Professor Melissa Brown
Professor

Melissa Brown

Email: 
Phone: 
+61 7 336 51609

Background

Melissa is no longer active in research, and so is unable to supervise new students.

BIOGRAPHY

Melissa Brown completed her PhD at the Walter and Eliza Hall Institute in Melbourne in 1993, on the structure and regulation of genes encoding colony-stimulating factor receptors in human leukaemia.

She then undertook postdoctoral training at the Imperial Cancer Research Fund (now Cancer Research UK) in London, funded firstly by an EMBO and then by an ICRF postdoctoral fellowship, working on the isolation and characterization of the first breast cancer susceptibility gene, BRCA1.

She joined The University of Queensland in 2000 as a Lecturer and is now a Professor and Executive Dean. In 2005 she undertook a six-month sabbatical at the Sir William Dunn School of Pathology at The University of Oxford.

The focus of Melissa’s research is cancer genetics, in particular understanding the transcriptional and post-transcriptional regulation of breast cancer genes and the impact of genetic variants on cancer risk and progression.

Availability

Professor Melissa Brown is:
Not available for supervision
Media expert

Fields of research

Biological Sciences Genetics Oncology and carcinogenesis

Qualifications

  • Bachelor of Science, University of Melbourne
  • Bachelor (Honours) of Science (Advanced), University of Melbourne
  • Doctor of Philosophy, University of Melbourne

Research interests

  • Regulation and function of cancer susceptibility genes

    Breast cancer is the most common cancer in women and results from abnormal expression or function of multiple tumour suppressor genes and oncogenes. Our laboratory is interested in the regulation and function of a number of breast cancer- associated genes including those encoding BRCA1, BRCA2, and a range of miRNAs. We use a wide variety of molecular and cellular techniques to study how the expression of these genes is regulated and to examine the molecular and cellular consequences of disrupting their function in breast epithelial cell-lines and the mammary gland of mouse models. Project 1: Regulation of the breast cancer susceptibility gene BRCA1 This project will involve identifying novel regulatory elements controlling the expression of the BRCA1 gene. We are especially interested in the 3�UTR of BRCA1 and miRNAs that target this region. This project will involve elucidating the structure, function and clinical relevance of functional elements in the BRCA1 3�UTR. These elements have the potential to form the basis of improved pre-symptomatic diagnostics for breast cancer. Project 2: Regulation of microRNA genes in advanced breast cancer The aim of this project is to identify and functionally characterize miRNA promoters and their downstream target genes. Particular interest will be given to miRNAs that may be susceptible to aberrant epigenetic regulation. These miRNA have the potential to be novel biomarkers for the identification and management of patients that are susceptible to advanced breast cancer. Project 3: Molecular & cellular consequences of disrupting breast cancer genes The aim of this project is to understand how changes in the regulation or function of breast cancer genes results in the development of breast cancer. This project will involve examining the effect of increasing and decreasing the expression of normal, variant and mutant forms of breast cancer genes on the expression of genes, including miRNAs, in breast epithelial cells. These molecules have the potential to be targets of novel therapeutic agents to treat breast cancer. Techniques: Bioinformatics, gene cloning and mutagenesis, mammalian cell culture and gene transfer, reporter gene assays, real-time PCR, Northern blotting, chromatin conformation assays, methylation specific DNA analysis, cell culture assays including cell proliferation and differentiation.

Search Professor Melissa Brown’s works on UQ eSpace

146 works between 1976 and 2023
All (146) Journal Article (111) Book Chapter (1) Conference Publication (34)

41 - 60 of 146 works

2012

Journal Article

Identification of fifteen novel germline variants in the BRCA1 3′UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site

Brewster, Brooke L., Rossiello, Francesca, French, Juliet D., Edwards, Stacey L., Wong, Ming, Wronski, Ania, Whiley, Phillip, Waddell, Nic, Chen, Xiaowei, Bove, Betsy, kConFab, Hopper, John L., John, Esther M., Andrulis, Irene, Daly, Mary, Volorio, Sara, Bernard, Loris, Peissel, Bernard, Manoukian, Siranoush, Barile, Monica, Pizzamiglio, Sara, Verderio, Paolo, Spurdle, Amanda B., Radice, Paolo, Godwin, Andrew K., Southey, Melissa C., Brown, Melissa A. and Peterlongo, Paolo (2012). Identification of fifteen novel germline variants in the BRCA1 3′UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site. Human Mutation, 33 (12), 1665-1675. doi: 10.1002/humu.22159

Identification of fifteen novel germline variants in the BRCA1 3′UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site

2012

Journal Article

Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors

Smart, Chanel E., Askarian Amiri, Marjan E., Wronski, Ania, Dinger, Marcel E., Crawford, Joanna, Ovchinnikov, Dmitry A., Vargas, Ana Cristina, Reid, Lynne, Simpson, Peter T., Song, Sarah, Wiesner, Christiane, French, Juliet D., Dave, Richa K., da Silva, Leonard, Purdon, Amy, Andrew, Megan, Mattick, John S., Lakhani, Sunil R., Brown, Melissa A. and Kellie, Stuart (2012). Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors. PLoS One, 7 (7) e40742, e40742.1-e40742.13. doi: 10.1371/journal.pone.0040742

Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors

2012

Journal Article

Androgen receptor expression predicts breast cancer survival: The role of genetic and epigenetic events

Peters, Kate M., Edwards, Stacey L., Nair, Shalima S., French, Juliet D., Bailey, Peter J., Salkield, Kathryn, Stein, Sandra, Wagner, Sarah, Francis, Glenn D., Clark, Susan J. and Brown, Melissa A. (2012). Androgen receptor expression predicts breast cancer survival: The role of genetic and epigenetic events. BMC Cancer, 12 (132) 132, 1-10. doi: 10.1186/1471-2407-12-132

Androgen receptor expression predicts breast cancer survival: The role of genetic and epigenetic events

2012

Journal Article

Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in adva

Wee, E.J.H., Peters, K., Nair, S.S., Hulf, T., Stein, S., Wagner, S., Bailey, P., Lee, S.Y., Qu, W.J., Brewster, B., French, J.D., Dobrovic, A., Francis, G.D., Clark, S.J. and Brown, M.A. (2012). Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in adva. Oncogene, 31 (38), 4182-4195. doi: 10.1038/onc.2011.584

Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in adva

2012

Journal Article

A guide for functional analysis of BRCA1 variants of uncertain significance

Millot, Gael A., Carvalho, Marcelo A., Caputo, Sandrine M., Vreeswijk, Maaike P. G., Brown, Melissa A., Webb, Michelle, Rouleau, Etienne, Hansen, Thomas v. O., Galli, Alvaro, Brand˜ao, Rita D., Blok, Marinus J., Velkova, Aneliya, Couch, Fergus J., Monteiro, Alvaro N. A. and ENIGMA (2012). A guide for functional analysis of BRCA1 variants of uncertain significance. Human Mutation, 33 (11), 1526-1537. doi: 10.1002/humu.22150

A guide for functional analysis of BRCA1 variants of uncertain significance

2012

Conference Publication

Cardiac transplantation for chemotherapy induced cardiomyopathy: Demographics and long term follow-up

McKenzie, S.C., Sharma, A., Chee, K.W., Platts, D., Javorskky, G. and Brown, M. (2012). Cardiac transplantation for chemotherapy induced cardiomyopathy: Demographics and long term follow-up. 32nd Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation/Meeting of the ISHLT Academy Core Competencies in Mechanical Circulatory Support, Prague, Czech Republic, 17-21 April 2012. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.healun.2012.01.448

Cardiac transplantation for chemotherapy induced cardiomyopathy: Demographics and long term follow-up

2011

Journal Article

p53-Dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage

Jiang, Juhong, Yang, Eddy S., Jiang, Guochun, Nowsheen, Somaira, Wang, Hong, Wang, Tong, Wang, Yihan, Billheimer, Dean, Chakravarthy, A. Bapsi, Brown, Melissa, Haffty, Bruce and Xia, Fen (2011). p53-Dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage. Cancer Research, 71 (16), 5546-5557. doi: 10.1158/0008-5472.CAN-10-3423

p53-Dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage

2011

Journal Article

Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary

Whiley, Phillip J., Guidugli, Lucia, Walker, Logan C., Healey, Sue, Thompson, Bryony A., Lakhani, Sunil R., Da Silva, Leonard M., kConFab Investigators, Tavtigian, Sean V., Goldgar, David E., Brown, Melissa A., Couch, Fergus J. and Spurdle, Amanda B. (2011). Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary. Human Mutation, 32 (6), 678-687. doi: 10.1002/humu.21495

Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary

2011

Journal Article

SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer

Askarian-Amiri, Marjan E., Crawford, Joanna, French, Juliet D., Smart, Chanel E., Smith, Martin A., Clark, Michael B., Ru, Kelin, Mercer, Tim R., Thompson, Ella R., Lakhani, Sunil R., Vargas, Ana C., Campbell, Ian G., Brown, Melissa A., Dinger, Marcel E. and Mattick, John S. (2011). SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. RNA, 17 (5), 878-891. doi: 10.1261/rna.2528811

SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer

2011

Journal Article

ORAI1-mediated calcium influx in lactation and in breast cancer

McAndrew, Damara, Grice, Desma M., Peters, Amelia A., Davis, Felicity M., Stewart, Teneale, Rice, Michelle, Smart, Chanel E., Brown, Melissa A., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). ORAI1-mediated calcium influx in lactation and in breast cancer. Molecular Cancer Therapeutics, 10 (3), 448-460. doi: 10.1158/1535-7163.MCT-10-0923

ORAI1-mediated calcium influx in lactation and in breast cancer

2011

Journal Article

Analysis of brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

Smart, C.E., Wronski, A., French, J.D., Edwards, S.L., Asselin-Labat, M.L., Waddell, N., Peters, K., Brewster, B.L., Brooks, K., Simpson, K., Manning, N., Lakhani, S.R., Grimmond, S., Lindeman, G.J., Visvader, J.E. and Brown, M.A. (2011). Analysis of brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit. Oncogene, 30 (13), 1597-1607. doi: 10.1038/onc.2010.538

Analysis of brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

2011

Journal Article

Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers

Ramus, Susan J., Kartsonaki, Christiana, Gayther, Simon A., Pharoah, Paul D. P., Sinilnikova, Olga M., Beesley, Jonathan, Chen, Xiaoqing, McGuffog, Lesley, Healey, Sue, Couch, Fergus J., Wang, Xianshu, Fredericksen, Zachary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Zaffaroni, Daniela, Roversi, Gaia, Barile, Monica, Viel, Alessandra, Allavena, Anna, Ottini, Laura, Papi, Laura, Gismondi, Viviana, Capra, Fabio, Radice, Paolo, Greene, Mark H., Mai, Phuong L., Andrulis, Irene L., Glendon, Gord ... Lakhani, Sunil (2011). Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Journal of the National Cancer Institiute, 103 (2), 105-116. doi: 10.1093/jnci/djq494

Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers

2011

Journal Article

Constitutional methylation of the BRCA1 promoter Is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer

Wong, Ee Ming, Southey, Melissa C., Fox, Stephen B., Brown, Melissa A., Dowty, James G., Jenkins, Mark A., Giles, Graham G., Hopper, John L. and Dobrovic, Alexander (2011). Constitutional methylation of the BRCA1 promoter Is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer. Cancer Prevention Research, 4 (1), 23-33. doi: 10.1158/1940-6207.CAPR-10-0212

Constitutional methylation of the BRCA1 promoter Is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer

2010

Journal Article

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Antoniou, Antonis C., Wang, Xianshu, Fredericksen, Zachary S., McGuffog, Lesley, Tarrell, Robert, Sinilnikova, Olga M., Healey, Sue, Morrison, Jonathan, Kartsonaki,Christiana, Lesnick, Timothy, Ghoussaini, Maya, Barrowdale, Daniel, Peock, Susan, Cook, Margaret, Oliver, Clare, Frost, Debra, Eccles, Diana, Evans, D. Gareth, Eeles, Ros, Izatt, Louise, Chu, Carol, Douglas, Fiona, Paterson, Joan, Stoppa-Lyonnet, Dominique, Houdayer, Claude, Mazoyer, Sylvie, Giraud, Sophie, Lasset, Christine, Remenieras, Audrey ... Lakhani, Sunil (2010). A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population. Nature Genetics, 42 (10), 885-892. doi: 10.1038/ng.669

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

2010

Journal Article

Common genetic variants and modification of penetrance of BRCA2-associated breast cancer

Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn, Candace Guiducci, Ayellet V. Segre, Kate McGee, Lesley McGuffog, Christiana Kartsonaki, Jonathan Morrison, Sue Healey, Olga M. Sinilnikova, Dominique Stoppa-Lyonnet, Sylvie Mazoyer, Marion Gauthier-Villars, Hagay Sobol, Michel Longy, Marc Frenay, GEMO Study Collaborators, Frans B. L. Hogervorst, Matti a. Rookus, J. Margriet Collee, Nicoline Hoogerbrugge, Kees E. P. van Roozendaal, HEBON Study Collaborators, Marion Piedmonte, Wendy Rubinstein, Stacy Nerenstone ... Lakhani, Sunil (2010). Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genetics, 6 (10), e1001183-1-e1001183-12. doi: 10.1371/journal.pgen.1001183

Common genetic variants and modification of penetrance of BRCA2-associated breast cancer

2010

Journal Article

Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers

Wang, Xianshu, Pankratz, V. Shane, Fredericksen, Zachary, Tarrell, Robert, Karaus, Mary, McGuffog, Lesley, Pharaoh, Paul D.P., Ponder, Bruce A.J., Dunning, Alison M., Peock, Susan, Cook, Margaret, Oliver, Clare, Frost, Debra, EMBRACE, Sinilnikova, Olga M., Stoppa-Lyonnet, Dominique, Mazoyer, Sylvie, Houdayer, Claude, GEMO, Hogervorst, Frans B.L., Hooning, Maartje J., Ligtenberg, Marjolijn J., HEBON, Spurdle, Amanda, Chenevix-Trench, Georgia, kConFab, Schmutzler, Rita K., Wappenschmidt, Barbara, Engel, Christoph ... Lakhani, Sunil (2010). Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers. Human Molecular Genetics, 19 (14), 2886-2897. doi: 10.1093/hmg/ddq174

Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers

2010

Journal Article

Detection of Splicing Aberrations Caused by BRCA1 and BRCA2 Sequence Variants Encoding Missense Substitutions: Implications for Prediction of Pathogenicity

Walker, Logan C., Whiley, Phillip J., Couch, Fergus J., Farrugia, Daniel J., Healey, Sue, Eccles, Diana M., Lin, Feng, Butler, Samantha A., Goff, Sheila A., Thompson, Bryony A., Lakhani, Sunil R., Da Silva, Leonard M., Tavtigian, Sean V., Goldgar, David E., Brown, Melissa A. and Spurdle, Amanda B. (2010). Detection of Splicing Aberrations Caused by BRCA1 and BRCA2 Sequence Variants Encoding Missense Substitutions: Implications for Prediction of Pathogenicity. Human Mutation, 31 (6), E1484-E1505. doi: 10.1002/humu.21267

Detection of Splicing Aberrations Caused by BRCA1 and BRCA2 Sequence Variants Encoding Missense Substitutions: Implications for Prediction of Pathogenicity

2010

Journal Article

Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts

Whiley, Phillip J., Pettigrew, Christopher A., Brewster, Brooke L., Walker, Logan C., Spurdle, Amanda B. and Brown, Melissa A. (2010). Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts. BMC Medical Genetics, 11 (1) 80, 80-1-80-5. doi: 10.1186/1471-2350-11-80

Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts

2010

Journal Article

DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status

Flanagan, James M., Cocciardi, Sibylle, Waddell, Nic, Johnstone, Cameron N., Marsh, Anna, Henderson, Stephen, Simpson, Peter, da Silva, Leonard, kConFab Investigators, Khanna, Kumkum, Lakhani, Sunil, Boshoff, Chris, Chenevix-Trench, Georgia, Brown, Melissa, Cummings, Margaret and Edwards, Stacey (2010). DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status. American Journal of Human Genetics, 86 (3), 420-433. doi: 10.1016/j.ajhg.2010.02.008

DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status

2010

Journal Article

Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study

Milne, Roger L., Gaudet, Mia M., Spurdle, Amanda B., Fasching, Peter A., Couch, Fergus J., Benitez, Javier, Arias Perez, Jose Ignacio, Zamora, M. Pilar, Malats, Nuria, dos Santos Silva, Isabel, Gibson, Lorna J., Fletcher, Olivia, Johnson, Nichola, Anton-Culver, Hoda, Ziogas, Argyrios, Figueroa, Jonine, Brinton, Louise, Sherman, Mark E., Lissowska, Jolanta, Hopper, John L., Dite, Gillian S., Apicella, Carmel, Southey, Melissa C., Sigurdson, Alice J., Linet, Martha S., Schonfeld, Sara J., Freedman, D. Michal, Mannermaa, Arto, Kosma, Veli-Matti ... Lakhani, Sunil (2010). Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study. Breast Cancer Research, 12 (6) R110, R110.1-R110.11. doi: 10.1186/bcr2797

Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study

Past funding

  • 2016 - 2019
    Clinical classification of regulatory variants in breast cancer susceptibility genes
    NHMRC Project Grant
    Open grant
  • 2015 - 2018
    Profiling the intratumoural microbiome and host reactions in breast cancer tissue
    Wesley Merdical Research
    Open grant
  • 2015 - 2017
    Exploiting the overexpression of a specific calcium permeable ion channel in breast cancer cells: a new pharmacological approach to targeting breast cancer.
    NHMRC Project Grant
    Open grant
  • 2015 - 2016
    Making Herceptin-resistant tumours Herceptin responsive: adapting new therapeutic potential from Head and Neck Cancer research to improve breast cancer outcomes
    National Breast Cancer Foundation
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2019
    Enabling Clinical Epigenetic Diagnostics: The Next Generation of Personalized Breast Cancer Care
    National Breast Cancer Foundation
    Open grant
  • 2013 - 2015
    Examination of the Expression and Potential Role of Cancer Associated Viral Sequences in the Causation and Outcomes of Breast Cancer Patients
    Wesley Merdical Research
    Open grant
  • 2013 - 2015
    The role of BRCA non-coding mutations in breast cancer susceptibility
    Cancer Council Queensland
    Open grant
  • 2012 - 2017
    The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (NBCF Infrastructure Grant led by UoM)
    University of Melbourne
    Open grant
  • 2012
    An intergrated fluidic circuit system for digital PCR analysis, single-cell gene- expression, and high-throughput preparation of next-generation sequencing libraries.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2013
    Functional analysis of breast cancer susceptibility regions
    NHMRC Project Grant
    Open grant
  • 2012 - 2015
    Transcriptional regulation of non-code RNA genes implicated in breast cancer
    Cancer Council Queensland
    Open grant
  • 2011 - 2015
    Translating health discoveries into products
    Queensland Government Smart Futures Co-Investment Fund
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Establishment of a digital Scanscope system for virtual microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    Identifying long-range regulatory elements of the breast cancer susceptibility gene, BRCA1
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    The role of the BRCA1 3'UTR in breast cancer
    Cancer Council Queensland
    Open grant
  • 2010 - 2013
    Two recently identified calcium transporters in lactation and during mammary epithelial cell apoptosis.
    NHMRC Project Grant
    Open grant
  • 2009 - 2011
    The MYB gene as a model for global transcriptional regulation: stopping, starting and looping
    ARC Discovery Projects
    Open grant
  • 2008 - 2013
    Novel strategies for prediction and control of advanced breast cancer via nanoscaled epigenetic-based biosensors
    National Breast Cancer Foundation
    Open grant
  • 2008 - 2009
    The role of the MYB oncogene in mammary carcinogenesis
    Cancer Council Queensland
    Open grant
  • 2008
    A high-throughput facility for the identification and analysis of gene regulatory elements and factors
    UQ Major Equipment and Infrastructure
    Open grant
  • 2008 - 2009
    Investigating the role of gene loops in regulating gene expression
    ARC Discovery Projects
    Open grant
  • 2007
    Early detection of breast cancer via nanoscaled biomarker discovery and diagnostics
    National Breast Cancer Foundation
    Open grant
  • 2007 - 2009
    Noncoding RNAs as prognostic markers and therapeutic targets in breast cancer
    NHMRC Project Grant
    Open grant
  • 2006 - 2008
    Identification of new mutations that contribute to breast cancer
    NHMRC Project Grant
    Open grant
  • 2006 - 2007
    Investigating the molecular and cellular origin of BRCA-1 associated breast tumours
    National Breast Cancer Foundation
    Open grant
  • 2006 - 2007
    The role of DEP-1 as a tumour suppressor in breast cancer
    Queensland Cancer Fund
    Open grant
  • 2005 - 2006
    ESEG_The role of DEP-1 as a tumour suppressor in breast cancer
    UQ External Support Enabling Grant
    Open grant
  • 2004
    Identification Of Critical Gene Regulatory Elements Using A Combination Of Molecular Biology And Information Theory Approaches
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003 - 2004
    Investigating the Role of BRCA1 in Mammary Differentiation and Morphogenesis
    Queensland Cancer Fund
    Open grant
  • 2002 - 2003
    Investigating the role of BRCA1 in mammary differentiation and morphogenesis
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2002 - 2004
    BRCA1, PML and telomere maintenance: understanding how abnormalities in chromosome ends contribute to breast cancer
    NHMRC Project Grant
    Open grant
  • 2001 - 2002
    BRCA1 in DNA repair and tumourigenesis
    Queensland Cancer Fund
    Open grant
  • 2001 - 2003
    Identification of Critical Regulatory Elements in the BRCA1 Gene
    NHMRC Project Grant
    Open grant
  • 2001
    Understanding how molecular abnormalities contribute to breast cancer
    UQ Early Career Researcher
    Open grant
  • 2000 - 2001
    Molecular biology of the breast cancer susceptibility gene BRCA1
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Professor Melissa Brown is:
Not available for supervision

Supervision history

Completed supervision

Enquiries

Contact Professor Melissa Brown directly for media enquiries about:

  • Animal models of human diseases
  • Biology - cells
  • Biology - molecular
  • Breast cancer
  • Cancer - breast
  • Cancer - genetics
  • Cancer susceptibility genes
  • Cellular biology
  • Diseases - animal models of human diseases
  • Gene regulation
  • Genetics
  • Human diseases - animal models of
  • Molecular biology

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au