Professor Joanne Blanchfield
Professor

Joanne Blanchfield

Email: 
Phone: 
+61 7 336 53622

Background

Natural Products from Traditional Medicines and drug development.

My group focuses on isolating bioactive natural products from plants and organisms used in traditional and herbal medicines in cultures across the globe. We screen extracts and purified compounds for biological activity and for bioavailability using cell techniques. We are also involved in synthesising analogues of natural compounds and components of subunit vaccines. We also work with first responders to develop methods for detection and decompostion of dangerous chemicals.

Availability

Professor Joanne Blanchfield is:
Available for supervision

Fields of research

Medicinal and biomolecular chemistry Organic chemistry

Qualifications

  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Natural products from traditional medicines

    Plants used for thousands of years for their medicinal properties are valuable sources of potential drug leads. We use the ancient knowledge of traditional medicines from across the globe to guide our search for potential bioactive compounds.

  • Detection and decomposition of hazardous chemicals

    The accurate detection and effective decomposition of dangerous chemicals such as illicit drugs and toxic agents is essential for the safety of first responders and military personal. We work closely with these groups to ensure that they have the best protocols for detection in real time and the most effective and safe decomposition methods available.

Research impacts

Our work with first responders and the Defence Force has identified a more effective method of decomposition of dangerous pharceutical agents encountered in various field settings. We are also working on optimising a method of detection for the most dangerous of compounds that can be performed on site and in real time. This work leads to a safer environment for first responders and for the community.

Our work with the indigenous communities and herbal medicine industry partners has identified bioactive compounds in Australian native plants that have been used by indigenous groups for hundreds of years.

Search Professor Joanne Blanchfield’s works on UQ eSpace

142 works between 1991 and 2024
All (142) Journal Article (82) Book Chapter (2) Conference Publication (57) Other Outputs (1)

21 - 40 of 142 works

2019

Journal Article

Pyrrolizidine alkaloids of Blue Heliotrope (Heliotropium amplexicaule) and their presence in Australian honey

Carpinelli de Jesus, Matheus, Hungerford, Natasha L., Carter, Steve J., Anuj, Shalona R., Blanchfield, Joanne T., De Voss, James Joseph and Fletcher, Mary T. (2019). Pyrrolizidine alkaloids of Blue Heliotrope (Heliotropium amplexicaule) and their presence in Australian honey. Journal of Agricultural and Food Chemistry, 67 (28) acs.jafc.9b02136, 7995-8006. doi: 10.1021/acs.jafc.9b02136

Pyrrolizidine alkaloids of Blue Heliotrope (Heliotropium amplexicaule) and their presence in Australian honey

2019

Journal Article

Caco-2 monolayer permeability and stability of Chamaelirium luteum (false unicorn) open-chain steroidal saponins

Stockdale, Tegan P., Challinor, Victoria L., Lehmann, Reginald P., De Voss, James J. and Blanchfield, Joanne T. (2019). Caco-2 monolayer permeability and stability of Chamaelirium luteum (false unicorn) open-chain steroidal saponins. ACS Omega, 4 (4), 7658-7666. doi: 10.1021/acsomega.9b00496

Caco-2 monolayer permeability and stability of Chamaelirium luteum (false unicorn) open-chain steroidal saponins

2018

Conference Publication

Identifying the pyrrolizidine alkaloid LC-MS/MS profile of Blue heliotrope (Heliotropium amplexicaule)

Matheus Carpinelli de Jesus, Natasha Hungerford, Steve Carter, Shalona Anuj, Joanne Blanchfield, James De Voss and Mary Fletcher (2018). Identifying the pyrrolizidine alkaloid LC-MS/MS profile of Blue heliotrope (Heliotropium amplexicaule). QMSS 2018 – 3rd Queensland Mass Spectrometry Symposium, QUT, Brisbane, 6-7 December 2018.

Identifying the pyrrolizidine alkaloid LC-MS/MS profile of Blue heliotrope (Heliotropium amplexicaule)

2018

Journal Article

Chromolactol, an Oxygenated Diterpene from the Indo-Pacific Nudibranch Goniobranchus coi: Spectroscopic and Computational Studies

Dewi, Ariyanti S., Pierens, Gregory K., Cheney, Karen L., Blanchfield, Joanne T. and Garson, Mary J. (2018). Chromolactol, an Oxygenated Diterpene from the Indo-Pacific Nudibranch Goniobranchus coi: Spectroscopic and Computational Studies. Australian Journal of Chemistry, 71 (10), 798-803. doi: 10.1071/CH18243

Chromolactol, an Oxygenated Diterpene from the Indo-Pacific Nudibranch Goniobranchus coi: Spectroscopic and Computational Studies

2018

Conference Publication

Pyrrolizidine alkaloids in Blue Heliotrope (Heliotropium amplexicaule) in Australia

Carpinelli de Jesus, M., Hungerford, N. L., Carter, S. J., Anuj, S. R., De Voss, J. J., Blanchfield, J. T. and Fletcher, M. T. (2018). Pyrrolizidine alkaloids in Blue Heliotrope (Heliotropium amplexicaule) in Australia. 10th International Symposium of Poisonous Plants (ISOPP10), St George, Utah, United States, 16-20 September 2018.

Pyrrolizidine alkaloids in Blue Heliotrope (Heliotropium amplexicaule) in Australia

2016

Journal Article

The sequestration of oxy-polybrominated diphenyl ethers in the nudibranchs Miamira magnifica and Miamira miamirana

Dewi, Ariyanti S., Cheney, Karen L., Urquhart, Holly H., Blanchfield, Joanne T. and Garson, Mary J. (2016). The sequestration of oxy-polybrominated diphenyl ethers in the nudibranchs Miamira magnifica and Miamira miamirana. Marine Drugs, 14 (11) 198, 198. doi: 10.3390/md14110198

The sequestration of oxy-polybrominated diphenyl ethers in the nudibranchs Miamira magnifica and Miamira miamirana

2016

Journal Article

Oxygenated diterpenes from the Indo-Pacific nudibranchs Goniobranchus splendidus and Ardeadoris egretta

White, Andrew M., Dewi, Ariyanti S., Cheney, Karen L., Winters, Anne E., Blanchfield, Joanne T. and Garson, Mary J. (2016). Oxygenated diterpenes from the Indo-Pacific nudibranchs Goniobranchus splendidus and Ardeadoris egretta. Natural Product Communications, 11 (7), 921-924. doi: 10.1177/1934578X1601100714

Oxygenated diterpenes from the Indo-Pacific nudibranchs Goniobranchus splendidus and Ardeadoris egretta

2016

Journal Article

The synthesis and ring-opening metathesis polymerization of glycomonomers

Weaver, Lucy G., Singh, Yogendra, Burn, Paul L. and Blanchfield, Joanne T. (2016). The synthesis and ring-opening metathesis polymerization of glycomonomers. RSC Advances, 6 (37), 31256-31264. doi: 10.1039/c5ra25732h

The synthesis and ring-opening metathesis polymerization of glycomonomers

2015

Journal Article

Isolation of norsesterterpenes and spongian diterpenes from Dorisprismatica (= Glossodoris) atromarginata

Yong, Ken W. L., Mudianta, I. Wayan, Cheney, Karen L., Mollo, Ernesto, Blanchfield, Joanne T. and Garson, Mary J. (2015). Isolation of norsesterterpenes and spongian diterpenes from Dorisprismatica (= Glossodoris) atromarginata. Journal of Natural Products, 78 (3), 421-430. doi: 10.1021/np500797b

Isolation of norsesterterpenes and spongian diterpenes from Dorisprismatica (= Glossodoris) atromarginata

2014

Journal Article

Enhanced transdermal peptide delivery and stability by lipid conjugation: epidermal permeation, stereoselectivity and mechanistic insights

Namjoshi, Sarika, Toth, Istvan, Blanchfield, Joanne T., Trotter, Nicholas, Mancera, Ricardo L. and Benson, Heather A. E. (2014). Enhanced transdermal peptide delivery and stability by lipid conjugation: epidermal permeation, stereoselectivity and mechanistic insights. Pharmaceutical Research, 31 (12), 3304-3312. doi: 10.1007/s11095-014-1420-5

Enhanced transdermal peptide delivery and stability by lipid conjugation: epidermal permeation, stereoselectivity and mechanistic insights

2014

Journal Article

Delivery of a lactose derivative of endomorphin 1 to the brain via the olfactory epithelial pathway

Cros, Cécile D., Toth, Istvan and Blanchfield, Joanne T. (2014). Delivery of a lactose derivative of endomorphin 1 to the brain via the olfactory epithelial pathway. Bioorganic and Medicinal Chemistry Letters, 24 (5), 1373-1375. doi: 10.1016/j.bmcl.2014.01.041

Delivery of a lactose derivative of endomorphin 1 to the brain via the olfactory epithelial pathway

2014

Journal Article

Erratum: Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: A mechanism for antigenotoxic action against a model epoxide (J. Nat. Prod. (2013) 76 (1958-1965) DOI: 10.1021/np4005807)

Mölzer, Christine, Huber, Hedwig, Steyrer, Andrea, Ziesel, Gesa V., Wallner, Marlies, Hong, Hung T., Blanchfield, Joanne T., Bulmer, Andrew C. and Wagner, Karl-Heinz (2014). Erratum: Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: A mechanism for antigenotoxic action against a model epoxide (J. Nat. Prod. (2013) 76 (1958-1965) DOI: 10.1021/np4005807). Journal of Natural Products, 77 (2), 436-436. doi: 10.1021/np500101y

Erratum: Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: A mechanism for antigenotoxic action against a model epoxide (J. Nat. Prod. (2013) 76 (1958-1965) DOI: 10.1021/np4005807)

2014

Journal Article

Carbohydrate globules: molecular asterisk-cored dendrimers for carbohydrate presentation

Weaver, Lucy G., Singh, Yogendra, Vamvounis, George, Wyatt, Mark F., Burn, Paul L. and Blanchfield, Joanne T. (2014). Carbohydrate globules: molecular asterisk-cored dendrimers for carbohydrate presentation. Polymer Chemistry, 5 (4), 1173-1179. doi: 10.1039/c3py01123b

Carbohydrate globules: molecular asterisk-cored dendrimers for carbohydrate presentation

2014

Journal Article

Acanthocyclamine A from the Indonesian marine sponge Acanthostrongylophora ingens

Dewi, Ariyanti S., Hadi, Tri A., Fajarningsih, Nurrahmi D., Blanchfield, Joanne T., Bernhardt, Paul V. and Garson, Mary J. (2014). Acanthocyclamine A from the Indonesian marine sponge Acanthostrongylophora ingens. Australian Journal of Chemistry, 67 (8-9), 1205-1210. doi: 10.1071/CH14107

Acanthocyclamine A from the Indonesian marine sponge Acanthostrongylophora ingens

2014

Journal Article

Chemistry for the masses

Sharpe, Philip C. and Blanchfield, Joanne T. (2014). Chemistry for the masses. International Journal of Innovation in Science and Mathematics Education, 22 (4), 33-47.

Chemistry for the masses

2013

Journal Article

Erratum: Oxygenated terpenoids from the Australian sponges Coscinoderma matthewsi and Dysidea sp., and the nudibranch Chromodoris albopunctata (Australian Journal of Chemistry (2012) 65:5 (531-538))

Katavic, Peter L., Jumaryatno, Pinus, Hooper, John N. A., Blanchfield, Joanne T. and Garson, Mary J. (2013). Erratum: Oxygenated terpenoids from the Australian sponges Coscinoderma matthewsi and Dysidea sp., and the nudibranch Chromodoris albopunctata (Australian Journal of Chemistry (2012) 65:5 (531-538)). Australian Journal of Chemistry, 66 (11). doi: 10.1071/CH12010-CO

Erratum: Oxygenated terpenoids from the Australian sponges Coscinoderma matthewsi and Dysidea sp., and the nudibranch Chromodoris albopunctata (Australian Journal of Chemistry (2012) 65:5 (531-538))

2013

Journal Article

Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide

Mölzer, Christine, Huber, Hedwig, Steyrer, Andrea, Ziesel, Gesa V., Wallner, Marlies, Hong, Hung T., Blanchfield, Joanne T., Bulmer, Andrew C. and Wagner, Karl-Heinz (2013). Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide. Journal of Natural Products, 76 (10), 1958-1965. doi: 10.1021/np4005807

Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide

2013

Journal Article

Structure and stereochemistry of an anti-inflammatory anhydrosugar from the Australian marine sponge Plakinastrella clathrata and the synthesis of two analogues

Katavic, Peter L., Yong, Ken W. L., Herring, Joel N., Deseo, Myrna A., Blanchfield, Joanne T., Ferro, Vito and Garson, Mary J. (2013). Structure and stereochemistry of an anti-inflammatory anhydrosugar from the Australian marine sponge Plakinastrella clathrata and the synthesis of two analogues. Tetrahedron, 69 (37), 8074-8079. doi: 10.1016/j.tet.2013.06.079

Structure and stereochemistry of an anti-inflammatory anhydrosugar from the Australian marine sponge Plakinastrella clathrata and the synthesis of two analogues

2013

Journal Article

Endomorphin derivatives with improved pharmacological properties

Varamini, Pegah, Blanchfield, Joanne T. and Toth, Istvan (2013). Endomorphin derivatives with improved pharmacological properties. Current Medicinal Chemistry, 20 (22), 2741-2758. doi: 10.2174/0929867311320220002

Endomorphin derivatives with improved pharmacological properties

2013

Journal Article

Cyclic peroxides from a two-sponge association of Plakortis communis-Agelas mauritiana

Jumaryatn, Pinus, Lambert, Lynette K., Hooper, John N. A., Blanchfield, Joanne T. and Garson, Mary J. (2013). Cyclic peroxides from a two-sponge association of Plakortis communis-Agelas mauritiana. Natural Product Communications, 8 (6), 725-728. doi: 10.1177/1934578x1300800611

Cyclic peroxides from a two-sponge association of Plakortis communis-Agelas mauritiana

Past funding

  • 2020 - 2022
    Surface Enhanced Raman Spectroscopy (SERS) using Spatial Offset Raman Spectroscopy (SORS) for spectral analysis of selected threats
    Commonwealth Defence Science and Technology Group
    Open grant
  • 2015 - 2016
    Online, virtual and adaptive learning environments: improving the journey through large first year chemistry courses
    Technology-Enhanced Learning Grants
    Open grant
  • 2014 - 2017
    Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines
    ARC Linkage Projects
    Open grant
  • 2014 - 2015
    An evaluation of the effectiveness of various absorption enhancers on the bioavailability of herbal extracts
    UniQuest Pty Ltd
    Open grant
  • 2010 - 2011
    Assessing the oral bioavailability of components of herbal extracts using Caco-2 cell monolayers
    UQ FirstLink Scheme
    Open grant
  • 2009 - 2013
    Physiological effects of bile pigments (Austrian Science Fund project administered by the University of Vienna)
    University of Vienna
    Open grant
  • 2008 - 2010
    New neuropathic pain drugs
    NHMRC Development Grant
    Open grant
  • 2008 - 2009
    Analytical and preparative enantioselective chromatography
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2006
    A high resolution, high-throughput chromatographic system for separation and characterisation of complex samples
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2006 - 2008
    Next Generation Polymer Nanostructures
    ARC Discovery Projects
    Open grant
  • 2004 - 2005
    Biological membrane transporters:  Delivery of an oligonucleotide inhibitor of vascular endothelial growth factor (VEGF)
    NHMRC Development Grant
    Open grant
  • 2004 - 2006
    Synthesis Of Glycopeptide CNS Drug Candidates Applying Chemical And Chemo-Enzymatic Methods
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003 - 2004
    A novel liposaccharide system for the delivery of opioid peptides across the blood brain barrier
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2003 - 2006
    A combinatorial approach to creation of new epitopes with biological activity
    ARC Linkage Projects
    Open grant

Availability

Professor Joanne Blanchfield is:
Available for supervision

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Available projects

  • Identification of bioactive compounds from Australian native plants

    In consultation with indigenous collaborators and herbal medicine industry collaborators, we extract Australian native plants that have been identifying as having some medicinal properties and screen the extracts for selected biological activities. We then fractionate the extracts using a variety of chromatographic techniques to isolate individual natural products present in the plants. The structures of these compounds are then identified using modern analytical techniques including mass spectrometry and 1 and 2 dimensional nuclear magnetic resonance (NMR) techniques. The isolated compounds and extracts can also be screened for potential bioavailability using Caco-2 cell monolayers.

Supervision history

Current supervision

  • Doctor Philosophy

    Isolation and identification of natural products from Australian Native Medicinal Plants

    Principal Advisor

    Other advisors: Professor James De Voss

  • Doctor Philosophy

    The construction of synthetic mimics of complex conformational epitopes of HIV

    Principal Advisor

    Other advisors: Professor Paul Burn

  • Doctor Philosophy

    Identification of the Structure and bioavailability of bioactive compounds from Australian native plants.

    Principal Advisor

    Other advisors: Professor James De Voss

  • Doctor Philosophy

    Isolation and identification of natural products from Australian Native Medicinal Plants

    Principal Advisor

    Other advisors: Professor James De Voss

  • Doctor Philosophy

    Clicking Conjugates into Place for the Fight Against Antibiotic Resistance

    Associate Advisor

    Other advisors: Dr Anthony Verderosa, Professor Mark Blaskovich

  • Doctor Philosophy

    Synthesis of peptide antibiotic constituents for elucidation of their biosyntheses and II) Characterization of bacterial cytochromes P450

    Associate Advisor

    Other advisors: Professor James De Voss

  • Doctor Philosophy

    Selenium - The SuperElement against Superbugs

    Associate Advisor

    Other advisors: Professor Mark Blaskovich

  • Doctor Philosophy

    Conotoxins - advanced probes for studying pain pathways

    Associate Advisor

    Other advisors: Professor Mark Blaskovich

  • Doctor Philosophy

    Bioactive Phytochemicals from Australian Native Plants used as Ingienous medicines

    Associate Advisor

    Other advisors: Professor James De Voss

Completed supervision

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