Overview
Background
Professor Obermair is the Director of Queensland Centre for Gynaecological Cancer Research (QCGC Research). He is a Professor of Gynaecological Oncology since 2007, a Senior Medical Officer at Royal Brisbane & Women’s Hospital and a Visiting Medical Officer at St Andrews War Memorial Hospital and Buderim Private Hospital. He holds an Honorary title of Professor at UQ since 2006.
Professor Obermair is an internationally recognised leader in gynaecological oncology research and treatment and has lead the research team at QCGC Research since establishing it in 2003.
Availability
- Professor Andreas Obermair is:
- Available for supervision
Fields of research
Qualifications
- Doctoral Diploma of Medicine, International University Vienna
- Royal Australian and New Zealand College of Obstetricians and Gynaecologists, Royal Australian and New Zealand College of Obstetricians and Gynaecologists
Research interests
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Clinical Trials
Decisions on cancer management ideally are based on the results of high-level evidence, obtained through clinical trials whenever possible. As a principle, a new (proposed better) intervention should be compared to the current standard treatment before being made available generally. Outside a clinical trial new treatments should not become available until evidence has become available to demonstrate superiority over the current standard treatment. Retrospective studies harbour the risk that biases influenced outcomes. At QCGC Research we engage in phase 2 and 3 clinical trials. In large phase trials, patients are allocated randomly to one of two or more interventions in order to minimise the risk of bias. Generally, patients treated within clinical trials have a better outcome compared to patients who are not treated in clinical trials. As the Director of Research Gynaecological Oncology I am currently involved in developing and managing clinical trials in gynaecological cancers.
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Translational Research
The focus of QCGC Research's translational research program is the application of new technology (molecular, biochemical, imaging and surgical) to prevention, detection and therapy for gynaecological cancers.
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Quality of Life Research
Cancer specialists are aware that not only the survival time but also the quality of life is a key factor in cancer treatment. This is especially important when two treatments are equally effective but cause different side-effects. My Quality-of-Life research focuses on ovarian, endometrial, cervical and vulval cancer. I wish to provide the best, most effective and modern treatment to my patients with least possible detriments to quality of life.
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Minimally Invasive Surgery
In Australia, around 30,000 hysterectomies are conducted annually to treat uterine cancer and various benign gynaecological conditions. While open abdominal surgery may be necessary in around 10% of cases, evidence shows that less-invasive approaches, such as total laparoscopic hysterectomy (TLH) can achieve better outcomes for women at a lower overall cost to the health system. Yet, in Queensland, four of ten hysterectomies are still conducted by open abdominal surgery. Our own research has shown that many Australian surgeons are keen to adopt new techniques such as TLH, but that the lack of systematic training and mentoring opportunities is the main impediment to practice-change. Together with gynaecological surgical teams at hospitals and industry support we developed a prototype for system-level transformative practice change in gynaecological surgery.
Research impacts
Professor Obermair is an innovative and skilled gynaecologic oncologist, surgical teacher and consumer advocate. His international leadership and research impact was acknowledged in 2020 by the Australian community, when he was awarded an NHMRC Investigator Fellowship Level 2 (2021-25). The national impact of his research was recognised in 2017, when he was awarded Cancer Australia’s Jeannie Ferris Recognition Award (2017), for outstanding achievements in clinical practice and research. He is deeply engaged in consumer involvement and co-founded and serves on the Board of the Cherish Foundation, a consumer-focussed organisation that funds clinical research in better treatments for women with gynaecological cancers.
Works
Search Professor Andreas Obermair’s works on UQ eSpace
2012
Conference Publication
Nomograms to predict isolated loco-regional or distant recurrence among women with uterine cancer
Kondalsamy-Chennakesavan, Srinivas, Yu, Srinivas, Kattan, Michael W., Leung, Yee, Sykes, Peter, Nascimento, Marcelo, Nicklin, James, Perrin, Lewis, Crandon, Alex, Chetty, Naven, Land, Russell, Garrett, Andrea and Obermair, Andreas (2012). Nomograms to predict isolated loco-regional or distant recurrence among women with uterine cancer. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/j.ygyno.2012.02.022
2012
Journal Article
Improved surgical safety after laparoscopic compared to open surgery for apparent early stage endometrial cancer: Results from a randomised controlled trial
Obermair, Andreas, Janda, Monika, Baker, Jannah, Kondalsamy-Chennakesavan, Srinivas, Brand, Alison, Hogg, Russell, Jobling, Thomas W., Land, Russell, Manolitsas, Tom, Nascimento, Marcelo, Neesham, Deborah, Nicklin, James L., Oehler, Martin K., Otton, Geoff, Perrin, Lewis, Salfinger, Stuart, Hammond, Ian, Leung, Yee, Sykes, Peter, Ngan, Hextan, Garrett, Andrea, Laney, Michael, Ng, Tong Yow, Tam, Karfai, Chan, Karen, Wrede, David H., Pather, Selvan, Simcock, Bryony, Farrell, Rhonda ... Gebski, Vak (2012). Improved surgical safety after laparoscopic compared to open surgery for apparent early stage endometrial cancer: Results from a randomised controlled trial. European Journal of Cancer, 48 (8), 1147-1153. doi: 10.1016/j.ejca.2012.02.055
2012
Journal Article
Efficacy of oral or intrauterine device-delivered progestin in patients with complex endometrial hyperplasia with atypia or early endometrial adenocarcinoma: A meta-analysis and systematic review of the literature
Baker, J., Obermair, A., Gebski, V. and Janda, M. (2012). Efficacy of oral or intrauterine device-delivered progestin in patients with complex endometrial hyperplasia with atypia or early endometrial adenocarcinoma: A meta-analysis and systematic review of the literature. Gynecologic Oncology, 125 (1), 263-270. doi: 10.1016/j.ygyno.2011.11.043
2012
Journal Article
The value of serum CA125 for the development of virtual follow-up strategies for patients with epithelial ovarian cancer: A retrospective study
Varughese, Elizabeth, Kondalsamy-Chennakesavan, Srinivas and Obermair, Andreas (2012). The value of serum CA125 for the development of virtual follow-up strategies for patients with epithelial ovarian cancer: A retrospective study. Journal of Ovarian Research, 5 (1) 11, 11.1-11.5. doi: 10.1186/1757-2215-5-11
2012
Journal Article
Validation of the FIGO 2009 Staging System for Carcinoma of the Vulva
Tan, Jason, Chetty, Naven, Kondalsamy-Chennakesavan, Srinivas, Crandon, Alex, Garrett, Andrea, Land, Russell, Nascimento, Marcelo, Nicklin, Jim, Perrin, Lewis and Obermair, Andreas (2012). Validation of the FIGO 2009 Staging System for Carcinoma of the Vulva. International Journal of Gynecological Cancer, 22 (3), 498-502. doi: 10.1097/IGC.0b013e318241d994
2012
Conference Publication
Quality of life detriments through self-reported swelling associated with gynaecological cancer
Hayes, S.C, Obermair, A., Reul-Hirche, H., Ward, L. C, DiSipio, T. and Janda, M. (2012). Quality of life detriments through self-reported swelling associated with gynaecological cancer. 23rd International Congress of Lymphology, Malmö, Sweden, 19-23 September, 2011. Tucson, AZ, United States: International Society of Lymphology.
2011
Journal Article
Breast cancer susceptibility polymorphisms and endometrial cancer risk: a collaborative endometrial cancer study
Healey, Catherine S., Ahmed, Shahana, O'Mara, Tracy A., Ferguson, Kaltin, Lambrechts, Diether, Garcia-Dios, Diego A., Vergote, Ignace, Amant, Frederic, Howarth, Kimberley, Gorman, Maggie, Hodgson, Shirley, Tomlinson, Ian, Yang, Hannah P., Lissowska, Jolanta, Brinton, Louise A., Chanock, Stephen, Garcia-Closas, Montserrat, Hall, Per, Liu, Jianjun, Shah, Mitul, Pharoah, Paul D. P., Thompson, Deborah J., Rebbeck, Timothy R., Strom, Brian L., Dunning, Alison M., Easton, Douglas F., Spurdle, Amanda B., ANECS Group and Obermair, Andreas (2011). Breast cancer susceptibility polymorphisms and endometrial cancer risk: a collaborative endometrial cancer study. Carcinogenesis, 32 (12) bgr214, 1862-1866. doi: 10.1093/carcin/bgr214
2011
Journal Article
How to treat
Obermair, Andreas (2011). How to treat. Australian Doctor (16-September), 29-36.
2011
Journal Article
Safety, feasibility and effects of an individualised walking intervention for women undergoing chemotherapy for ovarian cancer: A pilot study
Newton, Melissa J ., Hayes, Sandi C., Janda, Monika, Webb, Penelope M., Obermair, Andreas, Eakin, Elizabeth G., Wyld, David, Gordon, Louisa G. and Beesley, Vanessa L. (2011). Safety, feasibility and effects of an individualised walking intervention for women undergoing chemotherapy for ovarian cancer: A pilot study. BMC Cancer, 11 (1) 389, 389-1-389-9. doi: 10.1186/1471-2407-11-389
2011
Journal Article
CHEK2, MGMT, SULT1E1 and SULT1A1 polymorphisms and endometrial cancer risk
O'Mara, Tracy A., Ferguson, Kaltin, Fahey, Paul, Marquart, Louise, Yang, Hannah P., Lissowska, Jolanta, Chanock, Stephen, Garcia-Closas, Montserrat, Thompson, Deborah J., Healey, Catherine S., Dunning, Alison M., Easton, Douglas F., ANECS, Webb, Penelope M., Spurdle, Amanda B. and Obermair, Andreas (2011). CHEK2, MGMT, SULT1E1 and SULT1A1 polymorphisms and endometrial cancer risk. Twin Research and Human Genetics, 14 (4), 328-332. doi: 10.1375/twin.14.4.328
2011
Journal Article
Quality of life of women with lower-limb lymphedema following gynecological cancer
Finnane, Anna, Hayes, Sandra C., Obermair, Andreas and Janda, Monika (2011). Quality of life of women with lower-limb lymphedema following gynecological cancer. Expert Review of Pharmacoeconomics and Outcomes Research, 11 (3), 287-297. doi: 10.1586/erp.11.30
2011
Journal Article
Hospital costs associated with adverse events in gynecological oncology
Kondalsamy-Chennakesavan, Srinivas, Gordon, Louisa G., Sanday, Karen, Bouman, Chantal, De Jong, Suzanne, Nicklin, James, Land, Russell and Obermair, Andreas (2011). Hospital costs associated with adverse events in gynecological oncology. Gynecologic Oncology, 121 (1), 70-75. doi: 10.1016/j.ygyno.2010.11.030
2011
Conference Publication
The utility of preoperative CA-125 in the management of apparent early-stage endometrial cancer
Nicklin, J., Janda, M., Gebski, V., Jobling, T., Land, R., Manolitsas, T., McCartney, A., Nascimento, M., Perrin, L. and Obermair, A. (2011). The utility of preoperative CA-125 in the management of apparent early-stage endometrial cancer. 42nd Annual Meeting Of The Society Of Gynecologic Oncologists, Orlando, FL, United States, 31 December 2011. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/j.ygyno.2010.12.043
2011
Journal Article
Prospective validation study of a predictive score for operability of recurrent ovarian cancer: The multicenter intergroup study DESKTOP II. A project of the AGO kommission OVAR, AGO study group, NOGGO, AGO-Austria, and MITO
Harter, Philipp, Sehouli, Jalid, Reuss, Alexander, Hasenburg, Annette, Scambia, Giovanni, Cibula, David, Mahner, Sven, Vergote, Ignace, Reinthaller, Alexander, Burges, Alexander, Hanker, Lars, Polcher, Martin, Kurzeder, Christian, Canzler, Ulrich, Petry, Karl Ulrich, Obermair, Andreas, Petru, Edgar, Schmalfeldt, Barbara, Lorusso, Domenica and du Bois, Andreas (2011). Prospective validation study of a predictive score for operability of recurrent ovarian cancer: The multicenter intergroup study DESKTOP II. A project of the AGO kommission OVAR, AGO study group, NOGGO, AGO-Austria, and MITO. International Journal of Gynecological Cancer, 21 (2), 289-295. doi: 10.1097/IGC.0b013e31820aaafd
2011
Journal Article
Prospective, non-randomized phase 2 clinical trial of carboplatin plus paclitaxel with sequential radical pelvic radiotherapy for uterine papillary serous carcinoma
Obermair, Andreas, Mileshkin, Linda, Bolz, Katharina, Kondalsamy-Chennakesavan, Srinivas, Cheuk, Robyn, Vasey, Paul, Wyld, David, Goh, Jeffrey, Nicklin, James L., Perrin, Lewis C., Sykes, Peter and Janda, Monika (2011). Prospective, non-randomized phase 2 clinical trial of carboplatin plus paclitaxel with sequential radical pelvic radiotherapy for uterine papillary serous carcinoma. Gynecologic Oncology, 120 (2), 179-184. doi: 10.1016/j.ygyno.2010.10.039
2011
Journal Article
Epidural anaesthesia and ovarian cancer survival
Belavy, David and Obermair, Andreas (2011). Epidural anaesthesia and ovarian cancer survival. British Journal of Anaesthesia
2011
Conference Publication
Quality of life in patients who self-report lower limb swelling after treatment for gynaecological cancer
Hayes, S., Janda, M., Reul-Hirche, H., Ward, L. and Obermair, A. (2011). Quality of life in patients who self-report lower limb swelling after treatment for gynaecological cancer. 23rd International Congress of Lymphology, Malmo, Sweden, 19-23 September 2011.
2011
Journal Article
The utility of serum CA-125 in predicting extra-uterine disease in apparent early-stage endometrial cancer
Nicklin, James, Janda, Monika, Gebski, Val, Jobling, Thomas, Land, Russell, Manolitsas, Tom, McCartney, Anthony, Nascimento, Marcelo, Perrin, Lewis, Baker, Jannah F. and Obermair, Andreas (2011). The utility of serum CA-125 in predicting extra-uterine disease in apparent early-stage endometrial cancer. International Journal of Cancer, 131 (4), 885-890. doi: 10.1002/ijc.26433
2011
Conference Publication
Charlson's index: A validation study to predict surgical adverse
Kondalsamy-Chennakesavan, S., Johnson, S., Nicklin, J., Land, R., Garrett, A. and Obermair, A. (2011). Charlson's index: A validation study to predict surgical adverse. 42nd Annual Meeting Of The Society Of Gynecologic Oncologists, Orlando, FL United States, 6-9 March 2011. Maryland Heights, MO United States: Academic Press. doi: 10.1016/j.ygyno.2010.12.291
2010
Journal Article
Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma
Obermair, Andreas, Youlden, Danny R., Young, Joanne P., Lindor, Noralane M., Baron, John A., Newcomb, Polly, Parry, Susan, Hopper, John L., Haile, Robert and Jenkins, Mark A. (2010). Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma. International Journal of Cancer, 127 (11), 2678-2684. doi: 10.1002/ijc.25501
Funding
Current funding
Past funding
Supervision
Availability
- Professor Andreas Obermair is:
- Available for supervision
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Available projects
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feMMe: Uterus-preserving treatment of endometrial cancer
In 2020 we completed the feMMe, phase 2 cliniccal trial which established anticancer activity of levonorgestrel intrauterrine device (LNG-IUD) to treat endometrial cancer. The next two steps towards estabnlioshing this treatment for larger groups of patients include:
1. To determine factors that predict response to LNG-IUD
2. To determine long-term patient outcomes including survival, fertility, and patient needs.
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Improving Quality of Survival for Women with Gynaecological Cancer
- Focus on improving quality of life, health & function during & after gynaecological cancer treatment, with a focus on biomarker research, implementation research and cancer survivorship.
Supervision history
Current supervision
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Doctor Philosophy
Advanced methods for biomarker informed endometrial cancer
Principal Advisor
Other advisors: Dr Eva Baxter, Dr Zoe West, Professor Andrew Martin
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Master Philosophy
Patterns of care in endometrial cancer management in Queensland: a retrospective analysis.
Principal Advisor
Other advisors: Dr Eva Baxter
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Doctor Philosophy
Diet quality and composition in Australian women with endometrial cancer
Associate Advisor
Other advisors: Professor Monika Janda
Completed supervision
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2014
Doctor Philosophy
Hereditary endometrial cancer: Improving identification and referral of patients with suspected Lynch syndrome
Principal Advisor
Other advisors: Honorary Professor Amanda Spurdle, Associate Professor Lisa Fitzgerald
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2008
Doctor Philosophy
Nutritional status of patients with gynaecological cancer -
Joint Principal Advisor
Other advisors: Emeritus Professor Geoffrey Cleghorn
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Media
Enquiries
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