
Overview
Background
Naomi Wray is the Michael Davys Professor in the Department of Psychiatry, University of Oxford. She holds an appointment at the Institute for Molecular Bioscience (IMB) within the University of Queensland. She joined UQ Queensland Brain Institute in 2011 moving to the IMB in 2015. She was Head of the Centre for Population & Disease Genomics within IMB 2018-2023. Her Oxford appointment started in 2023.
Her research focuses on development and application of quantitative genetics and genomics methodologies across complex diseases, disorders and traits, but particularly psychiatric-related traits.
She is a National Health and Medical Research Council (NHMRC) Leadership Fellow, a Fellow of the Australian Academy of Science and a Fellow of the Australian Academy of Health and Medical Science. In 2020 she was awarded the NHMRC Elizabeth Blackburn Award for Leadership in Basic Science and the 2021 International Society of Psychiatric Genetics Ming Tsuang Lifetime Achievement Award. She is a Clarivate Highly Cited researcher.
She was Director of the Program in Complex Trait Genomics (PCTG) funded as an NHMRC Program Grant 2017-2022. She plays a key role in the International Psychiatric Genomics Consortium and established the sporadic ALS Australia systems genomics consortium (SALSA) funded by the MND Research Australia IceBucket Challenge and FightMND. She is a co-investigator on the Australian Genetics of Depression Study (AGDS) and is currently launching the AGDS-Cello project focussed on establishing a cell line resource from participants with a detailed history of anti-depressant use and response measures. She is part of an NHMRC Synergy (2023-2027) "Rhythms and blues: Personalising care for body clock dysfunction in mood disorders".
She is secretary of the International Society of Psychiatric Genetics, and is on the editorial advisory boards of JAMA Psychiatry, Neuron, Royal Society Open and Research Directions: Depression.
Availability
- Professor Naomi Wray is:
- Not available for supervision
Qualifications
- Doctor of Philosophy, University of Edinburgh
Research interests
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Genetics of complex genetic traits, disease and disorders
Quantitative genetics methodology Genetics of Psychiatric Disorder Genetics of Motor Neurone Disease Genetics of Cognitive Ageing Systems Genomics
Works
Search Professor Naomi Wray’s works on UQ eSpace
2019
Journal Article
Genome-wide association study identifies 30 loci associated with bipolar disorder
Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R. I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Byrne, Enda M., Pers, Tune H., Holmans, Peter A., Richards, Alexander L., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie ... Sklar, Pamela (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics, 51 (5), 793-803. doi: 10.1038/s41588-019-0397-8
2019
Journal Article
Evidence of causal effect of major depression on alcohol dependence: Findings from the psychiatric genomics consortium
Polimanti, Renato, Peterson, Roseann E., Ong, Jue-Sheng, MacGregor, Stuart, Edwards, Alexis C., Clarke, Toni-Kim, Frank, Josef, Gerring, Zachary, Gillespie, Nathan A., Lind, Penelope A., Maes, Hermine H., Martin, Nicholas G., Mbarek, Hamdi, Medland, Sarah E., Streit, Fabian, Agrawal, Arpana, Edenberg, Howard J., Kendler, Kenneth S., Lewis, Cathryn M., Sullivan, Patrick F., Wray, Naomi R., Gelernter, Joel and Derks, Eske M. (2019). Evidence of causal effect of major depression on alcohol dependence: Findings from the psychiatric genomics consortium. Psychological Medicine, 49 (07), 1-9. doi: 10.1017/S0033291719000667
2019
Journal Article
Genome-wide association study of medication-use and associated disease in the UK Biobank
Wu, Yeda, Byrne, Enda M., Zheng, Zhili, Kemper, Kathryn E., Yengo, Loic, Mallett, Andrew J., Yang, Jian, Visscher, Peter M. and Wray, Naomi R. (2019). Genome-wide association study of medication-use and associated disease in the UK Biobank. Nature Communications, 10 (1) 1891, 1891. doi: 10.1038/s41467-019-09572-5
2019
Journal Article
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability
Reynolds, Regina H., Botia, Juan, Nalls, Mike A., Hardy, John, Taliun, Sarah A. Gagliano, Ryten, Mina, Noyce, Alastair J., Nicolas, Aude, Cookson, Mark R., Bandres-Ciga, Sara, Gibbs, J. Raphael, Hernandez, Dena G., Singleton, Andrew B., Reed, Xylena, Leonard, Hampton, Blauwendraat, Cornelis, Faghri, Faraz, Bras, Jose, Guerreiro, Rita, Tucci, Arianna, Kia, Demis A., Houlden, Henry, Plun-Favreau, Helene, Mok, Kin Y., Wood, Nicholas W., Lovering, Ruth, R'Bibo, Lea, Rizig, Mie, Chelban, Viorica ... Pearson, John (2019). Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability. Npj Parkinsons Disease, 5 (1) 6, 6. doi: 10.1038/s41531-019-0076-6
2019
Journal Article
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Huckins, Laura M., Dobbyn, Amanda, Ruderfer, Douglas M., Hoffman, Gabriel, Wang, Weiqing, Pardiñas, Antonio F., Rajagopal, Veera M., Als, Thomas D., T. Nguyen, Hoang, Girdhar, Kiran, Boocock, James, Roussos, Panos, Fromer, Menachem, Kramer, Robin, Domenici, Enrico, Gamazon, Eric R., Purcell, Shaun, Johnson, Jessica S., Shah, Hardik R., Klein, Lambertus L., Dang, Kristen K., Logsdon, Benjamin A., Mahajan, Milind C., Mangravite, Lara M., Toyoshiba, Hiroyoshi, Gur, Raquel E., Hahn, Chang-Gyu, Schadt, Eric, Lewis, David A. ... Stahl, Eli A. (2019). Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51 (4), 659-674. doi: 10.1038/s41588-019-0364-4
2019
Journal Article
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia
Harold, Denise, Connolly, Siobhan, Riley, Brien P., Kendler, Kenneth S., McCarthy, Shane E., McCombie, William R., Richards, Alex, Owen, Michael J., O'Donovan, Michael C., Walters, James, Donnelly, Peter, Bates, Lesley, Barroso, Ines, Blackwell, Jenefer M., Bramon, Elvira, Brown, Matthew A., Casas, Juan P., Corvin, Aiden, Deloukas, Panos, Duncanson, Audrey, Jankowski, Janusz, Markus, Hugh S., Mathew, Christopher G., Palmer, Colin N. A., Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J., Trembath, Richard C., Viswanathan, Ananth C. ... Morris, Derek W. (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 180 (3), 223-231. doi: 10.1002/ajmg.b.32716
2019
Journal Article
Complex trait prediction from genome data: contrasting EBV in livestock to PRS in humans: genomic prediction
Wray, Naomi R., Kemper, Kathryn E., Hayes, Benjamin J., Goddard, Michael E. and Visscher, Peter M. (2019). Complex trait prediction from genome data: contrasting EBV in livestock to PRS in humans: genomic prediction. Genetics, 211 (4), 1131-1141. doi: 10.1534/genetics.119.301859
2019
Journal Article
Assessment of bidirectional relationships between physical activity and depression among adults A 2-Sample mendelian randomization study
Choi, Karmel W., Chen, Chia-Yen, Stein, Murray B., Klimentidis, Yann C., Wang, Min-Jung, Koenen, Karestan C., Smoller, Jordan W., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, TracyM., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Hvarregaard, Jane ... Sullivan, Patrick F. (2019). Assessment of bidirectional relationships between physical activity and depression among adults A 2-Sample mendelian randomization study. JAMA Psychiatry, 76 (4), 399-408. doi: 10.1001/jamapsychiatry.2018.4175
2019
Journal Article
Cumulative influence of parity-related genomic changes in multiple sclerosis
Mehta, Divya, Wani, Shivangi, Wallace, Leanne, Henders, Anjali K., Wray, Naomi R. and McCombe, Pamela A. (2019). Cumulative influence of parity-related genomic changes in multiple sclerosis. Journal of Neuroimmunology, 328, 38-49. doi: 10.1016/j.jneuroim.2018.12.004
2019
Journal Article
Identification of common genetic risk variants for autism spectrum disorder
Grove, Jakob, Ripke, Stephan, Als, Thomas D., Mattheisen, Manuel, Walters, Raymond K., Won, Hyejung, Pallesen, Jonatan, Agerbo, Esben, Andreassen, Ole A., Anney, Richard, Awashti, Swapnil, Belliveau, Rich, Bettella, Francesco, Buxbaum, Joseph D., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Christensen, Jane H., Churchhouse, Claire, Dellenvall, Karin, Demontis, Ditte, De Rubeis, Silvia, Devlin, Bernie, Djurovic, Srdjan, Dumont, Ashley L., Goldstein, Jacqueline I., Hansen, Christine S., Hauberg, Mads Engel ... Børglum, Anders D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51 (3), 431-444. doi: 10.1038/s41588-019-0344-8
2019
Journal Article
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Howard, David M., Adams, Mark J., Clarke, Toni-Kim, Hafferty, Jonathan D., Gibson, Jude, Shirali, Masoud, Coleman, Jonathan R. I., Hagenaars, Saskia P., Ward, Joey, Wigmore, Eleanor M., Alloza, Clara, Shen, Xueyi, Barbu, Miruna C., Xu, Eileen Y., Whalley, Heather C., Marioni, Riccardo E., Porteous, David J., Davies, Gail, Deary, Ian J., Hemani, Gibran, Berger, Klaus, Teismann, Henning, Rawal, Rajesh, Arolt, Volker, Baune, Bernhard T., Dannlowski, Udo, Domschke, Katharina, Tian, Chao, Hinds, David A. ... McIntosh, Andrew M. (2019). Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nature Neuroscience, 22 (3), 343-352. doi: 10.1038/s41593-018-0326-7
2019
Journal Article
Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland
Arnau-Soler, Aleix, Macdonald-Dunlop, Erin, Adams, Mark J., Clarke, Toni-Kim, MacIntyre, Donald J., Milburn, Keith, Navrady, Lauren, Hayward, Caroline, McIntosh, Andrew M., Thomson, Pippa A., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenscon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2019). Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Translational Psychiatry, 9 (1) 14. doi: 10.1038/s41398-018-0360-y
2019
Journal Article
Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder
Trzaskowski, Maciej, Mehta, Divya, Peyrot, Wouter J., Hawkes, David, Davies, Daniel, Howard, David M., Kemper, Kathryn E., Sidorenko, Julia, Maier, Robert, Ripke, Stephan, Mattheisen, Manuel, Baune, Bernhard T., Grabe, Hans J., Heath, Andrew C., Jones, Lisa, Jones, Ian, Madden, Pamela A.F., McIntosh, Andrew M., Breen, Gerome, Lewis, Cathryn M., Børglum, Anders D., Sullivan, Patrick F., Martin, Nicholas G., Kendler, Kenneth S., Levinson, Douglas F. and Wray, Naomi R. (2019). Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 (6), 439-447. doi: 10.1002/ajmg.b.32713
2019
Journal Article
Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome
Niarchou, Maria, Chawner, Samuel J. R. A., Fiksinski, Ania, Vorstman, Jacob A. S., Maeder, Johanna, Schneider, Maude, Eliez, Stephan, Armando, Marco, Pontillo, Maria, Vicari, Stefano, McDonald-McGinn, Donna M., Emanuel, Beverly S., Zackai, Elaine H., Bearden, Carrie E., Shashi, Vandana, Hooper, Stephen R., Owen, Michael J., Gur, Raquel E., Wray, Naomi R., van den Bree, Marianne B. M. and Thapar, Anita (2019). Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome. Schizophrenia Research, 204, 320-325. doi: 10.1016/j.schres.2018.07.044
2019
Journal Article
A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment
Schork, Andrew J., Won, Hyejung, Appadurai, Vivek, Nudel, Ron, Gandal, Mike, Delaneau, Olivier, Revsbech Christiansen, Malene, Hougaard, David M., Bækved-Hansen, Marie, Bybjerg-Grauholm, Jonas, Giørtz Pedersen, Marianne, Agerbo, Esben, Bøcker Pedersen, Carsten, Neale, Benjamin M., Daly, Mark J., Wray, Naomi R., Nordentoft, Merete, Mors, Ole, Børglum, Anders D., Bo Mortensen, Preben, Buil, Alfonso, Thompson, Wesley K., Geschwind, Daniel H. and Werge, Thomas (2019). A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. Nature Neuroscience, 22 (3), 353-361. doi: 10.1038/s41593-018-0320-0
2019
Conference Publication
Genetic risk for depression and treatment response in the Australian genetics of depression study
Byrne, Enda, Medland, Sarah E., Hickie, Ian, Martin, Nicholas G. and Wray, Naomi (2019). Genetic risk for depression and treatment response in the Australian genetics of depression study. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, CA, United States, 26-31 October 2019. Amsterdam, The Netherlands: Elsevier . doi: 10.1016/j.euroneuro.2019.07.109
2019
Conference Publication
Genome-wide meta-analysis of depression
Howard, David, Adams, Mark J., Clarke, Toni-Kim, Hafferty, Jonathan D., Gibson, Jude, Coleman, Jonathan R. I., Deary, Ian J., Smith, Daniel J., Sullivan, Patrick F., Wray, Naomi R., Breen, Gerome, Lewis, Cathryn M. and McIntosh, Andrew M. (2019). Genome-wide meta-analysis of depression. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October 2018. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2018.08.010
2019
Conference Publication
Leveraging individual-level data and GWAS summary statistics to improve polygenic scores for psychiatric disorders
Climent, Clara Albinana, Prive, Florian, Grove, Jakob, Pedersen, Emil M., Als, Thomas, Nordentoft, Merete, Mors, Ole, Hougaard, David M., Werge, Thomas, Borglum, Anders, Wray, Naomi, Agerbo, Esben, Mortensen, Preben Bo, McGrath, John and Vilhjalmsson, Bjarni (2019). Leveraging individual-level data and GWAS summary statistics to improve polygenic scores for psychiatric disorders. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, California, 26-31 October 2019 . Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2019.08.119
2019
Journal Article
Sleep disorders and risk of incident depression: a population case-control study
Byrne, Enda M., Timmerman, Allan, Wray, Naomi R. and Agerbo, Esben (2019). Sleep disorders and risk of incident depression: a population case-control study. Twin Research and Human Genetics, 22 (03) PII S1832427419000227, 140-146. doi: 10.1017/thg.2019.22
2019
Conference Publication
Examining the shared genetics between educational attainment and depression: results from the Australian Genetics of Depression Study
Mitchell, Brittany, Renteria, Miguel E., Byrne, Enda, Conde, Lucia Colodro, Han, Xikun, Medland, Sarah E., Wray, Naomi and Martin, Nick (2019). Examining the shared genetics between educational attainment and depression: results from the Australian Genetics of Depression Study. 27th World Congress of Psychiatric Genetics, Los Angeles, United States, 26-31 October 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2019.07.172
Funding
Current funding
Past funding
Supervision
Availability
- Professor Naomi Wray is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
Multi-Omic Analyses of a Clinical Trial Cohort of Young People at Ultra-High Risk for Psychosis
Principal Advisor
Other advisors: Dr Enda Byrne, Dr Allan McRae
-
Doctor Philosophy
Genetics of childhood onset psychiatric symptoms, their persistence and comorbidity with other traits
Associate Advisor
Other advisors: Dr Enda Byrne
-
Doctor Philosophy
Genetic architecture and evolution of complex traits across populations in humans
Associate Advisor
Other advisors: Professor Peter Visscher, Dr Fleur Garton, Dr Jian Zeng
-
Doctor Philosophy
Understanding cellular and molecular heterogeneity in endometriosis using multi-omics data
Associate Advisor
Other advisors: Dr Sally Mortlock, Dr Allan McRae
Completed supervision
-
2022
Doctor Philosophy
Studying the effects of DNA methylation variation across neurodegenerative disorders
Principal Advisor
Other advisors: Dr Allan McRae
-
2022
Doctor Philosophy
Genetic analyses of complex traits using biobank data
Principal Advisor
Other advisors: Professor Peter Visscher
-
2021
Doctor Philosophy
A Complex Trait Genomics Approach to Investigating Amyotrophic Lateral Sclerosis
Principal Advisor
Other advisors: Dr Allan McRae
-
2017
Doctor Philosophy
The Genetic Architecture of Psychiatric Disorders
Principal Advisor
Other advisors: Professor Peter Visscher
-
2016
Doctor Philosophy
The Role of Cytokines and Inflammatory Markers in Depression in Adolescents
Principal Advisor
Other advisors: Professor James Scott, Professor Nick Martin
-
2024
Doctor Philosophy
Using genomic data to advance understanding of heart failure aetiology
Associate Advisor
Other advisors: Associate Professor Sonia Shah
-
2024
Doctor Philosophy
Development and application of statistical methods to identify genes and cell types associated with complex traits
Associate Advisor
Other advisors: Dr Jian Zeng
-
2024
Doctor Philosophy
Complement Modulation of Peripheral Immunity in Motor Neurone Disease and Huntington's Disease
Associate Advisor
Other advisors: Dr John Lee, Professor Trent Woodruff
-
2023
Doctor Philosophy
The Genomics of Perinatal Depression
Associate Advisor
Other advisors: Dr Enda Byrne
-
2022
Doctor Philosophy
Exploring the influence of genetics and heritability on the heterogeneity of ADHD presentations
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
-
2022
Doctor Philosophy
Systems biology of motor neurone disease
Associate Advisor
Other advisors: Associate Professor Shyuan Ngo, Dr Allan McRae
-
2022
Doctor Philosophy
Multi-omics data offer systemic insights into autism
Associate Advisor
Other advisors: Professor Gerald Holtmann, Honorary Professor Jake Gratten
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2020
Doctor Philosophy
Genetic influences on substance use behaviour, substance use disorders and psychiatric disorders
Associate Advisor
Other advisors: Honorary Professor Sarah Medland, Professor Nick Martin, Dr Lucia Colodro-Conde
-
2020
Doctor Philosophy
Improving fine-mapping methodology using DNA methylation as a model trait
Associate Advisor
Other advisors: Professor Peter Visscher, Dr Allan McRae
-
2018
Master Philosophy
Integrating genome-wide association study data with gene expression to understand complex traits and common diseases
Associate Advisor
Other advisors: Dr Allan McRae, Honorary Professor Jake Gratten
Media
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