
Overview
Background
Professor Obermair is the Director of Queensland Centre for Gynaecological Cancer Research (QCGC Research). He is a Professor of Gynaecological Oncology since 2007, a Senior Medical Officer at Royal Brisbane & Women’s Hospital and a Visiting Medical Officer at St Andrews War Memorial Hospital and Buderim Private Hospital. He holds an Honorary title of Professor at UQ since 2006.
Professor Obermair is an internationally recognised leader in gynaecological oncology research and treatment and has lead the research team at QCGC Research since establishing it in 2003.
Availability
- Professor Andreas Obermair is:
- Available for supervision
Fields of research
Qualifications
- Doctoral Diploma of Medicine, International University Vienna
- Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Royal Australian and New Zealand College of Obstetricians and Gynaecologists
Research interests
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Clinical Trials
Decisions on cancer management ideally are based on the results of high-level evidence, obtained through clinical trials whenever possible. As a principle, a new (proposed better) intervention should be compared to the current standard treatment before being made available generally. Outside a clinical trial new treatments should not become available until evidence has become available to demonstrate superiority over the current standard treatment. Retrospective studies harbour the risk that biases influenced outcomes. At QCGC Research we engage in phase 2 and 3 clinical trials. In large phase trials, patients are allocated randomly to one of two or more interventions in order to minimise the risk of bias. Generally, patients treated within clinical trials have a better outcome compared to patients who are not treated in clinical trials. As the Director of Research Gynaecological Oncology I am currently involved in developing and managing clinical trials in gynaecological cancers.
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Translational Research
The focus of QCGC Research's translational research program is the application of new technology (molecular, biochemical, imaging and surgical) to prevention, detection and therapy for gynaecological cancers.
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Quality of Life Research
Cancer specialists are aware that not only the survival time but also the quality of life is a key factor in cancer treatment. This is especially important when two treatments are equally effective but cause different side-effects. My Quality-of-Life research focuses on ovarian, endometrial, cervical and vulval cancer. I wish to provide the best, most effective and modern treatment to my patients with least possible detriments to quality of life.
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Minimally Invasive Surgery
In Australia, around 30,000 hysterectomies are conducted annually to treat uterine cancer and various benign gynaecological conditions. While open abdominal surgery may be necessary in around 10% of cases, evidence shows that less-invasive approaches, such as total laparoscopic hysterectomy (TLH) can achieve better outcomes for women at a lower overall cost to the health system. Yet, in Queensland, four of ten hysterectomies are still conducted by open abdominal surgery. Our own research has shown that many Australian surgeons are keen to adopt new techniques such as TLH, but that the lack of systematic training and mentoring opportunities is the main impediment to practice-change. Together with gynaecological surgical teams at hospitals and industry support we developed a prototype for system-level transformative practice change in gynaecological surgery.
Research impacts
Professor Obermair is an innovative and skilled gynaecologic oncologist, surgical teacher and consumer advocate. His international leadership and research impact was acknowledged in 2020 by the Australian community, when he was awarded an NHMRC Investigator Fellowship Level 2 (2021-25). The national impact of his research was recognised in 2017, when he was awarded Cancer Australia’s Jeannie Ferris Recognition Award (2017), for outstanding achievements in clinical practice and research. He is deeply engaged in consumer involvement and co-founded and serves on the Board of the Cherish Foundation, a consumer-focussed organisation that funds clinical research in better treatments for women with gynaecological cancers.
Works
Search Professor Andreas Obermair’s works on UQ eSpace
2015
Journal Article
Incidence, risk factors, and estimates of a woman's risk for developing secondary lower limb lymphedema and lymphedema-specific supportive care needs in women treated for endometrial cancer
Beesley, Vanessa L., Rowlands, Ingrid J., Hayes, Sandi C., Janda, Monika, O'Rourke, Peter, Marquart, Louise, Quinn, Michael A., Spurdle, Amanda B., Obermair, Andreas, Brand, Alison, Oehler, Martin K., Leung, Yee, McQuire, Lesley and Webb, Penelope M. (2015). Incidence, risk factors, and estimates of a woman's risk for developing secondary lower limb lymphedema and lymphedema-specific supportive care needs in women treated for endometrial cancer. Obstetrical and Gynecological Survey, 70 (3), 176-177. doi: 10.1097/OGX.0000000000000167
2015
Journal Article
Women with self-reported lower limb lymphedema after treatment for gynecological cancers: are they more likely to self-report psychosocial symptoms and less likely to use services?
Kusters, Iris, Williams, Merran, Obermair, Andreas and Janda, Monika (2015). Women with self-reported lower limb lymphedema after treatment for gynecological cancers: are they more likely to self-report psychosocial symptoms and less likely to use services?. Journal of Community and Supportive Oncology, 13 (2), 55-61. doi: 10.12788/jcso.0109
2015
Journal Article
Serum HE4 detects recurrent endometrial cancer in patients undergoing routine clinical surveillance
Brennan, Donal J, Hackethal, Andreas, Mann, Kristy P, Mutz-Dehbalaie, Irene, Fiegl, Heidi, Marth, Christian and Obermair, Andreas (2015). Serum HE4 detects recurrent endometrial cancer in patients undergoing routine clinical surveillance. BMC Cancer, 15 (33) 33, 33. doi: 10.1186/s12885-015-1028-0
2015
Journal Article
Incidence, risk factors and estimates of a woman's risk of developing secondary lower limb lymphedema and lymphedema-specific supportive care needs in women treated for endometrial cancer
Beesley, Vanessa L., Rowlands, Ingrid J., Hayes, Sandi C., Janda, Monika, O'Rourke, Peter, Marquart, Louise, Quinn, Michael A., Spurdle, Amanda B., Obermair, Andreas, Brand, Alison, Oehler, Martin K., Leung, Yee, McQuire, Lesley, Webb, Penelope M. and On behalf of the Australian National Endometrial Cancer Study Group (2015). Incidence, risk factors and estimates of a woman's risk of developing secondary lower limb lymphedema and lymphedema-specific supportive care needs in women treated for endometrial cancer. Gynecologic Oncology, 136 (1), 87-93. doi: 10.1016/j.ygyno.2014.11.006
2014
Journal Article
Comment on 'External multicentre validation of a nomogram predicting the risk of relapse in patients with borderline ovarian tumours'
Obermair, A. (2014). Comment on 'External multicentre validation of a nomogram predicting the risk of relapse in patients with borderline ovarian tumours'. British journal of cancer, 111 (12), 2375-2375. doi: 10.1038/bjc.2014.8
2014
Journal Article
Survival of Australian women with Invasive Epithelial Ovarian Cancer: A Population-based Study.
Anuradha, Satyamurthy, Webb, Penelope M., Blomfield, Penny, Brand, Alison, H., Friedlander, Michael, Leung, Yee, Obermair, Andreas, Oehler, Martin K., Quinn, Michael, Steer, Christopher and Jordan, Susan J. (2014). Survival of Australian women with Invasive Epithelial Ovarian Cancer: A Population-based Study.. Medical Journal of Australia, 201 (5), 283-288. doi: 10.5694/mja14.00132
2014
Journal Article
Improving treatment for obese women with early stage cancer of the uterus: Rationale and design of the levonorgestrel intrauterine device ± Metformin ± weight loss in endometrial cancer (feMME) trial
Hawkes, A. L., Quinn, M., Gebski, V., Armes, J., Brennan, D., Janda, M., for the feMME Trial Committee and Obermair, A. (2014). Improving treatment for obese women with early stage cancer of the uterus: Rationale and design of the levonorgestrel intrauterine device ± Metformin ± weight loss in endometrial cancer (feMME) trial. Contemporary Clinical Trials, 39 (1), 14-21. doi: 10.1016/j.cct.2014.06.014
2014
Journal Article
Reply to J. Moline et al
Buchanan, Daniel D., Tan, Yen Y., Walsh, Michael D., Clendenning, Mark, Metcalf, Alexander M., Ferguson, Kaltin, Arnold, Sven T., Thompson, Bryony A., Lose, Felicity A., Parsons, Michael T., Walters, Rhiannon J., Pearson, Sally-Ann, Cummings, Margaret, Oehler, Martin K., Blomfield, Penelope B., Quinn, Michael A., Kirk, Judy A., Stewart, Colin J., Obermair, Andreas, Young, Joanne P., Webb, Penelope M. and Spurdle, Amanda B. (2014). Reply to J. Moline et al. Journal of Clinical Oncology, 32 (21), 2278-2279. doi: 10.1200/JCO.2014.55.8213
2014
Journal Article
The impact of risk-reducing hysterectomy and bilateral salpingo- oophorectomy on survival in patients with a history of breast cancer - A population-based data linkage study
Obermair, Andreas, Youlden, Danny R., Baade, Peter D. and Janda, Monika (2014). The impact of risk-reducing hysterectomy and bilateral salpingo- oophorectomy on survival in patients with a history of breast cancer - A population-based data linkage study. International Journal of Cancer, 134 (9), 2211-2222. doi: 10.1002/ijc.28537
2014
Journal Article
Quality of life of women with lower limb swelling or lymphedema 3–5 years following endometrial cancer
Rowlands, Ingrid J., Beesley, Vanessa L., Janda, Monika, Hayes, Sandra C., Obermair, Andreas, Quinn, Michael A., Brand, Alison, Leung, Yee, McQuire, Lesley, Webb, Penelope M. and on behalf of the Australian National Endometrial Cancer Study Group (2014). Quality of life of women with lower limb swelling or lymphedema 3–5 years following endometrial cancer. Gynecologic Oncology, 133 (2), 314-318. doi: 10.1016/j.ygyno.2014.03.003
2014
Journal Article
Can the use of quality assurance tools reduce the impact of surgical complications on the well-being of obstetricians and gynaecologists in Australia and New Zealand?
Varughese, Elizabeth, Janda, Monika and Obermair, Andreas (2014). Can the use of quality assurance tools reduce the impact of surgical complications on the well-being of obstetricians and gynaecologists in Australia and New Zealand?. Australian and New Zealand Journal of Obstetrics and Gynaecology, 54 (1), 30-35. doi: 10.1111/ajo.12162
2014
Journal Article
Serum HE4 as a prognostic marker in endometrial cancer: a population based study
Brennan, Donal J., Hackethal, Andreas, Metcalf, Alex M., Coward, Jermaine, Ferguson, Kaltin, Oehler, Martin K., Quinn, Michael A., Janda, Monika, Leung, Yee, Freemantle, Michael, Webb, Penelope M., Spurdle, Amanda B., Obermair, Andreas, ANECS Group, Spurdle, A. B., Webb, P. M. and Young, J. (2014). Serum HE4 as a prognostic marker in endometrial cancer: a population based study. Gynecologic Oncology, 132 (1), 159-165. doi: 10.1016/j.ygyno.2013.10.036
2014
Journal Article
Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing
Buchanan, Daniel D., Tan, Yen Y., Walsh, Michael D., Clendenning, Mark, Metcalf, Alexander M., Ferguson, Kaltin, Arnold, Sven T., Thompson, Bryony A., Lose, Felicity A., Parsons, Michael T., Walters, Rhiannon J., Pearson, Sally-Ann, Cummings, Margaret, Oehler, Martin K., Blomfield, Penelope B., Quinn, Michael A., Kirk, Judy A., Stewart, Colin J., Obermair, Andreas, Young, Joanne P., Webb, Penelope M. and Spurdle, Amanda B. (2014). Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing. Journal of Clinical Oncology, 32 (2), 90-100. doi: 10.1200/JCO.2013.51.2129
2014
Journal Article
Metastasis of ovarian cancer is mediated by kallikrein related peptidases
Dong, Ying, Loessner, Daniela, Irving-Rodgers, Helen, Obermair, Andreas, Nicklin, James L. and Clements, Judith A. (2014). Metastasis of ovarian cancer is mediated by kallikrein related peptidases. Clinical and Experimental Metastasis, 31 (1), 135-147. doi: 10.1007/s10585-013-9615-4
2014
Conference Publication
Quality of Life and Nutritional Status After Early Enteral Feeding Versus Standard Care After Surgery for Advanced Epithelial Ovarian Cancer
Janda, M., Graves, N., Bauer, J., Baker, J. and Obermair, A. (2014). Quality of Life and Nutritional Status After Early Enteral Feeding Versus Standard Care After Surgery for Advanced Epithelial Ovarian Cancer. 15th Biennial Meeting of the International Gynecologic Cancer Society, Melbourne, Australia, 8 -11 November 2014. London, United Kingdom: Lippincott Williams & Wilkins. doi: 10.1097/01.IGC.0000457075.08973.89
2014
Conference Publication
Exercise During Chemotherapy for Ovarian Cancer (Echo): Study Design Features and Outcomes of a Cancer Australia and Cancer Council Australia Funded Randomised, Controlled Trial
Hayes, S., Friedlander, M., Obermair, A., Mileshkin, L., Janda, M., Gordon, L., Barnes, E., Beesley, V., Eakin, E., Sommeijer, D., Martyn, J., Stockler, M., Gebski, V. A. L., Naumann, F., Schmitz, K. and Webb, P. (2014). Exercise During Chemotherapy for Ovarian Cancer (Echo): Study Design Features and Outcomes of a Cancer Australia and Cancer Council Australia Funded Randomised, Controlled Trial. 15th Biennial Meeting of the International Gynecologic Cancer Society, Melbourne, VIC Australia, 8-11 November 2014. London, United Kingdom: Lippincott Williams and Wilkins. doi: 10.1097/01.IGC.0000457075.08973.89
2014
Journal Article
Knowledge, attitudes and referral patterns of lynch syndrome: a survey of clinicians in Australia
Tan, Yen Y., Spurdle, Amanda B. and Obermair, Andreas (2014). Knowledge, attitudes and referral patterns of lynch syndrome: a survey of clinicians in Australia. Journal of Personalized Medicine, 4 (2), 218-244. doi: 10.3390/jpm4020218
2013
Journal Article
Identification of doctors at risk of recurrent complaints: a national study of healthcare complaints in Australia
Obermair, Andreas, Janda, Monika and Gebski, Val (2013). Identification of doctors at risk of recurrent complaints: a national study of healthcare complaints in Australia. BMJ Quality and Safety, 22 (10), 878-878. doi: 10.1136/bmjqs-2013-002209
2013
Journal Article
Predicting positive and negative impacts of cancer among long-term endometrial cancer survivors
Rowlands, Ingrid J., Lee, Christina, Janda, Monika, Nagle, Christina M., Obermair, Andreas, Webb, Penelope M. and Australian National Endometrial Cancer Study Group (2013). Predicting positive and negative impacts of cancer among long-term endometrial cancer survivors. Psycho-Oncology, 22 (9), 1963-1971. doi: 10.1002/pon.3236
2013
Journal Article
Vaginal cuff dehiscence associated with laparoscopic hysterectomy
Obermair, Andreas (2013). Vaginal cuff dehiscence associated with laparoscopic hysterectomy. Gynecological Surgery, 10 (3), 227-227. doi: 10.1007/s10397-013-0793-5
Funding
Current funding
Past funding
Supervision
Availability
- Professor Andreas Obermair is:
- Available for supervision
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Available projects
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feMMe: Uterus-preserving treatment of endometrial cancer
In 2020 we completed the feMMe, phase 2 cliniccal trial which established anticancer activity of levonorgestrel intrauterrine device (LNG-IUD) to treat endometrial cancer. The next two steps towards estabnlioshing this treatment for larger groups of patients include:
1. To determine factors that predict response to LNG-IUD
2. To determine long-term patient outcomes including survival, fertility, and patient needs.
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Improving Quality of Survival for Women with Gynaecological Cancer
- Focus on improving quality of life, health & function during & after gynaecological cancer treatment, with a focus on biomarker research, implementation research and cancer survivorship.
Supervision history
Current supervision
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Doctor Philosophy
Advanced methods for biomarker informed endometrial cancer
Principal Advisor
Other advisors: Dr Eva Baxter, Dr Zoe West, Professor Andrew Martin
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Master Philosophy
Patterns of care in endometrial cancer management in Queensland: a retrospective analysis.
Principal Advisor
Other advisors: Dr Eva Baxter
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Doctor Philosophy
Diet quality and composition in Australian women with endometrial cancer
Associate Advisor
Other advisors: Professor Monika Janda
Completed supervision
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2014
Doctor Philosophy
Hereditary endometrial cancer: Improving identification and referral of patients with suspected Lynch syndrome
Principal Advisor
Other advisors: Honorary Professor Amanda Spurdle, Associate Professor Lisa Fitzgerald
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2008
Doctor Philosophy
Nutritional status of patients with gynaecological cancer -
Joint Principal Advisor
Other advisors: Emeritus Professor Geoffrey Cleghorn
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Media
Enquiries
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