Professor James De Voss
Professor

James De Voss

Email: 
Phone: 
+61 7 336 54622

Background

James De Voss received a B. Sc (Hons) in Chemistry and a University Medal from the University of Queensland in 1984. He was a Royal Commission for the Exhibition of 1851 scholar at Cambridge University, where he worked on the biosynthesis of Vitamin B12 with Prof. Sir Alan Battersby. A postdoctoral fellowship, again from the Royal Commission for the Exhibition of 1851, allowed him to work with Prof. Craig Townsend at Johns Hopkins University on the mechanism of DNA cleavage caused by the enediyne antibiotic calicheamicin. He was then introduced to the cytochromes P450 by Prof. Paul Ortiz de Montellano with whom he worked while at the University of California, San Francisco. Since returning to the University of Queensland to take up an academic appointment, initially as a Senior lecturer and subsequently as a Reader and then a Professor, he has continued his interest in problems at the interface of chemistry and biology and currently works with a range of bacterial, insect and mammalian P450s, as well as on the biogenesis of insect pheromones and phytochemistry of herbal medicines.

Availability

Professor James De Voss is:
Available for supervision
Media expert

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy, University of Cambridge

Search Professor James De Voss’s works on UQ eSpace

252 works between 1985 and 2025
All (252) Journal Article (196) Book Chapter (5) Conference Publication (50) Other Outputs (1)

181 - 200 of 252 works

2004

Journal Article

A precision apparatus, with solid phase micro-extraction monitoring capability, for incorporation studies of gaseous precursors into insect-derived metabolites

Fletcher, Mary T., Wood, Barry J., Schwartz, Brett D., Rahm, Fredrik, Lambert, Lynette K., Brereton, Ian M., Moore, Christopher J., De Voss, James J. and Kitching, William (2004). A precision apparatus, with solid phase micro-extraction monitoring capability, for incorporation studies of gaseous precursors into insect-derived metabolites. Arkivoc, 2004 (x), 109-117. doi: 10.3998/ark.5550190.0005.a12

A precision apparatus, with solid phase micro-extraction monitoring capability, for incorporation studies of gaseous precursors into insect-derived metabolites

2004

Journal Article

Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450(BM3)-catalysed hydroxylations

Cryle, Max J., Stuthe, Julia M. U., Ortiz de Montellano, Paul R. and De Voss, James J. (2004). Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450(BM3)-catalysed hydroxylations. Chemical Communications, 10 (5), 512-513. doi: 10.1039/b315911f

Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450(BM3)-catalysed hydroxylations

2004

Journal Article

Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9)

Davies, C., Witham, K., Scott, J. R., Pearson, A., De Voss, J. J., Graham, S. E. and Gillam, E. M. J. (2004). Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9). Drug Metabolism and Disposition, 32 (4), 431-436. doi: 10.1124/dmd.32.4.431

Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9)

2004

Conference Publication

Is Asn242 important in P450cin catalysis?

Slessor, K. E., Cavaignac, S. M., Hawkes, D. B. and De Voss, J. J. (2004). Is Asn242 important in P450cin catalysis?. 7th International Symposium on Cytochrome P450 Biodiversity &y, Hyogo, Japan, 1-5 Aug, 2004.

Is Asn242 important in P450cin catalysis?

2004

Journal Article

Carbon-carbon bond cleavage by cytochrome P450Biol (CYP107H1)

Cryle, Max J. and De Voss, James J. (2004). Carbon-carbon bond cleavage by cytochrome P450Biol (CYP107H1). Chemical Communications, 2004 (1), 86-87. doi: 10.1039/b311652b

Carbon-carbon bond cleavage by cytochrome P450Biol (CYP107H1)

2004

Conference Publication

Delineating the biosynthetic pathway to spiroacetal pheromones in Bactrocera tryoni (Queensland fruit fly)

Booth, Y. K. and De Voss, J. J. (2004). Delineating the biosynthetic pathway to spiroacetal pheromones in Bactrocera tryoni (Queensland fruit fly). BBOCS, Brisbane, 26 Nov, 2004.

Delineating the biosynthetic pathway to spiroacetal pheromones in Bactrocera tryoni (Queensland fruit fly)

2004

Journal Article

Permeability studies of alkylamides and caffeic acid conjugates from echinacea using a Caco-2 cell monolayer model

Matthias, A., Blanchfield, J. T., Penman, K. G., Toth, I., Lang, C. S., De Voss, J. J. and Lehmann, R. P. (2004). Permeability studies of alkylamides and caffeic acid conjugates from echinacea using a Caco-2 cell monolayer model. Journal of Clinical Pharmacy And Therapeutics, 29 (1), 7-13. doi: 10.1046/j.1365-2710.2003.00530.x

Permeability studies of alkylamides and caffeic acid conjugates from echinacea using a Caco-2 cell monolayer model

2004

Conference Publication

Reaffirmation of the radical recombination mechanism of cytochrome P450-catalyzed hydroxylations

He, X., Deng, D., Cryle, M. J., De Voss, J. J., Groves, J. and Ortiz de Montellano, P.R. (2004). Reaffirmation of the radical recombination mechanism of cytochrome P450-catalyzed hydroxylations. 3rd Int Congress of Porphyrins and Pthalocyanines, New Orleans, 11-16 July, 2004.

Reaffirmation of the radical recombination mechanism of cytochrome P450-catalyzed hydroxylations

2004

Conference Publication

Chemical constituents of Chamaelirum luteum by NMR

Stuthe, J. M. U., Lambert, L. K., Lehmann, R.P., Kitching, W. and De Voss, J. J. (2004). Chemical constituents of Chamaelirum luteum by NMR. ANZMAG 2004, Barossa Valley, 15-19 Feb, 2004.

Chemical constituents of Chamaelirum luteum by NMR

2004

Conference Publication

The radical recombination mechanism of cytochrome P450-catalyzed hydroxylations

Ortiz de Montellano, P. R., He, X., Cryle, M. J. and De Voss, J. J. (2004). The radical recombination mechanism of cytochrome P450-catalyzed hydroxylations. ISSX 2004: 7th International Society for Study of Xenobiotics Meeting, Vancouver, 29 August - 2 September, 2004. UK: Informa Healthcare. doi: 10.1081/DMR-200027024

The radical recombination mechanism of cytochrome P450-catalyzed hydroxylations

2004

Conference Publication

Small molecule probes of cytochrome P450 mechanism

De Voss, J. J., Cryle, M. J. and Ortiz de Montellano, P.R. (2004). Small molecule probes of cytochrome P450 mechanism. 20th RACI Organic Chemistry Meeting, Cairns, 4-8 July, 2004.

Small molecule probes of cytochrome P450 mechanism

2004

Conference Publication

NMR elucidation of the products from cationic rearrangement of cyclopropane rings

Cryle, M. J., Stuthe, J. M. U., Lambert, L. K. and De Voss, J. J. (2004). NMR elucidation of the products from cationic rearrangement of cyclopropane rings. ANZMAG 2004, Tanunda, South Australia, 15-19 Feb, 2004.

NMR elucidation of the products from cationic rearrangement of cyclopropane rings

2004

Journal Article

Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam

Meharenna, Y. T., Li, H. Y., Hawkes, D. B., Pearson, A. G., De Voss, J. and Poulos, T. L. (2004). Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam. Biochemistry, 43 (29), 9487-9494. doi: 10.1021/bi049293p

Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam

2003

Conference Publication

Dioxygen bond activation in P450cin

Slessor, K., Cavaignac, S. M., Hawkes, D. and De Voss, J. J. (2003). Dioxygen bond activation in P450cin. The Brisbane Biological & Organic Chemistry Symposium, Brisbane, 28 Nov, 2003.

Dioxygen bond activation in P450cin

2003

Journal Article

Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids

Cryle, M. J., Matovic, N. J. and De Voss, J. J. (2003). Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids. Organic Letters, 5 (18), 3341-3344. doi: 10.1021/ol035254e

Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids

2003

Conference Publication

Directed evolution of mammalian cytochrome P450 enzymes involved in xenobiotic metabolism

Rosic, Nedeljka, Lonhienne, Thierry G.A., DeVoss, James J. and Gillam, Elizabeth M.J. (2003). Directed evolution of mammalian cytochrome P450 enzymes involved in xenobiotic metabolism. 8th European Meeting of the International-Society-for-the-Study-of-Xenobiotics (ISSX), Dijon, France, 27 April - 1 May, 2003. New York: Marcel Dekker. doi: 10.1081/DMR-120020120

Directed evolution of mammalian cytochrome P450 enzymes involved in xenobiotic metabolism

2003

Journal Article

Electrochemistry of P450cin: new insights into P450 electron transfer

Aguey-Zinsou, Kondo-François, Bernhardt, Paul V., De Voss, James J. and Slessor, Kate E. (2003). Electrochemistry of P450cin: new insights into P450 electron transfer. Chemical Communications, 3 (3), 418-419. doi: 10.1039/b211567k

Electrochemistry of P450cin: new insights into P450 electron transfer

2003

Conference Publication

Direct electrochemistry of cytochrome P450cin : new insights into P450 mechanism

Bernhardt, Paul V., Aguey-Zinsou, Kondo-Francois, De Voss, James J. and Slessor, Kate E. (2003). Direct electrochemistry of cytochrome P450cin : new insights into P450 mechanism. 11th International Conference on Biological Inorganic Chemistry, Cairns, Qld, 19-23 July, 2003. New York: Elsevier. doi: 10.1016/S0162-0134(03)80462-2

Direct electrochemistry of cytochrome P450cin : new insights into P450 mechanism

2003

Journal Article

Insect chemistry and chirality

Hayes, Patricia Y., Fletcher, Mary T., Chow, Sharon, McGrath, Matthew J., Tu, Yong Q., Zhang, Hesheng, Hungerford, Natasha L., McErlean, Christopher S. P., Stok, Jeannette E., Moore, Christopher J., De Voss, James J. and Kitching, William (2003). Insect chemistry and chirality. Chirality, 15 (S1), S116-S127. doi: 10.1002/chir.10273

Insect chemistry and chirality

2003

Journal Article

Reactions catalyzed by bacterial cytochromes P450

Cryle, M. J., Stok, J. E. and De Voss, J. J. (2003). Reactions catalyzed by bacterial cytochromes P450. Australian Journal of Chemistry, 56 (8), 749-762. doi: 10.1071/CH03040

Reactions catalyzed by bacterial cytochromes P450

Current funding

  • 2024 - 2027
    New biocatalysts for selective chemical oxidations under extreme conditions (ARC Discovery Project administered by The University of Adelaide)
    University of Adelaide
    Open grant

Past funding

  • 2021 - 2024
    Mycobacterial Cholesterol Degradation: A Unique Metabolic Weakness?
    ARC Discovery Projects
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Enabling at Traditional Australian Medicinal Plants Agribusiness (CRCNA project administered by Integria Healthcare Pty Ltd)
    CRC for Developing Northern Australia
    Open grant
  • 2018 - 2019
    Gas chromatography: Separating inseparables, identifying unidentifiables (ARC LIEF grant administered by Monash University)
    Monash University
    Open grant
  • 2017 - 2019
    Development of a bio-enabled synthesis for the glycopeptide antibiotics (ARC Discovery Project administered by Monash University)
    Monash University
    Open grant
  • 2016 - 2017
    Bio-actives: Value-adding to industrial hemp production
    UQ Collaboration and Industry Engagement Fund - FirstLink
    Open grant
  • 2015
    Separation of Terpenes
    UniQuest Pty Ltd
    Open grant
  • 2015 - 2016
    Online, virtual and adaptive learning environments: improving the journey through large first year chemistry courses
    Technology-Enhanced Learning Grants
    Open grant
  • 2014 - 2015
    Identification of Dopamine Receptor Agonists from Chaste Tree Berry
    UniQuest Pty Ltd
    Open grant
  • 2014 - 2017
    Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines
    ARC Linkage Projects
    Open grant
  • 2014 - 2016
    Understanding the mechanism of two important cytochrome P450 catalysed reactions: dehydrogenation and C-C cleavage
    ARC Discovery Projects
    Open grant
  • 2013 - 2014
    Can understanding antibiotic biogenesis allow construction of chemotherapeutics?
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2013 - 2015
    Understanding the structural basis for catalysis and substrate specificity in non-heme diiron medium-chain alkane hydroxylases (ARC Discovery Project administered by Monash University)
    Monash University
    Open grant
  • 2011 - 2013
    A NEW CHEMOTHERAPEUTIC TARGET FROM LEISHMANIA SPP. UNDERSTANDING AND INHIBITING CYP61LD, A STEROL C22 DESATURASE
    ARC Discovery Projects
    Open grant
  • 2010 - 2011
    Biotransformation of Cholesterol into Commercially Important Steroidal Saponins Present in Herbal Medicines
    UQ FirstLink Scheme
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009 - 2010
    Cytochrome P450 libraries for Lead Optimisation in Drug Discovery
    UQ FirstLink Scheme
    Open grant
  • 2009 - 2011
    Putting smells into context: Using in vivo technologies to understand plant-insect odour signalling.
    ARC Discovery Projects
    Open grant
  • 2008 - 2009
    Analytical and preparative enantioselective chromatography
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2008 - 2010
    Understanding and Inhibiting P450 CYP24, a target for cancer chemotherapeutics
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    An X-Ray Diffraction Facility for Molecular Structure Determination
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2007
    Understanding and Inhibiting P450 CYP24, a target for cancer chemotherapuetics.
    UQ External Support Enabling Grant
    Open grant
  • 2006
    A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2008
    Biocatalysts mined from cytochrome P450 Libraries: an innovative tool for accelerating drug development
    ARC Linkage Projects
    Open grant
  • 2004 - 2005
    Molecular Breeding Of Biocatalysts Mined From Cytochrome P450 Libraries: An Innovative Tool for Accelerating Drug Development
    UQ FirstLink Scheme
    Open grant
  • 2004 - 2007
    What is in therapeutically prescribed herbal medicines? Phytochemical characterisation of steroidal saponins from two popular nutraceuticals, False Unicorn and Tribulus terrestris.
    ARC Linkage Projects
    Open grant
  • 2004 - 2006
    Disruption of Sex Pheromone Biosynthesis: A Novel Control Method for Pestiferous Fruit Flies
    ARC Discovery Projects
    Open grant
  • 2004
    The Insect-Plant Chemical Ecology Network (IPCEN)
    ARC Seed Funding for Research Networks
    Open grant
  • 2003
    Unprecedented Alkaloid Hybrids that Selectively Modulate Various Cancers and the Central Nervous System
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2005
    Structural chacterization of active constituents in plant extracts with potential for the control of ovine lice and parasitic worms
    ARC Linkage Projects
    Open grant
  • 2002 - 2004
    Molecular breeding of cytochrome P450 enzymes
    ARC Discovery Projects
    Open grant
  • 2001 - 2003
    The Biosynthesis of Mycobactin T, a Virulence Factor from Mycobacterium Tuberculosis
    NHMRC Project Grant
    Open grant
  • 1998
    Characterisation of Biol, a Carbon Carbon Bond Cleaving P450
    ARC Australian Research Council (Small grants)
    Open grant
  • 1998 - 2000
    Fruit-fly sex pheromones: biosynthesis and enzymology
    ARC Australian Research Council (Large grants)
    Open grant
  • 1998 - 2000
    Polyketide synthases from marine molluscs
    ARC Australian Research Council (Large grants)
    Open grant
  • 1997
    Conversion of P450cn into P450 cam: a prelude to engineering biodegradative pathways
    ARC Australian Research Council (Small grants)
    Open grant
  • 1996
    Cloning, expression and characterisation of two novel proteins involved in biotin biosynthesis
    University of Queensland New Staff Research Grant
    Open grant
  • 1996 - 1998
    Pyochelin: a siderophore and virulence factor from pathogenic pseudomonads
    NHMRC Project Grant
    Open grant

Availability

Professor James De Voss is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Synthesis of peptide antibiotic constituents for elucidation of their biosyntheses and II) Characterization of bacterial cytochromes P450

    Principal Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Structure Elucidation in Pursuit of Bioactive Compounds

    Principal Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Biochemical and molecular characterization of Cytochrome P450 (CYPs) from extremophilic sources and their biotechnological applications

    Principal Advisor

  • Doctor Philosophy

    Microbial manufacturing of plant saponin-inspired vaccine adjuvants

    Principal Advisor

    Other advisors: Professor Craig Williams

  • Doctor Philosophy

    Bioactive Phytochemicals from Australian Native Plants used as Ingienous medicines

    Principal Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Exploiting plant biosynthesis to produce vaccine adjuvants

    Associate Advisor

    Other advisors: Dr Birgitta Ebert

  • Doctor Philosophy

    Synthesis of novel probes and inhibitors of carbohydrate-binding proteins

    Associate Advisor

    Other advisors: Professor Vito Ferro

  • Doctor Philosophy

    Engineering Saccharomyces cerevisiae for triterpenoid production

    Associate Advisor

    Other advisors: Dr Birgitta Ebert

  • Doctor Philosophy

    Stingless bee enzymes for biotransformation of cane sugar to a low GI sugar

    Associate Advisor

    Other advisors: Emerita Professor Mary Fletcher, Dr Loan Nguyen, Dr Natasha Hungerford

  • Doctor Philosophy

    Identification of the Structure and bioavailability of bioactive compounds from Australian native plants.

    Associate Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Isolation and identification of natural products from Australian Native Medicinal Plants

    Associate Advisor

    Other advisors: Professor Joanne Blanchfield

  • Doctor Philosophy

    Stingless bee enzymes for biotransformation of cane sugar to a low GI sugar

    Associate Advisor

    Other advisors: Emerita Professor Mary Fletcher, Dr Loan Nguyen, Dr Natasha Hungerford

  • Doctor Philosophy

    Isolation and identification of natural products from Australian Native Medicinal Plants

    Associate Advisor

    Other advisors: Professor Joanne Blanchfield

Completed supervision

Enquiries

Contact Professor James De Voss directly for media enquiries about:

  • Bio-organic chemistry
  • Biosynthesis of natural products
  • Chemistry - organic
  • Enzymes - P450
  • Enzymology
  • Herbs - bioactives
  • Natural products - chemistry of
  • Organic chemistry
  • P450 enzymes

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