
Overview
Background
John McGrath AM, MBBS, MD, PhD, FRANZCP, FAHMS
John McGrath is a psychiatrist interested in discovering the causes of serious mental disorders. He is the Director of the Queensland Centre for Mental Health Research and conjoint Professor at the Queensland Brain Institute His research aims to generate and evaluate nongenetic risk factors for schizophrenia. He has forged productive cross-disciplinary collaborations linking risk factor epidemiology with developmental neurobiology. For example, John and his colleagues have made discoveries linking prenatal vitamin D and later risk of mental illness in the offspring. In addition, John has supervised major systematic reviews of the epidemiology of schizophrenia. He was awarded a John Cade Fellowship by the Australian National Health and Medical Research Council. In 2016 he was also awarded a Neils Bohr Professorship by the Danish National Research Foundation.
Availability
- Professor John McGrath is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
- Royal Australian and New Zealand College of Psychiatrists, Royal Australian and New Zealand College of Psychiatrists
Research interests
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The association between vitamin D status and brain outcomes
In collaboration with Darryl Eyles, we are measuring early life vitamin D status and exploring if this changes the risk of later developing serious mental illness. These studies are in collaboration with colleagues in Denmark, Sweden and the Netherlands.
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The demographic and clinical correlates of psychotic-like experiences
Using two large surveys conducted in Australia in 1997 and 2007, our group have undertaken a suite of studies designed to understand the clinical relevance of isolated psychotic-like experiences. Over recent years we have published many papers on this topic, and have made important contributions with respect to how psychotic-like experiences are associated with (a) an increased risk of later psychotic disorders (based on the MUSP study), (b) depression, anxiety and substance use disorders, (c) a family history of mental illness, (d) exposure to trauma, (e) an increased risk of suicidal ideation and behaviour, (f) general physical health, and (g) help-seeking.
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The Survey of High Impact Psychosis (SHIP)
Our group was one of seven sites involved in the design and administration of the second Australian Survey of psychotic disorders. In collaboration with a large national team, we continue to explore key issues related to the needs of people with psychosis in Australia.
Research impacts
The Epidemiology team are interested in the frequency measures related to serious mental disorders (e.g. incidence, prevalence, mortality, recovery/remission). We are also interested in the clinical and demographic correlates of adverse mental health outcomes – some of these may be modifiable risk factors and thus important from a public health perspective. We use large, community-based surveys, and birth cohorts. Our focus has been on psychotic disorders and psychotic-like experiences in the general population. In addition, we are examining the links between early life vitamin D status and risk of later mental illness, by directly measuring vitamin D (in collaboration with Darryl Eyles and many international collaborators).
Works
Search Professor John McGrath’s works on UQ eSpace
2023
Journal Article
ADuLT: An efficient and robust time-to-event GWAS
Pedersen, Emil M., Agerbo, Esben, Plana-Ripoll, Oleguer, Steinbach, Jette, Krebs, Morten D., Hougaard, David M., Werge, Thomas, Nordentoft, Merete, Børglum, Anders D., Musliner, Katherine L., Ganna, Andrea, Schork, Andrew J., Mortensen, Preben B., McGrath, John J., Privé, Florian and Vilhjálmsson, Bjarni J. (2023). ADuLT: An efficient and robust time-to-event GWAS. Nature Communications, 14 (1) 5553, 1-12. doi: 10.1038/s41467-023-41210-z
2023
Journal Article
Disease burden attributed to drug use in the Nordic countries: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2019
Agardh, Emilie E., Allebeck, Peter, Knudsen, Ann Kristin Skrindo, Aronsson, Amanda E., Flodin, Pär, Eikemo, Terje A., Bangah, Paul R., Skogen, Jens Christoffer, Gissler, Mika, Rönkä, Sanna, McGrath, John J., Sigurvinsdóttir, Rannveig, Dadras, Omid, Deuba, Keshab, Hedna, Khedidja, Mentis, Alexios-Fotios A., Sagoe, Dominic, Shiri, Rahman, Weye, Nanna, Hay, Simon I., Murray, Christopher J. L., Naghavi, Mohsen, Pasovic, Maja, Vos, Theo, Wennberg, Peter and Danielsson, Anna-Karin (2023). Disease burden attributed to drug use in the Nordic countries: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2019. International Journal of Mental Health and Addiction, 23 (1), 618-649. doi: 10.1007/s11469-023-01131-w
2023
Journal Article
Multi-PGS enhances polygenic prediction by combining 937 polygenic scores
Albiñana, Clara, Zhu, Zhihong, Schork, Andrew J., Ingason, Andrés, Aschard, Hugues, Brikell, Isabell, Bulik, Cynthia M., Petersen, Liselotte V., Agerbo, Esben, Grove, Jakob, Nordentoft, Merete, Hougaard, David M., Werge, Thomas, Børglum, Anders D., Mortensen, Preben Bo, McGrath, John J., Neale, Benjamin M., Privé, Florian and Vilhjálmsson, Bjarni J. (2023). Multi-PGS enhances polygenic prediction by combining 937 polygenic scores. Nature Communications, 14 (1) 4702, 1-11. doi: 10.1038/s41467-023-40330-w
2023
Journal Article
The burden and trend of diseases and their risk factors in Australia, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
GBD 2019 Australia Collaborators, Islam, Sheikh Mohammed Shariful, Islam, Mohammed, Uddin, Riaz, Khan, Ambereen, Anderlini, Deanna, Veerman, Lennert, Huda, M. Mamun, Lalloo, Ratilal, McGrath, John, Kelly, Jaimon and Mamun, Abdullah A. (2023). The burden and trend of diseases and their risk factors in Australia, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Public Health, 8 (8), E585-E599. doi: 10.1016/S2468-2667(23)00123-8
2023
Journal Article
The burden and trend of diseases and their risk factors in Australia, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
GBD 2019 Australia Collaborators, Lalloo, Ratilal, Uddin, Riaz, Khan, Asaduzzaman, Anderlini, Deanna, Endalamaw, Aklilu, Veerman, Lennert, Huda, M. Mamun, McGrath, John J., Mamun, Abdullah A. and Kelly, Jaimon Terence (2023). The burden and trend of diseases and their risk factors in Australia, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Public Health, 8 (8), e585-e599. doi: 10.1016/s2468-2667(23)00123-8
2023
Journal Article
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses
Als, Thomas D., Kurki, Mitja I., Grove, Jakob, Voloudakis, Georgios, Therrien, Karen, Tasanko, Elisa, Nielsen, Trine Tollerup, Naamanka, Joonas, Veerapen, Kumar, Levey, Daniel F., Bendl, Jaroslav, Bybjerg-Grauholm, Jonas, Zeng, Biao, Demontis, Ditte, Rosengren, Anders, Athanasiadis, Georgios, Bækved-Hansen, Marie, Qvist, Per, Bragi Walters, G., Thorgeirsson, Thorgeir, Stefánsson, Hreinn, Musliner, Katherine L., Rajagopal, Veera M., Farajzadeh, Leila, Thirstrup, Janne, Vilhjálmsson, Bjarni J., McGrath, John J., Mattheisen, Manuel, Meier, Sandra ... Børglum, Anders D. (2023). Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses. Nature Medicine, 29 (7), 1832-1844. doi: 10.1038/s41591-023-02352-1
2023
Journal Article
Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries
McGrath, John J, Al-Hamzawi, Ali, Alonso, Jordi, Altwaijri, Yasmin, Andrade, Laura H, Bromet, Evelyn J, Bruffaerts, Ronny, de Almeida, José Miguel Caldas, Chardoul, Stephanie, Chiu, Wai Tat, Degenhardt, Louisa, Demler, Olga V, Ferry, Finola, Gureje, Oye, Haro, Josep Maria, Karam, Elie G, Karam, Georges, Khaled, Salma M, Kovess-Masfety, Viviane, Magno, Marta, Medina-Mora, Maria Elena, Moskalewicz, Jacek, Navarro-Mateu, Fernando, Nishi, Daisuke, Plana-Ripoll, Oleguer, Posada-Villa, José, Rapsey, Charlene, Sampson, Nancy A, Stagnaro, Juan Carlos ... Zaslavsky, Alan M. (2023). Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries. The Lancet Psychiatry, 10 (9), 668-681. doi: 10.1016/s2215-0366(23)00193-1
2023
Journal Article
Agreement between survey- and register-based measures of depression in Denmark
Weye, Nanna, McGrath, John J., Lasgaard, Mathias, Momen, Natalie C., Knudsen, Ann Kristin, Musliner, Katherine and Plana-Ripoll, Oleguer (2023). Agreement between survey- and register-based measures of depression in Denmark. Acta Psychiatrica Scandinavica, 147 (6), 581-592. doi: 10.1111/acps.13555
2023
Journal Article
Schizophrenia spectrum disorders in Denmark between 2000 and 2018: incidence and early diagnostic transition
Köhler‐Forsberg, Ole, Antonsen, Sussie, Pedersen, Carsten B., Mortensen, Preben Bo, McGrath, John J. and Mors, Ole (2023). Schizophrenia spectrum disorders in Denmark between 2000 and 2018: incidence and early diagnostic transition. Acta Psychiatrica Scandinavica, 148 (2), 190-198. doi: 10.1111/acps.13565
2023
Journal Article
Development and evaluation of a risk algorithm predicting alcohol dependence after early onset of regular alcohol use
Bharat, Chrianna, Glantz, Meyer D., Aguilar‐Gaxiola, Sergio, Alonso, Jordi, Bruffaerts, Ronny, Bunting, Brendan, Caldas‐de‐Almeida, José Miguel, Cardoso, Graça, Chardoul, Stephanie, de Jonge, Peter, Gureje, Oye, Haro, Josep Maria, Harris, Meredith G., Karam, Elie G., Kawakami, Norito, Kiejna, Andrzej, Kovess‐Masfety, Viviane, Lee, Sing, McGrath, John J., Moskalewicz, Jacek, Navarro‐Mateu, Fernando, Rapsey, Charlene, Sampson, Nancy A., Scott, Kate M., Tachimori, Hisateru, ten Have, Margreet, Vilagut, Gemma, Wojtyniak, Bogdan, Xavier, Miguel ... Degenhardt, Louisa (2023). Development and evaluation of a risk algorithm predicting alcohol dependence after early onset of regular alcohol use. Addiction, 118 (5), 954-966. doi: 10.1111/add.16122
2023
Journal Article
Bidirectional associations between asthma and types of mental disorders
Liu, Xiaoqin, Plana-Ripoll, Oleguer, McGrath, John J., Petersen, Liselotte V., Dharmage, Shyamali C. and Momen, Natalie C. (2023). Bidirectional associations between asthma and types of mental disorders. The Journal of Allergy and Clinical Immunology: In Practice, 11 (3), 799-808.e14. doi: 10.1016/j.jaip.2022.11.027
2023
Journal Article
Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots
Albiñana, Clara, Zhu, Zhihong, Borbye-Lorenzen, Nis, Boelt, Sanne Grundvad, Cohen, Arieh S., Skogstrand, Kristin, Wray, Naomi R., Revez, Joana A, Privé, Florian, Petersen, Liselotte V., Bulik, Cynthia M., Plana-Ripoll, Oleguer, Musliner, Katherine L., Agerbo, Esben, Børglum, Anders D., Hougaard, David M., Nordentoft, Merete, Werge, Thomas, Mortensen, Preben Bo, Vilhjálmsson, Bjarni J. and McGrath, John J. (2023). Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots. Nature Communications, 14 (1) 852, 1-16. doi: 10.1038/s41467-023-36392-5
2023
Journal Article
The association between mental disorders and subsequent years of working life: a Danish population-based cohort study
Plana-Ripoll, Oleguer, Weye, Nanna, Knudsen, Ann Kristin, Hakulinen, Christian, Madsen, Kathrine Bang, Christensen, Maria Klitgaard, Agerbo, Esben, Laursen, Thomas Munk, Nordentoft, Merete, Timmermann, Allan, Whiteford, Harvey, Øverland, Simon, Iburg, Kim Moesgaard and McGrath, John J. (2023). The association between mental disorders and subsequent years of working life: a Danish population-based cohort study. The Lancet Psychiatry, 10 (1), 30-39. doi: 10.1016/s2215-0366(22)00376-5
2022
Journal Article
Representativeness of survey participants in relation to mental disorders: a linkage between national registers and a population-representative survey
Momen, Natalie C, Lasgaard, Mathias, Weye, Nanna, Edwards, Jordan, McGrath, John and Plana-Ripoll, Oleguer (2022). Representativeness of survey participants in relation to mental disorders: a linkage between national registers and a population-representative survey. International Journal of Population Data Science, 7 (4) 03, 1-18. doi: 10.23889/ijpds.v7i4.1759
2022
Journal Article
The contribution of general medical conditions to the non-fatal burden of mental disorders: register-based cohort study in Denmark
Weye, Nanna, Momen, Natalie C., Whiteford, Harvey A., Christensen, Maria Klitgaard, Iburg, Kim Moesgaard, Santomauro, Damian F., Agerbo, Esben, Mortensen, Preben Bo, Pedersen, Carsten Bøcker, McGrath, John J. and Plana-Ripoll, Oleguer (2022). The contribution of general medical conditions to the non-fatal burden of mental disorders: register-based cohort study in Denmark. BJPsych Open, 8 (6) e180, 1-7. doi: 10.1192/bjo.2022.583
2022
Journal Article
The health care cost of comorbidity in individuals with mental disorders: A Danish register-based study
Christensen, Maria K., McGrath, John J., Momen, Natalie, Weye, Nanna, Agerbo, Esben, Pedersen, Carsten Bøcker, Plana-Ripoll, Oleguer and Iburg, Kim M. (2022). The health care cost of comorbidity in individuals with mental disorders: A Danish register-based study. Australian and New Zealand Journal of Psychiatry, 57 (6), 1-9. doi: 10.1177/00048674221129184
2022
Conference Publication
Improving the predictive value of family history for psychiatric disorders
Steinbach, Jette, Pedersen, Emil, Prive, Florian, Albinana, Clara, Plana-Ripoll, Oleguer, Yilmaz, Zeynep, Petersen, Liselotte V., Bulik, Cynthia M., McGrath, John J., Mortensen, Preben B., Musliner, Katherine L., Agerbo, Esben and Vilhjalmsson, Bjarni J. (2022). Improving the predictive value of family history for psychiatric disorders. World Congress of Psychiatric Genetics (WCPG), Florence, Italy, 13-17 September 2022. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2022.07.107
2022
Journal Article
Developmental exposure to vitamin D deficiency and subsequent risk of schizophrenia
Albiñana, Clara, Boelt, Sanne Grundvad, Cohen, Arieh S., Zhu, Zhihong, Musliner, Katherine L., Vilhjálmsson, Bjarni J. and McGrath, John J. (2022). Developmental exposure to vitamin D deficiency and subsequent risk of schizophrenia. Schizophrenia Research, 247, 26-32. doi: 10.1016/j.schres.2021.06.004
2022
Journal Article
Increased risks for mental disorders among LGB individuals: cross-national evidence from the World Mental Health Surveys
Gmelin, Jan-Ole H., De Vries, Ymkje Anna, Baams, Laura, Aguilar-Gaxiola, Sergio, Alonso, Jordi, Borges, Guilherme, Bunting, Brendan, Cardoso, Graca, Florescu, Silvia, Gureje, Oye, Karam, Elie G., Kawakami, Norito, Lee, Sing, Mneimneh, Zeina, Navarro-Mateu, Fernando, Posada-Villa, José, Rapsey, Charlene, Slade, Tim, Stagnaro, Juan Carlos, Torres, Yolanda, Kessler, Ronald C., de Jonge, Peter, Aguilar-Gaxiola, Sergio, Al-Hamzawi, Ali, Alonso, Jordi, Andrade, Laura Helena, Atwoli, Lukoye, Benjet, Corina, Borges, Guilherme ... on behalf of The WHO World Mental Health Survey collaborators (2022). Increased risks for mental disorders among LGB individuals: cross-national evidence from the World Mental Health Surveys. Social Psychiatry and Psychiatric Epidemiology, 57 (11), 2319-2332. doi: 10.1007/s00127-022-02320-z
2022
Journal Article
Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020
Bryazka, Dana, Reitsma, Marissa B, Griswold, Max G, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbasi-Kangevari, Mohsen, Abbasi-Kangevari, Zeinab, Abdoli, Amir, Abdollahi, Mohammad, Abdullah, Abu Yousuf Md, Abhilash, E. S., Abu-Gharbieh, Eman, Acuna, Juan Manuel, Addolorato, Giovanni, Adebayo, Oladimeji M, Adekanmbi, Victor, Adhikari, Kishor, Adhikari, Sangeet, Adnani, Qorinah Estiningtyas Sakilah, Afzal, Saira, Agegnehu, Wubetu Yimam, Aggarwal, Manik, Ahinkorah, Bright Opoku, Ahmad, Araz Ramazan, Ahmad, Sajjad, Ahmad, Tauseef, Ahmadi, Ali, Ahmadi, Sepideh, Ahmed, Haroon ... Gakidou, Emmanuela (2022). Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020. The Lancet, 400 (10347), 185-235. doi: 10.1016/S0140-6736(22)00847-9
Funding
Current funding
Past funding
Supervision
Availability
- Professor John McGrath is:
- Available for supervision
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Supervision history
Completed supervision
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2019
Doctor Philosophy
Mental Disorders and Physical Activity: Epidemiological Analyses using Australian Datasets
Principal Advisor
Other advisors: Professor James Scott
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2016
Doctor Philosophy
The mental health of Aboriginal and Torres Strait Islander people in custody.
Principal Advisor
Other advisors: Professor Harvey Whiteford
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2010
Doctor Philosophy
The antecedents of schizophrenia, a birth cohort study
Principal Advisor
Other advisors: Emeritus Professor Gail Williams
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2007
Doctor Philosophy
AWARENESS OF MULTIPLE DIMENSIONS OF INSIGHT INTO SCHIZOPHRENIA: A COMPARISON OF PATIENTS WITH THEIR RELATIVES AND CLINICIANS
Principal Advisor
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2016
Doctor Philosophy
Contrasting the Expression of Psychotic Disorders in Ethnically Different Populations
Associate Advisor
Other advisors: Professor Bryan Mowry
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2016
Doctor Philosophy
The role of adult vitamin D deficiency in cognition and brain function in mice
Associate Advisor
Other advisors: Professor Thomas Burne
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2015
Doctor Philosophy
Neurochemical and neurophysiological bases of executive control
Associate Advisor
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2009
Doctor Philosophy
The effect of developmental vitamin D3 deficiency on brain development, immune function and behaviour in the adult rat
Associate Advisor
Other advisors: Professor Thomas Burne, Professor Darryl Eyles
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2009
Doctor Philosophy
The prevalence and correlates of psychotic-like experiences in the Australian community
Associate Advisor
Other advisors: Emeritus Professor Graham Martin
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2005
Doctor Philosophy
Startle eyeblink modification: Associations with haloperidol, caffeine and nicotine in schizophrenia-spectrum and health individuals
Associate Advisor
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2003
Doctor Philosophy
INFORMATION PROCESSING AND PSYCHOSIS
Associate Advisor
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2003
Doctor Philosophy
THE ASSESSMENT OF THE DYSEXECUTIVE SYNDROME IN INDIVIDUALS WITH PSYCHOSIS
Associate Advisor
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2002
Doctor Philosophy
THE ELECTRO-PHYSIOLOGY OF WORKING MEMORY IN SCHIZOPHRENIA
Associate Advisor
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2002
Doctor Philosophy
MOLECULAR CANDIDATES FOR SCHIZOPHRENIA
Associate Advisor
Other advisors: Professor Bryan Mowry
Media
Enquiries
Contact Professor John McGrath directly for media enquiries about:
- Brain development
- Neuroscience
- Schizophrenia
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