
Overview
Background
Naomi Wray is the Michael Davys Professor in the Department of Psychiatry, University of Oxford. She holds an appointment at the Institute for Molecular Bioscience (IMB) within the University of Queensland. She joined UQ Queensland Brain Institute in 2011 moving to the IMB in 2015. She was Head of the Centre for Population & Disease Genomics within IMB 2018-2023. Her Oxford appointment started in 2023.
Her research focuses on development and application of quantitative genetics and genomics methodologies across complex diseases, disorders and traits, but particularly psychiatric-related traits.
She is a National Health and Medical Research Council (NHMRC) Leadership Fellow, a Fellow of the Australian Academy of Science and a Fellow of the Australian Academy of Health and Medical Science. In 2020 she was awarded the NHMRC Elizabeth Blackburn Award for Leadership in Basic Science and the 2021 International Society of Psychiatric Genetics Ming Tsuang Lifetime Achievement Award. She is a Clarivate Highly Cited researcher.
She was Director of the Program in Complex Trait Genomics (PCTG) funded as an NHMRC Program Grant 2017-2022. She plays a key role in the International Psychiatric Genomics Consortium and established the sporadic ALS Australia systems genomics consortium (SALSA) funded by the MND Research Australia IceBucket Challenge and FightMND. She is a co-investigator on the Australian Genetics of Depression Study (AGDS) and is currently launching the AGDS-Cello project focussed on establishing a cell line resource from participants with a detailed history of anti-depressant use and response measures. She is part of an NHMRC Synergy (2023-2027) "Rhythms and blues: Personalising care for body clock dysfunction in mood disorders".
She is secretary of the International Society of Psychiatric Genetics, and is on the editorial advisory boards of JAMA Psychiatry, Neuron, Royal Society Open and Research Directions: Depression.
Availability
- Professor Naomi Wray is:
- Not available for supervision
Qualifications
- Doctor of Philosophy, University of Edinburgh
Research interests
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Genetics of complex genetic traits, disease and disorders
Quantitative genetics methodology Genetics of Psychiatric Disorder Genetics of Motor Neurone Disease Genetics of Cognitive Ageing Systems Genomics
Works
Search Professor Naomi Wray’s works on UQ eSpace
2016
Conference Publication
Multivariate Genetic Risk Scores Can Increase Risk Prediction Accuracy for a wide Range of Traits
Maier, Robert, Robinson, Matt, Wray, Naomi and Visscher, Peter (2016). Multivariate Genetic Risk Scores Can Increase Risk Prediction Accuracy for a wide Range of Traits. Annual Meeting of the International-Genetic-Epidemiology-Society, Toronto Canada, 24-26 October 2016. United States: John Wiley & Sons.
2016
Journal Article
DNA methylation-based measures of biological age: meta-analysis predicting time to death
Chen, Brian H., Marioni, Riccardo E., Colicino, Elena, Peters, Marjolein J., Ward-Caviness, Cavin K., Tsai, Pei-Chien, Roetker, Nicholas S., Just, Allan C., Demerath, Ellen W., Guan, Weihua, Bressler, Jan, Fornage, Myriam, Studenski, Stephanie, Vandiver, Amy R., Moore, Ann Zenobia, Tanaka, Toshiko, Kiel, Douglas P., Liang, Liming, Vokonas, Pantel, Schwartz, Joel, Lunetta, Kathryn L., Murabito, Joanne M., Bandinelli, Stefania, Hernandez, Dena G., Melzer, David, Nalls, Michael, Pilling, Luke C., Price, Timothy R., Singleton, Andrew B. ... Horvath, Steve (2016). DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging, 8 (9), 1844-1865. doi: 10.18632/aging.101020
2016
Conference Publication
Exploring heterogeneity in major depression
Mehta, Divya, Trzaskowski, Maciej, Maier, Robert and Wray, Naomi (2016). Exploring heterogeneity in major depression. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane Australia, Jun 20-23, 2016. New York, United States: Springer.
2015
Journal Article
Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling
Zannas, Anthony S., Arloth, Janine, Carrillo-Roa, Tania, Iurato, Stella, Roh, Simone, Ressler, Kerry J., Nemeroff, Charles B., Smith, Alicia K., Bradley, Bekh, Heim, Christine, Menke, Andreas, Lange, Jennifer F., Bruckl, Tanja, Ising, Marcus, Wray, Naomi R., Erhardt, Angelika, Binder, Elisabeth B. and Mehta, Divya (2015). Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. Genome Biology, 16 (1) 266, 1-12. doi: 10.1186/s13059-015-0828-5
2015
Journal Article
Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness
Bigdeli, Tim B., Ripke, Stephan, Bacanu, Silviu-Alin, Lee, Sang Hong, Wray, Naomi R., Gejman, Pablo V., Rietschel, Marcella, Cichon, Sven, St Clair, David, Corvin, Aiden, Kirov, George, Mcquillin, Andrew, Gurling, Hugh, Rujescu, Dan, Andreassen, Ole A., Werge, Thomas, Blackwood, Douglas H.R., Pato, Carlos N., Pato, Michele T., Malhotra, Anil K., O'Donovan, Michael C., Kendler, Kenneth S. and Fanous, Ayman H. (2015). Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 171 (2), 276-289. doi: 10.1002/ajmg.b.32402
2015
Journal Article
Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis
Loh, Po-Ru, Bhatia, Gaurav, Gusev, Alexander, Finucane, Hilary K., Bulik-Sullivan, Brendan K., Pollack, Samuela J., de Candia, Teresa R., Lee, Sang Hong, Wray, Naomi R., Kendler, Kenneth S., O'Donovan, Michael C., Neale, Benjamin M., Patterson, Nick, Price, Alkes L., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Visscher, Peter M. and Mowry, Bryan J. (2015). Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nature Genetics, 47 (12), 1385-1392. doi: 10.1038/ng.3431
2015
Other Outputs
Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases
Han, Buhm, Pouget, Jennie G, Slowikowski, Kamil, Stahl, Eli, Lee, Cue Hyunkyu, Diogo, Dorothee, Hu, Xinli, Park, Yu Rang, Kim, Eunji, Gregersen, Peter K, Dahlqvist, Solbritt Rantapää, Worthington, Jane, Martin, Javier, Eyre, Steve, Klareskog, Lars, Huizinga, Tom, Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S, Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics, Wray, Naomi and Raychaudhuri, Soumya (2015). Using genotype data to distinguish pleiotropy from heterogeneity: deciphering coheritability in autoimmune and neuropsychiatric diseases. doi: 10.1101/030783
2015
Journal Article
EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex
Lim, Jonathan W. C., Donahoo, Amber-Lee S., Bunt, Jens, Edwards, Timothy J., Fenlon, Laura R., Liu, Ying, Zhou, Jing, Moldrich, Randal X., Piper, Michael, Gobius, Ilan, Bailey, Timothy L., Wray, Naomi R., Kessaris, Nicoletta, Poo, Mu-Ming, Rubenstein, John L. R. and Richards, Linda J. (2015). EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex. Development, 142 (21), 3746-3757. doi: 10.1242/dev.119909
2015
Journal Article
High loading of polygenic risk in cases with chronic schizophrenia
Meier, S. M., Agerbo, E., Maier, R., Pedersen, C. B., Pedersen, C. B., Grove, J., Hollegaard, M. V., Demontis, D., Trabjerg, B. B., Hjorthoj, C., Ripke, S., Degenhardt, F., Nothen, M. M., Rujescu, D., Maier, W., Werge, T., Mors, O., Hougaard, D. M., Borglum, A. D., Wray, N. R., Rietschel, M., Nordentoft, M., Mortensen, P. B. and Mattheisen, M. (2015). High loading of polygenic risk in cases with chronic schizophrenia. Molecular Psychiatry, 21 (7), 1-6. doi: 10.1038/mp.2015.130
2015
Journal Article
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
Yang, Jian, Bakshi, Andrew, Zhu, Zhihong, Hemani, Gibran, Vinkhuyzen, Anna A. E., Lee, Sang Hong, Robinson, Matthew R., Perry, John R. B., Nolte, Ilja M., van Vliet-Ostaptchouk, Jana V., Snieder, Harold, The LifeLines Cohort Study, Esko, Tonu, Milani, Lili, Maegi, Reedik, Metspalu, Andres, Hamsten, Anders, Magnusson, Patrik K. E., Pedersen, Nancy L., Ingelsson, Erik, Soranzo, Nicole, Keller, Matthew C., Wray, Naomi R., Goddard, Michael E. and Visscher, Peter M. (2015). Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nature Genetics, 47 (10), 1114-1120. doi: 10.1038/ng.3390
2015
Journal Article
Evidence of CNIH3 involvement in opioid dependence
Nelson, E. C., Agrawal, A., Heath, A. C., Bogdan, R., Sherva, R., Zhang, B., Al-Hasani, R., Bruchas, M. R., Chou, Y.-L., Demers, C. H., Carey, C. E., Conley, E. D., Fakira, A. K., Farrer, L. A., Goate, A., Gordon, S., Henders, A. K., Hesselbrock, V., Kapoor, M., Lynskey, M. T., Madden, P. A. F., Moron, J. A., Rice, J. P., Saccone, N. L., Schwab, S. G., Shand, F. L., Todorov, A. A., Wallace, L., Wang, T. ... Montgomery, G. W. (2015). Evidence of CNIH3 involvement in opioid dependence. Molecular Psychiatry, 21 (5), 608-614. doi: 10.1038/mp.2015.102
2015
Journal Article
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
Marioni, Riccardo E., Shah, Sonia, McRae, Allan F., Ritchie, Stuart J., Muniz-Terrera, Graciela, Harris, Sarah E., Gibson, Jude, Redmond, Paul, Cox, Simon R., Pattie, Alison, Corley, Janie, Taylor, Adele, Murphy, Lee, Starr, John M., Horvath, Steve, Visscher, Peter M., Wray, Naomi R. and Deary, Ian J. (2015). The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936. International Journal of Epidemiology, 44 (4), 1388-1396. doi: 10.1093/ije/dyu277
2015
Journal Article
Improving phenotypic prediction by combining genetic and epigenetic associations
Shah, Sonia, Bonder, Marc J., Marioni, Riccardo E., Zhu, Zhihong, McRae, Allan F., Zhernakova, Alexandra, Harris, Sarah E., Liewald, Dave, Henders, Anjali K., Mendelson, Michael M., Liu, Chunyu, Joehanes, Roby, Liang, Liming, Levy, Daniel, Martin, Nicholas G., Starr, John M., Wijmenga, Cisca, Wray, Naomi R., Yang, Jian, Montgomery, Grant W., Franke, Luke, Deary, Ian J., Visscher, Peter M. and BIOS Consortium (2015). Improving phenotypic prediction by combining genetic and epigenetic associations. American Journal of Human Genetics, 97 (1), 75-85. doi: 10.1016/j.ajhg.2015.05.014
2015
Journal Article
Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: a Danish population-based study and meta-analysis
Agerbo, Esben, Sullivan, Patrick F., Vilhjalmsson, Bjarni J., Pedersen, Catsten B., Mors, Ole, Borglum, Anders D., Hougaard, David M., Hollegaard, Mads V., Meier, Sandra, Mattheisen, Manuel, Ripke, Stephen, Wray, Naomi R. and Mortensen, Preben B. (2015). Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: a Danish population-based study and meta-analysis. JAMA Psychiatry, 72 (7), 635-641. doi: 10.1001/jamapsychiatry.2015.0346
2015
Journal Article
The association between lower educational attainment and depression owing to shared genetic effects? results in ∼25 000 subjects
Peyrot, W. J., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A., Ripke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Penninx, B. W. J. H., Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium and Middeldorp, Christel (2015). The association between lower educational attainment and depression owing to shared genetic effects? results in ∼25 000 subjects. Molecular Psychiatry, 20 (6), 735-743. doi: 10.1038/mp.2015.50
2015
Journal Article
C9orf72 hexanucleotide repeat expansions in Chinese sporadic amyotrophic lateral sclerosis
He, Ji, Tang, Lu, Benyamin, Beben, Shah, Sonia, Hemani, Gib, Liu, Rong, Ye, Shan, Liu, Xiaolu, Ma, Yan, Zhang, Huagang, Cremin, Katie, Leo, Paul, Wray, Naomi R., Visscher, Peter M., Xu, Huji, Brown, Matthew A., Bartlett, Perry F., Mangelsdorf, Marie and Fan, Dongsheng (2015). C9orf72 hexanucleotide repeat expansions in Chinese sporadic amyotrophic lateral sclerosis. Neurobiology of Aging, 36 (9) 2660.e1, 2660.e1-2660.e8. doi: 10.1016/j.neurobiolaging.2015.06.002
2015
Journal Article
Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus
Jhaveri, Dhanisha J., O'Keeffe, Imogen, Robinson, Gregory J., Zhao, Qiong-Yi, Zhang, Zong Hong, Nink, Virginia, Narayanan, Ramesh K., Osborne, Geoffrey W., Wray, Naomi R. and Bartlett, Perry F. (2015). Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus. Journal of Neuroscience, 35 (21), 8132-8144. doi: 10.1523/JNEUROSCI.0504-15.2015
2015
Journal Article
Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model
Moser, Gerhard, Lee, Sang Hong, Hayes, Ben J., Goddard, Michael E., Wray, Naomi R. and Visscher, Peter M. (2015). Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model. PLoS Genetics, 11 (4) e1004969, 1-22. doi: 10.1371/journal.pgen.1004969
2015
Journal Article
Quantitative genetics of disease traits
Wray, N. R. and Visscher, P. M. (2015). Quantitative genetics of disease traits. Journal of Animal Breeding and Genetics, 132 (2), 198-203. doi: 10.1111/jbg.12153
2015
Journal Article
Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke
Holliday, Elizabeth G., Traylor, Matthew, Malik, Rainer, Bevan, Steve, Falcone, Guido, Hopewell, Jemma C., Cheng, Yu-Ching, Cotlarciuc, Ioana, Bis, Joshua C., Boerwinkle, Eric, Boncoraglio, Giorgio B., Clarke, Robert, Cole, John W., Fornage, Myriam, Furie, Karen L., Ikram, M. Arfan, Jannes, Jim, Kittner, Steven J., Lincz, Lisa F., Maguire, Jane M., Meschia, James F., Mosley, Thomas H., Nalls, Mike A., Oldmeadow, Christopher, Parati, Eugenio A., Psaty, Bruce M., Rothwell, Peter M., Seshadri, Sudha, Scott, Rodney J. ... Wray, Naomi R. (2015). Genetic Overlap Between Diagnostic Subtypes of Ischemic Stroke. Stroke, 46 (3), 615-615. doi: 10.1161/STROKEAHA.114.007930
Funding
Current funding
Past funding
Supervision
Availability
- Professor Naomi Wray is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
ELUCIDATING LIFESTYLE AND GENETIC FACTORS UNDERLYING DEPRESSION HETEROGENEITY AND TREATMENT RESPONSE
Principal Advisor
Other advisors: Dr Enda Byrne
-
Doctor Philosophy
Multi-Omic Analyses of a Clinical Trial Cohort of Young People at Ultra-High Risk for Psychosis
Principal Advisor
Other advisors: Dr Enda Byrne, Dr Allan McRae
-
Doctor Philosophy
Genetics of childhood onset psychiatric symptoms, their persistence and comorbidity with other traits
Associate Advisor
Other advisors: Dr Enda Byrne
-
Doctor Philosophy
Understanding cellular and molecular heterogeneity in endometriosis using multi-omics data
Associate Advisor
Other advisors: Dr Sally Mortlock, Dr Allan McRae
-
Doctor Philosophy
Genetic architecture and evolution of complex traits across populations in humans
Associate Advisor
Other advisors: Professor Peter Visscher, Dr Fleur Garton, Dr Jian Zeng
Completed supervision
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2022
Doctor Philosophy
Studying the effects of DNA methylation variation across neurodegenerative disorders
Principal Advisor
Other advisors: Dr Allan McRae
-
2022
Doctor Philosophy
Genetic analyses of complex traits using biobank data
Principal Advisor
Other advisors: Professor Peter Visscher
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2021
Doctor Philosophy
A Complex Trait Genomics Approach to Investigating Amyotrophic Lateral Sclerosis
Principal Advisor
Other advisors: Dr Allan McRae
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2017
Doctor Philosophy
The Genetic Architecture of Psychiatric Disorders
Principal Advisor
Other advisors: Professor Peter Visscher
-
2016
Doctor Philosophy
The Role of Cytokines and Inflammatory Markers in Depression in Adolescents
Principal Advisor
Other advisors: Professor Gerard Byrne, Professor James Scott, Professor Nick Martin
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2024
Doctor Philosophy
Using genomic data to advance understanding of heart failure aetiology
Associate Advisor
Other advisors: Associate Professor Sonia Shah
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2024
Doctor Philosophy
Development and application of statistical methods to identify genes and cell types associated with complex traits
Associate Advisor
Other advisors: Dr Jian Zeng
-
2024
Doctor Philosophy
Complement Modulation of Peripheral Immunity in Motor Neurone Disease and Huntington's Disease
Associate Advisor
Other advisors: Dr John Lee, Professor Trent Woodruff
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2023
Doctor Philosophy
The Genomics of Perinatal Depression
Associate Advisor
Other advisors: Dr Enda Byrne
-
2022
Doctor Philosophy
Exploring the influence of genetics and heritability on the heterogeneity of ADHD presentations
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
-
2022
Doctor Philosophy
Systems biology of motor neurone disease
Associate Advisor
Other advisors: Associate Professor Shyuan Ngo, Dr Allan McRae
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2022
Doctor Philosophy
Multi-omics data offer systemic insights into autism
Associate Advisor
Other advisors: Professor Gerald Holtmann, Honorary Professor Jake Gratten
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2020
Doctor Philosophy
Genetic influences on substance use behaviour, substance use disorders and psychiatric disorders
Associate Advisor
Other advisors: Honorary Professor Sarah Medland, Professor Nick Martin, Dr Lucia Colodro-Conde
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2020
Doctor Philosophy
Improving fine-mapping methodology using DNA methylation as a model trait
Associate Advisor
Other advisors: Professor Peter Visscher, Dr Allan McRae
-
2018
Master Philosophy
Integrating genome-wide association study data with gene expression to understand complex traits and common diseases
Associate Advisor
Other advisors: Dr Allan McRae, Honorary Professor Jake Gratten
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