10.1016/j.tetlet.2006.10.030

Asparinins, asparosides, curillins, curillosides and shavatarins: structural clarification with the isolation of shatavarin V, a new steroidal saponin from the root of Asparagus racemosus

2006

Journal Article

Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites

Avent, Kathryn M., DeVoss, J. J. and Gillam, Elizabeth M. J. (2006). Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites. Chemical Research In Toxicology, 19 (7), 914-920. doi: 10.1021/tx0600090

Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites

2006

Conference Publication

Bilberry adulteration using the food dye amaranth

Penman, K. G., Halstead, C. W., Matthias, A., De Voss, J J, Stuthe, J. M., Bone, K. M. and Lehmann, R P (2006). Bilberry adulteration using the food dye amaranth. RACI Natural Products Group Symposium, Wollongong, 29 Sept, 2006.

Bilberry adulteration using the food dye amaranth

Current funding

  • 2024 - 2027
    New biocatalysts for selective chemical oxidations under extreme conditions (ARC Discovery Project administered by The University of Adelaide)
    University of Adelaide
    Open grant

Past funding

  • 2021 - 2024
    Mycobacterial Cholesterol Degradation: A Unique Metabolic Weakness?
    ARC Discovery Projects
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Enabling at Traditional Australian Medicinal Plants Agribusiness (CRCNA project administered by Integria Healthcare Pty Ltd)
    CRC for Developing Northern Australia
    Open grant
  • 2018 - 2019
    Gas chromatography: Separating inseparables, identifying unidentifiables (ARC LIEF grant administered by Monash University)
    Monash University
    Open grant
  • 2017 - 2019
    Development of a bio-enabled synthesis for the glycopeptide antibiotics (ARC Discovery Project administered by Monash University)
    Monash University
    Open grant
  • 2016 - 2017
    Bio-actives: Value-adding to industrial hemp production
    UQ Collaboration and Industry Engagement Fund - FirstLink
    Open grant
  • 2015
    Separation of Terpenes
    UniQuest Pty Ltd
    Open grant
  • 2015 - 2016
    Online, virtual and adaptive learning environments: improving the journey through large first year chemistry courses
    Technology-Enhanced Learning Grants
    Open grant
  • 2014 - 2015
    Identification of Dopamine Receptor Agonists from Chaste Tree Berry
    UniQuest Pty Ltd
    Open grant
  • 2014 - 2017
    Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines
    ARC Linkage Projects
    Open grant
  • 2014 - 2016
    Understanding the mechanism of two important cytochrome P450 catalysed reactions: dehydrogenation and C-C cleavage
    ARC Discovery Projects
    Open grant
  • 2013 - 2014
    Can understanding antibiotic biogenesis allow construction of chemotherapeutics?
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2013 - 2015
    Understanding the structural basis for catalysis and substrate specificity in non-heme diiron medium-chain alkane hydroxylases (ARC Discovery Project administered by Monash University)
    Monash University
    Open grant
  • 2011 - 2013
    A NEW CHEMOTHERAPEUTIC TARGET FROM LEISHMANIA SPP. UNDERSTANDING AND INHIBITING CYP61LD, A STEROL C22 DESATURASE
    ARC Discovery Projects
    Open grant
  • 2010 - 2011
    Biotransformation of Cholesterol into Commercially Important Steroidal Saponins Present in Herbal Medicines
    UQ FirstLink Scheme
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2010
    Cytochrome P450 libraries for Lead Optimisation in Drug Discovery
    UQ FirstLink Scheme
    Open grant
  • 2009 - 2011
    Putting smells into context: Using in vivo technologies to understand plant-insect odour signalling.
    ARC Discovery Projects
    Open grant
  • 2008 - 2009
    Analytical and preparative enantioselective chromatography
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2008 - 2010
    Understanding and Inhibiting P450 CYP24, a target for cancer chemotherapeutics
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    An X-Ray Diffraction Facility for Molecular Structure Determination
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2007
    Understanding and Inhibiting P450 CYP24, a target for cancer chemotherapuetics.
    UQ External Support Enabling Grant
    Open grant
  • 2006
    A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2008
    Biocatalysts mined from cytochrome P450 Libraries: an innovative tool for accelerating drug development
    ARC Linkage Projects
    Open grant
  • 2004 - 2005
    Molecular Breeding Of Biocatalysts Mined From Cytochrome P450 Libraries: An Innovative Tool for Accelerating Drug Development
    UQ FirstLink Scheme
    Open grant
  • 2004 - 2007
    What is in therapeutically prescribed herbal medicines? Phytochemical characterisation of steroidal saponins from two popular nutraceuticals, False Unicorn and Tribulus terrestris.
    ARC Linkage Projects
    Open grant
  • 2004 - 2006
    Disruption of Sex Pheromone Biosynthesis: A Novel Control Method for Pestiferous Fruit Flies
    ARC Discovery Projects
    Open grant
  • 2004
    The Insect-Plant Chemical Ecology Network (IPCEN)
    ARC Seed Funding for Research Networks
    Open grant
  • 2003
    Unprecedented Alkaloid Hybrids that Selectively Modulate Various Cancers and the Central Nervous System
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2005
    Structural chacterization of active constituents in plant extracts with potential for the control of ovine lice and parasitic worms
    ARC Linkage Projects
    Open grant
  • 2002 - 2004
    Molecular breeding of cytochrome P450 enzymes
    ARC Discovery Projects
    Open grant
  • 2001 - 2003
    The Biosynthesis of Mycobactin T, a Virulence Factor from Mycobacterium Tuberculosis
    NHMRC Project Grant
    Open grant
  • 1998
    Characterisation of Biol, a Carbon Carbon Bond Cleaving P450
    ARC Australian Research Council (Small grants)
    Open grant
  • 1998 - 2000
    Fruit-fly sex pheromones: biosynthesis and enzymology
    ARC Australian Research Council (Large grants)
    Open grant
  • 1998 - 2000
    Polyketide synthases from marine molluscs
    ARC Australian Research Council (Large grants)
    Open grant
  • 1997
    Conversion of P450cn into P450 cam: a prelude to engineering biodegradative pathways
    ARC Australian Research Council (Small grants)
    Open grant
  • 1996
    Cloning, expression and characterisation of two novel proteins involved in biotin biosynthesis
    University of Queensland New Staff Research Grant
    Open grant
  • 1996 - 1998
    Pyochelin: a siderophore and virulence factor from pathogenic pseudomonads
    NHMRC Project Grant
    Open grant

Availability

Professor James De Voss is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Structure Elucidation in Pursuit of Bioactive Compounds

    Principal Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Bioactive Phytochemicals from Australian Native Plants used as Ingienous medicines

    Principal Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Microbial manufacturing of plant saponin-inspired vaccine adjuvants

    Principal Advisor

    Other advisors: Professor Craig Williams

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Synthesis of peptide antibiotic constituents for elucidation of their biosyntheses and II) Characterization of bacterial cytochromes P450

    Principal Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Exploiting plant biosynthesis to produce vaccine adjuvants

    Associate Advisor

    Other advisors: Dr Birgitta Ebert

  • Doctor Philosophy

    Isolation and identification of natural products from Australian Native Medicinal Plants

    Associate Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Engineering Saccharomyces cerevisiae for triterpenoid production

    Associate Advisor

    Other advisors: Dr Birgitta Ebert

  • Doctor Philosophy

    Stingless bee enzymes for biotransformation of cane sugar to a low GI sugar

    Associate Advisor

    Other advisors: Emerita Professor Mary Fletcher, Dr Loan Nguyen, Dr Natasha Hungerford

  • Doctor Philosophy

    Synthesis of novel probes and inhibitors of carbohydrate-binding proteins

    Associate Advisor

    Other advisors: Professor Vito Ferro

  • Doctor Philosophy

    Isolation and identification of natural products from Australian Native Medicinal Plants

    Associate Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Identification of the Structure and bioavailability of bioactive compounds from Australian native plants.

    Associate Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Stingless bee enzymes for biotransformation of cane sugar to a low GI sugar

    Associate Advisor

    Other advisors: Emerita Professor Mary Fletcher, Dr Loan Nguyen, Dr Natasha Hungerford

Completed supervision

Enquiries

Contact Professor James De Voss directly for media enquiries about:

  • Bio-organic chemistry
  • Biosynthesis of natural products
  • Chemistry - organic
  • Enzymes - P450
  • Enzymology
  • Herbs - bioactives
  • Natural products - chemistry of
  • Organic chemistry
  • P450 enzymes

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