Overview
Background
Professor Obermair is the Director of Queensland Centre for Gynaecological Cancer Research (QCGC Research). He is a Professor of Gynaecological Oncology since 2007, a Senior Medical Officer at Royal Brisbane & Women’s Hospital and a Visiting Medical Officer at St Andrews War Memorial Hospital and Buderim Private Hospital. He holds an Honorary title of Professor at UQ since 2006.
Professor Obermair is an internationally recognised leader in gynaecological oncology research and treatment and has lead the research team at QCGC Research since establishing it in 2003.
Availability
- Professor Andreas Obermair is:
- Available for supervision
Fields of research
Qualifications
- Doctoral Diploma of Medicine, International University Vienna
- Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Royal Australian and New Zealand College of Obstetricians and Gynaecologists
Research interests
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Clinical Trials
Decisions on cancer management ideally are based on the results of high-level evidence, obtained through clinical trials whenever possible. As a principle, a new (proposed better) intervention should be compared to the current standard treatment before being made available generally. Outside a clinical trial new treatments should not become available until evidence has become available to demonstrate superiority over the current standard treatment. Retrospective studies harbour the risk that biases influenced outcomes. At QCGC Research we engage in phase 2 and 3 clinical trials. In large phase trials, patients are allocated randomly to one of two or more interventions in order to minimise the risk of bias. Generally, patients treated within clinical trials have a better outcome compared to patients who are not treated in clinical trials. As the Director of Research Gynaecological Oncology I am currently involved in developing and managing clinical trials in gynaecological cancers.
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Translational Research
The focus of QCGC Research's translational research program is the application of new technology (molecular, biochemical, imaging and surgical) to prevention, detection and therapy for gynaecological cancers.
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Quality of Life Research
Cancer specialists are aware that not only the survival time but also the quality of life is a key factor in cancer treatment. This is especially important when two treatments are equally effective but cause different side-effects. My Quality-of-Life research focuses on ovarian, endometrial, cervical and vulval cancer. I wish to provide the best, most effective and modern treatment to my patients with least possible detriments to quality of life.
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Minimally Invasive Surgery
In Australia, around 30,000 hysterectomies are conducted annually to treat uterine cancer and various benign gynaecological conditions. While open abdominal surgery may be necessary in around 10% of cases, evidence shows that less-invasive approaches, such as total laparoscopic hysterectomy (TLH) can achieve better outcomes for women at a lower overall cost to the health system. Yet, in Queensland, four of ten hysterectomies are still conducted by open abdominal surgery. Our own research has shown that many Australian surgeons are keen to adopt new techniques such as TLH, but that the lack of systematic training and mentoring opportunities is the main impediment to practice-change. Together with gynaecological surgical teams at hospitals and industry support we developed a prototype for system-level transformative practice change in gynaecological surgery.
Research impacts
Professor Obermair is an innovative and skilled gynaecologic oncologist, surgical teacher and consumer advocate. His international leadership and research impact was acknowledged in 2020 by the Australian community, when he was awarded an NHMRC Investigator Fellowship Level 2 (2021-25). The national impact of his research was recognised in 2017, when he was awarded Cancer Australia’s Jeannie Ferris Recognition Award (2017), for outstanding achievements in clinical practice and research. He is deeply engaged in consumer involvement and co-founded and serves on the Board of the Cherish Foundation, a consumer-focussed organisation that funds clinical research in better treatments for women with gynaecological cancers.
Works
Search Professor Andreas Obermair’s works on UQ eSpace
2018
Conference Publication
Achieving healthy weight after endometrial cancer surgery-10-year follow-up of the Laparoscopic Approach to Cancer of the Endometrium (LACE) trial
Obermair, A., Armfield, N. R., Forder, P. and Janda, M. (2018). Achieving healthy weight after endometrial cancer surgery-10-year follow-up of the Laparoscopic Approach to Cancer of the Endometrium (LACE) trial. State of the Art Conference of the European Society of Gynaecological Oncology, Lyon, France, 4-6 October 2018. London, United Kingdom: BMJ Group.
2018
Journal Article
BRAF mutations in low-grade serous ovarian cancer and response to BRAF inhibition
Moujaber, Tania, Etemadmoghadam, Dariush, Kennedy, Catherine J., Chiew, Yoke-Eng, Balleine, Rosemary L., Saunders, Catherine, Wain, Gerard V., Gao, Bo, Hogg, Russell, Srirangan, Sivatharsny, Kan, Casina, Fereday, Sian, Traficante, Nadia, Patch, Ann-Marie, Pearson, John V., Waddell, Nicola, Grimmond, Sean M., Dobrovic, Alexander, Bowtell, David D.L., Harnett, Paul R., deFazio, Anna, Bowtell, D., Chenevix-Trench, G., Green, A., Webb, P., DeFazio, A., Gertig, D., Traficante, N., Fereday, S. ... Zeps, N. (2018). BRAF mutations in low-grade serous ovarian cancer and response to BRAF inhibition. JCO Precision Oncology, 2 (2), 1-14. doi: 10.1200/PO.17.00221
2017
Journal Article
ER and PR expression and survival after endometrial cancer
Smith, Deborah, Stewart, Colin J. R., Clarke, Edward M., Lose, Felicity, Davies, Claire, Armes, Jane, Obermair, Andreas, Brennan, Donal, Webb, Penelope M., Nagle, Christina M. and Spurdle, Amanda B. (2017). ER and PR expression and survival after endometrial cancer. Gynecologic Oncology, 148 (2), 258-266. doi: 10.1016/j.ygyno.2017.11.027
2017
Journal Article
The relative risk of second primary cancers in Austria's western states: a retrospective cohort study
Preyer, Oliver, Concin, Nicole, Obermair, Andreas, Concin, Hans, Ulmer, Hanno and Oberaigner, Willi (2017). The relative risk of second primary cancers in Austria's western states: a retrospective cohort study. BMC cancer, 17 (1) 699, 699. doi: 10.1186/s12885-017-3683-9
2017
Journal Article
Factors influencing women's decision making in hysterectomy
Janda, Monika, Armfield, Nigel R., Page, Katie, Kerr, Gayle, Kurz, Suzanne, Jackson, Graeme, Currie, Jason, Weaver, Edward, Yazdani, Anusch and Obermair, Andreas (2017). Factors influencing women's decision making in hysterectomy. Patient Education and Counseling, 101 (3), 504-510. doi: 10.1016/j.pec.2017.09.006
2017
Journal Article
Family history of cancer predicts endometrial cancer risk independently of Lynch Syndrome: implications for genetic counselling
Johnatty, Sharon E., Tan, Yen Y., Buchanan, Daniel D., Bowman, Michael, Walters, Rhiannon J., Obermair, Andreas, Quinn, Michael A., Blomfield, Penelope B., Brand, Alison, Leung, Yee, Oehler, Martin K., ANECS Group, Kirk, Judy A., O'Mara, Tracy A., Webb, Penelope M. and Spurdle, Amanda B. (2017). Family history of cancer predicts endometrial cancer risk independently of Lynch Syndrome: implications for genetic counselling. Gynecologic Oncology, 147 (2), 381-387. doi: 10.1016/j.ygyno.2017.08.011
2017
Journal Article
Survival after laparoscopic vs abdominal hysterectomy - reply
Gebski, Val, Janda, Monika and Obermair, Andreas (2017). Survival after laparoscopic vs abdominal hysterectomy - reply. Journal of the American Medical Association, 318 (6), 574-575. doi: 10.1001/jama.2017.8161
2017
Journal Article
The shift toward neo-adjuvant chemotherapy and interval debulking surgery for management of advanced ovarian and related cancers in a population-based setting: Impact on clinical outcomes
Nicklin, James L., McGrath, Shaun, Tripcony, Lee, Garrett, Andrea, Land, Russell, Tang, Amy, Perrin, Lewis, Chetty, Naven, Jagasia, Nisha, Crandon, Alex J., Nascimento, Marcelo, Walker, Graeme, Sanday, Karen and Obermair, Andreas (2017). The shift toward neo-adjuvant chemotherapy and interval debulking surgery for management of advanced ovarian and related cancers in a population-based setting: Impact on clinical outcomes. Australian & New Zealand Journal of Obstetrics and Gynaecology, 57 (6), 651-658. doi: 10.1111/ajo.12665
2017
Journal Article
Lymphedema following gynecological cancer: results from a prospective, longitudinal cohort study on prevalence, incidence and risk factors
Hayes, Sandra C., Janda, Monika, Ward, Leigh C., Reul-Hirche, Hildegard, Steele, Megan L., Carter, Johnathan, Quinn, Michael, Cornish, Bruce and Obermair, Andreas (2017). Lymphedema following gynecological cancer: results from a prospective, longitudinal cohort study on prevalence, incidence and risk factors. Gynecologic Oncology, 146 (3), 623-629. doi: 10.1016/j.ygyno.2017.06.004
2017
Journal Article
Effect of Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy on Disease-Free Survival Among Women With Stage I Endometrial Cancer A Randomized Clinical Trial
Janda, Monika, Gebski, Val, Davies, Lucy C., Forder, Peta, Brand, Alison, Hogg, Russell, Jobling, Thomas W., Land, Russell, Manolitsas, Tom, Nascimento, Marcelo, Neesham, Deborah, Nicklin, James L., Oehler, Martin K., Otton, Geoff, Perrin, Lewis, Salfinger, Stuart, Hammond, Ian, Leung, Yee, Sykes, Peter, Ngan, Hextan, Garrett, Andrea, Laney, Michael, Ng, Tong Yow, Tam, Karfai, Chan, Karen, Wrede, C. David, Pather, Selvan, Simcock, Bryony, Farrell, Rhonda ... Obermair, Andreas (2017). Effect of Total Laparoscopic Hysterectomy vs Total Abdominal Hysterectomy on Disease-Free Survival Among Women With Stage I Endometrial Cancer A Randomized Clinical Trial. Jama-Journal of the American Medical Association, 317 (12), 1224-1233. doi: 10.1001/jama.2017.2068
2017
Journal Article
Nutrition interventions in patients with gynecological cancers requiring surgery
Obermair, Andreas, Simunovic, Marko, Isenring, Liz and Janda, Monika (2017). Nutrition interventions in patients with gynecological cancers requiring surgery. Gynecologic Oncology, 145 (1), 192-199. doi: 10.1016/j.ygyno.2017.01.028
2017
Journal Article
Do breast cancer survivors benefit from prophylactic removal of uterus and ovaries? A population-based data linkage replication study
Obermair, Andreas, Youlden, Danny, Baade, Peter and Janda, Monika (2017). Do breast cancer survivors benefit from prophylactic removal of uterus and ovaries? A population-based data linkage replication study. Asia-Pacific Journal of Clinical Oncology, 13 (1), 68-78. doi: 10.1111/ajco.12508
2017
Conference Publication
The association of lymphedema trajectories with symptoms and symptom severity following gynaecological cancer treatment in Queensland: a prospective cohort study
Obermair, A., Fleming, S., Hayes, S., Ward, L., Kneul-Hirche, H. and Janda, M. (2017). The association of lymphedema trajectories with symptoms and symptom severity following gynaecological cancer treatment in Queensland: a prospective cohort study. ESGO 20: European Gynaecological Oncology Congress 2017, Vienna, Austria, 4-7 November 2017. London, United Kingdom: Lippincott Williams & Wilkins.
2016
Journal Article
Real-world surgical outcomes of a gelatin-hemostatic matrix in women requiring a hysterectomy: a matched case–control study
Obermair, Helena, Janda, Monika and Obermair, Andreas (2016). Real-world surgical outcomes of a gelatin-hemostatic matrix in women requiring a hysterectomy: a matched case–control study. Acta Obstetricia et Gynecologica Scandinavica, 95 (9), 1008-1014. doi: 10.1111/aogs.12924
2016
Journal Article
Cost-efficiency of robotic surgery
Covens, Al, Köhler, Christhardt, Nam, Joo-Hyun, Naumann, R. Wendel, Obermair, Andreas and Querleu, Denis (2016). Cost-efficiency of robotic surgery. International Journal of Gynecological Cancer, 26 (6), 992-993. doi: 10.1097/IGC.0000000000000747
2016
Journal Article
Surgical safety and personal costs in morbidly obese, multimorbid patients diagnosed with early-stage endometrial cancer having a hysterectomy
Obermair, Andreas, Brennan, Donal J., Baxter, Eva, Armes, Jane E., Gebski, Val and Janda, Monika (2016). Surgical safety and personal costs in morbidly obese, multimorbid patients diagnosed with early-stage endometrial cancer having a hysterectomy. Gynecologic Oncology Research and Practice, 3 (1), 1. doi: 10.1186/s40661-016-0023-8
2016
Conference Publication
Disease-free and overall-survival after total laparoscopy versus open abdominal hysterectomy for early stage endometrial cancer: results from the lace trial
Obermair, A., Gebski, V., Davies, L., Brand, A., Hogg, R., Jobling, T. W., Land, R., Manolitsas, T., Nascimento, M., Neesham, D., Nicklin, J. L., Oehler, M. K., Otton, G., Perrin, L., Salfinger, S., Hammond, I., Leung, Y., Sykes, P., Ngan, H., Garrett, A., Forder, P., Laney, M., Ng, T. Y., Tam, K., Chan, K., Wrede, D. H., Pather, S., Simcock, B., Farrell, R. ... Janda, M. (2016). Disease-free and overall-survival after total laparoscopy versus open abdominal hysterectomy for early stage endometrial cancer: results from the lace trial. Unknown, Unknown, Unknown. London, United Kingdom: Lippincott Williams & Wilkins.
2015
Journal Article
Consideration for safe and effective gynaecological laparoscopy in the obese patient
Hackethal, A., Brennan, D., Rao, A., Land, R., Obermair, A., Nicklin, J., Garrett, A., Nascimento, M., Crandon, A., Perrin, L. and Chetty, N. (2015). Consideration for safe and effective gynaecological laparoscopy in the obese patient. Archives of Gynecology and Obstetrics, 292 (1), 135-141. doi: 10.1007/s00404-014-3600-2
2015
Journal Article
Quality of life after early enteral feeding versus standard care for proven or suspected advanced epithelial ovarian cancer: Results from a randomised trial
Baker, Jannah, Janda, Monika, Graves, Nick, Bauer, Judy, Banks, Merrilyn, Garrett, Andrea, Chetty, Naven, Crandon, Alex J, Land, Russell, Nascimento, Marcelo, Nicklin, James L, Perrin, Lewis C and Obermair, Andreas (2015). Quality of life after early enteral feeding versus standard care for proven or suspected advanced epithelial ovarian cancer: Results from a randomised trial. Gynecologic Oncology, 137 (3), 516-522. doi: 10.1016/j.ygyno.2015.03.048
2015
Journal Article
Lower preoperative quality of life increases postoperative risk of adverse events in women with endometrial cancer: results from the LACE trial
Baker, Jannah, Janda, Monika, Gebski, Val, Forder, Peta, Hogg, Russell, Manolitsas, Tom and Obermair, Andreas (2015). Lower preoperative quality of life increases postoperative risk of adverse events in women with endometrial cancer: results from the LACE trial. Gynecologic Oncology, 137 (1), 102-105. doi: 10.1016/j.ygyno.2015.02.008
Funding
Current funding
Past funding
Supervision
Availability
- Professor Andreas Obermair is:
- Available for supervision
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Available projects
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feMMe: Uterus-preserving treatment of endometrial cancer
In 2020 we completed the feMMe, phase 2 cliniccal trial which established anticancer activity of levonorgestrel intrauterrine device (LNG-IUD) to treat endometrial cancer. The next two steps towards estabnlioshing this treatment for larger groups of patients include:
1. To determine factors that predict response to LNG-IUD
2. To determine long-term patient outcomes including survival, fertility, and patient needs.
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Improving Quality of Survival for Women with Gynaecological Cancer
- Focus on improving quality of life, health & function during & after gynaecological cancer treatment, with a focus on biomarker research, implementation research and cancer survivorship.
Supervision history
Current supervision
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Master Philosophy
Patterns of care in endometrial cancer management in Queensland: a retrospective analysis.
Principal Advisor
Other advisors: Dr Eva Baxter
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Doctor Philosophy
Advanced methods for biomarker informed endometrial cancer
Principal Advisor
Other advisors: Dr Eva Baxter, Dr Zoe West, Professor Andrew Martin
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Doctor Philosophy
Diet quality and composition in Australian women with endometrial cancer
Associate Advisor
Other advisors: Professor Monika Janda
Completed supervision
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2014
Doctor Philosophy
Hereditary endometrial cancer: Improving identification and referral of patients with suspected Lynch syndrome
Principal Advisor
Other advisors: Honorary Professor Amanda Spurdle, Associate Professor Lisa Fitzgerald
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2008
Doctor Philosophy
Nutritional status of patients with gynaecological cancer -
Joint Principal Advisor
Other advisors: Emeritus Professor Geoffrey Cleghorn
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Media
Enquiries
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