Professor

Wally Thomas

Email: 
Phone: 
+61 7 336 51074

Availability

Professor Wally Thomas is:
Available for supervision
Media expert

Fields of research

Biological Sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Science, The University of Queensland
  • Bachelor (Honours) of Science (Advanced), The University of Queensland
  • Doctor of Philosophy, The University of Queensland

Search Professor Wally Thomas’s works on UQ eSpace

174 works between 1985 and 2024
All (174) Journal Article (139) Book Chapter (4) Conference Publication (31)

21 - 40 of 174 works

2019

Conference Publication

Cardiomyocyte ErbB4 receptors are essential for developmental cardiac hypertrophy and cardiac function in adult hearts

Reichelt, M., Wang, Z., Thorn, C., Paravicini, T. and Thomas, W. G. (2019). Cardiomyocyte ErbB4 receptors are essential for developmental cardiac hypertrophy and cardiac function in adult hearts. ESC Congress / World Congress of Cardiology, Paris, France, 31 August - 4 September 2019. Oxford, United Kingdom: Oxford University Press.

Cardiomyocyte ErbB4 receptors are essential for developmental cardiac hypertrophy and cardiac function in adult hearts

2019

Journal Article

Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors

Ragnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2019). Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors. Science Signaling, 12 (572) eaas9485, eaas9485. doi: 10.1126/scisignal.aas9485

Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors

2018

Journal Article

BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes

O'Brien, Shannon L., Johnstone, Elizabeth K. M., Devost, Dominic, Conroy, Jacinta, Reichelt, Melissa E., Purdue, Brooke W., Ayoub, Mohammed A., Kawai, Tatsuo, Inoue, Asuka, Eguchi, Satoru, Hébert, Terence E., Pfleger, Kevin D.G. and Thomas, Walter G. (2018). BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes. Biochemical Pharmacology, 158, 232-242. doi: 10.1016/j.bcp.2018.10.017

BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes

2017

Journal Article

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R. and Hudson, James E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proceedings of the National Academy of Sciences of the United States of America, 114 (40), E8372-E8381. doi: 10.1073/pnas.1707316114

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

2017

Journal Article

Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity

Kaakinen, Mika, Reichelt, Melissa E., Ma, Zhibin, Ferguson, Charles, Martel, Nick, Porrello, Enzo R., Hudson, James E., Thomas, Walter G., Parton, Robert G. and Headrick, John P. (2017). Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity. Basic Research in Cardiology, 112 (3) 24, 24. doi: 10.1007/s00395-017-0613-6

Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity

2017

Journal Article

Gaq proteins: molecular pharmacology and therapeutic potential

Kamato, Danielle, Mitra, Partha, Davis, Felicity, Osman, Narin, Chaplin, Rebecca, Cabot, Peter J., Afroz, Rizwana, Thomas, Walter, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret and Little, Peter J. (2017). Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences, 74 (8), 1379-1390. doi: 10.1007/s00018-016-2405-9

Gaq proteins: molecular pharmacology and therapeutic potential

2017

Journal Article

Transactivation of the epidermal growth factor receptor in responses to myocardial stress and cardioprotection

Reichelt, Melissa E., O'Brien, Shannon, Thomas, Walter G. and Headrick, John P. (2017). Transactivation of the epidermal growth factor receptor in responses to myocardial stress and cardioprotection. International Journal of Biochemistry and Cell Biology, 83, 97-110. doi: 10.1016/j.biocel.2016.12.014

Transactivation of the epidermal growth factor receptor in responses to myocardial stress and cardioprotection

2017

Journal Article

CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis

Iyer, Swati, Chhabra, Yash, Harvey, Tracey J., Wang, Richard, Chiu, Han Sheng, Smith, A. G., Thomas, Walter G., Pennisi, David J. and Piper, Michael (2017). CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis. Journal of Molecular Histology, 48 (1), 53-61. doi: 10.1007/s10735-016-9702-3

CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis

2017

Conference Publication

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Hudson, J., Mills, R., Titmarsh, D., Koenig, X., Parker, B., Ryall, J., Quaife-Ryan, G., Voges, H., Hodson, M., Ferguson, C., Drowley, L., Plowright, A., Wang, Q., Gregorevic, P., Xin, M., Thomas, W., Parton, R., Nielsen, L., Launikonis, B., James, D., Elliott, D. and Porrello, E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Abstracts for the 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Perth, Australia, 10 - 13 August 2017. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2017.06.375

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

2016

Conference Publication

Cellular transcriptomic analysis of multiple cardiac lineages during heart development and regeneration

Ryan, Quaife-G., Ma, Z., Sim, C., Ramialison, M., Thomas, W., Hudson, J. and Porrello, E. (2016). Cellular transcriptomic analysis of multiple cardiac lineages during heart development and regeneration. 64th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Adelaide, SA Australia, 4 – 7 August 2016. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2016.06.079

Cellular transcriptomic analysis of multiple cardiac lineages during heart development and regeneration

2016

Conference Publication

TAS2Rs-A new class of functional G protein-coupled receptors in heart.

Thomas, Walter (2016). TAS2Rs-A new class of functional G protein-coupled receptors in heart.. 25th Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Istanbul Turkey, Sep 01-05, 2015. OXFORD: OXFORD UNIV PRESS.

TAS2Rs-A new class of functional G protein-coupled receptors in heart.

2016

Journal Article

Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling

Little, P. J., Hollenberg, M. D, Kamato, D., Thomas, W., Chen, J., Wang, T., Zheng, W. and Osman, N. (2016). Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling. British Journal of Pharmacology, 173 (20), 2992-3000. doi: 10.1111/bph.13398

Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling

2016

Journal Article

Crim1 has cell-autonomous and paracrine roles during embryonic heart development

Iyer, Swati, Chou, Fang Yu, Wang, Richard, Chiu, Han Sheng, Raju, Vinay K. Sundar, Little, Melissa H., Thomas, Walter G., Piper, Michael and Pennisi, David J. (2016). Crim1 has cell-autonomous and paracrine roles during embryonic heart development. Scientific Reports, 6 (1) 19832, 19832 .1-19832 .15. doi: 10.1038/srep19832

Crim1 has cell-autonomous and paracrine roles during embryonic heart development

2016

Journal Article

Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system

Forrester, Steven J., Kawai, Tatsuo, O'Brien, Shannon, Thomas, Walter, Harris, Raymond C. and Eguchi, Satoru (2016). Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system. Annual Review of Pharmacology and Toxicology, 56 (1), 627-653. doi: 10.1146/annurev-pharmtox-070115-095427

Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system

2016

Journal Article

Taste and hypertension in humans: targeting cardiovascular disease

Roura, Eugeni, Foster, Simon, Winklebach, Anja, Navarro, Marta, Thomas, Walter, Campbell, Katrina and Stowasser, Michael (2016). Taste and hypertension in humans: targeting cardiovascular disease. Current Pharmaceutical Design, 22 (15), 2290-2305. doi: 10.2174/1381612822666160216151545

Taste and hypertension in humans: targeting cardiovascular disease

2015

Journal Article

Angiotensin receptors: Interpreters of pathophysiological angiotensinergic stimulis

Karnik, Sadashiva S., Unal, Hamiyet, Kemp, Jacqueline R., Tirupula, Kalyan C., Eguchi, Satoru, Vanderheyden, Patrick M. L. and Thomas, Walter G. (2015). Angiotensin receptors: Interpreters of pathophysiological angiotensinergic stimulis. Pharmacological Reviews, 67 (4), 754-819. doi: 10.1124/pr.114.010454

Angiotensin receptors: Interpreters of pathophysiological angiotensinergic stimulis

2015

Journal Article

Variability in human bitter taste sensitivity to chemically diverse compounds can be accounted for by differential TAS2R activation

Roura, Eugeni, Aldayyani, Asya, Thavaraj, Pridhuvi, Prakash, Sangeeta, Greenway, Delma, Thomas, Walter G., Meyerhof, Wolfgang, Roudnitzky, Natacha and Foster, Simon R. (2015). Variability in human bitter taste sensitivity to chemically diverse compounds can be accounted for by differential TAS2R activation. Chemical Senses, 40 (6), 427-435. doi: 10.1093/chemse/bjv024

Variability in human bitter taste sensitivity to chemically diverse compounds can be accounted for by differential TAS2R activation

2015

Journal Article

Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion

Hirst, Daniel J., Lee, Tzong-Hsien, Pattenden, Leonard K., Thomas, Walter G. and Aguilar, Marie-Isabel (2015). Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion. Scientific Reports, 5 (1) 9972, 1-14. doi: 10.1038/srep09972

Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion

2015

Journal Article

Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation

Foster, Simon R., Porrello, Enzo R., Stefani, Maurizio, Smith, Nicola J., Molenaar, Peter, Dos Remedios, Cristobal G., Thomas, Walter G. and Ramialison, Mirana (2015). Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 388 (10) 1118, 1009-1027. doi: 10.1007/s00210-015-1118-1

Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation

2015

Journal Article

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2

Clayton, Daniel, Hanchapola, Iresha, Thomas, Walter G., Widdop, Robert E., Smith, Alexander I., Perlmutter, Patrick and Aguilar, Marie-Isabel (2015). Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2. Frontiers in Pharmacology, 6 (JAN) 05, 5.1-5.9. doi: 10.3389/fphar.2015.00005

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2

Current funding

  • 2023 - 2025
    Studying the basis of and developing new therapies to treat heart disease
    IPF Healthy - Medical Research
    Open grant
  • 2023 - 2025
    Protecting hearts from trastuzumab-induced cardiomyopathy
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2022 - 2024
    Targeting cavin-1 via gene therapy in a model of metabolic/low-level chronic stress
    Diabetes Australia Research Program
    Open grant
  • 2020 - 2023
    Understanding how an old heart gets stiff
    ARC Discovery Projects
    Open grant
  • 2019 - 2022
    How tissues generate the peptide hormone angiotensin II
    ARC Discovery Projects
    Open grant
  • 2019
    Vevo 3100 Imaging System for ultrahigh resolution and frame rate echocardiographic assessment of small animals.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017 - 2018
    A potential role for C5a antagonism in the medical management of feline hypertrophic cardiornyopathy
    Peter & Mary Ellen Stone Memorial Fund
    Open grant
  • 2017 - 2018
    A Pharmacology Screening Facility to Accelerate Drug Discovery and Development
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    A state-of-the-art spinning disc confocal microscope for high speed imaging of live cells and super resolution microscopy
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2017
    New mediators of GPCR-growth factor receptor transactivation
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    PIPS regulate the type 1 angiotensin receptor (NHMRC Project Grant administered by Monash University)
    Monash University
    Open grant
  • 2014 - 2016
    Dietary Na reduction, food hedonism and hypertension
    UQ Collaboration and Industry Engagement Fund - Seed Research Grant
    Open grant
  • 2014
    Establishment of a small animal surgical suite for integrative physiology.
    Open grant
  • 2014
    Mitochondrial analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2015
    Chemosensory receptors in heart
    National Heart Foundation of Australia
    Open grant
  • 2013
    Establishment of an Integrated Facility for Single Cell Analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012
    Establishment of Integrated Small Animal Metabolic and Physiology Assessment Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012
    Examining vascular structure and function using pressurised myography
    NHMRC Equipment Grant
    Open grant
  • 2012 - 2016
    Manipulating store-operated Ca2+ entry to improve muscle function in dystrophy
    NHMRC Project Grant
    Open grant
  • 2012 - 2014
    Mechanism of Epidermal Growth Factor Receptor Transactivation
    NHMRC Project Grant
    Open grant
  • 2011
    A Multi-Channel Fluorescence Plate Reader for Studying Receptor-Ligand Interactions
    NHMRC Equipment Grant
    Open grant
  • 2011 - 2013
    Role of extracellular surface residues in agonist activation of the alpha1 adrenoceptor
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    Improving muscle function in dystrophy
    UQ Collaboration and Industry Engagement Fund
    Open grant
  • 2010
    Dual channel electrophysiological recordings
    NHMRC Equipment Grant
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Molecular regulation of angiotensin receptors
    NHMRC Project Grant
    Open grant
  • 2010 - 2012
    Unravelling the sub-nuclear complexity of the brain (ARC Discovery Project administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2009
    "Real Time PCR Facility for Biomedical Researchers"
    UQ School/Centre Co-Funding
    Open grant
  • 2009
    Establishment of a rodent cardiovascular and metabolic phenotyping platform
    UQ School/Centre Co-Funding
    Open grant
  • 2009
    Liquid Scintillation Spectroscopy Facility
    UQ School/Centre Co-Funding
    Open grant
  • 2008 - 2010
    NHMRC Senior Research Fellowship B
    NHMRC Research Fellowship
    Open grant
  • 2008 - 2010
    EGFR transactivation in cardiac hypertrophy
    NHMRC Project Grant
    Open grant
  • 2008 - 2009
    Molecular regulation of the type 1 angiotensin receptor
    NHMRC Project Grant
    Open grant
  • 2008 - 2010
    Regulation of Cardiac Hypertrophy (NHMRC grant administered by the University of Melbourne)
    Peter MacCallum Cancer Centre
    Open grant
  • 2008
    Understanding cell physiology by confocal laser scanning microscopy
    UQ Major Equipment and Infrastructure
    Open grant

Availability

Professor Wally Thomas is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    The role of neuregulin in cardiac function and failure

    Principal Advisor

    Other advisors: Dr Melissa Reichelt

  • Doctor Philosophy

    Epidermal growth factor receptors in cardiac function and disease

    Principal Advisor

    Other advisors: Dr Melissa Reichelt

  • Doctor Philosophy

    Understanding the role of HER2 in cardiac function.

    Associate Advisor

    Other advisors: Professor Fiona Simpson, Dr Melissa Reichelt

  • Doctor Philosophy

    Deciphering the Role of Immune Signalling in Cardiac Dysfunction

    Associate Advisor

  • Doctor Philosophy

    Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.

    Associate Advisor

    Other advisors: Associate Professor Dominic Ng, Dr Melissa Reichelt

  • Doctor Philosophy

    Understanding cardiomyocyte-endothelial cell interactions in regulating cardiac function

    Associate Advisor

    Other advisors: Dr Melissa Reichelt

  • Doctor Philosophy

    The role of C5a and ß-1 adrenergic receptors on cardiovascular function in cats

    Associate Advisor

    Other advisors: Professor Trent Woodruff, Professor Paul Mills

  • Doctor Philosophy

    Understanding cardiomyocyte-endothelial cell interactions in regulating cardiac function

    Associate Advisor

    Other advisors: Dr Melissa Reichelt

  • Doctor Philosophy

    Understanding the role of WD40-Repeat Protein 62 (WDR62) in the regulation of heart function.

    Associate Advisor

    Other advisors: Associate Professor Dominic Ng, Dr Melissa Reichelt

Completed supervision

Enquiries

Contact Professor Wally Thomas directly for media enquiries about:

  • Cardiovascular disease
  • Cardiovascular system
  • Cell biology
  • Cell signalling
  • G protein-coupled receptors
  • Heart disease

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