Overview
Background
Doctor James Falconer has been an academic at the School of Pharmacy, The University of Queensland since June 2015. Dr Falconer was an assistant lecturer, then research & teaching fellow at the School of Pharmacy, the University of Auckland from 2011 – 2015.
In 2007 he was awarded with the Technology for Industry Fellowship (TIF) from the New Zealand Foundation for Research, Science & Technology (FRST) from the NZ Government with joint funding from Pharmaceutical Compounding New Zealand (PCNZ) to complete a PhD under A/Professor Jingyuan Wen and Professor Raid Alany from the University of Auckland, New Zealand for development of a supercritical fluid platform and transdermal delivery of poorly aqueous soluble steriods. As a post-doctoral researcher under A/Professor Zimei Wu and collaboration with Argenta Global in Auckland he worked to help stabilise a veterinary pour-on which resulted in international patents and registered product for cattle. He was then appointed as a lecturer in pharmacy practice and pharmaceutical sciences at The University of Queensland in Brisbane, Australia. Prior to his academic career, he received a BSc in Genetics 1999 and a Masters in Health Sciences (Bioethics) in 2003 under A/Professor Neil Pickering on the anatomy of the GMO debate from the University of Otago, Dunedin, New Zealand. In 2005, he completed a BPharm (Hons) from the University of Auckland and undertook an internship at Middlemore Hospital in 2006, then was employed from 2007 as a ward pharmacist in general surgery and the hospital dispensary and as a community pharmacist - including the 'graveyard' shifts at day/night pharmacies.
Doctor Falconer has established research in supercritical fluid applications for selective extraction as well as in engineering advanced nanoparticulate dosage forms based on lipid and polymeric systems. A backbone to this work is the search for green/er technology to replace organic solvent driven material manufacturing processes and the repurposing of carbon dioxide for good.
Availability
- Dr James Robert Falconer is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, University of Otago
- Postgraduate Diploma, University of Otago
- Bachelor of Pharmacy, The University of Auckland
- Masters (Research) of Bioethics, University of Otago
- Doctor of Philosophy, The University of Auckland
Research interests
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Primary Research 1: Supercritical fluid technology
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Primary Research 2: Sustainable solvent processing
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SCF preparation of advanced delivery systems such as liposomes and solid lipid nanoparticles
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Selective SCF extraction of principle molecules from indigenous and non-indigenous plants
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Preformulation
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Solid state compounds and dosage forms
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Quantitative analysis using Raman and IR spectroscopy and chemometrics
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Synthesis and characterization of solid state polymorphic transformations
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Spray jet behaviour during SCF rapid exapnsion using in-situ spectroscopy
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Non-linear release modelling such as dual first order
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In-situ gelling systems for systemic and non-systemic drug delivery
Works
Search Professor James Robert Falconer’s works on UQ eSpace
2021
Journal Article
Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process
Xu, Weizhi, Zhao, Zonglan, Falconer, James, Whittaker, Andrew K., Popat, Amirali, Smith, Maree T., Kumeria, Tushar and Han, Felicity Y. (2021). Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process. Drug Delivery and Translational Research, 12 (3), 676-694. doi: 10.1007/s13346-021-00991-w
2021
Journal Article
PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery
Raza, Aun, Miles, Jared A., Bruck Sime, Fekade, Ross, Benjamin P., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2021). PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery. International Journal of Pharmaceutics, 597 120280, 120280. doi: 10.1016/j.ijpharm.2021.120280
2021
Journal Article
Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution
Ndayishimiye, John, Popat, Amirali, Kumeria, Tushar, Blaskovich, Mark A.T. and Falconer, James Robert (2021). Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution. International Journal of Pharmaceutics, 596 120240, 120240. doi: 10.1016/j.ijpharm.2021.120240
2021
Journal Article
Extraction of medicinal cannabinoids through supercritical carbon dioxide technologies: a review
Qamar, Sadia, Torres, Yady J.M., Parekh, Harendra S. and Falconer, James Robert (2021). Extraction of medicinal cannabinoids through supercritical carbon dioxide technologies: a review. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1167 122581, 1-10. doi: 10.1016/j.jchromb.2021.122581
2021
Journal Article
Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem
Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Falconer, James R., Kumeria, Tushar and Popat, Amirali (2021). Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem. ACS Biomaterials Science and Engineering, 7 (5) acsbiomaterials.0c01284, 1836-1853. doi: 10.1021/acsbiomaterials.0c01284
2021
Journal Article
A systematic review and meta-analysis of the association between clozapine and norclozapine serum levels and peripheral adverse drug reactions
Tan, Madeleine S. A., Honarparvar, Faraz, Falconer, James R., Parekh, Harendra S., Pandey, Preeti and Siskind, Dan J. (2021). A systematic review and meta-analysis of the association between clozapine and norclozapine serum levels and peripheral adverse drug reactions. Psychopharmacology, 238 (3), 615-637. doi: 10.1007/s00213-020-05746-y
2021
Journal Article
Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin
Ndayishimiye, John, Cao, Yuxue, Kumeria, Tushar, Blaskovich, Mark A. T., Falconer, James Robert and Popat, Amirali (2021). Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin. Journal of Materials Chemistry B, 9 (35), 7145-7166. doi: 10.1039/d1tb01430g
2020
Conference Publication
Can monitoring clozapine and norclozapine levels reduce the occurrence of peripheral ADRs?
Tan, Madeleine S. A., Honarparvar, Faraz , Falconer, James R., Parekh, Harendra S., Pandey, Preeti and Siskind, Dan J. (2020). Can monitoring clozapine and norclozapine levels reduce the occurrence of peripheral ADRs?. ASCEPT-APSA Joint Virtual Scientific Meeting, Hamilton Central, QLD, Australia, 24-26 November 2020.
2020
Conference Publication
Therapeutic drug monitoring as a tool for clozapine therapy in minimising peripheral ADRs
Tan, Madeleine , Honarparvar, Faraz , Falconer, James , Parekh, Harendra , Pandey, Preeti and Siskind, Dan (2020). Therapeutic drug monitoring as a tool for clozapine therapy in minimising peripheral ADRs. Australian Society for Medical Research (ASMR) Queensland Post Graduate Students Virtual Scientific Symposium, Sydney, NSW Australia, 10-11 November 2020.
2020
Journal Article
Oral meropenem for superbugs: challenges and opportunities
Raza, Aun, Ngieng, Shih Chen, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2020). Oral meropenem for superbugs: challenges and opportunities. Drug Discovery Today, 26 (2), 551-560. doi: 10.1016/j.drudis.2020.11.004
2020
Journal Article
Non-ionic surfactant vesicles as a carrier system for dermal delivery of C and their antioxidant effects
Li, Danhui, Martini, Nataly, Liu, Mengyang, Falconer, James R., Locke, Michelle, Wu, Zimei and Wen, Jingyuan (2020). Non-ionic surfactant vesicles as a carrier system for dermal delivery of C and their antioxidant effects. Journal of Drug Targeting, 29 (3), 1-31. doi: 10.1080/1061186x.2020.1835923
2020
Conference Publication
Development and optimization of clozapine-loaded PLGA nanoparticles for nose-to-brain delivery using supercritical fluid technology
Tan, Madeleine S. A. , Parekh, Harendra S., Pandey, Preeti , Siskind, Dan J. and Falconer, James R. (2020). Development and optimization of clozapine-loaded PLGA nanoparticles for nose-to-brain delivery using supercritical fluid technology. 7th FIP Pharmaceutical Sciences World Congress, The Hague, Netherlands, 4-6 October 2020.
2020
Journal Article
Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial peptides
Ndayishimiye, John, Popat, Amirali, Blaskovich, Mark and Falconer, James Robert (2020). Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial peptides. Journal of Controlled Release, 324, 728-749. doi: 10.1016/j.jconrel.2020.05.002
2020
Journal Article
Supercritical fluid assembly of albendazole liposomes targeting gastrin-releasing peptide receptor overexpressing tumors
Maqbool, Faheem, Falconer, James R. and Moyle, Peter M. (2020). Supercritical fluid assembly of albendazole liposomes targeting gastrin-releasing peptide receptor overexpressing tumors. Nanomedicine, 15 (13), 1315-1330. doi: 10.2217/nnm-2020-0048
2020
Journal Article
Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice
Khaw, Kooi-Yeong, Shaw, Paul Nicholas, Parat, Marie-Odile, Pandey, Saurabh and Falconer, James Robert (2020). Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice. Processes, 8 (5) 610, 610. doi: 10.3390/pr8050610
2020
Journal Article
Nose-to-brain delivery of antipsychotics using nanotechnology: a review
Tan, Madeleine S. A., Parekh, Harendra S., Pandey, Preeti, Siskind, Dan J. and Falconer, James R. (2020). Nose-to-brain delivery of antipsychotics using nanotechnology: a review. Expert Opinion on Drug Delivery, 17 (6) 17425247.2020.1762563, 839-853. doi: 10.1080/17425247.2020.1762563
2019
Journal Article
Nuts, cereals, seeds and legumes proteins derived emulsifiers as a source of plant protein beverages: a review
Qamar, Sadia, Manrique, Yady J., Parekh, Harendra and Falconer, James Robert (2019). Nuts, cereals, seeds and legumes proteins derived emulsifiers as a source of plant protein beverages: a review. Critical Reviews in Food Science and Nutrition, 60 (16), 1-21. doi: 10.1080/10408398.2019.1657062
2019
Journal Article
Recent advances in non-ionic surfactant vesicles (niosomes): fabrication, characterization, pharmaceutical and cosmetic applications
Chen, Shuo, Hanning, Sara, Falconer, James, Locke, Michelle and Wen, Jingyuan (2019). Recent advances in non-ionic surfactant vesicles (niosomes): fabrication, characterization, pharmaceutical and cosmetic applications. European Journal of Pharmaceutics and Biopharmaceutics, 144, 18-39. doi: 10.1016/j.ejpb.2019.08.015
2019
Journal Article
Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology
Maqbool, Faheem, Moyle, Peter M., Thurecht, Kristofer J. and Falconer, James R. (2019). Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology. International Journal of Pharmaceutics, 563, 174-183. doi: 10.1016/j.ijpharm.2019.03.053
2019
Journal Article
Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice
Khaw, Kooi-Yeong, Parat, Marie-Odile, Shaw, Paul Nicholas, Nguyen, Thao T. T., Pandey, Saurabh, Thurecht, Kristofer J. and Falconer, James Robert (2019). Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice. Scientific Reports, 9 (1) 1716, 1716. doi: 10.1038/s41598-018-37171-9
Funding
Past funding
Supervision
Availability
- Dr James Robert Falconer is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Extraction of psilocybin and psilocin from the psilocybe mushroom (Magic Mushroom) utilising a single-pot supercritical carbon dioxide (scCO2) method
Principal Advisor
Other advisors: Associate Professor Peter Moyle
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Doctor Philosophy
Extraction of bioactives from natural resources using supercritical fluid technology and their activity testing for the pharmaceutical and food industry
Principal Advisor
Other advisors: Associate Professor Marie-Odile Parat
Completed supervision
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2022
Doctor Philosophy
Advanced Formulation Technologies for Oral Delivery of Antimicrobial Agents
Principal Advisor
Other advisors: Professor Amirali Popat, Professor Mark Blaskovich
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2022
Doctor Philosophy
Nose-to-Brain Delivery of Clozapine in Sol-Gel Systems
Principal Advisor
Other advisors: Professor Dan Siskind, Dr Harendra Parekh
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2022
Doctor Philosophy
Investigation into the selective extraction of cannabinoids from cannabis using supercritical carbon dioxide
Principal Advisor
Other advisors: Dr Harendra Parekh
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2021
Doctor Philosophy
Advanced Oral Antibiotic Formulations
Principal Advisor
Other advisors: Professor Jason Roberts, Professor Peter Cabot, Professor Amirali Popat, Dr Fekade Sime
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2020
Doctor Philosophy
Development of a liposomal platform using green supercritical fluid technology: application towards repurposing and tumour-targeting of albendazole for cancer therapy
Principal Advisor
Other advisors: Associate Professor Peter Moyle
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2019
Doctor Philosophy
Novel extraction and evaluation of papaya leaf for chemotherapeutic molecules
Principal Advisor
Other advisors: Professor Nick Shaw, Associate Professor Marie-Odile Parat
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2024
Doctor Philosophy
The development and optimization of a transdermal firocoxib microemulsion gel for dogs
Associate Advisor
Other advisors: Dr Halley Ravuri, Professor Paul Mills
Media
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