
Overview
Background
Educated at the University of Copenhagen, Denmark, and the Australian National University, Canberra. Career at the Université de Lausanne, Switzerland, and the Universität Marburg, Germany. Professor and Chair of Organic Chemistry and Head of the Organic Chemistry Section, The University of Queensland from 1985. Emeritus professor from 2008. Chair of the National Committee for Chemistry of the Australian Academy of Science 2009-2014. Editor-in-Chief, Australian Journal of Chemistry 2008-15. Editor, Journal of Analytical and Applied Pyrolysis (Elsevier, IF 3.65) 2016-. Visiting Professor Université de Pau, France, 2011-19; Visiting Professor University of Kuwait 2014-18; Visiting Professor / Special Appointed Professor Hiroshima University 2014-18. Fellow of the Australian Academy of Science. Centenary Medal of the Australian Commonwealth 2003 for research in organic and physical chemistry. David Craig Medal of the Academy of Science 2014 for research in chemistry. JSPS Fellowship (Japan) 2014. Honorary doctorate, University of Pau, France, 2014. A.J. Birch Medal of the Royal Australian Chemical Institute (RACI) for ecellence in research in organic chemistry, 2014. Leighton Medal of the RACI 2018.
Research on Unusual Molecules and Reactive Intermediates: Synthesis and Reaction Mechanism. Heterocyclic chemistry. Pyrolysis reactions. Photochemistry
Research in the Wentrup group is concerned with the discovery of novel types of molecules with new and unusual bonding patterns. Such molecules are mostly highly reactive, and special methods are required both for their generation and for their detection. The group has developed these methods over many years and acquired world-class equipment for these purposes, including flash vacuum thermolysis apparatus, cryostats for matrix isolation of reaction products at cryogenic temperatures (down to 7 K), matrix and solution photochemistry equipment, infrared, UV and mass spectrometers, as well as modern computational facilities.
This research has resulted in the synthesis and characterization of many novel compounds, including extended cumulenes of the types RN=C=C=C=X, which themselves are used in the synthesis of many novel types of molecules, some of them of potential pharmaceutical interest (quinolone antibiotics; diazepines).
The research group has a world reputation in the field of carbene and nitrene chemistry, involving reactive intermediates with sextet carbon or nitrogen. These species are also very useful in synthesis, for example in the preparation of diazepines and diazepinones, a family of pharmaceutically interesting compounds. Numerous mechanistic studies and synthetic applications of ketenes have been carried out in our group.
Active collaborations are ongoing with scientists in Australia (UQ and CSIRO), China (Suzhou), France (Pau), Germany (Oldenburg), Japan (Hiroshima), Spain (Donostia - San Sebastian), and Portugal (Coimbra).
Availability
- Emeritus Professor Curt Wentrup is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Australian National University
- Doctor of Philosophy of Science (Advanced), University of Copenhagen
- Doctoral Diploma, Institution to be confirmed
- Australian Academy of Science, Australian Academy of Science
- Royal Australian Chemical Institute, Royal Australian Chemical Institute
Research interests
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Organic, physical, and historical chemistry
Reactive intermediates, pyrolysis, photochemistry, reaction mechanism. History of science.
Research impacts
This research leads to the development of new pharmaceuticals, e.g. new antibiotics (quinolones and naphthyridones) and new leads towards a treatment for scizophrenia (diazepine molecules).
Chemical industry has used our pyrolysis techniques in specialized manufacturing processes.
Our analytical/spectroscopic work has led to cooperation with chemical and energy firms and agencies involved in forensic science, and our research has generated collaborations with many scientists at universities in Australia, Austria, Belgium, China, Denmark, France, Germany, Hungary, Japan, Portugal, Singapore, Switzerland, and USA.
Works
Search Professor Curt Wentrup’s works on UQ eSpace
1994
Journal Article
Contribution of Photoelectron-Spectroscopy to the Study of the Flash Vacuum Pyrolysis of Amino-Substituted Meldrum Acid-Derivatives
Chuburu, F., Lacombe, S., Guillouzo, G. P. and Wentrup, C. (1994). Contribution of Photoelectron-Spectroscopy to the Study of the Flash Vacuum Pyrolysis of Amino-Substituted Meldrum Acid-Derivatives. New Journal of Chemistry, 18 (8-9), 879-888.
1994
Journal Article
IMINOETHENONE RADICAL CATIONS (RN=C=C=O-CENTER-DOT+) - TANDEM MASS-SPECTROMETRY AND AB-INITIO MO STUDIES
FLAMMANG, R, VANHAVERBEKE, Y, LAURENT, S, BARBIEUXFLAMMANG, M, WONG, MW and WENTRUP, C (1994). IMINOETHENONE RADICAL CATIONS (RN=C=C=O-CENTER-DOT+) - TANDEM MASS-SPECTROMETRY AND AB-INITIO MO STUDIES. Journal of Physical Chemistry, 98 (23), 5801-5806. doi: 10.1021/j100074a002
1994
Journal Article
Synthesis of Isoxazolo[4,5-D]Pyrimidinones, and Their Isomerization Into Oxazolo[4,5-D]Pyrimidinones On Flash Vacuum Pyrolysis
Laurent, S, Barbieuxflammang, M, Vanhaverbeke, Y, Flammang, R and Wentrup, C (1994). Synthesis of Isoxazolo[4,5-D]Pyrimidinones, and Their Isomerization Into Oxazolo[4,5-D]Pyrimidinones On Flash Vacuum Pyrolysis. Bulletin Des Societes Chimiques Belges, 103 (5-6), 181-184. doi: 10.1002/bscb.19941030502
1994
Journal Article
Synthesis and Flash Vacuum Pyrolysis of Isoxazolo[5,4-D]Pyrimidines and Isothiazolo[5,4-D]Pyrimidines
Kappe, CO, Flammang, R and Wentrup, C (1994). Synthesis and Flash Vacuum Pyrolysis of Isoxazolo[5,4-D]Pyrimidines and Isothiazolo[5,4-D]Pyrimidines. Heterocycles, 37 (3), 1615-1622.
1994
Journal Article
Characterization of New Diimines of Carbon Suboxide by Tandem Mass-Spectrometry
Flammang, R, Laurent, S, Barbieuxflammang, M, Vanhaverbeke, Y and Wentrup, C (1994). Characterization of New Diimines of Carbon Suboxide by Tandem Mass-Spectrometry. Rapid Communications in Mass Spectrometry, 8 (4), 329-332. doi: 10.1002/rcm.1290080410
1994
Journal Article
AN IMPROVED SYNTHESIS OF 5-ALKYL-2,3-DIHYDRO-FURAN-2,3-DIONES
KAPPE, CO, KOLLENZ, G and WENTRUP, C (1994). AN IMPROVED SYNTHESIS OF 5-ALKYL-2,3-DIHYDRO-FURAN-2,3-DIONES. Heterocycles, 38 (4), 779-784.
1994
Journal Article
IMINOETHENETHIONES, RN=C=C=S - CHARACTERIZATION BY NEUTRALIZATION-REIONIZATION MASS-SPECTROMETRY AND G2(MP2) THEORY
FLAMMANG, R, LANDU, D, LAURENT, S, BARBIEUXFLAMMANG, M, KAPPE, CO, WONG, MW and WENTRUP, C (1994). IMINOETHENETHIONES, RN=C=C=S - CHARACTERIZATION BY NEUTRALIZATION-REIONIZATION MASS-SPECTROMETRY AND G2(MP2) THEORY. Journal of the American Chemical Society, 116 (5), 2005-2013. doi: 10.1021/ja00084a046
1994
Journal Article
Nitrile Imines: From Matrix Characterization to Stable Compounds
Bertrand G. and Wentrup C. (1994). Nitrile Imines: From Matrix Characterization to Stable Compounds. Angewandte Chemie International Edition in English, 33 (5), 527-545. doi: 10.1002/anie.199405271
1994
Journal Article
Synthesis of a Photoactivatable 9-Z-Oleic Acid for Protein-Kinase-C Labeling
Ruhmann, A and Wentrup, C (1994). Synthesis of a Photoactivatable 9-Z-Oleic Acid for Protein-Kinase-C Labeling. Tetrahedron, 50 (12), 3785-3796. doi: 10.1016/S0040-4020(01)90398-9
1994
Journal Article
Iminopropadienones, RN=C=C=C=O: Theory and experiment
Mosandl T., Stadtmuller S., Wong M.W. and Wentrup C. (1994). Iminopropadienones, RN=C=C=C=O: Theory and experiment. Journal of Physical Chemistry, 98 (4), 1080-1086. doi: 10.1021/j100055a007
1993
Journal Article
[2+4] CYCLOADDITION REACTIONS OF NEAT DIPIVALOYLKETENE
KAPPE, CO, WENTRUP, C and KOLLENZ, G (1993). [2+4] CYCLOADDITION REACTIONS OF NEAT DIPIVALOYLKETENE. Monatshefte Fur Chemie, 124 (11-12), 1133-1141. doi: 10.1007/BF00810021
1993
Journal Article
Direct Observation and Trapping of a Heterocyclic Alpha-Oxo Ketene - 3-Carbonyl-1,3-Dihydro-1-Methyl-2H-Indol-2-One
Kappe, CO, Farber, G, Wentrup, C and Kappe, T (1993). Direct Observation and Trapping of a Heterocyclic Alpha-Oxo Ketene - 3-Carbonyl-1,3-Dihydro-1-Methyl-2H-Indol-2-One. Chemische Berichte-Recueil, 126 (10), 2357-2360. doi: 10.1002/cber.19931261026
1993
Journal Article
Formation and Identification of Ionized and Neutral Cumulenes, Rn=C=C=C=Nh, by Tandem Mass-Spectrometry
Flammang, R, Laurent, S, Flammangbarbieux, M and Wentrup, C (1993). Formation and Identification of Ionized and Neutral Cumulenes, Rn=C=C=C=Nh, by Tandem Mass-Spectrometry. Organic Mass Spectrometry, 28 (10), 1161-1166. doi: 10.1002/oms.1210281030
1993
Journal Article
Matrix-Isolation and Infrared-Spectrum of Thioformyl Cyanide
Kappe, CO, Wong, MW and Wentrup, C (1993). Matrix-Isolation and Infrared-Spectrum of Thioformyl Cyanide. Tetrahedron Letters, 34 (41), 6623-6626. doi: 10.1016/0040-4039(93)88121-X
1993
Journal Article
ON THE THERMAL FRAGMENTATION OF 3-METHYL-1-PHENYLPYRAZOLE-4,5-DIONE
KAPPE, CO, KOLLENZ, G and WENTRUP, C (1993). ON THE THERMAL FRAGMENTATION OF 3-METHYL-1-PHENYLPYRAZOLE-4,5-DIONE. Acta Chemica Scandinavica, 47 (9), 940-942. doi: 10.3891/acta.chem.scand.47-0940
1993
Journal Article
Structure of Nitrilimine - Allenic or Propargylic
Wong, MW and Wentrup, C (1993). Structure of Nitrilimine - Allenic or Propargylic. Journal of the American Chemical Society, 115 (17), 7743-7746. doi: 10.1021/ja00070a019
1993
Journal Article
Tautomeric Equilibrium and Hydrogen Shifts of Tetrazole in the Gas-Phase and in Solution
Wong, MW, Leungtoung, R and Wentrup, C (1993). Tautomeric Equilibrium and Hydrogen Shifts of Tetrazole in the Gas-Phase and in Solution. Journal of the American Chemical Society, 115 (6), 2465-2472. doi: 10.1021/ja00059a048
1993
Journal Article
CHARACTERIZATION OF THE BISKETENE PHOTOISOMER OF BENZOCYCLOBUTENEDIONE
MOSANDL, T and WENTRUP, C (1993). CHARACTERIZATION OF THE BISKETENE PHOTOISOMER OF BENZOCYCLOBUTENEDIONE. Journal of Organic Chemistry, 58 (3), 747-749. doi: 10.1021/jo00055a034
1993
Journal Article
Reactions of Dipivaloylketene Dimer with Nucleophiles: New Access to the 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-diene Ring System (Bridged Bis-Dioxines)
Kappe C.O., Kollenz G., Fabian W.M.F., Wentrup C. and Farber G. (1993). Reactions of Dipivaloylketene Dimer with Nucleophiles: New Access to the 2,6,9-Trioxabicyclo[3.3.1]nona-3,7-diene Ring System (Bridged Bis-Dioxines). Journal of Organic Chemistry, 58 (12), 3361-3367. doi: 10.1021/jo00064a024
1992
Journal Article
Dipivaloylketene and Its Dimers. [2+4] versus [2+2] Cycloaddition Reactions of α-Oxo Ketenes
Kappe C.O., Farber G., Wentrup C. and Kollenz G. (1992). Dipivaloylketene and Its Dimers. [2+4] versus [2+2] Cycloaddition Reactions of α-Oxo Ketenes. Journal of Organic Chemistry, 57 (26), 7078-7083. doi: 10.1021/jo00052a018
Funding
Supervision
Availability
- Emeritus Professor Curt Wentrup is:
- Not available for supervision
Supervision history
Completed supervision
-
2006
Doctor Philosophy
SYNTHESES AND REACTIONS OF IMINOPROPADIENONES, SYDNONES AND OXAZINONES
Principal Advisor
Other advisors: Professor Craig Williams
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2002
Doctor Philosophy
HETEROCYCLIC SYNTHESIS BASED ON IMINOPROPADIENONES
Principal Advisor
-
2002
Doctor Philosophy
SYNTHESIS AND CHARACTERISATION OF 1,3- and 1,4- DIAZEPINES AND DERIVATIVES
Principal Advisor
-
Doctor Philosophy
NITRENES REARRANGEMENTS: FORMATION OF REACTIVE INTERMEDIATES AND UNUSUAL MOLECULES
Principal Advisor
Other advisors: Professor Craig Williams
Media
Enquiries
Contact Emeritus Professor Curt Wentrup directly for media enquiries about:
- Organic reaction mechanisms
- Photochemistry
- Pyrolysis
- Reactive intermediates
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