
Overview
Background
Naomi Wray is the Michael Davys Professor in the Department of Psychiatry, University of Oxford. She holds an appointment at the Institute for Molecular Bioscience (IMB) within the University of Queensland. She joined UQ Queensland Brain Institute in 2011 moving to the IMB in 2015. She was Head of the Centre for Population & Disease Genomics within IMB 2018-2023. Her Oxford appointment started in 2023.
Her research focuses on development and application of quantitative genetics and genomics methodologies across complex diseases, disorders and traits, but particularly psychiatric-related traits.
She is a National Health and Medical Research Council (NHMRC) Leadership Fellow, a Fellow of the Australian Academy of Science and a Fellow of the Australian Academy of Health and Medical Science. In 2020 she was awarded the NHMRC Elizabeth Blackburn Award for Leadership in Basic Science and the 2021 International Society of Psychiatric Genetics Ming Tsuang Lifetime Achievement Award. She is a Clarivate Highly Cited researcher.
She was Director of the Program in Complex Trait Genomics (PCTG) funded as an NHMRC Program Grant 2017-2022. She plays a key role in the International Psychiatric Genomics Consortium and established the sporadic ALS Australia systems genomics consortium (SALSA) funded by the MND Research Australia IceBucket Challenge and FightMND. She is a co-investigator on the Australian Genetics of Depression Study (AGDS) and is currently launching the AGDS-Cello project focussed on establishing a cell line resource from participants with a detailed history of anti-depressant use and response measures. She is part of an NHMRC Synergy (2023-2027) "Rhythms and blues: Personalising care for body clock dysfunction in mood disorders".
She is secretary of the International Society of Psychiatric Genetics, and is on the editorial advisory boards of JAMA Psychiatry, Neuron, Royal Society Open and Research Directions: Depression.
Availability
- Professor Naomi Wray is:
- Not available for supervision
Qualifications
- Doctor of Philosophy, University of Edinburgh
Research interests
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Genetics of complex genetic traits, disease and disorders
Quantitative genetics methodology Genetics of Psychiatric Disorder Genetics of Motor Neurone Disease Genetics of Cognitive Ageing Systems Genomics
Works
Search Professor Naomi Wray’s works on UQ eSpace
2013
Journal Article
Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'
Robinson, E. B., Howrigan, D., Yang, J., Ripke, S., Anttila, V., Duncan, L. E., Jostins, L., Barrett, J. C., Medland, S. E., Macarthur, D. G., Breen, G., O'Donovan, M. C., Wray, N. R., Devlin, B., Daly, M. J., Visscher, P. M., Sullivan, P. F. and Neale, B. M. (2013). Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'. Molecular Psychiatry, 19 (8), 859-861. doi: 10.1038/mp.2013.125
2013
Journal Article
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Ripke, Stephan, O'Dushlaine, Colm, Chambert, Kimberly, Moran, Jennifer L., Kaehler, Anna K., Akterin, Susanne, Bergen, Sarah E., Collins, Ann L., Crowley, James J., Fromer, Menachem, Kim, Yunjung, Lee, Sang Hong, Magnusson, Patrik K. E., Sanchez, Nick, Stahl, Eli A., Williams, Stephanie, Wray, Naomi R., Xia, Kai, Bettella, Francesco, Borglum, Anders D., Bulik-Sullivan, Brendan K., Cormican, Paul, Craddock, Nick, de Leeuw, Christiaan, Durmishi, Naser, Gill, Michael, Golimbet, Vera, Hamshere, Marian L., Holmans, Peter ... Brown, Matthew A (2013). Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics, 45 (10), 1150-U282. doi: 10.1038/ng.2742
2013
Journal Article
Additive genetic variation in schizophrenia risk is shared by populations of African and European descent
de Candia, Teresa R., Lee, S. Hong, Yang, Jian, Browning, Brian L., Gejman, Pablo V., Levinson, Douglas F., Mowry, Bryan J., Hewitt, Bryan J., Goddard, Michael E., O'Donovan, Michael C., Purcell, Shaun M., Posthuma, Danielle, The International Schizophrenia Consortium, The Molecular Genetics of Schizophrenia Collaboration, Visscher, Peter M., Wray, Naomi R. and Keller, Matthew C. (2013). Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. American Journal of Human Genetics, 93 (3), 463-470. doi: 10.1016/j.ajhg.2013.07.007
2013
Journal Article
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Lee, S. Hong, Ripke, Stephan, Neale, Benjamin M., Faraone, Stephen V., Purcell, Shaun M., Perlis, Roy H., Mowry, Bryan J., Thapar, Anita, Goddard, Michael E., Witte, John S., Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A., Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E., Asherson, Philip, Azevedo, Maria H., Backlund, Lena, Badner, Judith A., Bailey, Anthony J., Banaschewski, Tobias, Barchas, Jack D., Barnes, Michael R., Barrett, Thomas B., Bass, Nicholas ... Wray, Naomi R. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45 (9), 984-995. doi: 10.1038/ng.2711
2013
Journal Article
Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia
McGrath, John J., Mortensen, Preben Bo, Visscher, Peter M. and Wray, Naomi R. (2013). Where GWAS and epidemiology meet: opportunities for the simultaneous study of genetic and environmental risk factors in schizophrenia. Schizophrenia Bulletin, 39 (5), 955-959. doi: 10.1093/schbul/sbt108
2013
Journal Article
Novel genetic analysis for case-control genome-wide association studies: quantification of power and genomic prediction accuracy
Lee, Sang Hong and Wray, Naomi R. (2013). Novel genetic analysis for case-control genome-wide association studies: quantification of power and genomic prediction accuracy. PLoS One, 8 (8) e71494, e71494. doi: 10.1371/journal.pone.0071494
2013
Journal Article
Research review: the role of cytokines in depression in adolescents: a systematic review
Mills, Natalie T., Scott, James G., Wray, Naomi R., Cohen-Woods, Sarah and Baune, Bernhard T. (2013). Research review: the role of cytokines in depression in adolescents: a systematic review. Journal of Child Psychology and Psychiatry, 54 (8), 816-835. doi: 10.1111/jcpp.12080
2013
Journal Article
Pitfalls of predicting complex traits from SNPs
Wray, Naomi R., Yang, Jian, Hayes, Ben J., Price, Alkes L., Goddard, Michael E. and Visscher, Peter M. (2013). Pitfalls of predicting complex traits from SNPs. Nature Reviews Genetics, 14 (7), 507-515. doi: 10.1038/nrg3457
2013
Journal Article
Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits
Stringer, Sven, Derks, Eske M., Kahn, Rene S., Hill, William G. and Wray, Naomi R. (2013). Assumptions and properties of limiting pathway models for analysis of epistasis in complex traits. PLoS One, 8 (7) e68913, e68913.1-e68913.9. doi: 10.1371/journal.pone.0068913
2013
Journal Article
Assessment of response to lithium maintenance treatment in bipolar disorder: a Consortium on Lithium Genetics (ConLiGen) report
Manchia, Mirko, Adli, Mazda, Akula, Nirmala, Ardau, Raffaella, Aubry, Jean-Michel, Backlund, Lena, Banzato, Claudio E. M., Baune, Bernhard T., Bellivier, Frank, Bengesser, Susanne, Biernacka, Joanna M., Brichant-Petitjean, Clara, Bui, Elise, Calkin, Cynthia V., Cheng, Andrew Tai Ann, Chillotti, Caterina, Cichon, Sven, Clark, Scott, Czerski, Piotr M., Dantas, Clarissa, Del Zompo, Maria, DePaulo, J. Raymond, Detera-Wadleigh, Sevilla D., Etain, Bruno, Falkai, Peter, Frisen, Louise, Frye, Mark A., Fullerton, Jan, Gard, Sebastien ... Alda, Martin (2013). Assessment of response to lithium maintenance treatment in bipolar disorder: a Consortium on Lithium Genetics (ConLiGen) report. PLoS One, 8 (6) e65636, e65636.1-e65636.9. doi: 10.1371/journal.pone.0065636
2013
Journal Article
Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin
Byrne, E. M., Carrillo-Roa, T., Henders, A. K., Bowdler, L., McRae, A. F., Heath, A. C., Martin, N. G., Montgomery, G. W., Krause, L. and Wray, N. R. (2013). Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin. Translational Psychiatry, 3 (6) e269, e269.1-e269.6. doi: 10.1038/tp.2013.45
2013
Journal Article
A genome-wide association study of sleep habits and insomnia
Byrne, Enda M., Gehrman, Philip R., Medland, Sarah E., Nyholt, Dale R., Heath, Andrew C., Madden, Pamela A. F., Hickie, Ian B., Van Duijn, Cornelia M., Henders, Anjali K., Montgomery, Grant W., Martin, Nicholas G., Wray, Naomi R. and The Chronogen Consortium (2013). A genome-wide association study of sleep habits and insomnia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162 (5), 439-451. doi: 10.1002/ajmg.b.32168
2013
Journal Article
The neuroprogressive nature of major depressive disorder: Pathways to disease evolution and resistance, and therapeutic implications
Moylan, S., Maes, M., Wray, N. R. and Berk, M. (2013). The neuroprogressive nature of major depressive disorder: Pathways to disease evolution and resistance, and therapeutic implications. Molecular Psychiatry, 18 (5), 595-606. doi: 10.1038/mp.2012.33
2013
Journal Article
A mega-analysis of genome-wide association studies for major depressive disorder
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Wray, Naomi, Byrne, Enda M., Martin, Nicholas G., Gordon, Scott D., Henders, Anjali K., Montgomery, Grant M., Nyholt, Dale R. and Middeldorp, Christel M. (2013). A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry, 18 (4), 497-511. doi: 10.1038/mp.2012.21
2013
Journal Article
Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease
Gratten, Jacob, Visscher, Peter M., Mowry, Bryan J. and Wray, Naomi R. (2013). Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease. Nature Genetics, 45 (3), 234-238. doi: 10.1038/ng.2555
2013
Journal Article
ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure
Nelson, Elliot C., Lynskey, Michael T., Heath, Andrew C., Wray, Naomi, Agrawal, Arpana, Shand, Fiona L., Henders, Anjali K., Wallace, Leanne, Todorov, Alexandre A., Schrage, Andrew J., Saccone, Nancy L., Madden, Pamela A. F., Degenhardt, Louisa, Martin, Nicholas G. and Montgomery, Grant W. (2013). ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. JAMA Psychiatry, 70 (3), 325-333. doi: 10.1001/jamapsychiatry.2013.282
2013
Journal Article
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis
Lee, S. Hong, Harold, Denise, Nyholt, Dale R., ANZGene Consortium, International Endogene Consortium, Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium, Goddard, Michael E., Zondervan, Krina T., Williams, Julie, Montgomery, Grant W., Wray, Naomi R. and Visscher, Peter M. (2013). Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis. Human Molecular Genetics, 22 (4) dds491, 832-841. doi: 10.1093/hmg/dds491
2013
Journal Article
Estimation of SNP heritability from dense genotype data
Lee, S. Hong, Yang, Jian, Chen, Guo-Bo, Ripke, Stephan, Stahl, Eli A., Hultman, Christina M., Sklar, Pamela, Visscher, Peter M., Sullivan, Patrick F., Goddard, Michael E. and Wray, Naomi (2013). Estimation of SNP heritability from dense genotype data. American Journal Of Human Genetics, 93 (6), 1151-1155. doi: 10.1016/j.ajhg.2013.10.015
2013
Journal Article
Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants
Yang, Li, Neale, Benjamin M., Liu, Lu, Lee, S. Hong, Wray, Naomi R., Ji, Ning, Li, Haimei, Qian, Qiujin, Wang, Dongliang, Li, Jun, Faraone, Stephen V. and Wang, Yufeng (2013). Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics, 162 (5), 419-430. doi: 10.1002/ajmg.b.32169
2013
Journal Article
The heritability of delusional-like experiences
Varghese, D., Wray, N. R., Scott, J. G., Williams, G. M., Najman, J. M. and McGrath, J. J. (2013). The heritability of delusional-like experiences. Acta Psychiatrica Scandinavica, 127 (1), 48-52. doi: 10.1111/j.1600-0447.2012.01905.x
Funding
Current funding
Past funding
Supervision
Availability
- Professor Naomi Wray is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
Multi-Omic Analyses of a Clinical Trial Cohort of Young People at Ultra-High Risk for Psychosis
Principal Advisor
Other advisors: Dr Enda Byrne, Dr Allan McRae
-
Doctor Philosophy
ELUCIDATING LIFESTYLE AND GENETIC FACTORS UNDERLYING DEPRESSION HETEROGENEITY AND TREATMENT RESPONSE
Principal Advisor
Other advisors: Dr Enda Byrne
-
Doctor Philosophy
Understanding cellular and molecular heterogeneity in endometriosis using multi-omics data
Associate Advisor
Other advisors: Dr Sally Mortlock, Dr Allan McRae
-
Doctor Philosophy
Genetics of childhood onset psychiatric symptoms, their persistence and comorbidity with other traits
Associate Advisor
Other advisors: Dr Enda Byrne
-
Doctor Philosophy
Genetic architecture and evolution of complex traits across populations in humans
Associate Advisor
Other advisors: Professor Peter Visscher, Dr Fleur Garton, Dr Jian Zeng
Completed supervision
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2022
Doctor Philosophy
Studying the effects of DNA methylation variation across neurodegenerative disorders
Principal Advisor
Other advisors: Dr Allan McRae
-
2022
Doctor Philosophy
Genetic analyses of complex traits using biobank data
Principal Advisor
Other advisors: Professor Peter Visscher
-
2021
Doctor Philosophy
A Complex Trait Genomics Approach to Investigating Amyotrophic Lateral Sclerosis
Principal Advisor
Other advisors: Dr Allan McRae
-
2017
Doctor Philosophy
The Genetic Architecture of Psychiatric Disorders
Principal Advisor
Other advisors: Professor Peter Visscher
-
2016
Doctor Philosophy
The Role of Cytokines and Inflammatory Markers in Depression in Adolescents
Principal Advisor
Other advisors: Professor Gerard Byrne, Professor James Scott, Professor Nick Martin
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2024
Doctor Philosophy
Using genomic data to advance understanding of heart failure aetiology
Associate Advisor
Other advisors: Associate Professor Sonia Shah
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2024
Doctor Philosophy
Development and application of statistical methods to identify genes and cell types associated with complex traits
Associate Advisor
Other advisors: Dr Jian Zeng
-
2024
Doctor Philosophy
Complement Modulation of Peripheral Immunity in Motor Neurone Disease and Huntington's Disease
Associate Advisor
Other advisors: Dr John Lee, Professor Trent Woodruff
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2023
Doctor Philosophy
The Genomics of Perinatal Depression
Associate Advisor
Other advisors: Dr Enda Byrne
-
2022
Doctor Philosophy
Exploring the influence of genetics and heritability on the heterogeneity of ADHD presentations
Associate Advisor
Other advisors: Honorary Professor Sarah Medland
-
2022
Doctor Philosophy
Systems biology of motor neurone disease
Associate Advisor
Other advisors: Associate Professor Shyuan Ngo, Dr Allan McRae
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2022
Doctor Philosophy
Multi-omics data offer systemic insights into autism
Associate Advisor
Other advisors: Professor Gerald Holtmann, Honorary Professor Jake Gratten
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2020
Doctor Philosophy
Genetic influences on substance use behaviour, substance use disorders and psychiatric disorders
Associate Advisor
Other advisors: Honorary Professor Sarah Medland, Professor Nick Martin, Dr Lucia Colodro-Conde
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2020
Doctor Philosophy
Improving fine-mapping methodology using DNA methylation as a model trait
Associate Advisor
Other advisors: Professor Peter Visscher, Dr Allan McRae
-
2018
Master Philosophy
Integrating genome-wide association study data with gene expression to understand complex traits and common diseases
Associate Advisor
Other advisors: Dr Allan McRae, Honorary Professor Jake Gratten
Media
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