Overview
Background
Prof Siskind trained as a psychiatrist in Australia and the United States. He graduated from medicine at the University of Queensland in 1998. After working with Doctors Without Borders in Chechnya in 2000, he became interested in psychiatry. He moved to Boston in 2002, where he did his psychiatry residency at Boston University and a Master of Public Health at Harvard University. He returned to Brisbane in June 2008 as a clinical academic psychiatrist at the Metro South Addiction and Mental Health Service. He completed his Ph.D in Feb 2014. His research interests include clozapine and treatment refractory schizophrenia, the physical health of people with severe and persistent mental illness, supported accommodation, assertive community treatment and mental health services research. He was awarded an NHMRC Investigator Grant as a Leadership Fellow (L1 2027-2031) an Emerging Leadership Fellow (EL2 2021-2025) and an NHMRC Early Career Fellowship (ECF 2016-2019). He has a current CIA MRFF RCRDUN grant looking at treatments to reduce cardiometabolic morbidity among people with schizophrenia. He was the SIRS 2026 Outstanding Clinical and Community Research Award recipient, and was elected to the Australian Academy of Health and Medical Sciences in 2025. He has over 350 peer reviewed publications, including first author in the highly ranked Lancet, World Psychiatry, Lancet Psychiatry, BJPsych, ANZJP, & Schizophrenia Bulletin. He is a named investigator on over $65 million in competitive research grants, with over $9 million as CIA.
Availability
- Professor Dan Siskind is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Schizophrenia
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Physical Health Comorbidity
Research impacts
Prof Siskind's research has had direct, measurable impact on clinical practice and policy. His landmark studies on clozapine-associated neutropenia demonstrated that routine monitoring could safely cease after two years, evidence that has driven the removal of long-term monitoring mandates by regulators — improving safe and quality access to clozapine for more than 2.5 million people globally. His work establishing optimal plasma clozapine reference ranges is now used by pathology providers across Australia, while his findings on antipsychotic-associated metabolic risk and weight gain have been incorporated into international guidelines and adopted into clinical practice, with metformin augmentation now regularly prescribed for patients commencing antipsychotics. His Lancet Psychiatry Commission on physical health in people with mental illness helped set the global agenda for integrating physical and mental healthcare, informing policy from the WHO, OECD, and across multiple countries. As Chair of the INTEGRATE Steering Committee, he led development of the first consensus-based, algorithmic international guidelines for schizophrenia treatment, which have been endorsed by peak bodies. Through sustained engagement with regulators, professional colleges and health services, Prof Siskind has ensured his research translates rapidly from bench to bedside to policy, cementing his reputation as a global leader in schizophrenia care.
Works
Search Professor Dan Siskind’s works on UQ eSpace
2024
Journal Article
Metformin for the prevention of antipsychotic-induced weight gain: guideline development and consensus validation
Carolan, Aoife, Hynes-Ryan, Caroline, Agarwal, Sri Mahavir, Bourke, Rita, Cullen, Walter, Gaughran, Fiona, Hahn, Margaret K., Krivoy, Amir, Lally, John, Leucht, Stefan, Lyne, John, McCutcheon, Robert A., Norton, Michael J., O’Connor, Karen, Perry, Benjamin I., Pillinger, Toby, Shiers, David, Siskind, Dan, Thompson, Andrew, O’Shea, Donal, Keating, Dolores and O’Donoghue, Brian (2024). Metformin for the prevention of antipsychotic-induced weight gain: guideline development and consensus validation. Schizophrenia Bulletin, 51 (5), 1193-1205. doi: 10.1093/schbul/sbae205
2024
Journal Article
The association between respiratory failure and psychotropic medications: A systematic review
Winter, Sara, Lee, Kyung Rok, Fung, Edward, Kirkpatrick, Tara, Winckel, Karl, Tanzer, Timothy, Warren, Nicola, Siskind, Dan and Ellender, Claire Michelle (2024). The association between respiratory failure and psychotropic medications: A systematic review. Journal of Psychiatric Research, 180, 121-130. doi: 10.1016/j.jpsychires.2024.10.003
2024
Journal Article
Clozapine rechallenge following myocarditis: a systematic review and rechallenge protocol
McMahon, Laura, Giudice, Maddison, Wagner, Elias, Hasan, Alkomiet, Burrage, Matthew K., Amarena, John, Fox, Cooper, Winckel, Karl, Tanzer, Timothy, Smith, Lesley, Warren, Nicola, Siskind, Dan and Korman, Nicole (2024). Clozapine rechallenge following myocarditis: a systematic review and rechallenge protocol. CNS Spectrums, 29 (6), 585-592. doi: 10.1017/S1092852924002219
2024
Journal Article
Which behavioral regulations predict physical activity and sedentary behavior in people with mental illness?
Chapman, Justin, Korman, Nicole, Malacova, Eva, Robertson, Caroline, Arnautovska, Urska, Siskind, Dan, Suetani, Shuichi, Stubbs, Brendon and Vancampfort, Davy (2024). Which behavioral regulations predict physical activity and sedentary behavior in people with mental illness?. Psychological Medicine, 54 (15), 4129-4139. doi: 10.1017/s0033291724001879
2024
Journal Article
Participation in the National Bowel Cancer Screening Program by people with severe mental illness, Australia, 2006–2019: a national data linkage study
Kisely, Steve, Seth, Rebecca, Jordan, Susan J., Kendall, Bradley, Siskind, Dan J., Sara, Grant, Chapman, Justin, Brophy, Lisa and Lawrence, David M. (2024). Participation in the National Bowel Cancer Screening Program by people with severe mental illness, Australia, 2006–2019: a national data linkage study. Medical Journal of Australia, 221 (11), 617-622. doi: 10.5694/mja2.52521
2024
Conference Publication
Preliminary Results from the ClozaGene Study Examining the Experiences of 1021 Australians Prescribed Clozapine
Lind, Penelope A., Parker, Richard K., Northwood, Korinne, Siskind, Dan J. and Medland, Sarah E. (2024). Preliminary Results from the ClozaGene Study Examining the Experiences of 1021 Australians Prescribed Clozapine. 54th Annual Meeting of the Behavior-Genetics-Association (BGA), London England, Jun 26-29, 2024. NEW YORK: SPRINGER.
2024
Journal Article
Antipsychotic medications and risk of respiratory failure in the respiratory high dependency unit
Winter, Sara, Kirkpatrick, Tara, Winckel, Karl, Honarparvar, Faraz, Robinson, Lewis, Tanzer, Timothy, Smith, Lesley, Warren, Nicola, Siskind, Dan and Ellender, Claire Michelle (2024). Antipsychotic medications and risk of respiratory failure in the respiratory high dependency unit. BJPsych open, 10 (6) e211, 1-6. doi: 10.1192/bjo.2024.773
2024
Journal Article
Emergency department presentations and admission for common mental disorders following agency-notified child maltreatment at 40-year follow-up: results from the Childhood Adversity and Lifetime Morbidity study
Kisely, Steve, Bull, Claudia, Trott, Mike, Arnautovska, Urska, Siskind, Dan, Warren, Nicola and Najman, Jake Moses (2024). Emergency department presentations and admission for common mental disorders following agency-notified child maltreatment at 40-year follow-up: results from the Childhood Adversity and Lifetime Morbidity study. BJPsych Open, 10 (6) e220, 1-7. doi: 10.1192/bjo.2024.776
2024
Journal Article
A randomised controlled trial of interventions to promote adoption of physical activity in adults with severe mental illness
Chapman, Justin J., Miatke, Aaron, Dumuid, Dorothea, Migueles, Jairo, Suetani, Shuichi, Korman, Nicole, Trott, Mike, Byrne, Jacqueline, Siskind, Dan, Johnston, Donni, Sewell, Jeanette, Breakspear, Michael and Patterson, Sue (2024). A randomised controlled trial of interventions to promote adoption of physical activity in adults with severe mental illness. Mental Health and Physical Activity, 27 100652, 1-11. doi: 10.1016/j.mhpa.2024.100652
2024
Journal Article
Interventions for smoking cessation in inpatient psychiatry settings
Plever, Sally, Kisely, Steve R, Bonevski, Billie, Siskind, Dan, Guillaumier, Ashleigh, McCarter, Kristen and Gartner, Coral E. (2024). Interventions for smoking cessation in inpatient psychiatry settings. Cochrane Database of Systematic Reviews, 2024 (9) CD015934, CD015934. doi: 10.1002/14651858.CD015934
2024
Journal Article
Risk factors, prevention and treatment of weight gain associated with the use of antidepressants and antipsychotics: a state-of-the-art clinical review
Solmi, Marco, Miola, Alessandro, Capone, Federico, Pallottino, Simone, Højlund, Mikkel, Firth, Joseph, Siskind, Dan, Holt, Richard Ig, Corbeil, Olivier, Cortese, Samuele, Dragioti, Elena, Du Rietz, Ebba, Nielsen, Rene Ernst, Nordentoft, Merete, Fusar-Poli, Paolo, Hartman, Catharina A, Høye, Anne, Koyanagi, Ai, Larsson, Henrik, Lehto, Kelli, Lindgren, Peter, Manchia, Mirko, Skonieczna-Żydecka, Karolina, Stubbs, Brendon, Vancampfort, Davy, Vieta, Eduard, Taipale, Heidi and Correll, Christoph U. (2024). Risk factors, prevention and treatment of weight gain associated with the use of antidepressants and antipsychotics: a state-of-the-art clinical review. Expert Opinion on Drug Safety, 23 (10), 1249-1269. doi: 10.1080/14740338.2024.2396396
2024
Journal Article
Protocol for Cancloz: multicentre randomised, placebo-controlled, double-blind, parallel-group adaptive trial of cannabidiol for clozapine-resistant schizophrenia
Siskind, Dan, Bull, Claudia, Suetani, Shuichi, Warren, Nicola, Suraev, Anastasia, McGregor, Iain, Kisely, Steve, De Monte, Veronica, Trott, Mike, Shine, Manju, Moudgil, Vikas, Robinson, Gail, Parker, Stephen, Krishnaiah, Ravikumar, Stedman, Terry, Drummond, Allan, Medland, Sarah, Iyer, Ravi and Baker, Andrea (2024). Protocol for Cancloz: multicentre randomised, placebo-controlled, double-blind, parallel-group adaptive trial of cannabidiol for clozapine-resistant schizophrenia. BJPsych Open, 10 (5) e156, 1-7. doi: 10.1192/bjo.2024.748
2024
Journal Article
The role of human involvement and support in digital mental health interventions for people with schizophrenia spectrum disorders: a critical review
Arnautovska, Urska, Milton, Alyssa, Trott, Mike, Soole, Rebecca and Siskind, Dan (2024). The role of human involvement and support in digital mental health interventions for people with schizophrenia spectrum disorders: a critical review. Current Opinion in Psychiatry, 37 (5), 356-362. doi: 10.1097/yco.0000000000000957
2024
Journal Article
GLP-1 receptor agonists and weight loss in schizophrenia – past, present, and future
Trott, Mike, Arnautovska, Urska and Siskind, Dan (2024). GLP-1 receptor agonists and weight loss in schizophrenia – past, present, and future. Current Opinion in Psychiatry, 37 (5), 363-369. doi: 10.1097/yco.0000000000000952
2024
Journal Article
Hospital admissions and community health service contacts for mental illness following self-reported child maltreatment: results from the Childhood Adversity and Lifetime Morbidity (CALM) study
Trott, Mike, Bull, Claudia, Najman, Jake Moses, Arnautovska, Urska, Siskind, Dan, Warren, Nicola and Kisely, Steve (2024). Hospital admissions and community health service contacts for mental illness following self-reported child maltreatment: results from the Childhood Adversity and Lifetime Morbidity (CALM) study. Child Abuse and Neglect, 154 106912, 106912. doi: 10.1016/j.chiabu.2024.106912
2024
Journal Article
Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders – An individual patient data meta-analysis
Campana, Mattia, Yakimov, Vladislav, Moussiopoulou, Joanna, Maurus, Isabel, Löhrs, Lisa, Raabe, Florian, Jäger, Iris, Mortazavi, Matin, Benros, Michael E., Jeppesen, Rose, Meyer zu Hörste, Gerd, Heming, Michael, Giné-Servén, Eloi, Labad, Javier, Boix, Ester, Lennox, Belinda, Yeeles, Ksenija, Steiner, Johann, Meyer-Lotz, Gabriela, Dobrowolny, Henrik, Malchow, Berend, Hansen, Niels, Falkai, Peter, Siafis, Spyridon, Leucht, Stefan, Halstead, Sean, Warren, Nicola, Siskind, Dan, Strube, Wolfgang ... Wagner, Elias (2024). Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders – An individual patient data meta-analysis. Brain, Behavior, and Immunity, 119, 353-362. doi: 10.1016/j.bbi.2024.04.011
2024
Journal Article
Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis
Rogdaki, Maria, McCutcheon, Robert A., D'Ambrosio, Enrico, Mancini, Valentina, Watson, Cameron J., Fanshawe, Jack B., Carr, Richard, Telesia, Laurence, Martini, Maria Giulia, Philip, Aaron, Gilbert, Barnabas J., Salazar-de-Pablo, Gonzalo, Kyriakopoulos, Marinos, Siskind, Dan, Correll, Christoph U., Cipriani, Andrea, Efthimiou, Orestis, Howes, Oliver D. and Pillinger, Toby (2024). Comparative physiological effects of antipsychotic drugs in children and young people: a network meta-analysis. The Lancet Child and Adolescent Health, 8 (7), 510-521. doi: 10.1016/S2352-4642(24)00098-1
2024
Journal Article
Prevalence of multimorbidity in people with and without severe mental illness: a systematic review and meta-analysis
Halstead, Sean, Cao, Chester, Høgnason Mohr, Grímur, Ebdrup, Bjørn H., Pillinger, Toby, McCutcheon, Robert A., Firth, Joseph, Siskind, Dan and Warren, Nicola (2024). Prevalence of multimorbidity in people with and without severe mental illness: a systematic review and meta-analysis. The Lancet Psychiatry, 11 (6), 431-442. doi: 10.1016/s2215-0366(24)00091-9
2024
Journal Article
Response rates to sequential trials of antipsychotic medications according to algorithms or treatment guidelines in psychotic disorders. A systematic review and meta-analysis
O'Donoghue, Brian, Piacenza, Francesco, Plapp, Helena, Siskind, Dan and Lyne, John (2024). Response rates to sequential trials of antipsychotic medications according to algorithms or treatment guidelines in psychotic disorders. A systematic review and meta-analysis. Schizophrenia Research, 268, 193-204. doi: 10.1016/j.schres.2024.02.035
2024
Journal Article
Overcoming clozapine’s adverse events: a narrative review of systematic reviews and meta-analyses
Tanzer, Timothy, Pham, Betty, Warren, Nicola, Barras, Michael, Kisely, Steve and Siskind, Dan (2024). Overcoming clozapine’s adverse events: a narrative review of systematic reviews and meta-analyses. Expert Opinion on Drug Safety, 23 (7), 811-831. doi: 10.1080/14740338.2024.2362796
Funding
Current funding
Supervision
Availability
- Professor Dan Siskind is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Food and nutrition security in individuals with severe mental illness
Principal Advisor
Other advisors: Dr Urska Arnautovska
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Doctor Philosophy
Manifestations, impacts, and clinical implications of physical multimorbidity in people living with severe mental illness
Principal Advisor
Other advisors: Associate Professor Nicola Warren, Professor Steve Kisely
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Master Philosophy
A quantitative and qualitative study of forensic orders in Queensland
Associate Advisor
Other advisors: Professor Steve Kisely, Dr Claudia Bull
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Doctor Philosophy
Smoking Cessation in People with a Serious Mental Illness
Associate Advisor
Other advisors: Professor Steve Kisely, Professor Coral Gartner
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Doctor Philosophy
Measuring cognitive flexibility in rodents
Associate Advisor
Other advisors: Professor Thomas Burne
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Doctor Philosophy
Management of myocarditis among people with schizophrenia commencing clozapine
Associate Advisor
Other advisors: Associate Professor Nicola Warren
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Doctor Philosophy
Genetic determinants of treatment outcomes in mental health: harnessing the shared genetic etiology of mental disorders for precision psychiatry.
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
Completed supervision
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2026
Doctor Philosophy
The Quality and Safe Use of Clozapine
Principal Advisor
Other advisors: Associate Professor Nicola Warren, Professor Michael Barras, Professor Steve Kisely
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2025
Doctor Philosophy
Investigating clozapine rechallenge using granulocyte-colony stimulating factor in people previously experiencing clozapine-associated neutropenia.
Principal Advisor
Other advisors: Professor Steve Kisely
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2021
Doctor Philosophy
Psychiatric clinical decision making in anti-NMDA receptor encephalitis
Principal Advisor
Other advisors: Associate Professor Stefan Blum, Professor Steve Kisely
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2024
Doctor Philosophy
The Role of the Gut Microbiome in Psychiatric Illness: From Prenatal Risk Factors to Treatment Resistance
Associate Advisor
Other advisors: Honorary Professor Jake Gratten, Honorary Professor Darryl Eyles
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2023
Doctor Philosophy
Measuring and improving cognition in a rodent model relevant to schizophrenia
Associate Advisor
Other advisors: Dr James Kesby, Professor Thomas Burne
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2022
Doctor Philosophy
Nose-to-Brain Delivery of Clozapine in Sol-Gel Systems
Associate Advisor
Other advisors: Associate Professor Harendra Parekh, Dr Preeti Pandey, Dr James Robert Falconer
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2020
Doctor Philosophy
Exploring the characteristics and service needs of carers for adults with mental illness to inform mental health service planning
Associate Advisor
Other advisors: Associate Professor Meredith Harris
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2020
Doctor Philosophy
Who receives what, from whom, and to what effect at clinically operated, community-based residential mental health rehabilitation for Severe and Persistent Mental Illness in Australia?
Associate Advisor
Other advisors: Associate Professor Meredith Harris
Media
Enquiries
Contact Professor Dan Siskind directly for media enquiries about:
- Cardiometabolic co-morbidity of schizophrenia
- Treatment Refractory Schizophrenia
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