Dr Janin Chandra
Dr

Janin Chandra

Email: 
Phone: 
+61 7 344 36976

Background

I received my Master of Science from the Johann-Wolfgang-Goethe Universitaet in Frankfurt am Main in Germany. I completed my Master’s project at the Paul Ehrlich Federal Institute for Sera and Vaccines in Langen where I investigated the impact of vaccinia virus‐induced type I interferons on T cells. Between 2007 and 2011, I completed my PhD studies in the Department of Experimental Immunology of the University of Zurich in Switzerland mentored by Prof. Burkhard Becher, where I investigated the role of NFkB‐inducing kinase (NIK) in cell‐mediated immunity and autoimmunity. It was then that I specialized in professional antigen-presenting cells and their properties in health and disease.

In 2012, I received a 3-year post-doctoral research fellowship to join Prof. Ian Frazer's research team at the University of Queensland (UQ). My studies here focussed on the role of different types of professional antigen-presenting cells in human papillomavirus (HPV)-driven immune suppression that enables development of cervical cancer and a proportion of head and neck cancers. In 2015, I joined the team of biotech company Admedus Vaccines Pty Ltd. as Senior Scientist, with the aim to develop immunotherapeutic vaccine strategies to combat chronic herpes-simplex 2 infections and HPV-induced malignancies. I delivered a pre-clinical research program leading to 3 clinical trials. In 2019, I re-joined UQ as Research Fellow, where I continued my research interest in human papillomavirus-driven immune suppression in antigen-presenting cells, with the aim to develop new experimental therapies that can modulate the performance of these cells.

Since 2023, I lead my own lab at the UQ Frazer Institute and focussed on deciphering intra-tumour and systemic immune regulations of professional antigen-presenting cells, with a special interest in cutaneous and mucosal squamous cell cancers of the head and neck.

Availability

Dr Janin Chandra is:
Available for supervision

Qualifications

  • Doctor of Philosophy of Immunology, Universität Zürich

Search Professor Janin Chandra’s works on UQ eSpace

40 works between 2009 and 2024
All (40) Journal Article (35) Book Chapter (1) Conference Publication (3) Other Outputs (1)

21 - 40 of 40 works

2020

Journal Article

A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC)

Chandra, J., Woo, W. P., Finlayson, N., Liu, H. Y., McGrath, M., Ladwa, R., Brauer, M., Xu, Y., Hanson, S., Panizza, B., Frazer, I. H. and Porceddu, Sandro V. (2020). A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC). Cancer Immunology, Immunotherapy, 70 (3), 743-753. doi: 10.1007/s00262-020-02720-7

A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC)

2020

Journal Article

Dysregulation of stemness pathways in HPV mediated cervical malignant transformation identifies potential oncotherapy targets

Budhwani, Megha, Lukowski, Samuel W., Porceddu, Sandro V., Frazer, Ian H. and Chandra, Janin (2020). Dysregulation of stemness pathways in HPV mediated cervical malignant transformation identifies potential oncotherapy targets. Frontiers in Cellular and Infection Microbiology, 10 307, 307. doi: 10.3389/fcimb.2020.00307

Dysregulation of stemness pathways in HPV mediated cervical malignant transformation identifies potential oncotherapy targets

2019

Journal Article

Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: a randomized double blinded phase I/IIa trial

Chandra, Janin, Woo, Wai-Ping, Dutton, Julie L., Xu, Yan, Li, Bo, Kinrade, Sally, Druce, Julian, Finlayson, Neil, Griffin, Paul, Laing, Kerry J., Koelle, David M. and Frazer, Ian H. (2019). Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: a randomized double blinded phase I/IIa trial. PLoS One, 14 (12) e0226320, 1-20. doi: 10.1371/journal.pone.0226320

Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: a randomized double blinded phase I/IIa trial

2019

Journal Article

Immunotherapy for HPV associated cancer

Frazer, Ian H. and Chandra, Janin (2019). Immunotherapy for HPV associated cancer. Papillomavirus Research, 8 100176, 100176. doi: 10.1016/j.pvr.2019.100176

Immunotherapy for HPV associated cancer

2019

Journal Article

HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development

Bashaw, Abate Assefa, Teoh, Siok M., Tuong, Zewen K., Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2019). HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development. Journal of Investigative Dermatology, 139 (12), 2467-2476.e3. doi: 10.1016/j.jid.2019.03.1162

HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development

2017

Journal Article

CD8+ lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury

Chakraborty, Rituparna, Chandra, Janin, Cui, Shuai, Tolley, Lynn, Cooper, Matthew A., Kendall, Mark and Frazer, Ian H. (2017). CD8+ lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury. Experimental Dermatology, 27 (1), 71-79. doi: 10.1111/exd.13436

CD8+ lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury

2017

Journal Article

Modulation of antigen presenting cell functions during chronic HPV infection

Bashaw, Abate Assefa, Leggatt, Graham R., Chandra, Janin, Tuong, Zewen K. and Frazer, Ian H. (2017). Modulation of antigen presenting cell functions during chronic HPV infection. Papillomavirus Research, 4, 58-65. doi: 10.1016/j.pvr.2017.08.002

Modulation of antigen presenting cell functions during chronic HPV infection

2017

Journal Article

DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection

Chandra, Janin, Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Xu, Yan, Tolley, Lynn K., Yong, Michelle, Wells, James W., Leggatt, Graham R., Finlayson, Neil and Frazer, Ian H. (2017). DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection. Journal of Immunotherapy, 40 (2), 62-70. doi: 10.1097/CJI.0000000000000156

DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection

2016

Journal Article

Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function

Chandra, Janin, Kuo, Paula T. Y., Hahn, Anne M., Belz, Gabrielle T. and Frazer, Ian H. (2016). Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function. Immunology and Cell Biology, 95 (2), 215-223. doi: 10.1038/icb.2016.83

Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function

2016

Journal Article

An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1

Dutton, Julie L., Woo, Wai-Ping, Chandra, Janin, Xu, Yan, Li, Bo, Finlayson, Neil, Griffin, Paul and Frazer, Ian H. (2016). An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1. Human Vaccines and Immunotherapeutics, 12 (12), 3079-3088. doi: 10.1080/21645515.2016.1221872

An escalating dose study to assess the safety, tolerability and immunogenicity of a Herpes Simplex Virus DNA vaccine, COR-1

2016

Journal Article

Epithelium expressing the E7 oncoprotein of HPV16 attracts immune-modulatory dendritic cells to the skin and suppresses their antigen-processing capacity

Chandra, Janin, Miao, Yan, Romoff, Natasha and Frazer, Ian H. (2016). Epithelium expressing the E7 oncoprotein of HPV16 attracts immune-modulatory dendritic cells to the skin and suppresses their antigen-processing capacity. Plos One, 11 (3) e0152886, e0152886. doi: 10.1371/journal.pone.0152886

Epithelium expressing the E7 oncoprotein of HPV16 attracts immune-modulatory dendritic cells to the skin and suppresses their antigen-processing capacity

2016

Conference Publication

Immunotherapy for persisting viral infection and associated cancer

Frazer, I, Mattarollo, S., Leggatt, G., Wells, J., Tuong, K., Kuo, P., Jazayeri, S., Lambert, P. and Chandra, J. (2016). Immunotherapy for persisting viral infection and associated cancer. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.

Immunotherapy for persisting viral infection and associated cancer

2013

Journal Article

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222

Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7

2011

Journal Article

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation

Winnik, Stephan, Lohmann, Christine, Richter, Eva K., Schäfer, Nicola, Song, Wen-Liang, Leiber, Florian, Mocharla, Pavani, Hofmann, Janin, Klingenberg, Roland, Borén, Jan, Becher, Burkhard, FitzGerald, Garret A., Lüscher, Thomas F., Matter, Christian M. and Beer, Jürg H. (2011). Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. European Heart Journal, 32 (20), 2573-2584. doi: 10.1093/eurheartj/ehq501

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation

2011

Journal Article

NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses

Hofmann, Janin, Mair, Florian, Greter, Melanie, Schmidt-Supprian, Marc and Becher, Burkhard (2011). NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses. Journal of Experimental Medicine, 208 (9), 1917-1929. doi: 10.1084/jem.20110128

NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses

2010

Journal Article

Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion

Frenz, Theresa, Waibler, Zoe, Hofmann, Janin, Hamdorf, Matthias, Lantermann, Markus, Reizis, Boris, Tovey, Michael G., Aichele, Peter, Sutter, Gerd and Kalinke, Ulrich (2010). Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion. European Journal of Immunology, 40 (10), 2769-2777. doi: 10.1002/eji.201040453

Concomitant type I IFN receptor-triggering of T cells and of DC is required to promote maximal modified vaccinia virus Ankara-induced T-cell expansion

2010

Journal Article

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

Stein, Sokrates, Lohmann, Christine, Schaefer, Nicola, Hofmann, Janin, Rohrer, Lucia, Besler, Christian, Rothgiesser, Karin M., Becher, Burkhard, Hottiger, Michael O., Boren, Jan, McBurney, Michael W., Landmesser, Ulf, Luescher, Thomas F. and Matter, Christian M. (2010). SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. European Heart Journal, 31 (18), 2301-2309. doi: 10.1093/eurheartj/ehq107

SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis

2010

Journal Article

Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins

Rozenberg, Izabela, Sluka, Susanna H. M., Rohrer, Lucia, Hofmann, Janin, Becher, Burkhard, Akhmedov, Alexander, Soliz, Jorge, Mocharla, Pavani, Boren, Jan, Johansen, Pal, Steffel, Jan, Watanabe, Takeshi, Luescher, Thomas F. and Tanner, Felix C. (2010). Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins. Arteriosclerosis Thrombosis and Vascular Biology, 30 (5), 923-U92. doi: 10.1161/ATVBAHA.109.201079

Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins

2010

Journal Article

B-cells need a proper house, whereas T-cells are happy in a cave: the dependence of lymphocytes on secondary lymphoid tissues during evolution

Hofmann, Janin, Greter, Melanie, Du Pasquier, Louis and Becher, Burkhard (2010). B-cells need a proper house, whereas T-cells are happy in a cave: the dependence of lymphocytes on secondary lymphoid tissues during evolution. Trends in Immunology, 31 (4), 144-153. doi: 10.1016/j.it.2010.01.003

B-cells need a proper house, whereas T-cells are happy in a cave: the dependence of lymphocytes on secondary lymphoid tissues during evolution

2009

Journal Article

Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity

Greter, Melanie, Hofmann, Janin and Becher, Burkhard (2009). Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity. PLoS Biology, 7 (5) e1000109, e1000109. doi: 10.1371/journal.pbio.1000109

Neo-lymphoid aggregates in the adult liver can initiate potent cell-mediated immunity

Current funding

  • 2023 - 2027
    Targeting cancer associated fibroblasts to overcome immune cell exclusion in head and neck cancer
    Garnett Passe and Rodney Williams Memorial Foundation Mid-Career Fellowship
    Open grant

Past funding

  • 2024 - 2025
    Onco-Derm: a single site prospective analysis of skin microbiome as a predictor of toxicity in patients receiving immune checkpoint inhibitor therapy
    Microba Pty Ltd
    Open grant
  • 2022 - 2024
    Elucidating early carcinogenic mechanisms dysregulating Langerhans cell differentiation during experimental oral squamous cell carcinoma (ZCAI Grant led by The Hebrew University of Jerusalem)
    The Hebrew University of Jerusalem
    Open grant
  • 2021 - 2023
    Assessment of predictors of response to checkpoint blockade
    PA Research Foundation
    Open grant
  • 2021 - 2023
    Cell therapies for improved treatment of diabetic foot ulcers (externally led by QUT)
    Queensland University of Technology
    Open grant
  • 2012 - 2016
    The role of different dendritic cell subsets in the clearance of papillomavirus infection
    UQ Postdoctoral Research Fellowship
    Open grant

Availability

Dr Janin Chandra is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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