Professor Gary Schenk
Professor

Gary Schenk

Email: 
Phone: 
+61 7 336 54144

Background

I obtained a Diploma in Chemistry from the University of Bern in Switzerland in 1992. Upon receiving the award of an International Postgraduate Research Scholarship (IPRS) I joined The University of Queensland (UQ) in 1993 to carry out research towards a PhD in Biochemistry(supervisors: Assoc. Profs. Peter Nixon and Ron Duggleby). I graduated in 1997 and continued postdoctoral research at UQ under the guidance of Profs John de Jersey, Susan Hamilton and Graeme Hanson. During this period, I was awarded Fellowships from both the Wellcome Trust and UQ. In 2000 I spent several months in the Department of Chemistry at the University of Newcastle-upon-Tyne, England, collaborating with Prof. Geoff Sykes, and later that year I commenced a Senior Postdoctoral Fellowship in the Chemistry Department at Stanford University (advisor: Prof. Edward Solomon). In 2003 I was appointed to a Lectureship in (Bio)Physical Chemistry at UQ. In 2006 I was promoted to Senior Lecturer. Following the award of a UQ Foundation Research Excellence Award (in 2007) I was promoted to Associate Professor (in 2008), and between 2011 and 2013 I was also on a fractional professorial appointment (50%) at Maynooth University, Ireland. From 2013 to 2017 I held a Future Fellowship from the Australian Research Council, and during this period I was promoted to Full Professor at UQ (2015). I also hold affiliate professorships in the Sustainable Minerals Institute and the Australian Institute for Bioengineering and Nanotechnology, both located at UQ.

I have successfully focused my research on the investigation of enzyme-catalysed reactions, their optimisation for applications in biotechnology and the synthesis of small molecules that mimic their structure and catalytic function (i.e. biomimetics). I advanced understanding of the contribution of metals to enzyme-catalysed reactions and employed state-of-the-art technologies (e.g. cryo-EM, ancestral gene reconstruction) to develop enzyme inhibitors as leads for novel biocides (herbicides, fungicides, antibacterial compounds) and engineer enzymes with enhanced catalytic properties for industrial applications in the advanced manufacturing sector (i.e. cell-free enzyme cascades, next-gen fertilisers). My work into enzyme mechanisms, regulation and engineering received international acclaim evidenced by invitations to provide plenary and keynote lectures and review articles in prestigious journals. I have published over 250 peer-reviewed articles, including over 40 papers in the ACS staple (J. Am. Chem. Soc, ACS Catalysis, ACS Sus. Chem. Eng., Inorg. Chem, Chem. Rev., Acc. Chem. Rev.) as well as landmark studies in Nature, Nature Catalysis, Nature Communications and Proc. Natl. Acad. Sci. (USA). For my leadership in enzymology I was awarded a Future Fellowship by the Australian Research Council, a Foundation Research Excellence Award by UQ and, most recently, the prestigious role as Ambassador for the Technical University of Munich (TUM), an honour bestowed upon me also for my leading role in building an extensive network of collaborations between UQ and TUM in the areas of bioengineering and bioeconomy. The network has since evolved into the Global Bioeconomy Alliance.

Availability

Professor Gary Schenk is:
Available for supervision

Fields of research

Biological Sciences Chemical Sciences Engineering Inorganic chemistry Medicinal and biomolecular chemistry Reaction engineering (excl. nuclear reactions)

Qualifications

  • Doctor of Philosophy, The University of Queensland

Research interests

  • Application of enzyme-driven processes in the bioeconomy

    I am interested in discovering and engineering enzymes for applications in biomanufacturing and bioremediation

Search Professor Gary Schenk’s works on UQ eSpace

264 works between 1996 and 2024
All (264) Journal Article (222) Book Chapter (5) Conference Publication (32) Book (1) Other Outputs (4)

241 - 260 of 264 works

2003

Conference Publication

Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre

Schenk, G., Carrington, L., Valizadeh, M., De Jersey, J., Hamilton, S. E. and Guddat, L.W. (2003). Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre. International Conference on Biological Inorganic Chemistry, Cairns, 19-23 July, 2003.

Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre

2003

Journal Article

Spectroscopic characterization of soybean lipoxygenase-1 mutants: the role of second coordination sphere residues in the regulation of enzyme activity

Schenk, Gerhard, Neidig, Michael L., Zhou, Jing, Holman, Theodore R. and Solomon, Edward I. (2003). Spectroscopic characterization of soybean lipoxygenase-1 mutants: the role of second coordination sphere residues in the regulation of enzyme activity. Biochemistry, 42 (24), 7294-7302. doi: 10.1021/bi027380g

Spectroscopic characterization of soybean lipoxygenase-1 mutants: the role of second coordination sphere residues in the regulation of enzyme activity

2002

Journal Article

Reactivity of M-II metal-substituted derivatives of pig purple acid phosphatase (Uteroferrin) with phosphate

Twitchett, M. B., Schenk, G., Aquino, M. A. S., Yiu, D. T. Y., Lau, T. C. and Sykes, A. G. (2002). Reactivity of M-II metal-substituted derivatives of pig purple acid phosphatase (Uteroferrin) with phosphate. Inorganic Chemistry, 41 (22), 5787-5794. doi: 10.1021/ic020037f

Reactivity of M-II metal-substituted derivatives of pig purple acid phosphatase (Uteroferrin) with phosphate

2001

Journal Article

A purple acid phosphatase from sweet potato contains an antiferromagnetically coupled binuclear Fe-Mn center

Schenk, Gerhard, Boutchard, Clare L., Carrington, Lyle E., Noble, Christopher J., Moubaraki, Boujemaa, Murray, Keith S., de Jersey, John, Hanson, Graeme R. and Hamilton, Susan (2001). A purple acid phosphatase from sweet potato contains an antiferromagnetically coupled binuclear Fe-Mn center. Journal of Biological Chemistry, 276 (22), 19084-19088. doi: 10.1074/jbc.M009778200

A purple acid phosphatase from sweet potato contains an antiferromagnetically coupled binuclear Fe-Mn center

2000

Journal Article

Structure, function and regulation of tartrate-resistant acid phosphatase

Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000). Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 (5), 575-584. doi: 10.1016/S8756-3282(00)00368-9

Structure, function and regulation of tartrate-resistant acid phosphatase

2000

Conference Publication

Modelling strain broadening in the EPR spectra of high spin FE(III) metalloproteins

Hanson, G. R., Schenk, G. and Noble, C. J. (2000). Modelling strain broadening in the EPR spectra of high spin FE(III) metalloproteins. 42nd Rocky Mountain Conference on Analytical Chemistry, Broomfield, Colorado, USA, 30 July - 3 August, 2000. USA: Milestone Presentations.

Modelling strain broadening in the EPR spectra of high spin FE(III) metalloproteins

2000

Journal Article

Identification of mammalian-like purple acid phosphatases in a wide range of plants

Schenk, G., Ge, Y., Guddat, L., Carrington, L. E., Hume, D. A., Hamilton, S. E. and deJersey, J. (2000). Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene, 250 (1-2), 117-125. doi: 10.1016/S0378-1119(00)00186-4

Identification of mammalian-like purple acid phosphatases in a wide range of plants

2000

Conference Publication

Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein

Schenk, G., Boutchard, C., Noble, C. J., Moubaraki, B., Murray, K. S., Hanson, G. R., De Jersey, J., Hamilton, S. E., Guddat, L. W. and Carrington, L. (2000). Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein. EUROBIC-5, Toulouse, France, 17-20 July 2000.

Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein

2000

Journal Article

Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes

Schenk, G., Korsinczky, M. L. J., Hume, D. A., Hamilton, S. E. and De Jersey, J. (2000). Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes. Gene, 255 (2), 419-424. doi: 10.1016/S0378-1119(00)00305-X

Purple acid phosphatases from bacteria: Structural similarities to mammalian and plant enzymes

2000

Conference Publication

The role of strain broadening in the EPR spectra of high spin Fe(III) metalloproteins

Noble, C. J., Hanson, G. R. and Schenk, G. (2000). The role of strain broadening in the EPR spectra of high spin Fe(III) metalloproteins. ANZMAG 2000, Mt Buller, Vic, 13-17 February 2000. Melbourne, Vic: ANZMAG.

The role of strain broadening in the EPR spectra of high spin Fe(III) metalloproteins

1999

Journal Article

Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato

Schenk, G., Carrington, L., Hamilton, S. E., De Jersey, J. and Guddat, L. W. (1999). Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato. Acta Crystallographica Section D: Biological Crystallography, 55 (12), 2051-2052. doi: 10.1107/S0907444999012597

Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato

1999

Conference Publication

Refinement of the EPR parameters from the high spin Fe(III) centre in sweet potato purple acid phsphatase - the influence of strain broadening

Hanson, G. R., Noble, C. J., Boutchard, C., Schenk, G., Hamilton, S. E. and De Jersey, J. (1999). Refinement of the EPR parameters from the high spin Fe(III) centre in sweet potato purple acid phsphatase - the influence of strain broadening. 2nd Asia-Pacific EPR/ESR Symposium Proceedings, Hangzhou, China, 31 October - 4 November 1999. China: Asia Pacific EPR/ESR Society.

Refinement of the EPR parameters from the high spin Fe(III) centre in sweet potato purple acid phsphatase - the influence of strain broadening

1999

Journal Article

Binuclear metal centres in plant purple acid phosphatase: Fe-Mn in sweet potato and Fe-Zn in soybean

Schenk, G., Ge, Y., Carrington, L., Wynne, C. J., Searle, I. R., Carroll, B. J., Hamilton, S. E. and De Jersey, J. (1999). Binuclear metal centres in plant purple acid phosphatase: Fe-Mn in sweet potato and Fe-Zn in soybean. Archives of Biochemistry and Biophysics, 370 (2), 183-189. doi: 10.1006/abbi.1999.1407

Binuclear metal centres in plant purple acid phosphatase: Fe-Mn in sweet potato and Fe-Zn in soybean

1999

Conference Publication

Sweet potato purple acid phosphatases: First example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre

Schenk, G., Carrington, L., Hanson, G. R., De Jersey, J. and Hamilton, S. E. (1999). Sweet potato purple acid phosphatases: First example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre. Specialist Meeting on Enzyme Structure and Mechanism, Kurong Resort, Fraser Island, 22-25 September, 1999. Brisbane: Univ. of Qld.

Sweet potato purple acid phosphatases: First example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre

1999

Conference Publication

Planrtpurple acid phosphatases: Novel forms of the enzyme

Schenk, G., Carrington, L., Guddat, L. W., De Jersey, J. and Hamilton, S. E. (1999). Planrtpurple acid phosphatases: Novel forms of the enzyme. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology.

Planrtpurple acid phosphatases: Novel forms of the enzyme

1999

Conference Publication

Refinement of the EPR parameters for the high spin FE(III) center in a sweet potato purple acid phosphatase - the influence of strain broadening

Hanson, G. R., Noble, C. J., Schenk, G., Hamilton, S. E., Boutchard, C. and De Jersey, J. (1999). Refinement of the EPR parameters for the high spin FE(III) center in a sweet potato purple acid phosphatase - the influence of strain broadening. 41st Rocky Mountain Conference on Analytical Chemistry, Denver, 1st - 5th August, 2000. Denver: American Chemical Society.

Refinement of the EPR parameters for the high spin FE(III) center in a sweet potato purple acid phosphatase - the influence of strain broadening

1998

Journal Article

Heterologous expression of human transketolase

Schenk, G, Duggleby, RG and Nixon, PF (1998). Heterologous expression of human transketolase. International Journal of Biochemistry and Cell Biology, 30 (3), 369-378. doi: 10.1016/S1357-2725(97)00154-4

Heterologous expression of human transketolase

1998

Journal Article

Properties and functions of the thiamin diphosphate dependent enzyme transketolase

Schenk, G, Duggleby, RG and Nixon, PF (1998). Properties and functions of the thiamin diphosphate dependent enzyme transketolase. International Journal of Biochemistry and Cell Biology, 30 (12), 1297-1318. doi: 10.1016/S1357-2725(98)00095-8

Properties and functions of the thiamin diphosphate dependent enzyme transketolase

1998

Conference Publication

Characterisation of the Binuclear Active Sites in Red Kidney Bean and Sweet Potato Purple Acid Phosphatase using Continuous Wave and Pulsed EPR Spectroscopy

Boutchard, C.L., Carrington, L., Schenk, G., Noble, C.J., Hanson, G.R., Hamilton, S.E., de Jersey, J. and Gahan, L.R. (1998). Characterisation of the Binuclear Active Sites in Red Kidney Bean and Sweet Potato Purple Acid Phosphatase using Continuous Wave and Pulsed EPR Spectroscopy. A joint 29th AMPERE — 13th ISMAR International Conference on Magnetic Resonance and Related Phenomena Revisited, Berlin, Germany, 2-7 August, 1998. Berlin, Germany: Springer Wien. doi: 10.1007/BF03162015

Characterisation of the Binuclear Active Sites in Red Kidney Bean and Sweet Potato Purple Acid Phosphatase using Continuous Wave and Pulsed EPR Spectroscopy

1997

Journal Article

The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis

Schenk, G, Leeper, FJ, England, R, Nixon, PF and Duggleby, RG (1997). The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis. European Journal of Biochemistry, 248 (1), 63-71. doi: 10.1111/j.1432-1033.1997.t01-1-00063.x

The role of His113 and His114 in pyruvate decarboxylase from Zymomonas mobilis

Current funding

  • 2022 - 2025
    Light-driven biocatalytic cell factories
    ARC Discovery Projects
    Open grant
  • 2022 - 2024
    Dual-function ribonucleases: unexpected agents of antibiotic resistance
    NHMRC IDEAS Grants
    Open grant
  • 2021 - 2025
    Cryo-EM inspired drug discovery to treat human fungal pathogenic infections
    NHMRC IDEAS Grants
    Open grant

Past funding

  • 2021 - 2024
    EnzOnomy - an enzyme-based production pipeline for the bioeconomy
    ARC Discovery Projects
    Open grant
  • 2021 - 2022
    Better Catalysts
    CSIRO
    Open grant
  • 2021 - 2023
    Biocatalytic nanomachines
    Technical University of Munich
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Imaging in the nano-scale age: terahertz and millimetre wave microanalysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2021
    Ketol-acid reductoisomerase: An important antituberculosis drug target
    NHMRC Project Grant
    Open grant
  • 2017 - 2018
    Centre for Geoanalytical Mass Spectrometry (CGMS) - Achieving excellence in isotope geochemistry and geochronology
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2016
    Next-generation multi-collector inductively-coupled plasma mass spectrometer (MC-ICP-MS) with laser-ablation capability for in situ high-throughput and high resolution isotope dating and characterizat
    UQ Major Research Facility Fund
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2018
    An integrated approach to combat antibiotic resistance
    NHMRC Project Grant
    Open grant
  • 2015 - 2017
    Harnessing the potential of metals in biocatalysis (ARC Discovery Project administered by the Australian National University)
    Australian National University
    Open grant
  • 2013 - 2014
    Extending frontiers of structural chemistry and biology through high resolution pulsed electron paramagnetic resonance (ARC LIEF Grant administered by the University of Melbourne)
    University of Melbourne
    Open grant
  • 2013 - 2017
    Metals in Biocatalysis: a Powerful Combination for the Chemistry of Life
    ARC Future Fellowships
    Open grant
  • 2012 - 2014
    Evolved enzymes and biomimetics for organophosphate degredation (ARC Discovery Project administered by the Australian National University)
    Australian National University
    Open grant
  • 2012
    Facilities for Integrated Bioinorganic and Materials Chemistry Research
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2011
    National Magnetochemical Facility (ARC LIEF administered by Monash University)
    ARC LIEF Collaborating/Partner Organisation Contributions
    Open grant
  • 2010
    An integrated high -throughput fluorescence imaging facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    Metallo-beta-lactamases: predicting and combating antibiotic resistance.
    NHMRC Project Grant
    Open grant
  • 2009
    Metallo-beta-lactamases: designing drug leads to combat antibiotic resistance
    UQ External Support Enabling Grant
    Open grant
  • 2009 - 2011
    Organophosphate pesticide degradation: evolved enzymes and biomimetics for bioremediation and medicine (ARC Discovery Project award administered by ANU)
    Australian National University
    Open grant
  • 2009 - 2011
    Structure-based design of anti-osteoporotic drug leads: an integrated approach
    ARC Discovery Projects
    Open grant
  • 2007 - 2008
    A National Biomedical Electron Paramagnetic Resonance and Molecular Imaging Centre (ARC LIEF Administered by Monash University)
    Monash University
    Open grant
  • 2007 - 2009
    Isotope Effects as a Highly Sensitive Probe for the Study of Enzymatic Reaction Mechanisms
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2007
    XAS studies of the binuclear metalloenzyme purple acid phosphatase and their biomimetic models
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2006
    Australian Synchrotron Research Program: Visit to Photon Factor Japan 27-29 October 2006 (3 days)
    Australian Synchrotron Research Program
    Open grant
  • 2006
    AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM: Support for Access to the Australian National Beamline Facility, Photon Factory, Japan (12-14 May 2006)
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2006 - 2008
    Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes
    Australian National University
    Open grant
  • 2005 - 2006
    XZS of FeIII-MeII binuclear complexes
    Australian Nuclear Science and Technology Organisation
    Open grant
  • 2005 - 2007
    An Integrated Approach Towards Development of Highly Specific Chemotherapeutics
    ARC Discovery Projects
    Open grant
  • 2004
    Unusual Coordination Chemistry Of Phosphate In A Novel Binuclear Metal Centre
    UQ Early Career Researcher
    Open grant
  • 2003 - 2004
    A unique coordination of phosphate in binuclear metal ion complexes
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Professor Gary Schenk is:
Available for supervision

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Supervision history

Current supervision

Completed supervision

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