Professor John McGrath
Professor

John McGrath

Email: 
Phone: 
+61 7 3271 8694

Background

John McGrath AM, MBBS, MD, PhD, FRANZCP, FAHMS

John McGrath is a psychiatrist interested in discovering the causes of serious mental disorders. He is the Director of the Queensland Centre for Mental Health Research and conjoint Professor at the Queensland Brain Institute His research aims to generate and evaluate nongenetic risk factors for schizophrenia. He has forged productive cross-disciplinary collaborations linking risk factor epidemiology with developmental neurobiology. For example, John and his colleagues have made discoveries linking prenatal vitamin D and later risk of mental illness in the offspring. In addition, John has supervised major systematic reviews of the epidemiology of schizophrenia. He was awarded a John Cade Fellowship by the Australian National Health and Medical Research Council. In 2016 he was also awarded a Neils Bohr Professorship by the Danish National Research Foundation.

Availability

Professor John McGrath is:
Available for supervision
Media expert

Fields of research

Clinical sciences Health Sciences Neurosciences

Qualifications

  • Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
  • Doctor of Philosophy, The University of Queensland
  • Royal Australian and New Zealand College of Psychiatrists, Royal Australian and New Zealand College of Psychiatrists

Research interests

  • The association between vitamin D status and brain outcomes

    In collaboration with Darryl Eyles, we are measuring early life vitamin D status and exploring if this changes the risk of later developing serious mental illness. These studies are in collaboration with colleagues in Denmark, Sweden and the Netherlands.

  • The demographic and clinical correlates of psychotic-like experiences

    Using two large surveys conducted in Australia in 1997 and 2007, our group have undertaken a suite of studies designed to understand the clinical relevance of isolated psychotic-like experiences. Over recent years we have published many papers on this topic, and have made important contributions with respect to how psychotic-like experiences are associated with (a) an increased risk of later psychotic disorders (based on the MUSP study), (b) depression, anxiety and substance use disorders, (c) a family history of mental illness, (d) exposure to trauma, (e) an increased risk of suicidal ideation and behaviour, (f) general physical health, and (g) help-seeking.

  • The Survey of High Impact Psychosis (SHIP)

    Our group was one of seven sites involved in the design and administration of the second Australian Survey of psychotic disorders. In collaboration with a large national team, we continue to explore key issues related to the needs of people with psychosis in Australia.

Research impacts

The Epidemiology team are interested in the frequency measures related to serious mental disorders (e.g. incidence, prevalence, mortality, recovery/remission). We are also interested in the clinical and demographic correlates of adverse mental health outcomes – some of these may be modifiable risk factors and thus important from a public health perspective. We use large, community-based surveys, and birth cohorts. Our focus has been on psychotic disorders and psychotic-like experiences in the general population. In addition, we are examining the links between early life vitamin D status and risk of later mental illness, by directly measuring vitamin D (in collaboration with Darryl Eyles and many international collaborators).

Search Professor John McGrath’s works on UQ eSpace

899 works between 1982 and 2025
All (899) Journal Article (672) Book Chapter (22) Conference Publication (196) Book (1) Other Outputs (8)

561 - 580 of 899 works

2009

Conference Publication

Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood in a general population birth cohort

McGrath, John Joseph, Barnett, A., Foldi, C., Burne, T. H., Eyles, D. W. and Buka, S. (2009). Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood in a general population birth cohort. 12th International Congress on Schizophrenia Research (ICOSR), San Diego, United States, 28 March -1 April 2009. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/schbul/sbn173

Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood in a general population birth cohort

2008

Journal Article

Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality

McGrath, John J., Saha, Sukanta, Chant, David C. and Welham, Joy (2008). Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality. Epidemiologic Reviews, 30 (1), 67-76. doi: 10.1093/epirev/mxn001

Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality

2008

Journal Article

Demographic correlates of psychotic-like experiences in young Australian adults

Scott, J., Welham, J., Martin, G., Bor, W., Najman, J, O'Callaghan, M., Williams, G., Aird, R. and McGrath, J. J. (2008). Demographic correlates of psychotic-like experiences in young Australian adults. Acta Psychiatrica Scandinavica, 118 (3), 230-237. doi: 10.1111/j.1600-0447.2008.01214.x

Demographic correlates of psychotic-like experiences in young Australian adults

2008

Journal Article

Modelling disease frequency measures in schizophrenia epidemiology

Saha, Sukanta, Barendregt, Jan J., Vos, Theo, Whiteford, Harvey and McGrath, John (2008). Modelling disease frequency measures in schizophrenia epidemiology. Schizophrenia Research, 104 (1-3), 246-254. doi: 10.1016/j.schres.2008.05.022

Modelling disease frequency measures in schizophrenia epidemiology

2008

Journal Article

Mental health: Don't overlook environment and its risk factors

McGrath, John J. and Selten, Jean-Paul (2008). Mental health: Don't overlook environment and its risk factors. Nature, 454 (7206), 824-824. doi: 10.1038/454824b

Mental health: Don't overlook environment and its risk factors

2008

Journal Article

Hypotheses desert us, while data defend us

McGrath, John (2008). Hypotheses desert us, while data defend us. Schizophrenia Research, 102 (1-3), 27-28. doi: 10.1016/j.schres.2008.04.004

Hypotheses desert us, while data defend us

2008

Journal Article

Fibroblast and lymphoblast gene expression profiles in schizophrenia: Are non-neural cells informative?

Matigian, Nicholas A., McCurdy, Richard D., Feron, Francois, Perry, Christopher, Smith, Heather, Filippich, Cheryl, McLean, Duncan, McGrath, John J., Mackay-Sim, Alan, Mowry, Bryan and Hayward, Nicholas K. (2008). Fibroblast and lymphoblast gene expression profiles in schizophrenia: Are non-neural cells informative?. PLoS One, 3 (6) e2412, e2412-1-e2412-5. doi: 10.1371/journal.pone.0002412

Fibroblast and lymphoblast gene expression profiles in schizophrenia: Are non-neural cells informative?

2008

Journal Article

Protein expression in the nucleus accumbens of rats exposed to developmental vitamin D deficiency

McGrath, John, Iwazaki, Takeshi, Eyles, Darryl, Burne, Thomas, Cui, Xiaoying, Ko, Pauline and Matsumoto, Izuru (2008). Protein expression in the nucleus accumbens of rats exposed to developmental vitamin D deficiency. PLoS One, 3 (6) e2383, e2383. doi: 10.1371/journal.pone.0002383

Protein expression in the nucleus accumbens of rats exposed to developmental vitamin D deficiency

2008

Journal Article

Correlates of delusion-like experiences in a non-psychotic community sample

Varghese, Daniel, Scott, James and McGrath, John (2008). Correlates of delusion-like experiences in a non-psychotic community sample. Australian & New Zealand Journal of Psychiatry, 42 (6), 505-508. doi: 10.1080/00048670802050595

Correlates of delusion-like experiences in a non-psychotic community sample

2008

Journal Article

Developmental vitamin D deficiency alters adult behavior in 129/SvJ and C57BL/6J mice

Harms, Lauren R., Eyles, Darryl W., McGrath, John J., Mackay-Sim, Alan and Burne, Thomas H. J. (2008). Developmental vitamin D deficiency alters adult behavior in 129/SvJ and C57BL/6J mice. Behavioural Brain Research, 187 (2), 343-350. doi: 10.1016/j.bbr.2007.09.032

Developmental vitamin D deficiency alters adult behavior in 129/SvJ and C57BL/6J mice

2008

Journal Article

Meta-analyses of the incidence and prevalence of schizophrenia: conceptual and methodological issues

Saha, Sukanta, Chant, David C. and McGrath, John J. (2008). Meta-analyses of the incidence and prevalence of schizophrenia: conceptual and methodological issues. International Journal of Methods in Psychiatric Research, 17 (1), 55-61. doi: 10.1002/mpr.240

Meta-analyses of the incidence and prevalence of schizophrenia: conceptual and methodological issues

2008

Journal Article

Associations between early development and outcome in schizophrenia - A 35-year follow-up of the Northern Finland 1966 Birth Cohort

Jaaskelainen, E, Miettunen, J, Veijola, J, McGrath, JJ, Murray, GK, Jones, PB and Isohanni, M (2008). Associations between early development and outcome in schizophrenia - A 35-year follow-up of the Northern Finland 1966 Birth Cohort. Schizophrenia Research, 99 (1-3), 29-37. doi: 10.1016/j.schres.2007.11.024

Associations between early development and outcome in schizophrenia - A 35-year follow-up of the Northern Finland 1966 Birth Cohort

2008

Journal Article

Dissecting the heterogeneity of schizophrenia outcomes

McGrath, J. (2008). Dissecting the heterogeneity of schizophrenia outcomes. Schizophrenia Bulletin, 34 (2), 247-248. doi: 10.1093/schbul/sbm133

Dissecting the heterogeneity of schizophrenia outcomes

2008

Journal Article

Animal models may help fractionate shared and discrete pathways underpinning schizophrenia and autism (Open Peer Commentary)

Burne, Thomas H. J., Eyles, Darryl and McGrath, John J. (2008). Animal models may help fractionate shared and discrete pathways underpinning schizophrenia and autism (Open Peer Commentary). Behavioral And Brain Sciences, 31 (3), 264-265. doi: 10.1017/S0140525X08004251

Animal models may help fractionate shared and discrete pathways underpinning schizophrenia and autism (Open Peer Commentary)

2008

Conference Publication

Psychopathology during childhood and adolescence predicts delusional-like experiences in adults: A 21 year birth cohort study

Scott, James, Welham, J., Martin, G., Bor, W., Najman, J., O'Callaghan, M., Williams, G., Aird, R. and McGrath, J. (2008). Psychopathology during childhood and adolescence predicts delusional-like experiences in adults: A 21 year birth cohort study. RANZCP Faculty of Child & Adolescent Psychiatry Annual Conference: child2008 - Challenges in the Digital Age, Port Douglas, Australia, 12-16 October 2008.

Psychopathology during childhood and adolescence predicts delusional-like experiences in adults: A 21 year birth cohort study

2008

Conference Publication

Advanced paternal age alters brain development and behaviour in C57BL/6J mice

Foldi, Claire Jennifer, Cowin G, Kurniawan, Nyoman D., McGrath, John J., Eyles, Darryl and Burne, Thomas H.J. (2008). Advanced paternal age alters brain development and behaviour in C57BL/6J mice. Australian Neuroscience Society, Hobart , Tasmania, 27-30 January, 2008. Bedford Park SA: Australian Neuroscience Society.

Advanced paternal age alters brain development and behaviour in C57BL/6J mice

2008

Journal Article

Validation of the comparative quantification method of real-time PCR analysis and a cautionary tale of housekeeping gene selection

McCurdy, Richard D., McGrath, John J. and Mackay-Sim, Alan (2008). Validation of the comparative quantification method of real-time PCR analysis and a cautionary tale of housekeeping gene selection. Gene Therapy and Molecular Biology, 12 (1), 15-24.

Validation of the comparative quantification method of real-time PCR analysis and a cautionary tale of housekeeping gene selection

2008

Conference Publication

Developmental vitamin D deficiency in the rat induces a sexually dimorphic delayed onset in sensitivity to MK-801

Kesby, J., O'Loan, J. C., McGrath, J. J., Eyles, D. W. and Burne, T. H. J. (2008). Developmental vitamin D deficiency in the rat induces a sexually dimorphic delayed onset in sensitivity to MK-801. 21st Congress of the European College of Neuropsychopharmacology, Barcelona, Spain, 30 August - 3rd September 2008. Amsterdam, Netherlands: Elsevier. doi: 10.1016/S0924-977X(08)70354-7

Developmental vitamin D deficiency in the rat induces a sexually dimorphic delayed onset in sensitivity to MK-801

2008

Conference Publication

Developmental vitamin D deficiency alters the trajectory of brain growth but not the response to psychomimetics in C57BL/6J mice

Harms, L., Cowin, G., Eyles, D., Kurniawan, N., Mackay-Sim, A., McGrath, J. and Burne T. (2008). Developmental vitamin D deficiency alters the trajectory of brain growth but not the response to psychomimetics in C57BL/6J mice. Australian Nueroscience Society Annual Meeting, Hobart; Australia, 27-30 Jan 2008. Kent Town, SA, Australia: Australian Neuroscience Society.

Developmental vitamin D deficiency alters the trajectory of brain growth but not the response to psychomimetics in C57BL/6J mice

2007

Journal Article

Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene

Avramopoulos, Dimitrios, Lasseter, Virginia K., Fallin, M. Daniele, Wolyniec, Paula S., McGrath, John A., Nestadt, Gerald, Valle, David and Pulver, Ann E. (2007). Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene. Genetics in Medicine, 9 (11), 745-751. doi: 10.1097/GIM.0b013e318159a37c

Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene

Current funding

  • 2021 - 2027
    Mental Health Australia General Clinical Trial Network (MAGNET) (MRFF Million Minds Mental Health Research Grant Led by Deakin University)
    Deakin University
    Open grant

Past funding

  • 2019 - 2023
    CREDIT: The CRE for the Development of Innovative Therapies for Psychiatric Disorders (NHMRC CRE administered by Deakin University)
    NHMRC Centres of Research Excellence
    Open grant
  • 2018 - 2022
    Developmental Vitamin D-deficiency and Autism; exploration of potential mechanisms and refining phenotype in an animal model
    NHMRC Project Grant
    Open grant
  • 2017 - 2019
    A comparison study of three physical activity measurement tools examining acceptability in people with psychotic disorders
    Society for Mental Health Research Inc
    Open grant
  • 2017 - 2022
    An Integrated Program of Psychiatric Epidemiology (IPPE)
    Aarhus University
    Open grant
  • 2017
    Voltage-gated calcium channels and vitamin D: investigating the convergent links between risk factors for schizophrenia
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2016 - 2019
    The efficacy of adjunctive Garcinia mangostana Linn (mangosteen) pericarp for the treatment of Schizophrenia: A double-blind, randomized, placebo controlled trial (SMRI grant admin. by Deakin Uni)
    Deakin University
    Open grant
  • 2016 - 2017
    World Mental Health Survey
    University of Otago
    Open grant
  • 2016 - 2020
    An empirical framework for assessing mortality and morbidity in people with psychotic disorders (NHMRC Project Grant administered by the University of Western Australia)
    University of Western Australia
    Open grant
  • 2016 - 2020
    Voltage gated calcium channels and vitamin D: exploring the convergent links between risk factors for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    Does adult vitamin D deficiency increase vulnerability to social stress resulting in altered brain function?
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Early life vitamin D levels and risk of autism spectrum disorders (NIH grant administered by Drexel University)
    Drexel University
    Open grant
  • 2014 - 2017
    Is developmental vitamin D deficiency associated with autism-related phenotypes: a birth cohort study
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Vitamin D in first episode psychosis - neuroprotective design (D-FEND)
    Stanley Medical Research Institute
    Open grant
  • 2013 - 2018
    NHMRC John Cade Fellowship in Mental Health: Modifiable risk factors for Serious Mental Illness - an integrated program of epidemiology, genetics and clinical trials
    NHMRC Targeted Research
    Open grant
  • 2013 - 2016
    Early pharmacological intervention in an animal model of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Exploring modifiable candidate risk factors for mental illness in young adults: Infection, vitamin D and stress (NHMRC Project Grant administered by QIMR)
    Queensland Institute of Medical Research
    Open grant
  • 2013 - 2015
    The outcomes of adolescents and young adults who experience hallucinations: A birth cohort study
    NHMRC Project Grant
    Open grant
  • 2012 - 2024
    Developmental Neurobiology of Vitamin D Deficiency Program Funding
    West Moreton Hospital and Health Service
    Open grant
  • 2012
    Developmental Neurobiology Programme Funding
    Queensland Health
    Open grant
  • 2012 - 2015
    Developmental vitamin D deficiency and prefrontal cortical dysfunction
    NHMRC Project Grant
    Open grant
  • 2011
    Advanced behavioural facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2014
    Attentional processing in developmentally vitamin D deficient rats: Modelling the cognitive symptoms of schizophrenia
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Neonatal vitamin D status and risk of schizophrenia: a replication in two independent samples
    NHMRC Project Grant
    Open grant
  • 2009 - 2012
    Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers
    NHMRC Project Grant
    Open grant
  • 2009 - 2011
    Physiological and neurochemical mechanisms of executive control
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    Facility for analysing behaviour, learning and motor skills in animal models
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2007
    Is adult neurogenesis in schizophrenia altered? A pilot study using 14C dating of post-mortem neuronal DNA
    Australian Institute of Nuclear Science and Engineering
    Open grant
  • 2007 - 2009
    Neonatal vitamin D status and risk of schizophrenia: a study using Danish dried bloods spots
    NHMRC Project Grant
    Open grant
  • 2007 - 2009
    The Developmental vitamin D model (DVD) as an animal model for schizophrenia
    NHMRC Project Grant
    Open grant
  • 2005 - 2012
    QCMHR Operational (Developmental Neurobiology Programme Funding)
    Queensland Health
    Open grant
  • 2004 - 2008
    Epidemiology Research Project
    Queensland Health
    Open grant
  • 2003 - 2005
    Linking clinical and basic research in order to understand the causes of schizophrenia: a collaborative network to study animal models of schizophrenia
    Neuroscience Institute of Schizophrenia Allied Disorders Ltd.
    Open grant
  • 2003 - 2004
    Developmental neurobiology
    Queensland Centre for Schizophrenia Research
    Open grant
  • 2003 - 2006
    Structural And Diffusion Tensor Neuroimaging In Twins Concordant And Discordant For Psychosis
    NHMRC Project Grant
    Open grant
  • 2000 - 2010
    QCMHR Operational (Developmental Neuroscience Laboratory Support)
    Queensland Health
    Open grant
  • 1998 - 2006
    An integrated research program examining risk factors for psychoses
    Stanley Foundation Research Awards Program
    Open grant
  • 1998
    Evoked Response Potential (ERP) and Behavioural Correlates of Working Memory in Psychoses
    Mayne Bequest Fund
    Open grant
  • 1998
    The assessment of functioning in families with a parent who has serious mental illness
    Australian Rotary Health Research Fund
    Open grant
  • 1998
    The assessment of motor and executive skills in infants at high risk for psychoses: a pilot study
    Ross U.C.V. Bequest
    Open grant
  • 1997 - 2013
    QCMHR Operational (Collaborative Research Projects Support)
    Queensland Health
    Open grant
  • 1996 - 1997
    Impact of clozapine
    Wolston Park Hospital
    Open grant
  • 1996 - 1997
    Impact of clozapine
    Queensland Health
    Open grant
  • 1996 - 1998
    Promoting positive outcomes for parents with serious mental illness
    Queensland Health Health Promotion
    Open grant
  • 1996 - 1999
    A survey of the needs of parents with serious psychiatric disorders
    Department Health & Family Services - RADGAC
    Open grant
  • 1996 - 1997
    The associations between working memory and the symptoms of schizophrenia
    ARC Australian Research Council (Small grants)
    Open grant

Availability

Professor John McGrath is:
Available for supervision

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Supervision history

Completed supervision

Enquiries

Contact Professor John McGrath directly for media enquiries about:

  • Brain development
  • Neuroscience
  • Schizophrenia

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