Professor Gary Schenk
Professor

Gary Schenk

Email: 
Phone: 
+61 7 336 54144

Background

I obtained a Diploma in Chemistry from the University of Bern in Switzerland in 1992. Upon receiving the award of an International Postgraduate Research Scholarship (IPRS) I joined The University of Queensland (UQ) in 1993 to carry out research towards a PhD in Biochemistry(supervisors: Assoc. Profs. Peter Nixon and Ron Duggleby). I graduated in 1997 and continued postdoctoral research at UQ under the guidance of Profs John de Jersey, Susan Hamilton and Graeme Hanson. During this period, I was awarded Fellowships from both the Wellcome Trust and UQ. In 2000 I spent several months in the Department of Chemistry at the University of Newcastle-upon-Tyne, England, collaborating with Prof. Geoff Sykes, and later that year I commenced a Senior Postdoctoral Fellowship in the Chemistry Department at Stanford University (advisor: Prof. Edward Solomon). In 2003 I was appointed to a Lectureship in (Bio)Physical Chemistry at UQ. In 2006 I was promoted to Senior Lecturer. Following the award of a UQ Foundation Research Excellence Award (in 2007) I was promoted to Associate Professor (in 2008), and between 2011 and 2013 I was also on a fractional professorial appointment (50%) at Maynooth University, Ireland. From 2013 to 2017 I held a Future Fellowship from the Australian Research Council, and during this period I was promoted to Full Professor at UQ (2015). I also hold affiliate professorships in the Sustainable Minerals Institute and the Australian Institute for Bioengineering and Nanotechnology, both located at UQ.

I have successfully focused my research on the investigation of enzyme-catalysed reactions, their optimisation for applications in biotechnology and the synthesis of small molecules that mimic their structure and catalytic function (i.e. biomimetics). I advanced understanding of the contribution of metals to enzyme-catalysed reactions and employed state-of-the-art technologies (e.g. cryo-EM, ancestral gene reconstruction) to develop enzyme inhibitors as leads for novel biocides (herbicides, fungicides, antibacterial compounds) and engineer enzymes with enhanced catalytic properties for industrial applications in the advanced manufacturing sector (i.e. cell-free enzyme cascades, next-gen fertilisers). My work into enzyme mechanisms, regulation and engineering received international acclaim evidenced by invitations to provide plenary and keynote lectures and review articles in prestigious journals. I have published over 250 peer-reviewed articles, including over 40 papers in the ACS staple (J. Am. Chem. Soc, ACS Catalysis, ACS Sus. Chem. Eng., Inorg. Chem, Chem. Rev., Acc. Chem. Rev.) as well as landmark studies in Nature, Nature Catalysis, Nature Communications and Proc. Natl. Acad. Sci. (USA). For my leadership in enzymology I was awarded a Future Fellowship by the Australian Research Council, a Foundation Research Excellence Award by UQ and, most recently, the prestigious role as Ambassador for the Technical University of Munich (TUM), an honour bestowed upon me also for my leading role in building an extensive network of collaborations between UQ and TUM in the areas of bioengineering and bioeconomy. The network has since evolved into the Global Bioeconomy Alliance.

Availability

Professor Gary Schenk is:
Available for supervision

Fields of research

Biological Sciences Chemical Sciences Engineering Inorganic chemistry Medicinal and biomolecular chemistry Reaction engineering (excl. nuclear reactions)

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Application of enzyme-driven processes in the bioeconomy

    I am interested in discovering and engineering enzymes for applications in biomanufacturing and bioremediation

Search Professor Gary Schenk’s works on UQ eSpace

264 works between 1996 and 2024
All (264) Journal Article (222) Book Chapter (5) Conference Publication (32) Book (1) Other Outputs (4)

201 - 220 of 264 works

2008

Journal Article

Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle

Schenk, Gerhard, Elliott, Tristan W., Leung, Eleanor, Carrington, Lyle E., Mitic, Natasa, Gahan, Lawrence R. and Guddat, Luke W. (2008). Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Structural Biology, 8 (6) 6, 1-13. doi: 10.1186/1472-6807-8-6

Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle

2008

Journal Article

Structural and spectroscopic studies of a model for catechol oxidase

Smith, Sarah J., Noble, Christopher J., Palmer, Randahl C., Hanson, Graeme R., Schenk, Gerhard, Gahan, Lawrence R. and Riley, Mark J. (2008). Structural and spectroscopic studies of a model for catechol oxidase. Journal of Biological Inorganic Chemistry, 13 (4), 499-510. doi: 10.1007/s00775-007-0334-7

Structural and spectroscopic studies of a model for catechol oxidase

2008

Conference Publication

Snapshots of the Structure and Function of Two Binuclear Metallohydrolases: The Proofreading 3'-5' Exonuclease Subunit of Escherichia coli DNA Polymerase III and the Purple Scid Phosphatase from Sweet Potato

Mitic, N., Noble, C. J., Dixon, N. E., Hanson, G. R. and Schenk, G. (2008). Snapshots of the Structure and Function of Two Binuclear Metallohydrolases: The Proofreading 3'-5' Exonuclease Subunit of Escherichia coli DNA Polymerase III and the Purple Scid Phosphatase from Sweet Potato. 6th Asia Pacific EPR/ESR Society Symposium, Cairns, Queensland, Australia, 13-18 July 2008.

Snapshots of the Structure and Function of Two Binuclear Metallohydrolases: The Proofreading 3'-5' Exonuclease Subunit of Escherichia coli DNA Polymerase III and the Purple Scid Phosphatase from Sweet Potato

2008

Conference Publication

Binuclear metallohydrolases: emerging bioremediators and drug targets

Schenk, G., Mitic, N., Gahan, L., Smith, S. and Hadler, K. (2008). Binuclear metallohydrolases: emerging bioremediators and drug targets. 9th European Biological Inorganic Chemistry Conference, Wroclaw, Poland, 2-6 Spetember 2008. Italy: Medimond.

Binuclear metallohydrolases: emerging bioremediators and drug targets

2008

Conference Publication

Electron paramagnetic resonance spectra of exchange coupled binuclear metalloenzymes and model complexes

Noble, Christopher J., Smith, S. J., Mitic, N., Schenk, G., Casselto, A. and Hanson, Graeme R. (2008). Electron paramagnetic resonance spectra of exchange coupled binuclear metalloenzymes and model complexes. 6th Asia Pacific EPR/ESR Symposium, Cairns, Australia, 13-18 July 2008. St Lucia, Australia: Asia Pacific EPR Society.

Electron paramagnetic resonance spectra of exchange coupled binuclear metalloenzymes and model complexes

2008

Journal Article

A structural and catalytic model for zinc phosphoesterases

Buchholz, Rebecca R., Etienne, Morgan E., Dorgelo, Anneke, Mirams, Ruth E., Smith, Sarah J., Chow, Shiao Yun, Hanton, Lyall R., Jameson, Geoffrey B., Schenk, Gerhard and Gahan, Lawrence R. (2008). A structural and catalytic model for zinc phosphoesterases. Dalton Transactions, 2008 (43), 6045-6054. doi: 10.1039/b806391e

A structural and catalytic model for zinc phosphoesterases

2008

Journal Article

Probing the role of the divalent metal ion in uteroferrin using metal ion replacement and a comparison to isostructural biomimetics

Schenk, Gerhard, Peralta, Rosely A., Batista, Suzana Cimara, Bortoluzzi, Adailton J., Szpoganicz, Bruno, Dick, Andrew K., Herrald, Paul, Hanson, Graeme R., Szilagyi, Robert K., Riley, Mark J., Gahan, Lawrence R. and Neves, Ademir (2008). Probing the role of the divalent metal ion in uteroferrin using metal ion replacement and a comparison to isostructural biomimetics. Journal of Biological Inorganic Chemistry, 13 (1), 139-155. doi: 10.1007/s00775-007-0305-z

Probing the role of the divalent metal ion in uteroferrin using metal ion replacement and a comparison to isostructural biomimetics

2008

Conference Publication

Spectroscopic and catalytic properties of uteroferrin and related model systems

Smith, S., Noble, C. J., Hanson, G. R., Riley, M., Schenk, G. and Gahan, L. R. (2008). Spectroscopic and catalytic properties of uteroferrin and related model systems. 6th Asia Pacific EPR/ESR Symposium, Cairns, Queensland, Australia, 13-18 July 2008.

Spectroscopic and catalytic properties of uteroferrin and related model systems

2008

Journal Article

Enzymatic bioremediation: Organophosphate degradation by binuclear metallo-hydrolases

Ely, F., Foo, J. L., Jackson, C. J., Gahan, L. R., Ollis, D. L. and Schenk, G. (2008). Enzymatic bioremediation: Organophosphate degradation by binuclear metallo-hydrolases. Current Topics in Biochemical Research, 2008 (9), 63-78.

Enzymatic bioremediation: Organophosphate degradation by binuclear metallo-hydrolases

2007

Journal Article

Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases

Boudalis, Athanassios K., Aston, Robyn E., Smith, Sarah J., Mirams, Ruth E., Riley, Mark J., Schenk, Gerhard, Blackman, Allan G., Hanton, Lyall R. and Gahan, Lawrence R. (2007). Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases. Dalton Transactions, 2007 (44), 5132-5139. doi: 10.1039/b709293h

Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand. A structural model for purple acid phosphatases

2007

Journal Article

The Reaction Mechanism of the Ga(III)Zn(II) Derivative of Uteroferrin and Corresponding Biomimetics

Smith, S. J., Casellato, A., Hadler, K. S., Mitic, N., Riley, M. J., Bortoluzzi, A. J., Szpoganicz, B., Schenk, G., Neves, A. and Gahan, L. R. (2007). The Reaction Mechanism of the Ga(III)Zn(II) Derivative of Uteroferrin and Corresponding Biomimetics. Journal of Biological Inorganic Chemistry, 12 (8), 1207-1220. doi: 10.1007/s00775-007-0286-y

The Reaction Mechanism of the Ga(III)Zn(II) Derivative of Uteroferrin and Corresponding Biomimetics

2007

Journal Article

Diesterase activity and substrate binding in purple acid phosphatases

Cox, R. S., Schenk, G., Mitic, N., Gahan, L. R. and Hengge, A. C. (2007). Diesterase activity and substrate binding in purple acid phosphatases. Journal of The American Chemical Society, 129 (31), 9550-9551. doi: 10.1021/ja072647q

Diesterase activity and substrate binding in purple acid phosphatases

2007

Journal Article

Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P - Implications for metal binding and protein stability

Liu, J. W., Hadler, K. S., Schenk, G. and Ollis, D. (2007). Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P - Implications for metal binding and protein stability. FEBS Journal, 274 (18), 4742-4751. doi: 10.1111/j.1742-4658.2007.06022.x

Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P - Implications for metal binding and protein stability

2007

Journal Article

Kinetic and Spectroscopic Studies of N694C Lipoxygenase: A Probe of the Substrate Activation Mechanism of a Nonheme Ferric Enzyme

Neidig, M., Wecksler, A., Schenk, G., Holman, T. and Solomon, E. (2007). Kinetic and Spectroscopic Studies of N694C Lipoxygenase: A Probe of the Substrate Activation Mechanism of a Nonheme Ferric Enzyme. Journal of the American Chemical Society, 129 (24), 7531-7537. doi: 10.1021/ja068503d

Kinetic and Spectroscopic Studies of N694C Lipoxygenase: A Probe of the Substrate Activation Mechanism of a Nonheme Ferric Enzyme

2007

Journal Article

An Unprecedented Fe-III(mu-OH)Zn-II Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases

Neves, A., Lanznaster, M., Bortoluzzi, A. J., Peralta, R. A., Casellato, A., Castellano, E. E., Herrald, P., Riley, M. J. and Schenk, G. (2007). An Unprecedented Fe-III(mu-OH)Zn-II Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases. Journal of The American Chemical Society, 129 (24), 7486-7487. doi: 10.1021/ja071184l

An Unprecedented Fe-III(mu-OH)Zn-II Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases

2007

Conference Publication

Magnetic circular dichroism study of a cobalt derivative of Enterobacter aerogenes GpdQ

Gahan, Lawrence R., Hadler, Kieran S., Larrabee, James A., Riley, Mark J. and Schenk, Gerhard (2007). Magnetic circular dichroism study of a cobalt derivative of Enterobacter aerogenes GpdQ. ICBIC13: 13th International Conference on Bio-Inorganic Chemistry, Vienna, Austria, 15-20 July, 2007. Berlin, Germany: Springer. doi: 10.1007/s00775-007-0256-4

Magnetic circular dichroism study of a cobalt derivative of Enterobacter aerogenes GpdQ

2007

Journal Article

Binuclear metallohydrases : emerging drug targets

Schenk, Gerhard (2007). Binuclear metallohydrases : emerging drug targets. Chemistry in Australia, 74 (8), 32-33.

Binuclear metallohydrases : emerging drug targets

2007

Conference Publication

Spectroscopic Studies into a series of biomimetic analogues for Red Kidney Bean Purple Acid Phosphatase

Dick, A., Gahan, L. R., Hanson, G., Krausz, E. R., Neves, A., Riley, M. J. and Schenk, G. (2007). Spectroscopic Studies into a series of biomimetic analogues for Red Kidney Bean Purple Acid Phosphatase. CPC2007: The 6th RACI Conference on Physical Chemistry, Adelaide, South Australia, 28 January - 2 February, 2007.

Spectroscopic Studies into a series of biomimetic analogues for Red Kidney Bean Purple Acid Phosphatase

2007

Conference Publication

Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand; a structural model for purple acid phosphatases

Aston, Robyn, Boudalis, Athanassios K., Gahan, Lawrence R., Riley, Mark J., Sanakis, Yiannis and Schenk, Gerhard (2007). Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand; a structural model for purple acid phosphatases. ICBIC13: 13th International Conference on Bio-Inorganic Chemistry, Vienna, Austria, 15-20 July, 2007. Berlin, Germany: Springer. doi: 10.1007/s00775-007-0258-2

Synthesis and characterization of the tetranuclear iron(III) complex of a new asymmetric multidentate ligand; a structural model for purple acid phosphatases

2007

Journal Article

Structure, function and diversity of plant purple acid phosphatases

Leung, Eleanor W. W., Teixeira, Marina, Guddat, Luke W., Mitić, Natasa and Schenk, Gerhard (2007). Structure, function and diversity of plant purple acid phosphatases. Current Topics in Plant Biology, 8, 21-31.

Structure, function and diversity of plant purple acid phosphatases

Current funding

  • 2024 - 2027
    Bio-based solutions for a sustainable agriculture
    Queensland-Germany Bioeconomy Collaborative Science Program
    Open grant
  • 2022 - 2025
    Light-driven biocatalytic cell factories
    ARC Discovery Projects
    Open grant
  • 2022 - 2024
    Dual-function ribonucleases: unexpected agents of antibiotic resistance
    NHMRC IDEAS Grants
    Open grant
  • 2021 - 2024
    EnzOnomy - an enzyme-based production pipeline for the bioeconomy
    ARC Discovery Projects
    Open grant
  • 2021 - 2025
    Cryo-EM inspired drug discovery to treat human fungal pathogenic infections
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2021 - 2022
    Better Catalysts
    CSIRO
    Open grant
  • 2021 - 2023
    Biocatalytic nanomachines
    Technical University of Munich
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Imaging in the nano-scale age: terahertz and millimetre wave microanalysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Ketol-acid reductoisomerase: An important antituberculosis drug target
    NHMRC Project Grant
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    An integrated approach to combat antibiotic resistance
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Harnessing the potential of metals in biocatalysis (ARC Discovery Project administered by the Australian National University)
    Australian National University
    Open grant
  • 2013 - 2014
    Extending frontiers of structural chemistry and biology through high resolution pulsed electron paramagnetic resonance (ARC LIEF Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2013 - 2017
    Metals in Biocatalysis: a Powerful Combination for the Chemistry of Life
    ARC Future Fellowships
    Open grant
  • 2012 - 2014
    Evolved enzymes and biomimetics for organophosphate degredation (ARC Discovery Project administered by the Australian National University)
    Australian National University
    Open grant
  • 2012
    Facilities for Integrated Bioinorganic and Materials Chemistry Research
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2011
    National Magnetochemical Facility (ARC LIEF administered by Monash University)
    ARC LIEF Collaborating/Partner Organisation Contributions
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    Metallo-beta-lactamases: predicting and combating antibiotic resistance.
    NHMRC Project Grant
    Open grant
  • 2009
    Metallo-beta-lactamases: designing drug leads to combat antibiotic resistance
    UQ External Support Enabling Grant
    Open grant
  • 2009 - 2011
    Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine (ARC Discovery Project award administered by ANU)
    Australian National University
    Open grant
  • 2009 - 2011
    Structure-based design of anti-osteoporotic drug leads: an integrated approach
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    A National Biomedical Electron Paramagnetic Resonance and Molecular Imaging Centre (ARC LIEF Administered by Monash University)
    Monash University
    Open grant
  • 2007 - 2009
    Isotope Effects as a Highly Sensitive Probe for the Study of Enzymatic Reaction Mechanisms
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2007
    XAS studies of the binuclear metalloenzyme purple acid phosphatase and their biomimetic models
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2006
    Australian Synchrotron Research Program: Visit to Photon Factor Japan 27-29 October 2006 (3 days)
    Australian Synchrotron Research Program
    Open grant
  • 2006
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for Access to the Australian National Beamline Facility, Photon Factory, Japan (12-14 May 2006)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2006 - 2008
    Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes
    Australian National University
    Open grant
  • 2005 - 2006
    XZS of FeIII-MeII binuclear complexes
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2005 - 2007
    An Integrated Approach Towards Development of Highly Specific Chemotherapeutics
    ARC Discovery Projects
    Open grant
  • 2004
    Unusual Coordination Chemistry Of Phosphate In A Novel Binuclear Metal Centre
    UQ Early Career Researcher
    Open grant
  • 2003 - 2004
    A unique coordination of phosphate in binuclear metal ion complexes
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Professor Gary Schenk is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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