Overview
Background
Critical Care Medicine focuses on supporting patients, often with one or multiple organ failures. Based at the largest Australian cardiac hospital, our research investigates better ways to support patients with heart and/or lung failure. We explore technological, pharmacological and engineering advances that could help our patients to live longer and better. Our group is world-renowned for clinically relevant large animal models, including heart failure, respiratory failure (ARDS), heart transplantation, sepsis, cardiogenic shock, and more. All our studies use hospital-grade equipment and follow the same clinical guideline to maximise translation. We actively take on honours, MPhil and PhD students from multi-disciplinary backgrounds (science, engineering, medicine, allied health), with a successful track record in supporting our students to secure their own grants and funding. Students are expected to contribute to other studies of the group. For more information about the group, please visit ccrg.org.au, and email if you are interested to join us.
Availability
- Associate Professor Jacky Suen is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Pharmacology, The University of Queensland
- Member, Extracorporeal Life Support Organization, Extracorporeal Life Support Organization
Works
Search Professor Jacky Suen’s works on UQ eSpace
2021
Journal Article
Extracorporeal membrane oxygenation-induced hemolysis: an in vitro study to appraise causative factors
Chan, Chris Hoi Houng, Ki, Katrina K., Zhang, Meili, Asnicar, Cooper, Cho, Hwajin, Ainola, Carmen, Bouquet, Mahe, Heinsar, Silver, Pauls, Jo Philipp, Li Bassi, Gianluigi, Suen, Jacky and Fraser, John F. (2021). Extracorporeal membrane oxygenation-induced hemolysis: an in vitro study to appraise causative factors. Membranes, 11 (5) 313, 313. doi: 10.3390/membranes11050313
2021
Journal Article
Studying the Endothelial Glycocalyx : What Is Missing?
Haymet, Andrew B., Bartnikowski, Nicole, Wood, Emily S., Vallely, Michael P., McBride, Angela, Yacoub, Sophie, Biering, Scott B., Harris, Eva, Suen, Jacky Y. and Fraser, John F. (2021). Studying the Endothelial Glycocalyx : What Is Missing?. Frontiers in Cardiovascular Medicine, 8 647086, 1-13. doi: 10.3389/fcvm.2021.647086
2021
Conference Publication
Donor heart preservation by hypothermic ex vivo perfusion - improved recipient survival and successful prolongation of ischemic time
Hoe, L. E. See, Wildi, K., Skeggs, K., Bouquet, M., Sato, K., Jung, J., Ainola, C., Hyslop, K., Heinsar, S., Abbate, G., Colombo, S. M., Passmore, M., Wood, E. S., Wells, M., Bartnikowski, N., O'Neill, H., Reid, J., Shuker, T., Haymet, A., Livingstone, S., Sato, N., Obonyo, N., James, L., He, T., McDonald, C., Mullins, D., Engkilde-Pedersen, S., Diab, S., Millar, J. E. ... Fraser, J. F. (2021). Donor heart preservation by hypothermic ex vivo perfusion - improved recipient survival and successful prolongation of ischemic time. ISHLT 41st Annual Meeting, Virtual, 24-28 April 2021. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2021.01.1864
2021
Journal Article
Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell lines
Morais, Christudas, Rajandram, Retnagowri, Blakeney, Jade S., Iyer, Abishek, Suen, Jacky Y., Johnson, David W., Gobe, Glenda C., Fairlie, David P. and Vesey, David A. (2021). Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell lines. PLoS One, 16 (3) e0248983, e0248983. doi: 10.1371/journal.pone.0248983
2021
Journal Article
Peritransplant cardio-metabolic and mitochondrial function: the missing piece in donor heart dysfunction and graft failure
Wells, Matthew A., See Hoe, Louise E., Heather, Lisa C., Molenaar, Peter, Suen, Jacky Y., Peart, Jason, McGiffin, David and Fraser, John F. (2021). Peritransplant cardio-metabolic and mitochondrial function: the missing piece in donor heart dysfunction and graft failure. Transplantation, 105 (3), 496-508. doi: 10.1097/tp.0000000000003368
2021
Journal Article
Correction to: the discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?
Wildi, Karin, Livingstone, Samantha, Palmieri, Chiara, LiBassi, Gianluigi, Suen, Jacky and Fraser, John (2021). Correction to: the discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?. Journal of Intensive Care, 9 (1) 22, 22. doi: 10.1186/s40560-021-00534-y
2021
Journal Article
Use of neuromuscular blocking agents in mechanically ventilated patients with COVID-19: a propensity score analysis
Li Bassi, Gianluigi, Gibbons, Kristen, Suen, Jacky Y., Dalton, Heidi J., White, Nicole, Corley, Amanda, Hinton, Samuel, Forsyth, Simon, Laffey, John G., Brodie, Daniel, Burrell, Aidan, Fan, Eddy, Bartlett, Robert, Torres, Antoni, Chiumello, Davide, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Ng, Pauline Yeung, Ogino, Mark, Panigada, Mauro, Pesenti, Antonio and Fraser, John F. (2021). Use of neuromuscular blocking agents in mechanically ventilated patients with COVID-19: a propensity score analysis. SSRN Electronic Journal. doi: 10.2139/ssrn.3773555
2021
Journal Article
Assessing potential for aortoiliac vascular injury from VA‐ECMO cannulae: an in vitro particle image velocimetry study
Haymet, A. B., Boone, A., Vallely, M. P., Malfertheiner, M. V., Pauls, J. P., Suen, J. Y. and Fraser, J. F. (2021). Assessing potential for aortoiliac vascular injury from VA‐ECMO cannulae: an in vitro particle image velocimetry study. Artificial Organs, 45 (2) aor.13807, E14-E25. doi: 10.1111/aor.13807
2021
Journal Article
PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR
Jiang, Yuhong, Lim, Junxian, Wu, Kai‐Chen, Xu, Weijun, Suen, Jacky Y. and Fairlie, David P. (2021). PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR. British Journal of Pharmacology, 178 (4) bph.15332, 913-932. doi: 10.1111/bph.15332
2021
Journal Article
The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?
Wildi, Karin, Livingstone, Samantha, Palmieri, Chiara, LiBassi, Gianluigi, Suen, Jacky and Fraser, John (2021). The discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?. Journal of Intensive Care, 9 (1) 14, 1-9. doi: 10.1186/s40560-021-00528-w
2021
Journal Article
Current understanding of leukocyte phenotypic and functional modulation during extracorporeal membrane oxygenation: a narrative review
Ki, Katrina K., Millar, Jonathan E., Langguth, Daman, Passmore, Margaret R., McDonald, Charles I., Shekar, Kiran, Shankar-Hari, Manu, Cho, Hwa Jin, Suen, Jacky Y. and Fraser, John F. (2021). Current understanding of leukocyte phenotypic and functional modulation during extracorporeal membrane oxygenation: a narrative review. Frontiers in Immunology, 11 600684, 600684. doi: 10.3389/fimmu.2020.600684
2021
Journal Article
The use of extracorporeal membrane oxygenation in children with acute fulminant myocarditis
Heinsar, Silver, Raman, Sainath, Suen, Jacky Y., Cho, Hwa Jin and Fraser, John F. (2021). The use of extracorporeal membrane oxygenation in children with acute fulminant myocarditis. Clinical and Experimental Pediatrics, 64 (5), 188-195. doi: 10.3345/cep.2020.00836
2020
Journal Article
Characterising pre-clinical sub-phenotypic models of Acute Respiratory Distress Syndrome: an experimental ovine study
Millar, Jonathan E., Wildi, Karin, Bartnikowski, Nicole, Bouquet, Mahe, Hyslop, Kieran, Passmore, Margaret R., Ki, Katrina K., See Hoe, Louise E., Obonyo, Nchafatso G., Neyton, Lucile, Pedersen, Sanne, Rozencwajg, Sacha, Baillie, J. Kenneth, Li Bassi, Gianluigi, Suen, Jacky Y, McAuley, Daniel F. and Fraser, John F. (2020). Characterising pre-clinical sub-phenotypic models of Acute Respiratory Distress Syndrome: an experimental ovine study.
2020
Journal Article
Design and rationale of the COVID-19 Critical Care Consortium international, multicentre, observational study
Bassi, Gianluigi Li, Suen, Jacky, Barnett, Adrian Gerard, Corley, Amanda, Millar, Jonathan, Fanning, Jonathon, Lye, India, Colombo, Sebastiano, Wildi, Karin, Livingstone, Samantha, Abbate, Gabriella, Hinton, Samuel, Liquet, Benoit, Shrapnel, Sally, Dalton, Heidi and Fraser, John F. (2020). Design and rationale of the COVID-19 Critical Care Consortium international, multicentre, observational study. BMJ Open, 10 (12) e041417, 1-6. doi: 10.1136/bmjopen-2020-041417
2020
Journal Article
The effect of hyperoxia on inflammation and platelet responses in an ex vivo extracorporeal membrane oxygenation circuit
Passmore, Margaret R., Ki, Katrina K., Chan, Chris H. H., Lee, Talvin, Bouquet, Mahé, Wood, Emily S., Raman, Sainath, Rozencwajg, Sacha, Burrell, Aidan J. C., McDonald, Charles I., Langguth, Daman, Shekar, Kiran, Malfertheiner, Maximilian V., Fraser, John F. and Suen, Jacky Y. (2020). The effect of hyperoxia on inflammation and platelet responses in an ex vivo extracorporeal membrane oxygenation circuit. Artificial Organs, 44 (12) aor.13771, 1276-1285. doi: 10.1111/aor.13771
2020
Journal Article
Heart transplantation from brain dead donors: a systematic review of animal models
See Hoe, Louise E., Wells, Matthew A., Bartnikowski, Nicole, Obonyo, Nchafatso G., Millar, Jonathan E., Khoo, Aimee, Ki, Katrina K., Shuker, Tristan, Ferraioli, Alessandro, Colombo, Sebastiano M., Chan, Wandy, McGiffin, David C., Suen, Jacky Y. and Fraser, John F. (2020). Heart transplantation from brain dead donors: a systematic review of animal models. Transplantation, 104 (11), 2272-2289. doi: 10.1097/tp.0000000000003217
2020
Journal Article
Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system
Walweel, K., Skeggs, K., Boon, A. C., See Hoe, L. E., Bouquet, M., Obonyo, N. G., Pedersen, S. E., Diab, S. D., Passmore, M. R., Hyslop, K., Wood, E. S., Reid, J., Colombo, S. M., Bartnikowski, N. J., Wells, M. A., Black, D., Pimenta, L. P., Stevenson, A. K., Bisht, K., Marshall, L., Prabhu, D. A., James, L., Platts, D. G., MacDonald, P. S., McGiffin, D. C., Suen, J. Y. and Fraser, J. F. (2020). Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system. Journal of Biomedical Science, 27 (1) 96, 96. doi: 10.1186/s12929-020-00690-7
2020
Journal Article
Reply to: MSC-derived exosomes: are they another therapeutic method for ECMO-supported ARDS?
Millar, Jonathan E, Suen, Jacky Y., McAuley, Daniel F., Fraser, John F. and on behalf of all authors of ‘Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome: A Controlled Experimental Study in Sheep.’ (2020). Reply to: MSC-derived exosomes: are they another therapeutic method for ECMO-supported ARDS?. American Journal of Respiratory and Critical Care Medicine, 202 (11) rccm.202007-2995LE, 1603-1604. doi: 10.1164/rccm.202007-2995le
2020
Journal Article
Acute Immune Response in Venoarterial and Venovenous Extracorporeal Membrane Oxygenation Models of Rats
Cho, Hwa-Jin, Kayumov, Mukhammad, Kim, Dowan, Lee, Kyoseon, Onyekachi, Francis Obiweluozor, Jeung, Kyung-Woon, Kim, Yongsook, Suen, Jacky Y., Fraser, John F. and Jeong, In-Seok (2020). Acute Immune Response in Venoarterial and Venovenous Extracorporeal Membrane Oxygenation Models of Rats. ASAIO Journal, 67 (5), 546-553. doi: 10.1097/MAT.0000000000001265
2020
Journal Article
Hypothermic ex vivo perfusion: protecting the donor heart and the recipient
See Hoe, Louise E., Suen, Jacky Y., Li Bassi, Gianluigi, McGiffin, David C. and Fraser, John F. (2020). Hypothermic ex vivo perfusion: protecting the donor heart and the recipient. ASAIO Journal, 66 (7), e99-e99. doi: 10.1097/MAT.0000000000001102
Funding
Current funding
Supervision
Availability
- Associate Professor Jacky Suen is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
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Sleep in the ICU
We are looking for a RHD student to be involved in a project investigating sleep in the ICU. The student will have access to formally collected sleep data under various ICU conditions and measured with various objective and subjective tools. The aim of the project includes validating new and innovative sleep measurement devices against the gold standard polysomnography, mapping sleep patterns and circadian rhythms of patients in ICU, and comparing sleep between different environmental conditions.
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Honours students for cardio-respiratory failure
We are looking for honours students to be involved in our range of studies on cardiac/respiratory failure. Projects include heart transplantation, acute respiratory failure, sepsis and advanced life support. Students will be expected and supported for grant application, as most of our previous honours students were awarded with $10,000 New Investigator Grant.
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Mitochondrial dysfunction and repair during circulatory death and heart transplantation
We are looking for Honours and RHD students to be involved in our NHMRC-funded heart transplantation program. Previously, we have successfully translated our research on extended organ preservation to clinical practice in Australia/New Zealand. As we explore on a new donor source, we are looking for talented students to join the team to study mitochondrial dysfunction, as a key parameter in determining post-transplant cardiac function.
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Systematic examination of ECMO parameters
Extra-Corporeal Membrane Oxygenation (ECMO) is an artificial heart/lung machine that is use to support patients with severe cardiac/respiratory failure. It has been invented for more than 30 years. To date, there is a lack of systematic examination of various parameters and settings for ECMO. Many of the current clinical practise are based on convention and tradition. This project aims to research and provide empirical evidences in order to optimise ECMO usage for patients, leading to improved patient outcome and reduced length of hospital stay. The project could involve bench-top ex vivo experiments, large animal in vivo study, and, perspective and retrospective analysis of clinical studies.
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Impact of blood flow for lung function
We are looking for Honours or RHD students to be involved in a project examining the impact of blood flow to support patients with respiratory failure. The student will be using human primary lung cells to model the condition of respiratory failure and advanced life support. The project will be in partnership with a leading biomed tech industry partner.
Supervision history
Current supervision
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Doctor Philosophy
An investigation of Veno-Arterial Extracorporeal Membrane Oxygenation (V-A ECMO) and its interaction with Continuous Renal Replacement Therapy (CRRT)
Principal Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Load-Independent Right Ventricular Assessment by Echocardiography
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Vascular Endothelial Injury, Repair and Preconditioning in the Artificial Circulation
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
The importance of blood flow pattern on ECMO and cardiogenic shock
Associate Advisor
Other advisors: Professor John Fraser
Completed supervision
-
2023
Doctor Philosophy
The differences in coagulation disturbances of the Acute Respiratory Distress Syndrome subphenotypes
Principal Advisor
Other advisors: Professor John Fraser
-
2024
Doctor Philosophy
Development of Speckle-Tracking Echocardiographic strain accounting for cardiac loading conditions
Associate Advisor
Other advisors: Professor John Fraser
-
2023
Doctor Philosophy
A Comprehensive Pre-Clinical Evaluation of Pulsatile Flow Veno-arterial Extracorporeal Membrane Oxygenation
Associate Advisor
Other advisors: Professor John Fraser
-
2023
Doctor Philosophy
The Significance of Different Phenotypes in Acute Respiratory Distress Syndrome (ARDS) for Effective Treatment
Associate Advisor
Other advisors: Professor John Fraser
-
2022
Master Philosophy
Pre-clinical model development of electrical impedance tomography in the assessment of the pulmonary distribution of nebulized solutions
Associate Advisor
Other advisors: Associate Professor Jayesh Dhanani, Dr Gianluigi Li Bassi, Professor John Fraser
-
2021
Doctor Philosophy
Combining Extracorporeal Life Support and Cell Therapy in Critical Illness: Mesenchymal stem cell therapy and extracorporeal membrane oxygenation in the Acute Respiratory Distress Syndrome
Associate Advisor
Other advisors: Professor John Fraser
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2019
Doctor Philosophy
A Translational Approach to Potential Toxicity of Stored Blood Components
Associate Advisor
Other advisors: Dr John-Paul Tung, Professor John Fraser
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2018
Doctor Philosophy
Modulating Protease-Activated Receptor 2
Associate Advisor
Other advisors: Dr Junxian Lim, Professor David Fairlie
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2014
Doctor Philosophy
Properties of C5a Receptor on Human Macrophages
Associate Advisor
Other advisors: Professor David Fairlie
Media
Enquiries
Contact Associate Professor Jacky Suen directly for media enquiries about:
- Critical Care Medicine
- ECMO
- Extracorporeal Membrane Oxygenation
- Heart Failure
- Heart transplant
- Respiratory Failure
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