Overview
Background
Associate Professor Arutha Kulasinghe leads the Clinical-oMx Lab at the Frazer Institute, University of Queensland and is the Founding Scientific Director of the Queensland Spatial Biology Centre (QSBC) at the Wesley Research Institute. A/Prof Kulasinghe has pioneered spatial transcriptomics, proteomics, and interactomics in the Asia-Pacific region, contributing to world-first studies in lung cancer, head and neck cancer, and tissue atlasing studies of infectious diseases across pandemics. His research aims to understand the underlying pathobiology by using an integrative multi-omics approach. A/Prof Kulasinghe is supported by the MRFF, NHMRC, US DoD, Cancer Australia, Cure Cancer and numerous hospital and philanthropic organisations.
Availability
- Associate Professor Arutha Kulasinghe is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Queensland University of Technology
Research interests
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Immuno-oncology
Applications in lung, skin, and head and neck cancers.
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Spatial transcriptomics
Applications across solid tumours and COVID-19
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Liquid Biopsies
Applications in lung cancer, and head and neck cancer
Works
Search Professor Arutha Kulasinghe’s works on UQ eSpace
2021
Journal Article
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis
Yekelchyk, Michail, Madan, Esha, Wilhelm, Jochen, Short, Kirsty R, Palma, António M, Liao, Linbu, Camacho, Denise, Nkadori, Everlyne, Winters, Michael T, Rice, Emily S, Rolim, Inês, Cruz‐Duarte, Raquel, Pelham, Christopher J, Nagane, Masaki, Gupta, Kartik, Chaudhary, Sahil, Braun, Thomas, Pillappa, Raghavendra, Parker, Mark S, Menter, Thomas, Matter, Matthias, Haslbauer, Jasmin Dionne, Tolnay, Markus, Galior, Kornelia D, Matkwoskyj, Kristina A, McGregor, Stephanie M, Muller, Laura K, Rakha, Emad A, Lopez‐Beltran, Antonio ... Gogna, Rajan (2021). Flower lose, a cell fitness marker, predicts COVID‐19 prognosis. EMBO Molecular Medicine, 13 (11) e13714, e13714. doi: 10.15252/emmm.202013714
2021
Conference Publication
Identification of ctDNA using MassARRAY Technology in a Cross-Sectional Study of NSCLC Patients
Kulasinghe, A., Monkman, J., Dutta, S., O’Leary, C., Ladwa, R. and O'Byrne, K. (2021). Identification of ctDNA using MassARRAY Technology in a Cross-Sectional Study of NSCLC Patients. 2021 World Conference on Lung Cancer, Virtual, 8-14 September 2021. New York, United States: Elsevier. doi: 10.1016/j.jtho.2021.08.375
2021
Journal Article
The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC)
Kulasinghe, Arutha, O'Leary, Connor, Monkman, James, Bharti, Vandhana, Irwin, Darryl, Dutta, Sanjay, Richard, Derek J., Hughes, Brett, Ladwa, Rahul and O'Byrne, Ken (2021). The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC). Lung Cancer, 160, 73-77. doi: 10.1016/j.lungcan.2021.08.005
2021
Conference Publication
Characterizing the Tumour-Immune Microenvironment in EGFR Mutant NSCLC
Monkman, J., O’Leary, C., Richard, D., O'Byrne, K. and Kulasinghe, A. (2021). Characterizing the Tumour-Immune Microenvironment in EGFR Mutant NSCLC. 2021 World Conference on Lung Cancer, Virtual, 8-14 September 2021. New York, United States: Elsevier. doi: 10.1016/j.jtho.2021.08.605
2021
Conference Publication
Immune signatures of second-line PD-1 immune checkpoint blockade
O'Byrne, K. J., Monkman, J., Mehdi, A., Matigian, N. and Kulasinghe, A. (2021). Immune signatures of second-line PD-1 immune checkpoint blockade. Congress of the European-Society-for-Medical-Oncology (ESMO), Paris France, Sep 16-21, 2021. AMSTERDAM: ELSEVIER. doi: 10.1016/j.annonc.2021.08.1904
2021
Conference Publication
Polo-like kinase-1 as a biomarker in resected non-small cell lung cancer
O'Leary, C., Monkman, J., Kirkby, B., Matigian, N., Kulasinghe, A., McCaffrey, E., Richard, D., Adams, M. and O'Byrne, K. (2021). Polo-like kinase-1 as a biomarker in resected non-small cell lung cancer. Congress of the European-Society-for-Medical-Oncology (ESMO), Paris France, Sep 16-21, 2021. AMSTERDAM: ELSEVIER. doi: 10.1016/j.annonc.2021.08.1739
2021
Journal Article
The effects of COVID-19 on the placenta during pregnancy
Rad, Habib Sadeghi, Röhl, Joan, Stylianou, Nataly, Allenby, Mark C., Bazaz, Sajad Razavi, Warkiani, Majid E., Guimaraes, Fernando S. F., Clifton, Vicki L. and Kulasinghe, Arutha (2021). The effects of COVID-19 on the placenta during pregnancy. Frontiers in Immunology, 12 743022. doi: 10.3389/fimmu.2021.743022
2021
Journal Article
Cardiovascular disease in SARS‐CoV‐2 infection
Sato, Kei, Sinclair, Jane E., Sadeghirad, Habib, Fraser, John F., Short, Kirsty R. and Kulasinghe, Arutha (2021). Cardiovascular disease in SARS‐CoV‐2 infection. Clinical and Translational Immunology, 10 (9) e1343, e1343. doi: 10.1002/cti2.1343
2021
Journal Article
The Pandora’s box of novel technologies that may revolutionize lung cancer
Rad, Habib Sadeghi, Rad, Hamid Sadeghi, Shiravand, Yavar, Radfar, Payar, Arpon, David, Warkiani, Majid Ebrahimi, O'Byrne, Ken and Kulasinghe, Arutha (2021). The Pandora’s box of novel technologies that may revolutionize lung cancer. Lung Cancer, 159, 34-41. doi: 10.1016/j.lungcan.2021.06.022
2021
Other Outputs
IL-2 stromal signatures dissect immunotherapy response groups in nonsmall cell lung cancer (NSCLC)
Monkman, James, Kim, Honesty, Mayer, Aaron, Mehdi, Ahmed, Matigian, Nicholas, Cumberbatch, Marie, Bhagat, Milan, Ladwa, Rahul, Mueller, Scott N., Adams, Mark N., O’Byrne, Ken and Kulasinghe, Arutha (2021). IL-2 stromal signatures dissect immunotherapy response groups in nonsmall cell lung cancer (NSCLC). doi: 10.1101/2021.08.05.21261528
2021
Journal Article
Emerging role of circulating tumor cells in immunotherapy
Rzhevskiy, Alexey, Kapitannikova, Alina, Malinina, Polina, Volovetsky, Arthur, Aboulkheyr Es, Hamidreza, Kulasinghe, Arutha, Thiery, Jean Paul, Maslennikova, Anna, Zvyagin, Andrei V. and Ebrahimi Warkiani, Majid (2021). Emerging role of circulating tumor cells in immunotherapy. Theranostics, 11 (16), 8057-8075. doi: 10.7150/thno.59677
2021
Journal Article
Isolation of circulating tumour cells in patients with glioblastoma using spiral microfluidic technology – a pilot study
Müller Bark, Juliana, Kulasinghe, Arutha, Hartel, Gunter, Leo, Paul, Warkiani, Majid Ebrahimi, Jeffree, Rosalind L., Chua, Benjamin, Day, Bryan W. and Punyadeera, Chamindie (2021). Isolation of circulating tumour cells in patients with glioblastoma using spiral microfluidic technology – a pilot study. Frontiers in Oncology, 11 681130, 681130. doi: 10.3389/fonc.2021.681130
2021
Conference Publication
The role of the immune microenvironment in EGFR mutant NSCLC
Monkman, James, Kulasinghe, Arutha, O’Leary, Connor, Richard, Derek and O’Byrne, Ken (2021). The role of the immune microenvironment in EGFR mutant NSCLC. 19th Annual British Thoracic Oncology Group Conference, Online, 22-23 April 2021. Shannon, Ireland: Elsevier Ireland. doi: 10.1016/s0169-5002(21)00204-x
2021
Conference Publication
Genetic mutations and signatures in lung cancer – findings from a whole exome sequencing platform
Dutta, Sanjay, Leo, Paul, Kulasinghe, Arutha, Monkman, James, Pennisi, David, Roberts, Kate, Ladwa, Rahul and O’Byrne, Ken (2021). Genetic mutations and signatures in lung cancer – findings from a whole exome sequencing platform. 19th Annual British Thoracic Oncology Group Conference 2021, Virtual, 22-23 April 2021. Shannon, Ireland: Elsevier Ireland. doi: 10.1016/s0169-5002(21)00200-2
2021
Conference Publication
The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC)
Kulasinghe, Arutha, Monkman, James, Dutta, Sanjay, O’Leary, Connor, Ladwa, Rahul and O’Byrne, Ken (2021). The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC). 19th Annual British Thoracic Oncology Group Conference 2021, Virtual, 22-23 April 2021. Shannon, Ireland: Elsevier Ireland. doi: 10.1016/s0169-5002(21)00199-9
2021
Conference Publication
The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC)
Kulasinghe, Arutha, Monkman, James, Dutta, Sanjay, O'Leary, Connor, Ladwa, Rahul and O'Byrne, Ken (2021). The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC). 19th Annual British Thoracic Oncology Group Conference 2021, Virtual, 22-23 April 2021. Shannon, Ireland: Elsevier. doi: 10.1016/S0169-5002(21)00199-9
2021
Journal Article
International scientific collaboration is needed to bridge science to society: USERN2020 consensus statement
Momtazmanesh, Sara, Saghazadeh, Amene, Becerra, Juan Carlos Aldave, Aramesh, Kiarash, Barba, Francisco J., Bella, Federico, Blakney, Anna, Capaccioli, Massimo, Castagna, Rossella, Crisanti, Umberto, Davtyan, Tigran, Dorigo, Tommaso, Ealy, Julie, Farokhnia, Mehdi, Grancini, Giulia, Gupta, Manoj, Harbi, Amine, Krysztofiak, Wojciech, Kulasinghe, Arutha, Lam, Chi-Ming, Leemans, Alexander, Lighthill, Brian, Limongelli, Vittorio, Lopreiato, Paola, Luongo, Livio, Maboloc, Christopher Ryan, Malekzadeh, Reza, Gomes, Orlando Costa, Milosevic, Milos ... Rezaei, Nima (2021). International scientific collaboration is needed to bridge science to society: USERN2020 consensus statement. SN Comprehensive Clinical Medicine, 3 (8), 1699-1703. doi: 10.1007/s42399-021-00896-2
2021
Journal Article
Understanding the tumor microenvironment for effective immunotherapy
Sadeghi Rad, Habib, Monkman, James, Warkiani, Majid E., Ladwa, Rahul, O'Byrne, Ken, Rezaei, Nima and Kulasinghe, Arutha (2021). Understanding the tumor microenvironment for effective immunotherapy. Medicinal Research Reviews, 41 (3), 1474-1498. doi: 10.1002/med.21765
2021
Journal Article
Spatial profiling technologies and applications for brain cancers
Kalita-de Croft, Priyakshi, Rad, Habib Sadeghi, Gasper, Harry, O'Byrne, Ken, Lakhani, Sunil R. and Kulasinghe, Arutha (2021). Spatial profiling technologies and applications for brain cancers. Expert Review of Molecular Diagnostics, 21 (3), 323-332. doi: 10.1080/14737159.2021.1900735
2021
Conference Publication
Spatial profiling of lung SARS-CoV-2 and influenza virus infection identifies virus specific host responses and gene signatures
Kulasinghe, Arutha (2021). Spatial profiling of lung SARS-CoV-2 and influenza virus infection identifies virus specific host responses and gene signatures. AACR Virtual Meeting: COVID-19 and Cancer, Virtual, 3-5 February 2021. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1557-3265.covid-19-21-s03-04
Funding
Current funding
Supervision
Availability
- Associate Professor Arutha Kulasinghe is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
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Master Philosophy
Defining the head and neck cancer tumour microenvironment across clinical contexts
Principal Advisor
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Master Philosophy
Spatial profiling of the tumour microenvironment in head and neck cancers
Principal Advisor
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Doctor Philosophy
Developing predictive biomarkers for immunotherapy using deep spatial profiling
Principal Advisor
Other advisors: Associate Professor Brett Hughes
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Doctor Philosophy
Lessons from a Century of Influenza Pandemics and Implications for Future Preparedness
Associate Advisor
Other advisors: Dr Keng Chew, Professor Kirsty Short
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Doctor Philosophy
Studying the tumour immune microenvironment in cutaneous squamous cell carcinoma
Associate Advisor
Other advisors: Professor Gabrielle Belz
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Doctor Philosophy
Immuno-genetic biomarkers of response in a prospective study of immune checkpoint therapy in primary CNS lymphoma
Associate Advisor
Other advisors: Dr Zachary Hawula, Associate Professor Colm Keane
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Doctor Philosophy
Improved diagnostics for respiratory viral infections
Associate Advisor
Other advisors: Dr Meagan Carney, Professor Kirsty Short
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Master Philosophy
Spatial multi-omics to study hard-to-cure lung infections
Associate Advisor
Other advisors: Dr Ahmed Mehdi, Associate Professor Fernando Guimaraes
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Doctor Philosophy
Deciphering mechanisms of fibroblast-mediated immune regulation in dysplastic cutaneous and oral mucosal epithelium
Associate Advisor
Other advisors: Dr Debottam Sinha, Dr Janin Chandra
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Doctor Philosophy
Understanding the role of immature myeloid cells in early melanoma establishment
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor James Wells
Completed supervision
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2025
Doctor Philosophy
The investigation of the tumour microenvironment in head and neck squamous cell carcinoma to identify predictive biomarkers of response to immunotherapy
Principal Advisor
Other advisors: Dr Quan Nguyen, Associate Professor Brett Hughes
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2025
Doctor Philosophy
Comprehensive characterisation of tumour microenvironment and therapeutic insights into paediatric cancers through multi-omics profiling
Associate Advisor
Other advisors: Professor Andrew Barbour, Associate Professor Fernando Guimaraes
Media
Enquiries
Contact Associate Professor Arutha Kulasinghe directly for media enquiries about:
- COVID-19 biomarkers
- head and neck cancer
- immuno-oncology
- lung cancer
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