Dr

Katharine Irvine

Email: 
Phone: 
+61 7 344 38014

Availability

Dr Katharine Irvine is:
Available for supervision

Fields of research

Biological Sciences Genetics Immunology

Qualifications

  • Bachelor of Law, University of New South Wales
  • Bachelor (Honours) of Science (Advanced), University of New South Wales
  • Doctor of Philosophy, The University of Queensland

Search Professor Katharine Irvine’s works on UQ eSpace

161 works between 2004 and 2025
All (161) Journal Article (116) Book Chapter (3) Conference Publication (37) Other Outputs (5)

121 - 140 of 161 works

2014

Journal Article

Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4

Yu, C.-H., Nguyen, T.T.K., Irvine, K.M., Sweet, M.J., Frazer, I.H. and Blumenthal, A. (2014). Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. European Journal of Immunology, 44 (5), 1480-1490. doi: 10.1002/eji.201343959

Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4

2014

Conference Publication

Microbial burden is associated with clinical outcomes and reduced ascites innate immune cells in non-infected ascites

Fagan, K. J., Melino, M., Powell, E. E. and Irvine, K. M. (2014). Microbial burden is associated with clinical outcomes and reduced ascites innate immune cells in non-infected ascites. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22-24 October 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_5

Microbial burden is associated with clinical outcomes and reduced ascites innate immune cells in non-infected ascites

2013

Conference Publication

The Portal Inflammatory Infiltrate and Ductular Niche in Non-Alcoholic Fatty Liver Disease

Gadd, Victoria L., Skoien, Richard, Fagan, Kevin, Irvine, Katharine, Powell, Elizabeth E. and Clouston, Andrew D. (2013). The Portal Inflammatory Infiltrate and Ductular Niche in Non-Alcoholic Fatty Liver Disease. 64th Annual Meeting and Postgraduate Course of the American-Association-for-the-Study-of-Liver-Diseases, Washington Dc, Nov 01-05, 2013. HOBOKEN: WILEY-BLACKWELL.

The Portal Inflammatory Infiltrate and Ductular Niche in Non-Alcoholic Fatty Liver Disease

2013

Journal Article

BMI But Not Stage or Etiology of Nonalcoholic Liver Disease Affects the Diagnostic Utility of Carbohydrate-Deficient Transferrin

Fagan, Kevin J., Irvine, Katharine M., McWhinney, Brett C., Fletcher, Linda M., Horsfall, Leigh U., Johnson, Lambro A., Clouston, Andrew D., Jonsson, Julie R., O'Rourke, Peter, Martin, Jennifer, Pretorius, Carel J., Ungerer, Jacobus P. J. and Powell, Elizabeth E. (2013). BMI But Not Stage or Etiology of Nonalcoholic Liver Disease Affects the Diagnostic Utility of Carbohydrate-Deficient Transferrin. Alcoholism Clinical and Experimental Research, 37 (10), 1771-1778. doi: 10.1111/acer.12143

BMI But Not Stage or Etiology of Nonalcoholic Liver Disease Affects the Diagnostic Utility of Carbohydrate-Deficient Transferrin

2013

Journal Article

Assessment of alcohol histories obtained from patients with liver disease: opportunities to improve early intervention

Fagan, K. J., Irvine, K. M., Kumar, S., Bates, A., Horsfall, L. U., Feeney, G. F. and Powell, E. E. (2013). Assessment of alcohol histories obtained from patients with liver disease: opportunities to improve early intervention. Internal Medicine Journal, 43 (10), 1096-1102. doi: 10.1111/imj.12229

Assessment of alcohol histories obtained from patients with liver disease: opportunities to improve early intervention

2013

Journal Article

Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages

Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281

Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages

2013

Journal Article

Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C

Gadd, Victoria L., Melino, Michelle, Roy, Sandrine, Horsfall, Leigh, O'Rourke, Peter, Williams, Millicent R., Irvine, Katharine M., Sweet, Matthew J., Jonsson, Julie R., Clouston, Andrew D. and Powell, Elizabeth E. (2013). Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C. Liver International, 33 (4), 569-579. doi: 10.1111/liv.12050

Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C

2013

Conference Publication

The portal inflammatory infiltrate and ductular niche in non-alcoholic fatty liver disease

Gadd, V., Skoien, R., Fagan, K., Irvine, K., Powell, E. and Clouston, A. (2013). The portal inflammatory infiltrate and ductular niche in non-alcoholic fatty liver disease. Australian Gastroenterology Week 2013, Melbourne Australia, 7-9 October 2013. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365

The portal inflammatory infiltrate and ductular niche in non-alcoholic fatty liver disease

2013

Conference Publication

BMI but not aetiology or stage of liver disease affects the diagnostic sensitivity of carbohydrate deficient transferrin

Fagan, K., Irvine, K., McWhinney, B., Fletcher, L., Horsfall, L., Johnson, L., Clouston, A., Jonsson, J., O'Rourke, P., Martin, J., Pretorius, C., Ungerer, J. and Powell, E. (2013). BMI but not aetiology or stage of liver disease affects the diagnostic sensitivity of carbohydrate deficient transferrin. International Liver Congress / 48th Annual Meeting of the European Association for the Study of the Liver (EASL), Amsterdam, Netherlands, 24-28 April 2013. Amsterdam, Netherlands: Elsevier. doi: 10.1016/S0168-8278(13)60527-9

BMI but not aetiology or stage of liver disease affects the diagnostic sensitivity of carbohydrate deficient transferrin

2013

Conference Publication

Assessment of alcohol histories obtained from patients with liver disease: Opportunities to improve early intervention

Fagan, K., Irvine, K., Kumar, S., Bates, A., Horsfall, L., Feeney, G. and Powell, E. (2013). Assessment of alcohol histories obtained from patients with liver disease: Opportunities to improve early intervention. Australian Gastroenterology Week 2013, Melbourne, Australia, 7-9 October 2013. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365_5

Assessment of alcohol histories obtained from patients with liver disease: Opportunities to improve early intervention

2013

Conference Publication

Factors associated with mortality and unplanned hospital readmissions in patients with ascites

Zhao, E., Horsfall, L., Ruffin, B. J., Fagan, K. J., Irvine, K. M. and Powell, E. E. (2013). Factors associated with mortality and unplanned hospital readmissions in patients with ascites. Australian Gastroenterology Week 2013, Melbourne, Australia, 7-9 October 2013. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12365_5

Factors associated with mortality and unplanned hospital readmissions in patients with ascites

2012

Journal Article

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

Schroder, Kate, Sagulenko, Vitaliya, Zamoshnikova, Alina, Richards, Ayanthi A., Cridland, Jasmyn A., Irvine, Katharine M., Stacey, Katryn J. and Sweet, Matthew J. (2012). Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology, 217 (12), 1325-1329. doi: 10.1016/j.imbio.2012.07.020

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

2012

Journal Article

Liver repercussions of defective gut surveillance

Irvine, Katharine M., Schroder, Elizabeth E. and Powell, Elizabeth E. (2012). Liver repercussions of defective gut surveillance. Hepatology, 56 (3), 1174-1177. doi: 10.1002/hep.25944

Liver repercussions of defective gut surveillance

2012

Journal Article

Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes

Irvine, Katharine M., Gallego, Patricia, An, Xiaoyu, Best, Shannon E., Thomas, Gethin, Wells, Christine, Harris, Mark, Cotterill, Andrew and Thomas, Ranjeny (2012). Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes. Diabetes, 61 (5), 1281-1290. doi: 10.2337/db11-1549

Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes

2012

Journal Article

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A. and Sweet, Matthew J. (2012). Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences of the USA, 109 (16), E944-E953. doi: 10.1073/pnas.1110156109

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

2012

Conference Publication

Functional significance of evolutionary divergence in Toll-like receptor-regulated gene expression in human versus mouse

Sweet, M. J., Schroder, K., Irvine, K. M., Taylor, M., Bokil, N. J., Broomfield, S., Schembri, M. A., Stacey, K. J. and Hume, D. A. (2012). Functional significance of evolutionary divergence in Toll-like receptor-regulated gene expression in human versus mouse. European Congress of Immunology, Glasgow, Scotland, 5-8 September 2012. Oxford, United Kingdom: Wiley-Blackwell. doi: 10.1111/imm.12002

Functional significance of evolutionary divergence in Toll-like receptor-regulated gene expression in human versus mouse

2011

Journal Article

Histone deacetylases as regulators of inflammation and immunity

Shakespear, Melanie R., Halili, Maria A., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2011). Histone deacetylases as regulators of inflammation and immunity. Trends in Immunology, 32 (7), 335-343. doi: 10.1016/j.it.2011.04.001

Histone deacetylases as regulators of inflammation and immunity

2011

Journal Article

Update of the FANTOM web resource: From mammalian transcriptional landscape to its dynamic regulation

Kawaji, H, Severin, J, Lizio, M, Forrest, ARR, van Nimwegen, E, Rehli, M, Schroder, K, Irvine, K, Suzuki, H, Carninci, P, Hayashizaki, Y and Daub, CO (2011). Update of the FANTOM web resource: From mammalian transcriptional landscape to its dynamic regulation. Nucleic Acids Research, 39 (Supp. 1), D856-D860. doi: 10.1093/nar/gkq1112

Update of the FANTOM web resource: From mammalian transcriptional landscape to its dynamic regulation

2011

Journal Article

Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis

Van Zuylen, Wendy J., Garceau, Valerie, Idris, Adi, Schroder, Kate, Irvine, Katharine M., Lattin, Jane E., Ovchinnikov, Dmitry A., Perkins, Andrew C., Cook, Andrew D., Hamilton, John A., Hertzog, Paul J., Stacey, Katryn J., Kellie, Stuart, Hume, David A. and Sweet, Matthew J. (2011). Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One, 6 (1) e15723, e15723-1-e15723-13. doi: 10.1371/journal.pone.0015723

Macrophage activation and differentiation signals regulate Schlafen-4 gene expression: Evidence for Schlafen-4 as a modulator of myelopoiesis

2010

Journal Article

The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells

Kubosaki, A, Lindgren, G, Tagami, M, Simon, C, Tomaru, Y, Miura, H, Suzuki, T, Arner, E, Forrest, ARR, Irvine, KM, Schroder, K, Hasegawa, Y, Kanamori-Katayama, M, Rehli, M, Hume, DA, Kawai, J, Suzuki, M, Suzuki, H and Hayashizaki, Y (2010). The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology, 47 (14), 2295-2302. doi: 10.1016/j.molimm.2010.05.289

The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells

Current funding

  • 2025
    Hepatic delivery of Colony Stimulating Factor 1mRNA to promote liver repair
    Gastroenterological Society of Australia
    Open grant
  • 2024 - 2027
    A macrophage-centric holistic view of postnatal development
    ARC Discovery Projects
    Open grant

Past funding

  • 2022 - 2024
    Macrophage-driven lipid metabolism in health and disease - mechanisms and therapeutic opportunities
    NHMRC IDEAS Grants
    Open grant
  • 2021 - 2024
    Macrophage control of mammalian growth and development
    ARC Discovery Projects
    Open grant
  • 2020 - 2021
    CD14 inhibition in a Liver Inflammation mouse model
    Innovation Connections
    Open grant
  • 2019 - 2021
    Macrophage biology, inflammatory pathophysiology, transcriptional regulation, genetic analytics and clinical genetics
    Mater Foundation
    Open grant
  • 2019 - 2022
    CSF1 Therapy for Chronic Liver Disease
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Serum biomarkers for risk stratification in nonalcoholic fatty liver disease
    Siemens Ltd
    Open grant
  • 2015 - 2016
    Identifying Protective v Pathogenic Macrophages in Chronic Liver Disease: Critical for Macrophage-Targeted Therapy
    PA Research Foundation
    Open grant
  • 2014
    Human liver progenitor cell characterisation, isolation and manipulation
    UWA-UQ Bilateral Research Collaboration Award
    Open grant
  • 2013 - 2015
    Defining the role of MMP-9-expressing macrophages in liver injury in chronic liver disease
    NHMRC Project Grant
    Open grant
  • 2012 - 2015
    ALF Pauline Hall Research Fellowship: The role of macrophage in chronic liver disease progression
    Australian Liver Foundation
    Open grant
  • 2010 - 2012
    Pathological changes associated with chronic RelB activiation in T1D
    Juvenile Diabetes Research Foundation
    Open grant
  • 2005 - 2008
    Human macrophage transcriptional network
    Riken Genomic Sciences Center
    Open grant

Availability

Dr Katharine Irvine is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

Enquiries

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