Overview
Background
Associate Professor Arutha Kulasinghe leads the Clinical-oMx Lab at the Frazer Institute, University of Queensland. A/Prof Kulasinghe has pioneered spatial transcriptomics using digital spatial profiling approaches in the Asia-Pacific region, contributing to world-first studies for lung cancer, head and neck cancer, and COVID-19. His research aims to understand the underlying pathobiology by using an integrative multi-omics approach.
Availability
- Dr Arutha Kulasinghe is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Queensland University of Technology
Research interests
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Immuno-oncology
Applications in lung, skin, and head and neck cancers.
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Spatial transcriptomics
Applications across solid tumours and COVID-19
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Liquid Biopsies
Applications in lung cancer, and head and neck cancer
Works
Search Professor Arutha Kulasinghe’s works on UQ eSpace
Featured
2022
Journal Article
Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures
Kulasinghe, Arutha, Tan, Chin Wee, dos Santos Miggiolaro, Anna Flavia Ribeiro, Monkman, James, SadeghiRad, Habib, Bhuva, Dharmesh D., da Silva Motta Junior, Jarbas, Vaz de Paula, Caroline Busatta, Nagashima, Seigo, Baena, Cristina Pellegrino, Souza-Fonseca-Guimaraes, Paulo, de Noronha, Lucia, McCulloch, Timothy, Rodrigues Rossi, Gustavo, Cooper, Caroline, Tang, Benjamin, Short, Kirsty R., Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Belz, Gabrielle T. and O'Byrne, Ken (2022). Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures. European Respiratory Journal, 59 (6) 2101881, 1-19. doi: 10.1183/13993003.01881-2021
2024
Journal Article
Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma
Rouaen, Jourdin R. C., Salerno, Antonietta, Shai-Hee, Tyler, Murray, Jayne E., Castrogiovanni, Giulia, McHenry, Charlotte, Jue, Toni Rose, Pham, Vu, Bell, Jessica Lilian, Poursani, Ensieh, Valli, Emanuele, Cazzoli, Riccardo, Damstra, Naomi, Nelson, Delia J., Stevens, Kofi L. P., Chee, Jonathan, Slapetova, Iveta, Kasherman, Maria, Whan, Renee, Lin, Francis, Cochran, Blake J., Tedla, Nicodemus, Veli, Feyza Colakoglu, Yuksel, Aysen, Mayoh, Chelsea, Saletta, Federica, Mercatelli, Daniele, Chtanova, Tatyana, Kulasinghe, Arutha ... Vittorio, Orazio (2024). Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma. Nature Communications, 15 (1) 10462, 10462. doi: 10.1038/s41467-024-54689-x
2024
Conference Publication
110 Spatial dynamics and cellular architecture mapping in head and neck cancer: insights into immunotherapy response
Kulasinghe, Arutha (2024). 110 Spatial dynamics and cellular architecture mapping in head and neck cancer: insights into immunotherapy response. BMJ Publishing Group Ltd. doi: 10.1136/jitc-2024-sitc2024.0110
2024
Conference Publication
212 Multi-omic spatial data integration resolves immunometabolic heterogeneity associated with Nivolumab response in non-small cell lung cancer (NSCLC) patients
Yan, Raymond, Quinn, Shannon, Falkenstein, Brian, Monkman, James, O’Bryne, Kenneth, Chakra Chennubhotla, S, Pullara, Filippo and Kulasinghe, Arutha (2024). 212 Multi-omic spatial data integration resolves immunometabolic heterogeneity associated with Nivolumab response in non-small cell lung cancer (NSCLC) patients. BMJ Publishing Group Ltd. doi: 10.1136/jitc-2024-sitc2024.0212
2024
Conference Publication
558 An integrated approach to high dimensional spatial proteomics and interaction mapping in head and neck cancer tissues prior to immune checkpoint inhibitor therapy
Naei, Vahid Yaghoubi, Monkman, James, Hughes, Brett and Kulasinghe, Arutha (2024). 558 An integrated approach to high dimensional spatial proteomics and interaction mapping in head and neck cancer tissues prior to immune checkpoint inhibitor therapy. BMJ Publishing Group Ltd. doi: 10.1136/jitc-2024-sitc2024.0558
2024
Conference Publication
109 Development of a novel immuno-metabolic spatial signature to predict response and resistance to immunotherapy in NSCLC patients
Markovits, Ettai, Monkman, James, Aung, Thazin, Reeves, Jason, O’Byrne, Ken, Czertock, Rotem, Puig, Oscar, Rimm, David and Kulasinghe, Arutha (2024). 109 Development of a novel immuno-metabolic spatial signature to predict response and resistance to immunotherapy in NSCLC patients. BMJ Publishing Group Ltd. doi: 10.1136/jitc-2024-sitc2024.0109
2024
Conference Publication
Characterization of Circulating Tumor-Associated and Immune Cells in Advanced-Stage NSCLC
Yaghoubi Naei, V., Mullally, W., Warkiani, M., O'Byrne, K. and Kulasinghe, A. (2024). Characterization of Circulating Tumor-Associated and Immune Cells in Advanced-Stage NSCLC. 2024 World Conference on Lung Cancer, San Diego, CA United States, 7-10 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jtho.2024.09.473
2024
Conference Publication
Deciphering Single-Cell Resolved Tumour Microenvironment Profiles Using Spatial Metabolic Mapping
Kulasinghe, A., Monkman, J., Markovits, E. and O'Byrne, K. (2024). Deciphering Single-Cell Resolved Tumour Microenvironment Profiles Using Spatial Metabolic Mapping. 2024 World Conference on Lung Cancer, San Diego, CA United States, 7-10 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jtho.2024.09.032
2024
Conference Publication
Unraveling functionally distinct metabolic programs to predict immunotherapy response in non-small cell lung cancer (NSCLC)
Kulasinghe, A., Yan, R., Quinn, S., Falkenstein, B., Monkman, J., O'Byrne, K.J., Chennubhotla, S.C. and Pullara, F. (2024). Unraveling functionally distinct metabolic programs to predict immunotherapy response in non-small cell lung cancer (NSCLC). ESMO Congress 2024, Barcelona, Spain, 13-17 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2024.08.142
2024
Journal Article
Protocol for high-plex, whole-slide imaging of human formalin-fixed paraffin-embedded tissue using PhenoCycler-Fusion
Donovan, Meg L., Jhaveri, Niyati, Ma, Ning, Cheikh, Bassem Ben, DeRosa, James, Mihani, Ritu, Berrell, Naomi, Suen, Jacky Y., Monkman, James, Fraser, John F. and Kulasinghe, Arutha (2024). Protocol for high-plex, whole-slide imaging of human formalin-fixed paraffin-embedded tissue using PhenoCycler-Fusion. STAR Protocols, 5 (3) 103226, 103226. doi: 10.1016/j.xpro.2024.103226
2024
Conference Publication
Multiomic spatial profiling of whole-slide NSCLC tissues from patients receiving anti PD-1 therapy identifies metabolic phenotypes associated with therapy resistance
Kulasinghe, A., Monkman, J. and O'Byrne, K.J. (2024). Multiomic spatial profiling of whole-slide NSCLC tissues from patients receiving anti PD-1 therapy identifies metabolic phenotypes associated with therapy resistance. ESMO Congress 2024, Barcelona, Spain, 13-17 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2024.08.2037
2024
Journal Article
Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy response
Sadeghirad, Habib, Monkman, James, Tan, Chin Wee, Liu, Ning, Yunis, Joseph, Donovan, Meg L., Moradi, Afshin, Jhaveri, Niyati, Perry, Chris, Adams, Mark N., O’Byrne, Ken, Warkiani, Majid E., Ladwa, Rahul, Hughes, Brett G.M. and Kulasinghe, Arutha (2024). Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy response. Journal of Translational Medicine, 22 (1) 677, 677. doi: 10.1186/s12967-024-05409-y
2024
Journal Article
Spatial resolution of the head and neck cancer tumor microenvironment to identify tumor and stromal features associated with therapy response
Berrell, Naomi, Monkman, James, Donovan, Meg, Blick, Tony, O'Byrne, Ken, Ladwa, Rahul, Tan, Chin Wee and Kulasinghe, Arutha (2024). Spatial resolution of the head and neck cancer tumor microenvironment to identify tumor and stromal features associated with therapy response. Immunology & Cell Biology, 102 (9), 830-846. doi: 10.1111/imcb.12811
2024
Journal Article
A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissue
Shanmugasundaram, Karthik B., Ahmed, Emtiaz, Miao, Xinzhe, Kulasinghe, Arutha, Fletcher, James A., Monkman, James, Mainwaring, Paul, Masud, Mostafa Kamal, Park, Hyeongyu, Hossain, Md Shahriar A., Yamauchi, Yusuke, Sina, Abu A. I., O’Byrne, Kenneth, Wuethrich, Alain and Trau, Matt (2024). A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissue. ACS Sensors, 9 (6), 3009-3016. doi: 10.1021/acssensors.4c00192
2024
Journal Article
Mapping the spatial dynamics of the CD4+ T cell spectrum in classical Hodgkin lymphoma
Menéndez, Victoria, Solórzano, José L., García-Cosío, Mónica, Cereceda, Laura, Díaz, Eva, Estévez, Mónica, Roncador, Giovanna, Vega, Zaira, Montalbán, Carlos, Kulasinghe, Arutha and García, Juan F. (2024). Mapping the spatial dynamics of the CD4+ T cell spectrum in classical Hodgkin lymphoma. Modern Pathology, 37 (9) 100551, 100551. doi: 10.1016/j.modpat.2024.100551
2024
Journal Article
In situ characterization of the tumor microenvironment
Sadeghirad, Habib, Yaghoubi Naei, Vahid, O’Byrne, Ken, Warkiani, Majid E and Kulasinghe, Arutha (2024). In situ characterization of the tumor microenvironment. Current Opinion in Biotechnology, 86 103083, 103083. doi: 10.1016/j.copbio.2024.103083
2024
Conference Publication
Defining PD-1/PD-L1 receptor-ligand interactions in the head and neck cancer tumor microenvironment identifies unique ‘immune cell rivers’ of cellular interactions
Sadeghirad, Habib, Naei, Vahid Yaghoubi, Monkman, James, Basu, Subham, Wicher, Agata, Ladwa, Rahul, Hughes, Brett G.M. and Kulasinghe, Arutha (2024). Defining PD-1/PD-L1 receptor-ligand interactions in the head and neck cancer tumor microenvironment identifies unique ‘immune cell rivers’ of cellular interactions. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-5188
2024
Conference Publication
Spatial profiling of pediatric rhabdomyosarcoma to elucidate their immunosuppressive tumor microenvironment
Tu, Cui, Tan, Chin Wee, Liu, Ning, Kulasinghe, Arutha and Souza-Fonseca-Guimaraes, Fernando (2024). Spatial profiling of pediatric rhabdomyosarcoma to elucidate their immunosuppressive tumor microenvironment. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-73
2024
Conference Publication
Ultrahigh-plex spatial phenotyping of head and neck cancer tissue uncovers multiomic signatures of immunotherapy response
Pratapa, Aditya, Hernandez, Lydia, Cheikh, Bassem Ben, Jhaveri, Niyati and Kulasinghe, Arutha (2024). Ultrahigh-plex spatial phenotyping of head and neck cancer tissue uncovers multiomic signatures of immunotherapy response. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-5503
2024
Conference Publication
Spatially resolved cell profiling unveils tumor metabolic states associated with immunotherapy response in NSCLC
Monkman, James, Czertok, Rotem, Bookstein, Shai, Arbiv, Becky, Shachaf, Yuval, Elran, Ron, Bloom, Kenneth, Puig, Oscar, O'Byrne, Ken, Markovits, Ettai and Kulasinghe, Arutha (2024). Spatially resolved cell profiling unveils tumor metabolic states associated with immunotherapy response in NSCLC. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-1158
Funding
Current funding
Supervision
Availability
- Dr Arutha Kulasinghe is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The investigation of the tumour microenvironment in head and neck squamous cell carcinoma to identify predictive biomarkers of response to immunotherapy
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Characterising cytotoxic T cell fates in allogeneic stem cell transplantation
Principal Advisor
Other advisors: Associate Professor Fernando Guimaraes
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Doctor Philosophy
Understanding the tumour microenvironment of head and neck squamous cell carcinoma
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Improved diagnostics for respiratory viral infections
Associate Advisor
Other advisors: Dr Meagan Carney, Associate Professor Kirsty Short
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Doctor Philosophy
Immune regulation through bi-directional interactions between subsets of Natural Killer cells and Dendritic cells.
Associate Advisor
Other advisors: Professor Andrew Barbour, Dr Camille Guillerey, Dr Gustavo Rodrigues Rossi, Associate Professor Fernando Guimaraes
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Doctor Philosophy
Immuno-genetic biomarkers of response in a prospective study of immune checkpoint therapy in primary CNS lymphoma
Associate Advisor
Other advisors: Dr Zachary Hawula, Associate Professor Colm Keane
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Doctor Philosophy
Deciphering mechanisms of fibroblast-mediated immune regulation in dysplastic cutaneous and oral mucosal epithelium
Associate Advisor
Other advisors: Dr Debottam Sinha, Dr Janin Chandra
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Doctor Philosophy
Genesis and Pathognesis of avain influenza
Associate Advisor
Other advisors: Dr Keng Chew, Associate Professor Kirsty Short
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Doctor Philosophy
Studying the tumour immune microenvironment in cutaneous squamous cell carcinoma
Associate Advisor
Other advisors: Professor Gabrielle Belz
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Doctor Philosophy
Understanding the role of immature myeloid cells in early melanoma establishment
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor James Wells
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Master Philosophy
Spatial multi-omics to study hard-to-cure lung infections
Associate Advisor
Other advisors: Dr Ahmed Mehdi, Associate Professor Fernando Guimaraes
Media
Enquiries
Contact Dr Arutha Kulasinghe directly for media enquiries about:
- COVID-19 biomarkers
- head and neck cancer
- immuno-oncology
- lung cancer
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