Professor Carmel Hawley
Professor

Carmel Hawley

Email: 

Background

Carmel Hawley MBBS, FRACP, M.Med.Sci, is a Senior Staff Specialist and Director of Haemodialysis Services at Princess Alexandra Hospital. In addition, she is an Associate Professor (A/P) of Medicine at the School of Medicine, University of Queensland and current (inaugural) Chair for the Australasian Kidney Trials network (AKTN) formed in 2005. Under A/P Hawley’s stewardship, AKTN’s research output is now recognised internationally for its quality and impact. This has driven major advances in the evidence base, that directly informs care and outcomes for people living with chronic kidney disease. A/P Hawley also holds a Master’s degree in Biostatistics, has expertise in trial management, methodology, design and conduct. She is currently involved in numerous industry-led and/or investigator initiated international and national clinical trials as either a Principal or Associate Investigator, providing leadership and direction to emerging early and mid-career researchers.

Availability

Professor Carmel Hawley is:
Available for supervision
Media expert

Fields of research

Clinical sciences

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Masters (Coursework), Institution to be confirmed
  • Royal Australasian College of Physicians, Royal Australasian College of Physicians

Research interests

  • Chronic Kidney Disease

  • Kidney Transplant

  • Kidney Dialysis

  • Kidney Clinical Trials

Search Professor Carmel Hawley’s works on UQ eSpace

721 works between 1965 and 2025
All (721) Journal Article (490) Conference Publication (225) Book Chapter (6)

221 - 240 of 721 works

2019

Conference Publication

Challenges of health data-linkage in Australia

Palamuthusingam, Dharmenaan, Nadarajah, Arun, Johnson, David W., Hawley, Carmel, Pascoe, Elaine and Fahim, Magid (2019). Challenges of health data-linkage in Australia. RACP Congress 2019: Impacting Health Along the Life Course, Auckland, New Zealand, 6-8 May 2019. Richmond, VIC, Australia: Wiley-Blackwell.

Challenges of health data-linkage in Australia

2019

Journal Article

Metformin for preventing the progression of chronic kidney disease (Protocol)

El‐Damanawi, Ragada, Viecelli, Andrea K., Pascoe, Elaine M., Craig, Jonathan C., Johnson, David W., Mallett, Andrew J., Hawley, Carmel M. and Hiemstra, Thomas F. (2019). Metformin for preventing the progression of chronic kidney disease (Protocol). Cochrane Database of Systematic Reviews, 2019 (9) CD013414. doi: 10.1002/14651858.CD013414

Metformin for preventing the progression of chronic kidney disease (Protocol)

2019

Journal Article

A comparison of graft and patient outcomes following kidney transplantation in extended hour and conventional haemodialysis patients

See, Emily J., Hawley, Carmel M., Cho, Yeoungjee, Toussaint, Nigel D., Agar, John Wm, Pascoe, Elaine M., Lim, Wai H., Francis, Ross S., Collins, Michael G. and Johnson, David W. (2019). A comparison of graft and patient outcomes following kidney transplantation in extended hour and conventional haemodialysis patients. Nephrology, 24 (1), 111-120. doi: 10.1111/nep.13221

A comparison of graft and patient outcomes following kidney transplantation in extended hour and conventional haemodialysis patients

2018

Journal Article

Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients

Chan, Samuel, Ng, Samantha, Chan, Hooi P., Pascoe, Elaine, Playford, Elliott Geoffrey, Wong, Germaine, Chapman, Jeremy R., Lim, Wai H., Francis, Ross S., Isbel, Nicole M., Campbell, Scott B., Hawley, Carmel M. and Johnson, David W. (2018). Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients. Cochrane Database of Systematic Reviews, 2018 (12) CD013209, 1-12. doi: 10.1002/14651858.CD013209

Perioperative antibiotics for preventing post-surgical site infections in solid organ transplant recipients

2018

Journal Article

Type 2 diabetes in patients with end-stage kidney disease: influence on cardiovascular disease-related mortality risk

Lim, Wai H., Johnson, David W., Hawley, Carmel, Lok, Charmaine, Polkinghorne, Kevan R., Roberts, Matthew A., Boudville, Neil and Wong, Germaine (2018). Type 2 diabetes in patients with end-stage kidney disease: influence on cardiovascular disease-related mortality risk. Medical Journal of Australia, 209 (10), 440-446. doi: 10.5694/mja18.00195

Type 2 diabetes in patients with end-stage kidney disease: influence on cardiovascular disease-related mortality risk

2018

Journal Article

End-stage kidney disease following surgical management of kidney cancer

Ellis, Robert J., Edey, Daniel P., Del Vecchio, Sharon J., McStea, Megan, Campbell, Scott B., Hawley, Carmel M., Johnson, David W., Morais, Christudas, Jordan, Susan J., Francis, Ross S., Wood, Simon T. and Gobe, Glenda C. (2018). End-stage kidney disease following surgical management of kidney cancer. Clinical Journal of the American Society of Nephrology, 13 (11), 1641-1648. doi: 10.2215/cjn.06560518

End-stage kidney disease following surgical management of kidney cancer

2018

Journal Article

Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease

Lo, Clement, Toyama, Tadashi, Wang, Ying, Lin, Jin, Hirakawa, Yoichiro, Jun, Min, Cass, Alan, Hawley, Carmel M., Pilmore, Helen, Badve, Sunil V., Perkovic, Vlado and Zoungas, Sophia (2018). Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease. Cochrane Database of Systematic Reviews, 2018 (9) CD011798. doi: 10.1002/14651858.CD011798.pub2

Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease

2018

Journal Article

Early peritoneal dialysis technique failure: review

Cho, Yeoungjee, See, Emily J., Htay, Htay, Hawley, Carmel M. and Johnson, David W. (2018). Early peritoneal dialysis technique failure: review. Peritoneal Dialysis International, 38 (5), 319-327. doi: 10.3747/pdi.2018.00017

Early peritoneal dialysis technique failure: review

2018

Journal Article

Associations Between Peritoneal Glucose Exposure, Glucose Degradation Product Exposure, and Peritoneal Membrane Transport Characteristics in Peritoneal Dialysis Patients: Secondary Analysis of the balANZ Trial

Nataatmadja, Melissa S., Johnson, David W., Pascoe, Elaine M., Darssan, Darsy, Hawley, Carmel M., Cho, Yeoungjee and on behalf of the balANZ Trial Investigators (2018). Associations Between Peritoneal Glucose Exposure, Glucose Degradation Product Exposure, and Peritoneal Membrane Transport Characteristics in Peritoneal Dialysis Patients: Secondary Analysis of the balANZ Trial. Peritoneal Dialysis International, 38 (5), 349-355. doi: 10.3747/pdi.2017.00223

Associations Between Peritoneal Glucose Exposure, Glucose Degradation Product Exposure, and Peritoneal Membrane Transport Characteristics in Peritoneal Dialysis Patients: Secondary Analysis of the balANZ Trial

2018

Journal Article

Outcomes of cinacalcet withdrawal in Australian dialysis patients

Ruderman, Irene, Holt, Stephen G., Kirkland, Geoffrey S., Maslen, Sophie, Hawley, Carmel M., Oliver, Veronica, Krishnasamy, Rathika, Gray, Nicholas A., Talaulikar, Girish S., Nelson, Craig L., Rajaram, Yogeshwar, Gock, Hilton, Au, Eric, Elder, Grahame J., Mainra, Rahul and Toussaint, Nigel D. (2018). Outcomes of cinacalcet withdrawal in Australian dialysis patients. Internal Medicine Journal, 49 (1), 48-54. doi: 10.1111/imj.14036

Outcomes of cinacalcet withdrawal in Australian dialysis patients

2018

Journal Article

Predictors of new-onset chronic kidney disease in patients managed surgically for T1a renal cell carcinoma: an Australian population-based analysis

Ahn, Thomas, Ellis, Robert J., White, Victoria M., Bolton, Damien M., Coory, Michael D., Davis, Ian D., Francis, Ross S., Giles, Graham G., Gobe, Glenda C., Hawley, Carmel M., Johnson, David W., Marco, David J. T., McStea, Megan, Neale, Rachel E., Pascoe, Elaine M., Wood, Simon T., Jordan, Susan J. and IMPROVE investigators (2018). Predictors of new-onset chronic kidney disease in patients managed surgically for T1a renal cell carcinoma: an Australian population-based analysis. Journal of Surgical Oncology, 117 (7), 1597-1610. doi: 10.1002/jso.25037

Predictors of new-onset chronic kidney disease in patients managed surgically for T1a renal cell carcinoma: an Australian population-based analysis

2018

Journal Article

The relationship between body mass index and organism-specific peritonitis

Jegatheesan, Dev, Johnson, David W., Cho, Yeoungjee, Pascoe, Elaine M., Darssan, Darsy, Htay, Htay, Hawley, Carmel, Clayton, Philip A., Borlace, Monique, Badve, Sunil V., Sud, Kamal, Boudville, Neil, McDonald, Stephen P. and Nadeau-Fredette, Annie-Claire (2018). The relationship between body mass index and organism-specific peritonitis. Peritoneal Dialysis International, 38 (3), 206-214. doi: 10.3747/pdi.2017.00188

The relationship between body mass index and organism-specific peritonitis

2018

Journal Article

Design and methods of the REMOVAL-HD study: a tRial evaluating mid cut-off value membrane clearance of albumin and light chains in HaemoDialysis patients

Krishnasamy, R., Hawley, C. M., Jardine, M. J., Roberts, M. A., Cho, Y. J., Wong, M. G., Heath, A., Nelson, C. L., Sen, S., Mount, P. F., Pascoe, E. M., Darssan, D., Vergara, L. A., Paul-Brent, P. A., Toussaint, N. D., Johnson, D. W. and Hutchison, C. A. (2018). Design and methods of the REMOVAL-HD study: a tRial evaluating mid cut-off value membrane clearance of albumin and light chains in HaemoDialysis patients. BMC Nephrology, 19 (1) 89, 89. doi: 10.1186/s12882-018-0883-8

Design and methods of the REMOVAL-HD study: a tRial evaluating mid cut-off value membrane clearance of albumin and light chains in HaemoDialysis patients

2018

Journal Article

Association between causes of peritoneal dialysis technique failure and all-cause mortality

Chen, Jenny H C, Johnson, David W, Hawley, Carmel, Boudville, Neil and Lim, Wai H (2018). Association between causes of peritoneal dialysis technique failure and all-cause mortality. Scientific Reports , 8 (1) 3980, 3980. doi: 10.1038/s41598-018-22335-4

Association between causes of peritoneal dialysis technique failure and all-cause mortality

2018

Journal Article

Teaching peritoneal dialysis in Australia: An opportunity for improvement

Boudville, Neil, Cho, Yeoungjee, Equinox, Keri-Lu, Figueiredo, Ana Elizabeth, Hawley, Carmel M, Howard, Kirsten, Johnson, David W, Jose, Matthew, Lee, Anna, Maley, Moira Alison, Moodie, Jo-Anne, Pascoe, Elaine M., Steiner, Genevieve Z., Tomlins, Melinda, Voss, David and Chow, Josephine (2018). Teaching peritoneal dialysis in Australia: An opportunity for improvement. Nephrology , 23 (3), 259-263. doi: 10.1111/nep.12992

Teaching peritoneal dialysis in Australia: An opportunity for improvement

2018

Journal Article

Report of the standardized outcomes in nephrology-hemodialysis (SONG-HD) consensus workshop on establishing a core outcome measure for hemodialysis vascular access

Viecelli, Andrea K., Tong, Allison, O'Lone, Emma, Ju, Angela, Hanson, Camilla S, Sautenet, Benedicte, Craig, Jonathan C., Manns, Braden, Howell, Martin, Chemla, Eric, Hooi, Lai-Seong, Johnson, David W., Lee, Timmy, Lok, Charmaine E, Polkinghorne, Kevan R, Quinn, Robert R, Vachharajani, Tushar, Vanholder, Raymond, Zuo, Li, Hawley, Carmel M and SONG-HD Vascular Access Workshop Investigators (2018). Report of the standardized outcomes in nephrology-hemodialysis (SONG-HD) consensus workshop on establishing a core outcome measure for hemodialysis vascular access. American Journal of Kidney Diseases, 71 (5), 690-700. doi: 10.1053/j.ajkd.2017.12.003

Report of the standardized outcomes in nephrology-hemodialysis (SONG-HD) consensus workshop on establishing a core outcome measure for hemodialysis vascular access

2018

Journal Article

Scope and Consistency of Outcomes Reported in Randomized Trials Conducted in Adults Receiving Hemodialysis: A Systematic Review

Sautenet, Bénédicte, Tong, Allison, Williams, Gabrielle, Hemmelgarn, Brenda R, Manns, Braden, Wheeler, David C, Tugwell, Peter, van Biesen, Wim, Winkelmayer, Wolfgang C, Crowe, Sally, Harris, Tess, Evangelidis, Nicole, Hawley, Carmel M, Pollock, Carol, Johnson, David W, Polkinghorne, Kevan R, Howard, Kirsten, Gallagher, Martin P, Kerr, Peter G, McDonald, Stephen P, Ju, Angela and Craig, Jonathan C (2018). Scope and Consistency of Outcomes Reported in Randomized Trials Conducted in Adults Receiving Hemodialysis: A Systematic Review. American Journal of Kidney Diseases, 72 (1), 62-74. doi: 10.1053/j.ajkd.2017.11.010

Scope and Consistency of Outcomes Reported in Randomized Trials Conducted in Adults Receiving Hemodialysis: A Systematic Review

2018

Journal Article

Omega-3 Polyunsaturated Fatty Acid Supplementation to Prevent Arteriovenous Fistula and Graft Failure: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Viecelli, Andrea K., Irish, Ashley B., Polkinghorne, Kevan R., Hawley, Carmel M., Johnson, David W., Mori, Trevor A., Pascoe, Elaine M., Strippoli, Giovanni F. M., Lok, Charmaine E. and Palmer, Suetonia C. (2018). Omega-3 Polyunsaturated Fatty Acid Supplementation to Prevent Arteriovenous Fistula and Graft Failure: A Systematic Review and Meta-analysis of Randomized Controlled Trials. American Journal of Kidney Diseases , 72 (1), 50-61. doi: 10.1053/j.ajkd.2017.11.017

Omega-3 Polyunsaturated Fatty Acid Supplementation to Prevent Arteriovenous Fistula and Graft Failure: A Systematic Review and Meta-analysis of Randomized Controlled Trials

2018

Journal Article

Outcomes of Acinetobacter peritonitis in peritoneal dialysis patients: a multicenter registry analysis

Htay, Htay, Cho, Yeoungjee, Pascoe, Elaine M., Hawley, Carmel M., Clayton, Philip A., Borlace, Monique, Badve, Sunil V., Sud, Kamal, Boudville, Neil C., McDonald, Stephen P. and Johnson, David W. (2018). Outcomes of Acinetobacter peritonitis in peritoneal dialysis patients: a multicenter registry analysis. Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis, 38 (4), 257-265. doi: 10.3747/pdi.2017.00199

Outcomes of Acinetobacter peritonitis in peritoneal dialysis patients: a multicenter registry analysis

2018

Journal Article

Randomised controlled trial to determine the efficacy and safety of prescribed water intake to prevent kidney failure due to autosomal dominant polycystic kidney disease (PREVENT-ADPKD)

Wong, Annette T Y, Mannix, Carly, Grantham, Jared J, Allman-Farinelli, Margaret, Badve, Sunil V, Boudville, Neil, Byth, Karen, Chan, Jessie, Coulshed, Susan, Edwards, Marie E, Erickson, Bradley J, Fernando, Mangalee, Foster, Sheryl, Haloob, Imad, Harris, David C H, Hawley, Carmel M, Hill, Julie, Howard, Kirsten, Howell, Martin, Jiang, Simon H, Johnson, David W, Kline, Timothy L, Kumar, Karthik, Lee, Vincent W, Lonergan, Maureen, Mai, Jun, McCloud, Philip, Peduto, Anthony, Rangan, Anna ... Rangan, Gopala K (2018). Randomised controlled trial to determine the efficacy and safety of prescribed water intake to prevent kidney failure due to autosomal dominant polycystic kidney disease (PREVENT-ADPKD). BMJ Open, 8 (1) e018794, e018794. doi: 10.1136/bmjopen-2017-018794

Randomised controlled trial to determine the efficacy and safety of prescribed water intake to prevent kidney failure due to autosomal dominant polycystic kidney disease (PREVENT-ADPKD)

Current funding

  • 2024 - 2029
    A multi-centre randomised controlled trial to treat acute T-cell mediated rejection in kidney and kidney pancreas transplant recipients (TACKLE-IT trial) (USyd administered MRFF ICTC 2023 grant)
    University of Sydney
    Open grant
  • 2024 - 2029
    A randomised trial of intensive vs less intensive corticosteroids for children with nephrotic syndrome (OPEN trial) (Administered by Flinders University)
    Flinders University
    Open grant
  • 2021 - 2026
    Centre of Research Excellence: Partnering with patients with chronic kidney disease to transform care and outcomes (CRE-PACT) (administered by University of Sydney)
    University of Sydney
    Open grant

Past funding

  • 2021 - 2023
    Patient perspectives and involvement in co-design of a trial evaluating interventions to improve gut health in peritoneal dialysis - GUT PD Study (ISPD grant led by Eastern Institute of Technology)
    Eastern Institute of Technology
    Open grant
  • 2021 - 2024
    Better Evidence and Translation In Chronic Kidney Disease (BEAT-CKD) (administered by SAHMRI)
    South Australian Health and Medical Research Institute Limited
    Open grant
  • 2020 - 2024
    BEAT-Calci (Better Evidence And Translation in Calciphylaxis) (MRFF RCRDUN administered by University of Sydney)
    University of Sydney
    Open grant
  • 2020 - 2024
    Vascular Access outcome measure for function: a vaLidation study In haemoDialysis (VALID)
    Metro South Hospital and Health Service
    Open grant
  • 2020 - 2025
    Serum phosphate to improve outcomes for dialysis patients: The PHOSPHATE Trial (HRC New Zealand)
    University of Otago
    Open grant
  • 2019 - 2025
    Better health through better trials: A national network to develop and implement innovative clinical trials methodology (NHMRC CRE administered by Monash University)
    Monash University
    Open grant
  • 2019 - 2024
    NAVKIDS2 trial: a multi-centre, dynamic, waitlist randomized controlled trial of patient navigators in children with chronic kidney disease (MRFF RCRDUN administered by University of Sydney)
    University of Sydney
    Open grant
  • 2019 - 2021
    A Targeted Education ApproaCH to improve Peritoneal Dialysis outcomes - Cluster Randomised Controlled Trial (MSH Research Support Scheme Project Grant administered by MSHHS)
    Metro South Hospital and Health Service
    Open grant
  • 2018 - 2020
    IMPEDE-PKD (Implementation of Metformin therapy to Ease Decline of kidney function in PKD). A Clinical Trial Investigating Metformin to slow the progression of renal dysfunction in ADPKD
    PKD Foundation of Australia Limited
    Open grant
  • 2018 - 2024
    Better Evidence for Selecting Transplant Fluids: The BEST-Fluids Trial (MRFF LCTRC administered by University of Sydney)
    University of Sydney
    Open grant
  • 2017 - 2022
    Evaluation of the efficacy and safety of health service dialysate sodium practice on clinical outcomes (NHMRC Project Grant externally led by the University of Sydney)
    University of New South Wales
    Open grant
  • 2016 - 2021
    Mid Cut-Off Haemodialysis: a safety and efficacy study
    Baxter Healthcare Pty Ltd
    Open grant
  • 2016
    The BLOCADE Study
    Austin Medical Research Foundation
    Open grant
  • 2016 - 2019
    Pexivas - NIHR
    Cambridge University Hospitals NHS Foundation Trust
    Open grant
  • 2016
    The TECH-PD trial (pilot study)
    International Society of Peritoneal Dialysis
    Open grant
  • 2016 - 2021
    Better evidence, better care and outcomes for people with chronic kidney disease (NHMRC Program Grant administered by Flinders University)
    Flinders University
    Open grant
  • 2014 - 2019
    KHA Operations Support
    Kidney Health Australia
    Open grant
  • 2014 - 2017
    ANZSN Operations Support
    Australian and New Zealand Society of Nephrology
    Open grant
  • 2013 - 2018
    A randomised, double-blind, placebo-controlled trial to assess the effect of phosphate reduction with lanthanum carbonate on arterial compliance and vascular calcification in patients with chronic kid
    NHMRC Project Grant
    Open grant
  • 2013 - 2015
    FAVOURED Trial
    AMGEN Australia Pty. Ltd.
    Open grant
  • 2013
    IMPROVE: IMPROVE (IMpact of Phospate Reduction on Vascular Endpoints in Chronic Kidney Disease)
    PA Research Foundation
    Open grant
  • 2012 - 2013
    The utility of matrix metalloproteinase-2 (MMP-2) to predict peritoneal injury in the incident PD population
    Kidney Health Australia
    Open grant
  • 2012 - 2014
    Serial NT-proBNP Monitoring for Predicting Major Cardiovascular Events in the Dialysis Population
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    AVATAR: ACE Inhibition for the preservation of renal function and patient survival in kidney transplantation (Canadian Institutes of Health Research grant admin. by the Ottawa Hospital Research Inst.)
    Ottawa Hospital Research Institute
    Open grant
  • 2011 - 2015
    The Beta-blocker to Lower Cardiovascular Dialysis Events (BLOCADE) Feasibility Study (NHMRC Project Grant administered by Uni Melbourne)
    University of Melbourne
    Open grant
  • 2011 - 2012
    The Utility of Serial NT-proBNP Monitoring for Predicting Cardiac Outcomes in the Dialysis Population
    Kidney Health Australia
    Open grant
  • 2010 - 2017
    PEXIVAS: Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (NHMRC Project Grant administered by the University of Adelaide)
    Central Adelaide Local Health Network Incorporated, trading as Royal Adelaide Hospital
    Open grant
  • 2010 - 2016
    Favoured: fish oil and aspirin in vascular access outcomes in renal disease
    Abbott Products Operations AG
    Open grant
  • 2010 - 2020
    IMPROVE: IMpact of Phosphate Reduction On Vascular Endpoints in chronic kidney disease
    Shire
    Open grant
  • 2008 - 2013
    A randomised controlled trial of exit site application of Medihoney(TM) for the prevention of catheter associated infections in peritoneal dialysis patients
    Queensland Health Smart Health Research Grant
    Open grant
  • 2008 - 2011
    A randomised, placebo-controlled trial of oxpentifylline on haemoglobin levels in patients with erythropoietin-resistant anaemia
    AMGEN Australia Pty. Ltd.
    Open grant
  • 2007 - 2010
    HERO (A randomized, placebo-controlled trial of oxpentifylline on haemoglobin levels in patients with erythropoietin-resistant anaemia)
    Janssen-Cilag Pty Limited (Janssen-Cilag Australia)
    Open grant
  • 2007 - 2012
    A randomised placebo-controlled trial of Oxpentifylline (Trental) in erythropoietin-resistant anaemia (ERA) in chronic kidney disease
    The Roche Foundation for Anemia Research
    Open grant
  • 2007 - 2014
    A trial of aspirin and fish oil for the prevention of thrombosis in dialysis access
    University of Western Australia
    Open grant
  • 2005 - 2016
    Australasian Kidney Trials Network (AKTN)
    NHMRC Enabling Grant
    Open grant
  • 2005 - 2011
    Australasian Clinical Trials Network in Nephrology (CTNN)
    Australian Kidney Foundation
    Open grant
  • 2005 - 2011
    Australialian Kidney Trials (AKT) Network
    Australian and New Zealand Society of Nephrology
    Open grant

Availability

Professor Carmel Hawley is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Professor Carmel Hawley directly for media enquiries about:

  • Chronic Kidney Disease
  • Haemodialysis
  • Kidney Clinical Trials
  • Kidney Dialysis
  • Kidney Transplant
  • Nephrology
  • Peritoneal Dialysis

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