Overview
Background
Prof Siskind trained as a psychiatrist in Australia and the United States. He graduated from medicine at the University of Queensland in 1998. After working with Doctors Without Borders in Chechnya in 2000, he became interested in psychiatry. He moved to Boston in 2002, where he did his psychiatry residency at Boston University and a Master of Public Health at Harvard University. He returned to Brisbane in June 2008 as a clinical academic psychiatrist at the Metro South Addiction and Mental Health Service. He completed his Ph.D in Feb 2014. His research interests include clozapine and treatment refractory schizophrenia, the physical health of people with severe and persistent mental illness, supported accommodation, assertive community treatment and mental health services research. He was awarded an NHMRC Investigator Grant as a Leadership Fellow (L1 2027-2031) an Emerging Leadership Fellow (EL2 2021-2025) and an NHMRC Early Career Fellowship (ECF 2016-2019). He has a current CIA MRFF RCRDUN grant looking at treatments to reduce cardiometabolic morbidity among people with schizophrenia. He was the SIRS 2026 Outstanding Clinical and Community Research Award recipient, and was elected to the Australian Academy of Health and Medical Sciences in 2025. He has over 350 peer reviewed publications, including first author in the highly ranked Lancet, World Psychiatry, Lancet Psychiatry, BJPsych, ANZJP, & Schizophrenia Bulletin. He is a named investigator on over $65 million in competitive research grants, with over $9 million as CIA.
Availability
- Professor Dan Siskind is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Schizophrenia
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Physical Health Comorbidity
Research impacts
Prof Siskind's research has had direct, measurable impact on clinical practice and policy. His landmark studies on clozapine-associated neutropenia demonstrated that routine monitoring could safely cease after two years, evidence that has driven the removal of long-term monitoring mandates by regulators — improving safe and quality access to clozapine for more than 2.5 million people globally. His work establishing optimal plasma clozapine reference ranges is now used by pathology providers across Australia, while his findings on antipsychotic-associated metabolic risk and weight gain have been incorporated into international guidelines and adopted into clinical practice, with metformin augmentation now regularly prescribed for patients commencing antipsychotics. His Lancet Psychiatry Commission on physical health in people with mental illness helped set the global agenda for integrating physical and mental healthcare, informing policy from the WHO, OECD, and across multiple countries. As Chair of the INTEGRATE Steering Committee, he led development of the first consensus-based, algorithmic international guidelines for schizophrenia treatment, which have been endorsed by peak bodies. Through sustained engagement with regulators, professional colleges and health services, Prof Siskind has ensured his research translates rapidly from bench to bedside to policy, cementing his reputation as a global leader in schizophrenia care.
Works
Search Professor Dan Siskind’s works on UQ eSpace
2022
Journal Article
Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism
Radford-Smith, Daniel E., Patel, Preya J., Irvine, Katharine M., Russell, Anthony, Siskind, Dan, Anthony, Daniel C., Powell, Elizabeth E. and Probert, Fay (2022). Depressive symptoms in non-alcoholic fatty liver disease are identified by perturbed lipid and lipoprotein metabolism. PLoS ONE, 17 (1) e0261555, e0261555. doi: 10.1371/journal.pone.0261555
2022
Journal Article
Clozapine-encapsulated binary mixed micelles in thermosensitive sol–gels for intranasal administration
Tan, Madeleine S. A., Pandey, Preeti, Falconer, James R., Siskind, Dan J., Balmanno, Alexandra and Parekh, Harendra S. (2022). Clozapine-encapsulated binary mixed micelles in thermosensitive sol–gels for intranasal administration. Gels, 8 (1) 38, 38. doi: 10.3390/gels8010038
2022
Journal Article
An international adult guideline for making clozapine titration safer by using six ancestry-based personalized dosing titrations, CRP, and clozapine levels
de Leon, Jose, Schoretsanitis, Georgios, Smith, Robert L., Molden, Espen, Solismaa, Anssi, Seppälä, Niko, Kopeček, Miloslav, Švancer, Patrik, Olmos, Ismael, Ricciardi, Carina, Iglesias-Garcia, Celso, Iglesias-Alonso, Ana, Spina, Edoardo, Ruan, Can-Jun, Wang, Chuan-Yue, Wang, Gang, Tang, Yi-Lang, Lin, Shih-Ku, Lane, Hsien-Yuan, Kim, Yong Sik, Kim, Se Hyun, Rajkumar, Anto P., González-Esquivel, Dinora F., Jung-Cook, Helgi, Baptista, Trino, Rohde, Christopher, Nielsen, Jimmi, Verdoux, Hélène, Quiles, Clelia ... Müller, Daniel J. (2022). An international adult guideline for making clozapine titration safer by using six ancestry-based personalized dosing titrations, CRP, and clozapine levels. Pharmacopsychiatry, 55 (02), 73-86. doi: 10.1055/a-1625-6388
2021
Journal Article
Does the clozapine/norclozapine ratio predict cognitive performance in patients with clozapine-resistant schizophrenia?
Arnautovska, Urska, Neill, Erica, Rossell, Susan L, Yolland, Caitlin, Galletly, Cherrie, Harris, Anthony, Castle, David J and Siskind, Dan (2021). Does the clozapine/norclozapine ratio predict cognitive performance in patients with clozapine-resistant schizophrenia?. Australian and New Zealand Journal of Psychiatry, 56 (7) 00048674211062828, 48674211062828-878. doi: 10.1177/00048674211062828
2021
Conference Publication
Thermosensitive nanoemulsion-based Sol-Gel of Clozapine for nose-to-brain delivery
Tan, Madeleine S.A., Pandey, Preeti, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2021). Thermosensitive nanoemulsion-based Sol-Gel of Clozapine for nose-to-brain delivery. Micro and Nanoparticles in Drug and Vaccine Delivery Symposium, Brisbane, QLD Australia, 3 December 2021.
2021
Conference Publication
Nanoemulsion-based sol-gel of Clozapine for nose-to-brain delivery
Tan, Madeleine S. A., Pandey, Preeti, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2021). Nanoemulsion-based sol-gel of Clozapine for nose-to-brain delivery. Drug Delivery Australia Virtual Meeting: Advanced Materials in Drug Delivery, Online, 18 - 19 November 2021.
2021
Journal Article
Tardive seizures after electroconvulsive therapy
Warren, Nicola, Eyre-Watt, Brenton, Pearson, Ella, O'Gorman, Cullen, Watson, Emily, Lie, David and Siskind, Dan (2021). Tardive seizures after electroconvulsive therapy. The Journal of ECT, 38 (2), 95-102. doi: 10.1097/yct.0000000000000821
2021
Journal Article
Increased rates of respiratory disease in schizophrenia: A systematic review and meta-analysis including 619,214 individuals with schizophrenia and 52,159,551 controls
Suetani, Shuichi, Honarparvar, Faraz, Siskind, Dan, Hindley, Guy, Veronese, Nicola, Vancampfort, Davy, Allen, Lauren, Solmi, Marco, Lally, John, Gaughran, Fiona, Stubbs, Brendon and Pillinger, Toby (2021). Increased rates of respiratory disease in schizophrenia: A systematic review and meta-analysis including 619,214 individuals with schizophrenia and 52,159,551 controls. Schizophrenia Research, 237, 131-140. doi: 10.1016/j.schres.2021.08.022
2021
Journal Article
Clozapine levels as a predictor for therapeutic response: a systematic review and meta‐analysis
Siskind, Dan, Sharma, Meghna, Pawar, Mrinal, Pearson, Ella, Wagner, Elias, Warren, Nicola and Kisely, Steve (2021). Clozapine levels as a predictor for therapeutic response: a systematic review and meta‐analysis. Acta Psychiatrica Scandinavica, 144 (5), 422-432. doi: 10.1111/acps.13361
2021
Journal Article
CoMET: a randomised controlled trial of co-commencement of metformin versus placebo as an adjunctive treatment to attenuate weight gain in patients with schizophrenia newly commenced on clozapine
Siskind, Dan, Russell, Anthony W., Suetani, Shuichi, Flaws, Dylan, Kisely, Steve, Moudgil, Vikas, Northwood, Korinne, Robinson, Gail, Scott, James G., Stedman, Terry, Warren, Nicola, Winckel, Karl, Cosgrove, Peter and Baker, Andrea (2021). CoMET: a randomised controlled trial of co-commencement of metformin versus placebo as an adjunctive treatment to attenuate weight gain in patients with schizophrenia newly commenced on clozapine. Therapeutic Advances in Psychopharmacology, 11 204512532110452, 1-12. doi: 10.1177/20451253211045248
2021
Journal Article
Excess mortality from cancer in people with mental illness—Out of sight and out of mind
Kisely, Stephen and Siskind, Dan (2021). Excess mortality from cancer in people with mental illness—Out of sight and out of mind. Acta Psychiatrica Scandinavica, 144 (4), 315-317. doi: 10.1111/acps.13363
2021
Journal Article
Efficacy and safety of clozapine in psychotic disorders—a systematic quantitative meta-review
Wagner, Elias, Siafis, Spyridon, Fernando, Piyumi, Falkai, Peter, Honer, William G., Röh, Astrid, Siskind, Dan, Leucht, Stefan and Hasan, Alkomiet (2021). Efficacy and safety of clozapine in psychotic disorders—a systematic quantitative meta-review. Translational Psychiatry, 11 (1) 487, 1-18. doi: 10.1038/s41398-021-01613-2
2021
Journal Article
Prevalence of dental disorders among people with mental illness: an umbrella review
Choi, Jisu, Price, Josh, Ryder, Samuel, Siskind, Dan, Solmi, Marco and Kisely, Steve (2021). Prevalence of dental disorders among people with mental illness: an umbrella review. Australian and New Zealand Journal of Psychiatry, 56 (8), 48674211042239-963. doi: 10.1177/00048674211042239
2021
Journal Article
Metabolic adverse effects of off-label use of second-generation antipsychotics in the adult population: a systematic review and meta-analysis
Stogios, Nicolette, Smith, Emily, Bowden, Sylvie, Tran, Veronica, Asgariroozbehani, Roshanak, McIntyre, William Brett, Remington, Gary, Siskind, Dan, Agarwal, Sri Mahavir and Hahn, Margaret K. (2021). Metabolic adverse effects of off-label use of second-generation antipsychotics in the adult population: a systematic review and meta-analysis. Neuropsychopharmacology, 47 (3), 664-672. doi: 10.1038/s41386-021-01163-7
2021
Journal Article
An assessment of psychological distress and professional burnout in mental health professionals in Australia during the COVID-19 pandemic
Northwood, K., Siskind, D., Suetani, S. and McArdle, P.A. (2021). An assessment of psychological distress and professional burnout in mental health professionals in Australia during the COVID-19 pandemic. Australasian Psychiatry, 29 (6), 628-634. doi: 10.1177/10398562211038906
2021
Conference Publication
Thermosensitive Micellar Hydrogels of Clozapine for Nose-to-Brain Delivery
Tan, Madeleine SA, Pandey, Preeti, Balmanno, Alexandra, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2021). Thermosensitive Micellar Hydrogels of Clozapine for Nose-to-Brain Delivery. 2021 CRS Virtual Annual Meeting, Mount Laurel, NJ United States, 25-29 July 2021 .
2021
Journal Article
Treating cognitive impairment in schizophrenia with GLP-1RAs: an overview of their therapeutic potential
Flintoff, Jonathan, Kesby, James P., Siskind, Dan and Burne, Thomas H. J. (2021). Treating cognitive impairment in schizophrenia with GLP-1RAs: an overview of their therapeutic potential. Expert Opinion on Investigational Drugs, 30 (8), 877-891. doi: 10.1080/13543784.2021.1951702
2021
Journal Article
Colorectal cancer outcomes in people with severe mental illness cohort (COSMIC): a protocol for an Australian retrospective cohort using linked administrative data
Protani, Melinda M., Jordan, Susan J., Kendall, Bradley J., Siskind, Dan, Lawrence, David, Sara, Grant, Brophy, Lisa and Kisely, Steve (2021). Colorectal cancer outcomes in people with severe mental illness cohort (COSMIC): a protocol for an Australian retrospective cohort using linked administrative data. BMJ Open, 11 (6) 044737, e044737-6. doi: 10.1136/bmjopen-2020-044737
2021
Conference Publication
Inaccurate QT interval estimation in people taking antipsychotics: are we contributing to misinformed treatment decisions?
Andric, T., Winckel, K., Tanzer, T., Siskind, D., Hollingworth, S., Smith, L. and Isoardi, K. (2021). Inaccurate QT interval estimation in people taking antipsychotics: are we contributing to misinformed treatment decisions?. National Medicines Symposium, Online, 18 May 2021.
2021
Journal Article
Rates of treatment-resistant schizophrenia from first-episode cohorts: systematic review and meta-analysis
Siskind, Dan, Orr, Stacy, Sinha, Surabhi, Yu, Ou, Brijball, Bhavna, Warren, Nicola, MacCabe, James H., Smart, Sophie E. and Kisely, Steve (2021). Rates of treatment-resistant schizophrenia from first-episode cohorts: systematic review and meta-analysis. The British Journal of Psychiatry, 220 (3) PII S0007125021000611, 1-6. doi: 10.1192/bjp.2021.61
Funding
Current funding
Supervision
Availability
- Professor Dan Siskind is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Food and nutrition security in individuals with severe mental illness
Principal Advisor
Other advisors: Dr Urska Arnautovska
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Doctor Philosophy
Manifestations, impacts, and clinical implications of physical multimorbidity in people living with severe mental illness
Principal Advisor
Other advisors: Associate Professor Nicola Warren, Professor Steve Kisely
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Master Philosophy
A quantitative and qualitative study of forensic orders in Queensland
Associate Advisor
Other advisors: Professor Steve Kisely, Dr Claudia Bull, Dr Mike Trott
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Doctor Philosophy
Smoking Cessation in People with a Serious Mental Illness
Associate Advisor
Other advisors: Professor Steve Kisely, Professor Coral Gartner
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Doctor Philosophy
Measuring cognitive flexibility in rodents
Associate Advisor
Other advisors: Professor Thomas Burne
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Doctor Philosophy
Management of myocarditis among people with schizophrenia commencing clozapine
Associate Advisor
Other advisors: Associate Professor Nicola Warren
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Doctor Philosophy
Genetic determinants of treatment outcomes in mental health: harnessing the shared genetic etiology of mental disorders for precision psychiatry.
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
Completed supervision
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2026
Doctor Philosophy
The Quality and Safe Use of Clozapine
Principal Advisor
Other advisors: Associate Professor Nicola Warren, Professor Michael Barras, Professor Steve Kisely
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2025
Doctor Philosophy
Investigating clozapine rechallenge using granulocyte-colony stimulating factor in people previously experiencing clozapine-associated neutropenia.
Principal Advisor
Other advisors: Professor Steve Kisely
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2021
Doctor Philosophy
Psychiatric clinical decision making in anti-NMDA receptor encephalitis
Principal Advisor
Other advisors: Associate Professor Stefan Blum, Professor Steve Kisely
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2024
Doctor Philosophy
The Role of the Gut Microbiome in Psychiatric Illness: From Prenatal Risk Factors to Treatment Resistance
Associate Advisor
Other advisors: Honorary Professor Jake Gratten, Honorary Professor Darryl Eyles
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2023
Doctor Philosophy
Measuring and improving cognition in a rodent model relevant to schizophrenia
Associate Advisor
Other advisors: Dr James Kesby, Professor Thomas Burne
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2022
Doctor Philosophy
Nose-to-Brain Delivery of Clozapine in Sol-Gel Systems
Associate Advisor
Other advisors: Associate Professor Harendra Parekh, Dr Preeti Pandey, Dr James Robert Falconer
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2020
Doctor Philosophy
Exploring the characteristics and service needs of carers for adults with mental illness to inform mental health service planning
Associate Advisor
Other advisors: Associate Professor Meredith Harris
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2020
Doctor Philosophy
Who receives what, from whom, and to what effect at clinically operated, community-based residential mental health rehabilitation for Severe and Persistent Mental Illness in Australia?
Associate Advisor
Other advisors: Associate Professor Meredith Harris
Media
Enquiries
Contact Professor Dan Siskind directly for media enquiries about:
- Cardiometabolic co-morbidity of schizophrenia
- Treatment Refractory Schizophrenia
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