Overview
Background
Associate Professor Arutha Kulasinghe leads the Clinical-oMx Lab at the Frazer Institute, University of Queensland and is the Founding Scientific Director of the Queensland Spatial Biology Centre (QSBC). A/Prof Kulasinghe has pioneered spatial transcriptomics, proteomics and interactomics in the Asia-Pacific region, contributing to world-first studies for lung cancer, head and neck cancer, and organ atlas studies in COVID-19. His research aims to understand the underlying pathobiology by using an integrative multi-omics approach. A/Prof Kulasinghe is supported by the MRFF, NHMRC, US DoD, Cancer Australia, Cure Cancer and numerous hospital and philanthropic organisations.
Availability
- Associate Professor Arutha Kulasinghe is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Queensland University of Technology
Research interests
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Immuno-oncology
Applications in lung, skin, and head and neck cancers.
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Spatial transcriptomics
Applications across solid tumours and COVID-19
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Liquid Biopsies
Applications in lung cancer, and head and neck cancer
Works
Search Professor Arutha Kulasinghe’s works on UQ eSpace
2022
Conference Publication
Abstract 3817: A single-cell, spatial multiomics atlas and cellular interactome of all major skin cancer types
Grice, Laura, Ni, Guiyan, Jin, Xinnan, Tran, Minh, Killingbeck, Emily, Gregory, Mark, Mulay, Onkar, Teoh, Siok-Min, Kulasinghe, Arutha, Leon, Michael, Murphy, Sarah, Warren, Sarah, Kim, Youngmi and Nguyen, Quan (2022). Abstract 3817: A single-cell, spatial multiomics atlas and cellular interactome of all major skin cancer types. American Association for Cancer Research Annual Meeting, Philadelphia, PA, United States, 8-13 April 2022. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2022-3817
2022
Journal Article
Dissecting Tissue Compartment-Specific Protein Signatures in Primary and Metastatic Oropharyngeal Squamous Cell Carcinomas
Sadeghirad, Habib, Monkman, James, Mehdi, Ahmed M., Ladwa, Rahul, O’Byrne, Ken, Hughes, Brett G. M. and Kulasinghe, Arutha (2022). Dissecting Tissue Compartment-Specific Protein Signatures in Primary and Metastatic Oropharyngeal Squamous Cell Carcinomas. Frontiers in Immunology, 13 895513, 1-11. doi: 10.3389/fimmu.2022.895513
2022
Conference Publication
Mapping the spatial biology of COVID-19 immunopathology in placenta tissues
Ma, Ning, Braubach, Oliver, Rebutini, Patricia Zadorosnei, Machado-Souza, Cleber, Stonoga, Emanuele Therezinha Schueda, de Noronha, Lucia, Souza-Fonseca-Guimaraes, Fernando and Kulasinghe, Arutha (2022). Mapping the spatial biology of COVID-19 immunopathology in placenta tissues. Immunology 2022 Meeting, Portland, OR United States, 6-10 May 2022. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.208.supp.125.20
2022
Journal Article
Immune checkpoint inhibitors in cancer therapy
Shiravand, Yavar, Khodadadi, Faezeh, Kashani, Seyyed Mohammad Amin, Hosseini-Fard, Seyed Reza, Hosseini, Shadi, Sadeghirad, Habib, Ladwa, Rahul, O’Byrne, Ken and Kulasinghe, Arutha (2022). Immune checkpoint inhibitors in cancer therapy. Current Oncology, 29 (5), 3044-3060. doi: 10.3390/curroncol29050247
2022
Journal Article
Clinical applications of circulating tumour cells and circulating tumour dna in non-small cell lung cancer—an update
Kapeleris, Joanna, Ebrahimi Warkiani, Majid, Kulasinghe, Arutha, Vela, Ian, Kenny, Liz, Ladwa, Rahul, O’Byrne, Kenneth and Punyadeera, Chamindie (2022). Clinical applications of circulating tumour cells and circulating tumour dna in non-small cell lung cancer—an update. Frontiers in Oncology, 12 859152, 1-18. doi: 10.3389/fonc.2022.859152
2022
Journal Article
The role of circulating biomarkers in lung cancer
Herath, Sayuri, Sadeghi Rad, Habib, Radfar, Payar, Ladwa, Rahul, Warkiani, Majid, O’Byrne, Ken and Kulasinghe, Arutha (2022). The role of circulating biomarkers in lung cancer. Frontiers in Oncology, 11 801269, 1-13. doi: 10.3389/fonc.2021.801269
2022
Journal Article
Spatial profiling identifies prognostic features of response to adjuvant therapy in Triple Negative Breast Cancer (TNBC)
Kulasinghe, Arutha, Monkman, James, Shah, Esha T., Matigian, Nicholas, Adams, Mark N. and O’Byrne, Ken (2022). Spatial profiling identifies prognostic features of response to adjuvant therapy in Triple Negative Breast Cancer (TNBC). Frontiers in Oncology, 11 798296, 798296. doi: 10.3389/fonc.2021.798296
2022
Journal Article
Corrigendum: The effects of COVID-19 on the placenta during pregnancy
Rad, Habib Sadeghi, Röhl, Joan, Stylianou, Nataly, Allenby, Mark C., Bazaz, Sajad Razavi, Warkiani, Majid E., Guimaraes, Fernando S F, Clifton, Vicki L. and Kulasinghe, Arutha (2022). Corrigendum: The effects of COVID-19 on the placenta during pregnancy. Frontiers in immunology, 13 998406, 998406. doi: 10.3389/fimmu.2022.998406
2022
Journal Article
Understanding the tumor microenvironment in head and neck squamous cell carcinoma
Rad, Habib Sadeghi, Shiravand, Yavar, Radfar, Payar, Ladwa, Rahul, Perry, Chris, Han, Xiaoyuan, Warkiani, Majid Ebrahimi, Adams, Mark N., Hughes, Brett G.M., O'Byrne, Ken and Kulasinghe, Arutha (2022). Understanding the tumor microenvironment in head and neck squamous cell carcinoma. Clinical & Translational Immunology, 11 (6) e1397, e1397. doi: 10.1002/cti2.1397
2022
Journal Article
Modelling the tumor immune microenvironment for precision immunotherapy
Mackenzie, Nathan J, Nicholls, Clarissa, Templeton, Abby R, Perera, Mahasha PJ, Jeffery, Penny L, Zimmermann, Kate, Kulasinghe, Arutha, Kenna, Tony J, Vela, Ian, Williams, Elizabeth D and Thomas, Patrick B (2022). Modelling the tumor immune microenvironment for precision immunotherapy. Clinical and Translational Immunology, 11 (6) e1400, 1-22. doi: 10.1002/cti2.1400
2021
Conference Publication
Stromal compartment specific gene signatures dissect immunotherapy response groups in non-small cell lung cancer
Kulasinghe, A., Monkman, J. and O'Byrne, K. J. (2021). Stromal compartment specific gene signatures dissect immunotherapy response groups in non-small cell lung cancer. ESMO Immuno-Oncology Congres, Electr Network, Dec 08-11, 2021. AMSTERDAM: ELSEVIER. doi: 10.1016/j.annonc.2021.10.032
2021
Other Outputs
IFI27 transcription is an early predictor for COVID-19 outcomes; a multi-cohort observational study
Shojaei, Maryam, Shamshirian, Amir, Monkman, James, Grice, Laura, Tran, Minh, Tan, Chin Wee, Rossi, Gustavo Rodrigues, McCulloch, Timothy R., Nalos, Marek, Chew, Keng Yih, Zhu, Yanshan, Xia, Yao, Wells, Timothy J., Senegaglia, Alexandra Cristina, Rebelatto, Carmen Lúcia Kuniyoshi, Franck, Claudio Luciano, dos Santos, Anna Flavia Ribeiro, de Noronha, Lucia, Motamen, Sepideh, Valadan, Reza, Amjadi, Omolbanin, Gogna, Rajan, Madan, Esha, Alizadeh-Navaei, Reza, Lamperti, Liliana, Zuñiga, Felipe, Nova-Lamperti, Estefania, Labarca, Gonzalo, Knippenberg, Ben ... Tang, Benjamin (2021). IFI27 transcription is an early predictor for COVID-19 outcomes; a multi-cohort observational study. doi: 10.1101/2021.10.29.21265555
2021
Journal Article
Endothelial cells are not productively infected by SARS‐CoV‐2
Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350
2021
Journal Article
Novel systemic inflammation markers to predict COVID-19 prognosis
Karimi, Amirali, Shobeiri, Parnian, Kulasinghe, Arutha and Rezaei, Nima (2021). Novel systemic inflammation markers to predict COVID-19 prognosis. Frontiers in Immunology, 12 741061. doi: 10.3389/fimmu.2021.741061
2021
Journal Article
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis
Yekelchyk, Michail, Madan, Esha, Wilhelm, Jochen, Short, Kirsty R, Palma, António M, Liao, Linbu, Camacho, Denise, Nkadori, Everlyne, Winters, Michael T, Rice, Emily S, Rolim, Inês, Cruz‐Duarte, Raquel, Pelham, Christopher J, Nagane, Masaki, Gupta, Kartik, Chaudhary, Sahil, Braun, Thomas, Pillappa, Raghavendra, Parker, Mark S, Menter, Thomas, Matter, Matthias, Haslbauer, Jasmin Dionne, Tolnay, Markus, Galior, Kornelia D, Matkwoskyj, Kristina A, McGregor, Stephanie M, Muller, Laura K, Rakha, Emad A, Lopez‐Beltran, Antonio ... Gogna, Rajan (2021). Flower lose, a cell fitness marker, predicts COVID‐19 prognosis. EMBO Molecular Medicine, 13 (11) e13714, e13714. doi: 10.15252/emmm.202013714
2021
Journal Article
The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC)
Kulasinghe, Arutha, O'Leary, Connor, Monkman, James, Bharti, Vandhana, Irwin, Darryl, Dutta, Sanjay, Richard, Derek J., Hughes, Brett, Ladwa, Rahul and O'Byrne, Ken (2021). The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC). Lung Cancer, 160, 73-77. doi: 10.1016/j.lungcan.2021.08.005
2021
Journal Article
The effects of COVID-19 on the placenta during pregnancy
Rad, Habib Sadeghi, Röhl, Joan, Stylianou, Nataly, Allenby, Mark C., Bazaz, Sajad Razavi, Warkiani, Majid E., Guimaraes, Fernando S. F., Clifton, Vicki L. and Kulasinghe, Arutha (2021). The effects of COVID-19 on the placenta during pregnancy. Frontiers in Immunology, 12 743022. doi: 10.3389/fimmu.2021.743022
2021
Journal Article
Cardiovascular disease in SARS‐CoV‐2 infection
Sato, Kei, Sinclair, Jane E., Sadeghirad, Habib, Fraser, John F., Short, Kirsty R. and Kulasinghe, Arutha (2021). Cardiovascular disease in SARS‐CoV‐2 infection. Clinical and Translational Immunology, 10 (9) e1343, e1343. doi: 10.1002/cti2.1343
2021
Journal Article
The Pandora’s box of novel technologies that may revolutionize lung cancer
Rad, Habib Sadeghi, Rad, Hamid Sadeghi, Shiravand, Yavar, Radfar, Payar, Arpon, David, Warkiani, Majid Ebrahimi, O'Byrne, Ken and Kulasinghe, Arutha (2021). The Pandora’s box of novel technologies that may revolutionize lung cancer. Lung Cancer, 159, 34-41. doi: 10.1016/j.lungcan.2021.06.022
2021
Other Outputs
IL-2 stromal signatures dissect immunotherapy response groups in nonsmall cell lung cancer (NSCLC)
Monkman, James, Kim, Honesty, Mayer, Aaron, Mehdi, Ahmed, Matigian, Nicholas, Cumberbatch, Marie, Bhagat, Milan, Ladwa, Rahul, Mueller, Scott N., Adams, Mark N., O’Byrne, Ken and Kulasinghe, Arutha (2021). IL-2 stromal signatures dissect immunotherapy response groups in nonsmall cell lung cancer (NSCLC).
Funding
Current funding
Supervision
Availability
- Associate Professor Arutha Kulasinghe is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
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Doctor Philosophy
The investigation of the tumour microenvironment in head and neck squamous cell carcinoma to identify predictive biomarkers of response to immunotherapy
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Understanding the tumour microenvironment of head and neck squamous cell carcinoma
Principal Advisor
Other advisors: Dr Quan Nguyen
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Doctor Philosophy
Developing predictive biomarkers for immunotherapy using deep spatial profiling
Principal Advisor
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Master Philosophy
Spatial profiling of the tumour microenvironment in head and neck cancers
Principal Advisor
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Doctor Philosophy
Characterising cytotoxic T cell fates in allogeneic stem cell transplantation
Principal Advisor
Other advisors: Associate Professor Fernando Guimaraes
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Doctor Philosophy
Genesis and Pathognesis of avain influenza
Associate Advisor
Other advisors: Dr Keng Chew, Professor Kirsty Short
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Doctor Philosophy
Studying the tumour immune microenvironment in cutaneous squamous cell carcinoma
Associate Advisor
Other advisors: Professor Gabrielle Belz
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Doctor Philosophy
Understanding the role of immature myeloid cells in early melanoma establishment
Associate Advisor
Other advisors: Dr Jazmina Gonzalez Cruz, Associate Professor James Wells
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Master Philosophy
Spatial multi-omics to study hard-to-cure lung infections
Associate Advisor
Other advisors: Dr Ahmed Mehdi, Associate Professor Fernando Guimaraes
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Doctor Philosophy
Improved diagnostics for respiratory viral infections
Associate Advisor
Other advisors: Dr Meagan Carney, Professor Kirsty Short
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Doctor Philosophy
Immune regulation through bi-directional interactions between subsets of Natural Killer cells and Dendritic cells.
Associate Advisor
Other advisors: Professor Andrew Barbour, Associate Professor Fernando Guimaraes
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Doctor Philosophy
Immuno-genetic biomarkers of response in a prospective study of immune checkpoint therapy in primary CNS lymphoma
Associate Advisor
Other advisors: Dr Zachary Hawula, Associate Professor Colm Keane
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Doctor Philosophy
Deciphering mechanisms of fibroblast-mediated immune regulation in dysplastic cutaneous and oral mucosal epithelium
Associate Advisor
Other advisors: Dr Debottam Sinha, Dr Janin Chandra
Media
Enquiries
Contact Associate Professor Arutha Kulasinghe directly for media enquiries about:
- COVID-19 biomarkers
- head and neck cancer
- immuno-oncology
- lung cancer
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