Professor Melissa Brown
Professor

Melissa Brown

Email: 
Phone: 
+61 7 336 51609

Background

Melissa is no longer active in research, and so is unable to supervise new students.

BIOGRAPHY

Melissa Brown completed her PhD at the Walter and Eliza Hall Institute in Melbourne in 1993, on the structure and regulation of genes encoding colony-stimulating factor receptors in human leukaemia.

She then undertook postdoctoral training at the Imperial Cancer Research Fund (now Cancer Research UK) in London, funded firstly by an EMBO and then by an ICRF postdoctoral fellowship, working on the isolation and characterization of the first breast cancer susceptibility gene, BRCA1.

She joined The University of Queensland in 2000 as a Lecturer and is now a Professor and Executive Dean. In 2005 she undertook a six-month sabbatical at the Sir William Dunn School of Pathology at The University of Oxford.

The focus of Melissa’s research is cancer genetics, in particular understanding the transcriptional and post-transcriptional regulation of breast cancer genes and the impact of genetic variants on cancer risk and progression.

Availability

Professor Melissa Brown is:
Not available for supervision
Media expert

Fields of research

Biological Sciences Genetics Oncology and carcinogenesis

Qualifications

  • Bachelor of Science, University of Melbourne
  • Bachelor (Honours) of Science (Advanced), University of Melbourne
  • Doctor of Philosophy, University of Melbourne

Research interests

  • Regulation and function of cancer susceptibility genes

    Breast cancer is the most common cancer in women and results from abnormal expression or function of multiple tumour suppressor genes and oncogenes. Our laboratory is interested in the regulation and function of a number of breast cancer- associated genes including those encoding BRCA1, BRCA2, and a range of miRNAs. We use a wide variety of molecular and cellular techniques to study how the expression of these genes is regulated and to examine the molecular and cellular consequences of disrupting their function in breast epithelial cell-lines and the mammary gland of mouse models. Project 1: Regulation of the breast cancer susceptibility gene BRCA1 This project will involve identifying novel regulatory elements controlling the expression of the BRCA1 gene. We are especially interested in the 3�UTR of BRCA1 and miRNAs that target this region. This project will involve elucidating the structure, function and clinical relevance of functional elements in the BRCA1 3�UTR. These elements have the potential to form the basis of improved pre-symptomatic diagnostics for breast cancer. Project 2: Regulation of microRNA genes in advanced breast cancer The aim of this project is to identify and functionally characterize miRNA promoters and their downstream target genes. Particular interest will be given to miRNAs that may be susceptible to aberrant epigenetic regulation. These miRNA have the potential to be novel biomarkers for the identification and management of patients that are susceptible to advanced breast cancer. Project 3: Molecular & cellular consequences of disrupting breast cancer genes The aim of this project is to understand how changes in the regulation or function of breast cancer genes results in the development of breast cancer. This project will involve examining the effect of increasing and decreasing the expression of normal, variant and mutant forms of breast cancer genes on the expression of genes, including miRNAs, in breast epithelial cells. These molecules have the potential to be targets of novel therapeutic agents to treat breast cancer. Techniques: Bioinformatics, gene cloning and mutagenesis, mammalian cell culture and gene transfer, reporter gene assays, real-time PCR, Northern blotting, chromatin conformation assays, methylation specific DNA analysis, cell culture assays including cell proliferation and differentiation.

Search Professor Melissa Brown’s works on UQ eSpace

146 works between 1976 and 2023
All (146) Journal Article (111) Book Chapter (1) Conference Publication (34)

121 - 140 of 146 works

2000

Journal Article

Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice

Lane, T. F., Lin, C. W., Brown, M. A., Solomon, E. and Leder, P. (2000). Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice. Oncogene, 19 (36), 4085-4090. doi: 10.1038/sj.onc.1203760

Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice

1999

Journal Article

Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions

Catteau, A., Xu, C. F., Brown, M. A., Hodgson, S., Greenman, J., Mathew, C. G., Dunning, A. M. and Solomon, E. (1999). Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions. British Journal of Cancer, 79 (5-6), 759-763. doi: 10.1038/sj.bjc.6690122

Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions

1997

Journal Article

Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene

Xu, CF, Brown, MA, Nicolai, H, Chambers, JA, Griffiths, BL and Solomon, E (1997). Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. Human Molecular Genetics, 6 (7), 1057-1062. doi: 10.1093/hmg/6.7.1057

Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene

1997

Journal Article

Studies on inherited cancers: Outcomes and challenges of 25 years

Brown, MA and Solomon, E (1997). Studies on inherited cancers: Outcomes and challenges of 25 years. Trends in Genetics, 13 (5), 202-206. doi: 10.1016/S0168-9525(97)01132-3

Studies on inherited cancers: Outcomes and challenges of 25 years

1997

Journal Article

Mutations and alternative splicing of the BRCAI gene in UK breast/ovarian cancer families

Xu, CF, Chambers, JA, Nicolai, H, Brown, MA, Hujeirat, Y, Mohammed, S, Hodgson, S, Kelsell, DP, Spurr, NK, Bishop, DT and Solomon, E (1997). Mutations and alternative splicing of the BRCAI gene in UK breast/ovarian cancer families. Genes Chromosomes & Cancer, 18 (2), 102-110. doi: 10.1002/(SICI)1098-2264(199702)18:23.0.CO;2-6

Mutations and alternative splicing of the BRCAI gene in UK breast/ovarian cancer families

1997

Journal Article

Tumor suppressor genes and human cancer

Brown, MA (1997). Tumor suppressor genes and human cancer. Advances in Genetics, Vol 36, 36 (C), 45-135. doi: 10.1016/S0065-2660(08)60307-7

Tumor suppressor genes and human cancer

1996

Journal Article

The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21

Brown, MA, Xu, CF, Nicolai, H, Griffiths, B, Chambers, JA, Black, D and Solomon, E (1996). The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21. Oncogene, 12 (12), 2507-2513.

The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21

1995

Journal Article

Distinct Transcription Start Sites Generate 2 Forms of Brca1 Messenger-Rna

Xu, CF, Brown, MA, Chambers, JA, Griffiths, B, Nicolai, H and Solomon, E (1995). Distinct Transcription Start Sites Generate 2 Forms of Brca1 Messenger-Rna. Human Molecular Genetics, 4 (12), 2259-2264. doi: 10.1093/hmg/4.12.2259

Distinct Transcription Start Sites Generate 2 Forms of Brca1 Messenger-Rna

1995

Journal Article

Physical Mapping, Cloning, and Identification of Genes Within a 500-Kb Region Containing Brca1

Brown, MA, Jones, KA, Nicolai, H, Bonjardim, M, Black, D, McFarlane, R, Dejong, P, Quirk, JP, Lehrach, H and Solomon, E (1995). Physical Mapping, Cloning, and Identification of Genes Within a 500-Kb Region Containing Brca1. Proceedings of the National Academy of Sciences of the United States of America, 92 (10), 4362-4366. doi: 10.1073/pnas.92.10.4362

Physical Mapping, Cloning, and Identification of Genes Within a 500-Kb Region Containing Brca1

1995

Journal Article

Molecular genetics of sporadic and familial breast cancer

Jones, KA, Brown, MA and Solomon, E (1995). Molecular genetics of sporadic and familial breast cancer. Cancer Surveys, 25, 315-334.

Molecular genetics of sporadic and familial breast cancer

1994

Journal Article

Regulation of Brca1

Brown, MA, Nicolai, H, Xu, CF, Griffiths, BL, Jones, KA, Solomon, E, Hosking, L, Trowsdale, J, Black, DM and McFarlane, R (1994). Regulation of Brca1. Nature, 372 (6508), 733-733. doi: 10.1038/372733a0

Regulation of Brca1

1994

Journal Article

The Detailed Characterization of a 400-Kb Cosmid Walk in the Brca1 Region - Identification and Localization of 10 Genes Including a Dual-Specificity Phosphatase

Jones, KA, Black, DM, Brown, MA, Griffiths, BL, Nicolai, HM, Chambers, JA, Bonjardim, M, Xu, CF, Boyd, M, McFarlane, R, Korn, B, Poustka, A, North, MA, Schalkwyk, L, Lehrach, H and Solomon, E (1994). The Detailed Characterization of a 400-Kb Cosmid Walk in the Brca1 Region - Identification and Localization of 10 Genes Including a Dual-Specificity Phosphatase. Human Molecular Genetics, 3 (11), 1927-1934.

The Detailed Characterization of a 400-Kb Cosmid Walk in the Brca1 Region - Identification and Localization of 10 Genes Including a Dual-Specificity Phosphatase

1994

Journal Article

No Evidence for Gm-Csf Receptor a Chain Gene Mutation in Aml-M2 Leukemias Which Have Lost a Sex-Chromosome

Brown, MA, Harrisonsmith, M, Deluca, E, Begley, CG and Gough, NM (1994). No Evidence for Gm-Csf Receptor a Chain Gene Mutation in Aml-M2 Leukemias Which Have Lost a Sex-Chromosome. Leukemia, 8 (10), 1774-1779.

No Evidence for Gm-Csf Receptor a Chain Gene Mutation in Aml-M2 Leukemias Which Have Lost a Sex-Chromosome

1994

Journal Article

Leukemia Inhibitory Factor and Interleukin-6 Are Expressed At Very-Low Levels in the Normal Adult-Mouse and Are Induced by Inflammation

Brown, MA, Metcalf, D and Gough, NM (1994). Leukemia Inhibitory Factor and Interleukin-6 Are Expressed At Very-Low Levels in the Normal Adult-Mouse and Are Induced by Inflammation. Cytokine, 6 (3), 300-309. doi: 10.1016/1043-4666(94)90027-2

Leukemia Inhibitory Factor and Interleukin-6 Are Expressed At Very-Low Levels in the Normal Adult-Mouse and Are Induced by Inflammation

1994

Journal Article

Leukemia Inhibitory Factor (lif) Infusion Stimulates Skeletal-Muscle Regeneration After Injury - Injured Muscle Expresses Lif Messenger-Rna

Barnard, W, Bower, J, Brown, MA, Murphy, M and Austin, L (1994). Leukemia Inhibitory Factor (lif) Infusion Stimulates Skeletal-Muscle Regeneration After Injury - Injured Muscle Expresses Lif Messenger-Rna. Journal of the Neurological Sciences, 123 (1-2), 108-113. doi: 10.1016/0022-510X(94)90211-9

Leukemia Inhibitory Factor (lif) Infusion Stimulates Skeletal-Muscle Regeneration After Injury - Injured Muscle Expresses Lif Messenger-Rna

1994

Conference Publication

Familial Breast/ovarian Cancer - Progress Towards Isolation of a Predisposing Gene

Jones, K, Black, D, Nicolai, H, Griffiths, B, Bonjardim, M, Brown, M, North, M, Schwalkwyk, L, Lehrach, H, Korn, B, Poustka, A and Solomon, E (1994). Familial Breast/ovarian Cancer - Progress Towards Isolation of a Predisposing Gene. NEW YORK: WILEY-LISS.

Familial Breast/ovarian Cancer - Progress Towards Isolation of a Predisposing Gene

1993

Journal Article

Involvement of Leukemia Inhibitory Factor and Nerve Growth-Factor in the Development of Dorsal-Root Ganglion Neurons

Murphy, M, Reid, K, Brown, MA and Bartlett, PF (1993). Involvement of Leukemia Inhibitory Factor and Nerve Growth-Factor in the Development of Dorsal-Root Ganglion Neurons. Development, 117 (3), 1173-1182.

Involvement of Leukemia Inhibitory Factor and Nerve Growth-Factor in the Development of Dorsal-Root Ganglion Neurons

1993

Journal Article

Structure and Expression of the Gm-Csf Receptor Alpha-Chain and Beta-Chain Genes in Human Leukemia

Brown, MA, Gough, NM, Willson, TA, Rockman, S and Begley, CG (1993). Structure and Expression of the Gm-Csf Receptor Alpha-Chain and Beta-Chain Genes in Human Leukemia. Leukemia, 7 (1), 63-74.

Structure and Expression of the Gm-Csf Receptor Alpha-Chain and Beta-Chain Genes in Human Leukemia

1992

Journal Article

MOLECULAR-BIOLOGY OF THE LEUKEMIA INHIBITORY FACTOR GENE

GOUGH, NM, WILLSON, TA, STAHL, J and BROWN, MA (1992). MOLECULAR-BIOLOGY OF THE LEUKEMIA INHIBITORY FACTOR GENE. Ciba Foundation Symposia, 167, 24-46.

MOLECULAR-BIOLOGY OF THE LEUKEMIA INHIBITORY FACTOR GENE

1992

Conference Publication

Molecular-Biology of the Leukemia Inhibitory Factor Gene

Gough, NM, Willson, TA, Stahl, J and Brown, MA (1992). Molecular-Biology of the Leukemia Inhibitory Factor Gene. Symp On Polyfunctional Cytokines : Il-6 ( Interleukin 6 ) and Lif ( Leukemia Inhibitory Factor ), London England, Oct 01-03, 1991. CHICHESTER: JOHN WILEY & SONS LTD.

Molecular-Biology of the Leukemia Inhibitory Factor Gene

Past funding

  • 2016 - 2019
    Clinical classification of regulatory variants in breast cancer susceptibility genes
    NHMRC Project Grant
    Open grant
  • 2015 - 2018
    Profiling the intratumoural microbiome and host reactions in breast cancer tissue
    Wesley Merdical Research
    Open grant
  • 2015 - 2017
    Exploiting the overexpression of a specific calcium permeable ion channel in breast cancer cells: a new pharmacological approach to targeting breast cancer.
    NHMRC Project Grant
    Open grant
  • 2015 - 2016
    Making Herceptin-resistant tumours Herceptin responsive: adapting new therapeutic potential from Head and Neck Cancer research to improve breast cancer outcomes
    National Breast Cancer Foundation
    Open grant
  • 2014
    A confocal microscope for investigation of live bacterial and viral pathogens and for molecular cell biology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2019
    Enabling Clinical Epigenetic Diagnostics: The Next Generation of Personalized Breast Cancer Care
    National Breast Cancer Foundation
    Open grant
  • 2013 - 2015
    Examination of the Expression and Potential Role of Cancer Associated Viral Sequences in the Causation and Outcomes of Breast Cancer Patients
    Wesley Merdical Research
    Open grant
  • 2013 - 2015
    The role of BRCA non-coding mutations in breast cancer susceptibility
    Cancer Council Queensland
    Open grant
  • 2012 - 2017
    The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (NBCF Infrastructure Grant led by UoM)
    University of Melbourne
    Open grant
  • 2012
    An intergrated fluidic circuit system for digital PCR analysis, single-cell gene- expression, and high-throughput preparation of next-generation sequencing libraries.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2013
    Functional analysis of breast cancer susceptibility regions
    NHMRC Project Grant
    Open grant
  • 2012 - 2015
    Transcriptional regulation of non-code RNA genes implicated in breast cancer
    Cancer Council Queensland
    Open grant
  • 2011 - 2015
    Translating health discoveries into products
    Queensland Government Smart Futures Co-Investment Fund
    Open grant
  • 2011
    Cell culture facilities for studying host-pathogen interactions and immune function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Establishment of a digital Scanscope system for virtual microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    Identifying long-range regulatory elements of the breast cancer susceptibility gene, BRCA1
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    The role of the BRCA1 3'UTR in breast cancer
    Cancer Council Queensland
    Open grant
  • 2010 - 2013
    Two recently identified calcium transporters in lactation and during mammary epithelial cell apoptosis.
    NHMRC Project Grant
    Open grant
  • 2009 - 2011
    The MYB gene as a model for global transcriptional regulation: stopping, starting and looping
    ARC Discovery Projects
    Open grant
  • 2008 - 2013
    Novel strategies for prediction and control of advanced breast cancer via nanoscaled epigenetic-based biosensors
    National Breast Cancer Foundation
    Open grant
  • 2008 - 2009
    The role of the MYB oncogene in mammary carcinogenesis
    Cancer Council Queensland
    Open grant
  • 2008
    A high-throughput facility for the identification and analysis of gene regulatory elements and factors
    UQ Major Equipment and Infrastructure
    Open grant
  • 2008 - 2009
    Investigating the role of gene loops in regulating gene expression
    ARC Discovery Projects
    Open grant
  • 2007
    Early detection of breast cancer via nanoscaled biomarker discovery and diagnostics
    National Breast Cancer Foundation
    Open grant
  • 2007 - 2009
    Noncoding RNAs as prognostic markers and therapeutic targets in breast cancer
    NHMRC Project Grant
    Open grant
  • 2006 - 2008
    Identification of new mutations that contribute to breast cancer
    NHMRC Project Grant
    Open grant
  • 2006 - 2007
    Investigating the molecular and cellular origin of BRCA-1 associated breast tumours
    National Breast Cancer Foundation
    Open grant
  • 2006 - 2007
    The role of DEP-1 as a tumour suppressor in breast cancer
    Queensland Cancer Fund
    Open grant
  • 2005 - 2006
    ESEG_The role of DEP-1 as a tumour suppressor in breast cancer
    UQ External Support Enabling Grant
    Open grant
  • 2004
    Identification Of Critical Gene Regulatory Elements Using A Combination Of Molecular Biology And Information Theory Approaches
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003 - 2004
    Investigating the Role of BRCA1 in Mammary Differentiation and Morphogenesis
    Queensland Cancer Fund
    Open grant
  • 2002 - 2003
    Investigating the role of BRCA1 in mammary differentiation and morphogenesis
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2002 - 2004
    BRCA1, PML and telomere maintenance: understanding how abnormalities in chromosome ends contribute to breast cancer
    NHMRC Project Grant
    Open grant
  • 2001 - 2002
    BRCA1 in DNA repair and tumourigenesis
    Queensland Cancer Fund
    Open grant
  • 2001 - 2003
    Identification of Critical Regulatory Elements in the BRCA1 Gene
    NHMRC Project Grant
    Open grant
  • 2001
    Understanding how molecular abnormalities contribute to breast cancer
    UQ Early Career Researcher
    Open grant
  • 2000 - 2001
    Molecular biology of the breast cancer susceptibility gene BRCA1
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Professor Melissa Brown is:
Not available for supervision

Supervision history

Completed supervision

Enquiries

Contact Professor Melissa Brown directly for media enquiries about:

  • Animal models of human diseases
  • Biology - cells
  • Biology - molecular
  • Breast cancer
  • Cancer - breast
  • Cancer - genetics
  • Cancer susceptibility genes
  • Cellular biology
  • Diseases - animal models of human diseases
  • Gene regulation
  • Genetics
  • Human diseases - animal models of
  • Molecular biology

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