
Overview
Background
How to build a brain—2.0
For 25 years I was sole chief investigator on 17 NHMRC-ARC project grants that provided funding to decipher the molecular & cellular bases of brain development and regeneration in fish, frogs and mice. This work culminated in the discovery of how to genetically construct an evolutionary novel axon tract in the embryonic brain. This is what I now call an easy problem.
Now my lab has turned its attention to the hardest problem in the natural sciences—how does the brain experience subjective feelings?
Together with my collaborator Professor Deborah Brown (Professor of Philosophy at UQ) we have approached this problem through the sensation of pain and model organisms. We advance the framework of the brain as an inference machine that generates models of its own internal processes (Key and Brown, 2018). When hierarchically arranged, the outputs of these models represent progressive levels of awareness that are antecedent to feelings (i.e. the brain’s experience of its own neural activity). We have proposed a parallel forwards model algorithm and to date have found that fish and molluscs lack the required neural architecture to execute this algorithm and therefore do not feel pain.
Key, B. and Brown, D. (2018) Designing brains for pain: Human to mollusc. Frontiers in physiology 9:1027.
Availability
- Professor Brian Key is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Education, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research interests
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brain development
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fish pain
Works
Search Professor Brian Key’s works on UQ eSpace
2012
Journal Article
Frizzled-3a and slit2 genetically interact to modulate midline axon crossing in the telencephalon
Hofmeister, Wolfgang, Devine, Christine A., Rothnagel, Joseph A. and Key, Brian (2012). Frizzled-3a and slit2 genetically interact to modulate midline axon crossing in the telencephalon. Mechanisms of Development, 129 (5-8), 109-124. doi: 10.1016/j.mod.2012.05.004
2012
Journal Article
Chemoattractant axon guidance cues regulate de novo axon trajectories in the embryonic forebrain of zebrafish
Gaudin, Arnaud, Hofmeister, Wolfgang and Key, Brian (2012). Chemoattractant axon guidance cues regulate de novo axon trajectories in the embryonic forebrain of zebrafish. Developmental Biology, 367 (2), 126-139. doi: 10.1016/j.ydbio.2012.04.032
2012
Journal Article
Novel roles of the chemorepellent axon guidance molecule RGMa in cell migration and adhesion
Lah, Grace J. and Key, Brian (2012). Novel roles of the chemorepellent axon guidance molecule RGMa in cell migration and adhesion. Molecular and Cellular Biology, 32 (5), 968-980. doi: 10.1128/MCB.06128-11
2012
Journal Article
Repulsive guidance molecule A (RGMa): A molecule for all seasons
Key, Brian and Lah, Grace J. (2012). Repulsive guidance molecule A (RGMa): A molecule for all seasons. Cell Adhesion and Migration, 6 (2), 85-90. doi: 10.4161/cam.20167
2012
Journal Article
Dual roles of the chemorepellent axon guidance molecule RGMa in establishing pioneering axon tracts and neural fate decisions in embryonic vertebrate forebrain
Lah, Grace J. and Key, Brian (2012). Dual roles of the chemorepellent axon guidance molecule RGMa in establishing pioneering axon tracts and neural fate decisions in embryonic vertebrate forebrain. Developmental Neurobiology, 72 (11), 1458-1470. doi: 10.1002/dneu.22010
2011
Journal Article
Stimulation of olfactory ensheathing cell motility enhances olfactory axon growth
Windus, Louisa C. E., Chehrehasa, Fatemeh, Lineburg, Katie E., Claxton, Christina, Mackay-Sim, Alan, Key, Brian and St John, James A. (2011). Stimulation of olfactory ensheathing cell motility enhances olfactory axon growth. Cellular and Molecular Life Sciences, 68 (19), 3233-3247. doi: 10.1007/s00018-011-0630-9
2011
Journal Article
The carbohydrate CT1 is expressed in topographically fixed glomeruli in the mouse olfactory bulb
Lineburg, Katie E., Amaya, Daniel, Ekberg, Jenny A., Chehrehasa, Fatemeh, Mackay-Sim, Alan, Martin, Paul T., Key, Brian and St John, James A. (2011). The carbohydrate CT1 is expressed in topographically fixed glomeruli in the mouse olfactory bulb. Molecular and Cellular Neuroscience, 48 (1), 9-19. doi: 10.1016/j.mcn.2011.05.011
2011
Journal Article
OMP-ZsGreen fluorescent protein transgenic mice for visualization of olfactory sensory neurons in vivo and in vitro
Ekberg, Jenny A.K., Amaya, Daniel, Chehrehasa, Fatemeh, Lineburg, Katie, Claxton, Christina, Windus, Louisa C.E., Key, Brian, Mackay-Sim, Alan and St John, James A. (2011). OMP-ZsGreen fluorescent protein transgenic mice for visualization of olfactory sensory neurons in vivo and in vitro. Journal of Neuroscience Methods, 196 (1), 88-98. doi: 10.1016/j.jneumeth.2011.01.008
2011
Journal Article
Editorial
Key, Brian (2011). Editorial. Journal of Molecular Histology, 42 (1), 1-1. doi: 10.1007/s10735-011-9320-z
2011
Journal Article
Correction of aberrant axon growth in the developing mouse olfactory bulb
Chan, Caroline, Ekberg, Jenny A. K., Lineburg, Katie E., Scott, Susan E., Chehrehasa, Fatemeh, Windus, Louisa C. E., Claxton, Christina, Mackay-Sim, Alan, Key, Brian and St John, James A. (2011). Correction of aberrant axon growth in the developing mouse olfactory bulb. Molecular and Cellular Neuroscience, 46 (1), 282-295. doi: 10.1016/j.mcn.2010.09.012
2010
Journal Article
Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions
Windus, Louisa C. E., Lineburg, Katie E., Scott, Susan E., Claxton, Christina, Mackay-Sim, Alan, Key, Brian and St John, James A. (2010). Lamellipodia mediate the heterogeneity of central olfactory ensheathing cell interactions. Cellular and Molecular Life Sciences, 67 (10), 1735-1750. doi: 10.1007/s00018-010-0280-3
2010
Conference Publication
Using zebrafish to understand the neurodevelopment role of susceptibility genes for autism spectrum disorder
Key, B. (2010). Using zebrafish to understand the neurodevelopment role of susceptibility genes for autism spectrum disorder. 18th Biennial Meeting of the International-Society-for-Developmental-Neuroscience, Estoril, Portugal, 6-9 June 2010. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.ijdevneu.2010.07.134
2010
Conference Publication
Using zebrafish to understand the neurodevelopment role of susceptibility genes for autism spectrum disorder
Key, B (2010). Using zebrafish to understand the neurodevelopment role of susceptibility genes for autism spectrum disorder. 69th Annual Meeting of the Society-for-Developmental-Biology/Japanese-Society-of-Developmental-Biologists, Albuquerque NM, AUG 05-09, 2010. doi: 10.1016/j.ydbio.2010.05.486
2009
Conference Publication
LIVE CELL IMAGING REVEALS THE HETEROGENEITY OF OLFACTORY ENSHEATHING CELLS: IMPLICATIONS FOR NEURAL THERAPIES
St John, J, Windus, L, Lineburg, K, Scott, S, Ekberg, J, Hansen, E, Claxton, C, Key, B and Mackay-Sim, A (2009). LIVE CELL IMAGING REVEALS THE HETEROGENEITY OF OLFACTORY ENSHEATHING CELLS: IMPLICATIONS FOR NEURAL THERAPIES. 9th European Meeting on Glial Cells in Health and Disease, Paris FRANCE, SEP 08-12, 2009. HOBOKEN: Wiley-Liss.
2008
Journal Article
Neogenin and RGMa control neural tube closure and neuroepithelial morphology by regulating cell polarity
Kee, Nigel, Wilson, Nicole, De Vries, Melissa, Bradford, DanaKai, Key, Brian and Cooper, Helen M. (2008). Neogenin and RGMa control neural tube closure and neuroepithelial morphology by regulating cell polarity. The Journal of Neuroscience, 28 (48), 12643-12653. doi: 10.1523/JNEUROSCI.4265-08.2008
2008
Journal Article
Robo-Slit interactions regulate longitudinal axon pathfinding in the embryonic vertebrate brain
Devine, C. A. and Key, B. (2008). Robo-Slit interactions regulate longitudinal axon pathfinding in the embryonic vertebrate brain. Developmental Biology, 313 (1), 371-383. doi: 10.1016/j.ydbio.2007.10.040
2008
Journal Article
The cell surface carbohydrate blood group A regulates the selective fasciculation of regenerating accessory olfactory axons
Chehrehasa, F., Key, B. and St John, J. A. (2008). The cell surface carbohydrate blood group A regulates the selective fasciculation of regenerating accessory olfactory axons. Brain Research, 1203, 32-38. doi: 10.1016/j.brainres.2008.01.084
2007
Journal Article
Motile membrane protrusions regulate cell–cell adhesion and migration of olfactory ensheathing glia
Windus, L., Claxton, C., Allen, C., Key, B. and St John, J. A. (2007). Motile membrane protrusions regulate cell–cell adhesion and migration of olfactory ensheathing glia. Glia, 55 (16), 1708-1719. doi: 10.1002/glia.20586
2007
Journal Article
Neogenin: One receptor, many functions
Wilson, Nicole H. and Key, Brian (2007). Neogenin: One receptor, many functions. International Journal of Biochemistry & Cell Biology, 39 (5), 874-878. doi: 10.1016/j.biocel.2006.10.023
2007
Journal Article
Caveolin-1 is required for lateral line neuromast and notochord development
Nixon, S. J., Carter, A., Wegner, J., Ferguson, C., Floetenmeyer, M., Riches, J. D., Key, B., Westerfield, M. and Parton, R. G. (2007). Caveolin-1 is required for lateral line neuromast and notochord development. Journal of Cell Science, 120 (13), 2151-2161. doi: 10.1242/jcs.003830
Funding
Past funding
Supervision
Availability
- Professor Brian Key is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Towards closure of the fish pain debate
We are seeking an Arts-Biomedical Science graduate to partake in this ambitious project.
Arguments to the effect that certain animals do or do not have feelings, such as pain, are presumptive arguments. Like legal arguments, presumptive arguments are defeasible arguments, the conclusions of which are thought to be rationally acceptable on the balance of considerations (Walton 1996, 2011). Also like legal arguments, they invite paradoxical worries about how an argument can be both defeasible yet rationally binding (Walton et al, 2008). In legal contexts, we do not have the luxury of leaving questions of guilt or innocence hanging. A decision must be made. So too in matters pertaining to animal welfare, it is necessary to evaluate whether we have sufficient reason to decide whether a particular species of animal does or does not feel pain if we are to ensure that our treatment of that species is ethically appropriate.
Each of the arguments in the animal consciousness debate can and has been evaluated on its own terms, but an interesting pattern emerges when viewed together as constituting a single dialogue involving multiple reasoners operating on divergent background assumptions and principles of reasoning. From this perspective, it can be seen where the blockages to consensus lie and what it would take to move the debate towards some form of closure so that decisions of importance to animal welfare could be undertaken with more confidence than they currently are. No meta-analysis of this debate as an instance of multi-agent reasoning has hitherto been undertaken. The overarching aim of this project is to conduct just such an analysis in an effort to identify principles that both sides of the debate might rationally agree upon and move the debate towards epistemic closure.
The principal aims are:
Aim 1. To reconstruct the debate about pain in non-human animals as an instance of multi-agent reasoning or dialogue to clarify precise points of agreement and disagreement,
Aim 2. To argue for shared principles of reasoning drawing on available neuroscientific evidence in order to create avenues towards closure, and
Aim 3. To address concerns about moral risk exceeding epistemic risk in judgements about non-human animal pain.
Supervision history
Current supervision
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Doctor Philosophy
Scepticism of other minds in the animal pain debate
Associate Advisor
Other advisors: Professor Deborah Brown
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Doctor Philosophy
Scepticism of other minds in the animal pain debate
Associate Advisor
Other advisors: Professor Deborah Brown
Completed supervision
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2019
Doctor Philosophy
The Non-Invasive Detection of Anatomical Injury Locations in Low Back Pain Patients Using Laser Displacement Mechanomyography
Principal Advisor
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2013
Doctor Philosophy
The Autism susceptibility gene nrxn1 interacts with an intellectual disability gene lrrtm2 in vivo to regulate locomotor behaviours and spinal cord cytoarchitecture
Principal Advisor
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2012
Doctor Philosophy
Functional Analysis of Repulsive Guidance Molecule A during Early Vertebrate Development
Principal Advisor
Other advisors: Professor Helen Cooper
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2010
Doctor Philosophy
The cellular and molecular mechanisms of olfactory ensheathing cell and axon migration
Principal Advisor
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2009
Doctor Philosophy
Cellular mechanisms of axon guidance and targeting in the olfactory system
Principal Advisor
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2007
Doctor Philosophy
CELLULAR MECHANISMS OF AXON TARGETING IN THE REGENERATING OLFACTORY SYSTEM
Principal Advisor
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2006
Doctor Philosophy
ROBO AND SLIT HAVE AN AXON GUIDANCE ROLE IN THE EMBRYONIC VERTEBRATE BRAIN
Principal Advisor
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2006
Doctor Philosophy
AXON GROWTH AND GUIDANCE IN THE EMBRYONIC VERTEBRATE FOREBRAIN
Principal Advisor
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2003
Doctor Philosophy
MECHANISMS OF AXON GROWTH AND GUIDANCE IN THE VERTEBRATE NERVOUS SYSTEM
Principal Advisor
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2014
Doctor Philosophy
Odorant and taste receptor systems in the heart: investigation of novel cardiac biology
Associate Advisor
Other advisors: Professor Wally Thomas, Professor Eugeni Roura
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2008
Doctor Philosophy
Characterisation and expression of zebrafish frizzled-3a (zfzd3a) during embryonic development
Associate Advisor
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2005
Master Philosophy
THE EFFECTS OF COCAINE EXPOSURE DURING EARLY LIFE ON RAT BRAIN DEVELOPMENT
Associate Advisor
Media
Enquiries
Contact Professor Brian Key directly for media enquiries about:
- brain development
- fish pain
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