Overview
Background
Critical Care Medicine focuses on supporting patients, often with one or multiple organ failures. Based at the largest Australian cardiac hospital, our research investigates better ways to support patients with heart and/or lung failure. We explore technological, pharmacological and engineering advances that could help our patients to live longer and better. Our group is world-renowned for clinically relevant large animal models, including heart failure, respiratory failure (ARDS), heart transplantation, sepsis, cardiogenic shock, and more. All our studies use hospital-grade equipment and follow the same clinical guideline to maximise translation. We actively take on honours, MPhil and PhD students from multi-disciplinary backgrounds (science, engineering, medicine, allied health), with a successful track record in supporting our students to secure their own grants and funding. Students are expected to contribute to other studies of the group. For more information about the group, please visit ccrg.org.au, and email if you are interested to join us.
Availability
- Dr Jacky Suen is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Pharmacology, The University of Queensland
- Member, Extracorporeal Life Support Organization, Extracorporeal Life Support Organization
Works
Search Professor Jacky Suen’s works on UQ eSpace
2021
Journal Article
Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: an experimental ovine study
Millar, Jonathan E., Wildi, Karin, Bartnikowski, Nicole, Bouquet, Mahe, Hyslop, Kieran, Passmore, Margaret R., Ki, Katrina K., See Hoe, Louise E., Obonyo, Nchafatso G., Neyton, Lucile, Pedersen, Sanne, Rozencwajg, Sacha, Baillie, J. Kenneth, Li Bassi, Gianluigi, Suen, Jacky Y., McAuley, Daniel F. and Fraser, John F. (2021). Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: an experimental ovine study. Physiological Reports, 9 (19) e15048, e15048. doi: 10.14814/phy2.15048
2021
Journal Article
Design and rationale of a prospective international follow-up study on intensive care survivors of COVID-19: The long-term impact in intensive care survivors of coronavirus disease-19-AFTERCOR
Wildi, Karin, Li Bassi, Gianluigi, Barnett, Adrian, Panigada, Mauro, Colombo, Sebastiano M., Bandera, Alessandra, Muscatello, Antonio, McNicholas, Bairbre, Laffey, John G., Battaglini, Denise, Robba, Chiara, Torres, Antoni, Motos, Ana, Luna, Carlos M., Rainieri, Fernando, Hodgson, Carol, Burrell, Aidan J. C., Buscher, Hergen, Dalton, Heidi, Cho, Sung-Min, Choi, Huimahn Alex, Thomson, David, Suen, Jacky and Fraser, John F. (2021). Design and rationale of a prospective international follow-up study on intensive care survivors of COVID-19: The long-term impact in intensive care survivors of coronavirus disease-19-AFTERCOR. Frontiers in Medicine, 8 738086, 738086. doi: 10.3389/fmed.2021.738086
2021
Conference Publication
Use of neuromuscular blocking agents in mechanically ventilated patients with COVID-19: A propensity score analysis
Bassi, Gianluigi Li, Gibbons, Kristen, Suen, Jacky, Dalton, Heidi, White, Nicole, Corley, Amanda, Hinton, Samuel, Forsyth, Simon, Laffey, John, Brodie, Daniel, Burrell, Aidan, Fan, Eddy, Bartlett, Robert, Torres, Antoni, Chiumello, Davide, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Ng, Pauline Yeung, Panigada, Mauro and Fraser, John (2021). Use of neuromuscular blocking agents in mechanically ventilated patients with COVID-19: A propensity score analysis. European-Respiratory-Society (ERS) International Congress, Thessaloniki Greece, Sep 26-30, 2021. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2021.OA1259
2021
Conference Publication
An appraisal of respiratory system compliance in mechanically ventilated COVID-19 patients
Li Bassi, Gianluigi, Suen, Jacky, Dalton, Heidi J., White, Nicole, Sato, Kei, Shrapnel, Sally, Fanning, Jonathon P., Liquet, Benoit, Hinton, Samuel, Vuorinem, Aapeli, Booth, Gareth, Millar, Jonathan E., Forsyth, Simon, Panigada, Mauro, Laffey, John, Brodie, Daniel, Fan, Eddy, Torres, Antoni, Chiumello, Davide, Corley, Amanda, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Yeung, Pauline, Ogino, Mark, Pesenti, Antonio ... Fraser, John F. (2021). An appraisal of respiratory system compliance in mechanically ventilated COVID-19 patients. European-Respiratory-Society (ERS) International Congress, Thessaloniki Greece, Sep 26-30, 2021. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2021.PA3318
2021
Journal Article
Anti-thrombogenic surface coatings for extracorporeal membrane oxygenation: a narrative review
Zhang, Meili, Pauls, Jo P., Bartnikowski, Nicole, Haymet, Andrew B., Chan, Chris H. H., Suen, Jacky Y., Schneider, Bailey, Ki, Katrina K., Whittaker, Andrew K., Dargusch, Matthew S. and Fraser, John F. (2021). Anti-thrombogenic surface coatings for extracorporeal membrane oxygenation: a narrative review. ACS Biomaterials Science and Engineering, 7 (9), 4402-4419. doi: 10.1021/acsbiomaterials.1c00758
2021
Journal Article
Coagulation dysfunction in acute respiratory distress syndrome and its potential impact in inflammatory subphenotypes
Livingstone, Samantha A., Wildi, Karin S., Dalton, Heidi J., Usman, Asad, Ki, Katrina K., Passmore, Margaret R., Li Bassi, Gianluigi, Suen, Jacky Y. and Fraser, John F. (2021). Coagulation dysfunction in acute respiratory distress syndrome and its potential impact in inflammatory subphenotypes. Frontiers in Medicine, 8 723217, 723217. doi: 10.3389/fmed.2021.723217
2021
Journal Article
Neurological manifestations of coronavirus disease 2019: a comprehensive review and meta-analysis of the first 6 months of pandemic reporting
Huth, Samuel F., Cho, Sung-Min, Robba, Chiara, Highton, David, Battaglini, Denise, Bellapart, Judith, Suen, Jacky Y., Li Bassi, Gianluigi, Taccone, Fabio Silvio, Arora, Rakesh C., Whitman, Glenn, Fraser, John F. and Fanning, Jonathon P. (2021). Neurological manifestations of coronavirus disease 2019: a comprehensive review and meta-analysis of the first 6 months of pandemic reporting. Frontiers in Neurology, 12 664599, 664599. doi: 10.3389/fneur.2021.664599
2021
Conference Publication
Neurological manifestations of coronavirus disease 2019: a comprehensive review
Fanning, Jonathon, Huth, Samuel, Cho, Sung-Min, Robba, Chiara, Highton, David, Battaglini, Denise, Bellapart-Rubio, Judith, Suen, Jacky, Bassi, Gianluigi Li, Taccone, Fabio, Arora, Rakesh, Whitman, Glenn and Fraser, John (2021). Neurological manifestations of coronavirus disease 2019: a comprehensive review. ANZAN Annual Scientific Meeting 2021, February 2021, 20-21 November 2021. London, United Kingdom: BMJ Group. doi: 10.1136/bmjno-2021-anzan.1
2021
Journal Article
Ischemic and hemorrhagic stroke among critically ill patients with coronavirus disease 2019: an International Multicenter Coronavirus Disease 2019 Critical Care Consortium study
Cho, Sung-Min, Premraj, Lavienraj, Fanning, Jonathon, Huth, Samuel, Barnett, Adrian, Whitman, Glenn, Arora, Rakesh C., Battaglini, Denise, Porto, Diego Bastos, Choi, HuiMahn, Suen, Jacky, Bassi, Gianluigi Li, Fraser, John F., Robba, Chiara and Griffee, Matthew (2021). Ischemic and hemorrhagic stroke among critically ill patients with coronavirus disease 2019: an International Multicenter Coronavirus Disease 2019 Critical Care Consortium study. Critical Care Medicine, 49 (12), E1223-E1233. doi: 10.1097/CCM.0000000000005209
2021
Journal Article
Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death
Wells, Matthew A., See Hoe, Louise E., Molenaar, Peter, Pedersen, Sanne, Obonyo, Nchafatso G., McDonald, Charles I., Mo, Weilan, Bouquet, Mahè, Hyslop, Kieran, Passmore, Margaret R., Bartnikowski, Nicole, Suen, Jacky Y., Peart, Jason N., McGiffin, David C., Fraser, John F. and on behalf of the Dead Heart Project (2021). Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death. Pharmacological Research, 169 105631, 1-12. doi: 10.1016/j.phrs.2021.105631
2021
Journal Article
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
ISARIC Clinical Characterisation Group, Li Bassi, Gianluigi, Scarsbrook, Joshua, Shrapnel, Sally, Suen, Jacky and Forsyth, Simon J. (2021). COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. Infection, 49 (5), 889-905. doi: 10.1007/s15010-021-01599-5
2021
Journal Article
Ethical factors determining ECMO allocation during the COVID-19 pandemic
Dao, Bernadine, Savulescu, Julian, Suen, Jacky Y., Fraser, John F. and Wilkinson, Dominic J. C. (2021). Ethical factors determining ECMO allocation during the COVID-19 pandemic. BMC Medical Ethics, 22 (1) 70, 1-12. doi: 10.1186/s12910-021-00638-y
2021
Conference Publication
Validation of an ovine model of biological ARDS subphenotypes by reproducing mRNA expression profiles
Wildi, K., Hyslop, K., Livingstone, S., Ainola, C., Heinsar, S., Sato, K., Sato, N., Abbate, G., Bouquet, M., Passmore, M., Wilson, E., LiBassi, G., Suen, J. and Fraser, J. (2021). Validation of an ovine model of biological ARDS subphenotypes by reproducing mRNA expression profiles. American Thoracic Society 2021 International Conference, Virtual, 14-19 May 2021. New York, United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a2698
2021
Journal Article
Extracorporeal membrane oxygenation-induced hemolysis: an in vitro study to appraise causative factors
Chan, Chris Hoi Houng, Ki, Katrina K., Zhang, Meili, Asnicar, Cooper, Cho, Hwajin, Ainola, Carmen, Bouquet, Mahe, Heinsar, Silver, Pauls, Jo Philipp, Li Bassi, Gianluigi, Suen, Jacky and Fraser, John F. (2021). Extracorporeal membrane oxygenation-induced hemolysis: an in vitro study to appraise causative factors. Membranes, 11 (5) 313, 313. doi: 10.3390/membranes11050313
2021
Journal Article
Studying the Endothelial Glycocalyx : What Is Missing?
Haymet, Andrew B., Bartnikowski, Nicole, Wood, Emily S., Vallely, Michael P., McBride, Angela, Yacoub, Sophie, Biering, Scott B., Harris, Eva, Suen, Jacky Y. and Fraser, John F. (2021). Studying the Endothelial Glycocalyx : What Is Missing?. Frontiers in Cardiovascular Medicine, 8 647086, 1-13. doi: 10.3389/fcvm.2021.647086
2021
Conference Publication
Donor heart preservation by hypothermic ex vivo perfusion - improved recipient survival and successful prolongation of ischemic time
Hoe, L. E. See, Wildi, K., Skeggs, K., Bouquet, M., Sato, K., Jung, J., Ainola, C., Hyslop, K., Heinsar, S., Abbate, G., Colombo, S. M., Passmore, M., Wood, E. S., Wells, M., Bartnikowski, N., O'Neill, H., Reid, J., Shuker, T., Haymet, A., Livingstone, S., Sato, N., Obonyo, N., James, L., He, T., McDonald, C., Mullins, D., Engkilde-Pedersen, S., Diab, S., Millar, J. E. ... Fraser, J. F. (2021). Donor heart preservation by hypothermic ex vivo perfusion - improved recipient survival and successful prolongation of ischemic time. ISHLT 41st Annual Meeting, Virtual, 24-28 April 2021. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2021.01.1864
2021
Journal Article
Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell lines
Morais, Christudas, Rajandram, Retnagowri, Blakeney, Jade S., Iyer, Abishek, Suen, Jacky Y., Johnson, David W., Gobe, Glenda C., Fairlie, David P. and Vesey, David A. (2021). Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell lines. PLoS One, 16 (3) e0248983, e0248983. doi: 10.1371/journal.pone.0248983
2021
Journal Article
Peritransplant cardio-metabolic and mitochondrial function: the missing piece in donor heart dysfunction and graft failure
Wells, Matthew A., See Hoe, Louise E., Heather, Lisa C., Molenaar, Peter, Suen, Jacky Y., Peart, Jason, McGiffin, David and Fraser, John F. (2021). Peritransplant cardio-metabolic and mitochondrial function: the missing piece in donor heart dysfunction and graft failure. Transplantation, 105 (3), 496-508. doi: 10.1097/tp.0000000000003368
2021
Journal Article
Correction to: the discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?
Wildi, Karin, Livingstone, Samantha, Palmieri, Chiara, LiBassi, Gianluigi, Suen, Jacky and Fraser, John (2021). Correction to: the discovery of biological subphenotypes in ARDS: a novel approach to targeted medicine?. Journal of Intensive Care, 9 (1) 22, 22. doi: 10.1186/s40560-021-00534-y
2021
Journal Article
Use of neuromuscular blocking agents in mechanically ventilated patients with COVID-19: a propensity score analysis
Li Bassi, Gianluigi, Gibbons, Kristen, Suen, Jacky Y., Dalton, Heidi J., White, Nicole, Corley, Amanda, Hinton, Samuel, Forsyth, Simon, Laffey, John G., Brodie, Daniel, Burrell, Aidan, Fan, Eddy, Bartlett, Robert, Torres, Antoni, Chiumello, Davide, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Ng, Pauline Yeung, Ogino, Mark, Panigada, Mauro, Pesenti, Antonio and Fraser, John F. (2021). Use of neuromuscular blocking agents in mechanically ventilated patients with COVID-19: a propensity score analysis. SSRN Electronic Journal. doi: 10.2139/ssrn.3773555
Funding
Current funding
Supervision
Availability
- Dr Jacky Suen is:
- Available for supervision
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Available projects
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Sleep in the ICU
We are looking for a RHD student to be involved in a project investigating sleep in the ICU. The student will have access to formally collected sleep data under various ICU conditions and measured with various objective and subjective tools. The aim of the project includes validating new and innovative sleep measurement devices against the gold standard polysomnography, mapping sleep patterns and circadian rhythms of patients in ICU, and comparing sleep between different environmental conditions.
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Honours students for cardio-respiratory failure
We are looking for honours students to be involved in our range of studies on cardiac/respiratory failure. Projects include heart transplantation, acute respiratory failure, sepsis and advanced life support. Students will be expected and supported for grant application, as most of our previous honours students were awarded with $10,000 New Investigator Grant.
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Mitochondrial dysfunction and repair during circulatory death and heart transplantation
We are looking for Honours and RHD students to be involved in our NHMRC-funded heart transplantation program. Previously, we have successfully translated our research on extended organ preservation to clinical practice in Australia/New Zealand. As we explore on a new donor source, we are looking for talented students to join the team to study mitochondrial dysfunction, as a key parameter in determining post-transplant cardiac function.
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Systematic examination of ECMO parameters
Extra-Corporeal Membrane Oxygenation (ECMO) is an artificial heart/lung machine that is use to support patients with severe cardiac/respiratory failure. It has been invented for more than 30 years. To date, there is a lack of systematic examination of various parameters and settings for ECMO. Many of the current clinical practise are based on convention and tradition. This project aims to research and provide empirical evidences in order to optimise ECMO usage for patients, leading to improved patient outcome and reduced length of hospital stay. The project could involve bench-top ex vivo experiments, large animal in vivo study, and, perspective and retrospective analysis of clinical studies.
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Impact of blood flow for lung function
We are looking for Honours or RHD students to be involved in a project examining the impact of blood flow to support patients with respiratory failure. The student will be using human primary lung cells to model the condition of respiratory failure and advanced life support. The project will be in partnership with a leading biomed tech industry partner.
Supervision history
Current supervision
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Doctor Philosophy
The importance of blood flow pattern on ECMO and cardiogenic shock
Associate Advisor
Other advisors: Professor John Fraser
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Doctor Philosophy
Vascular Endothelial Injury, Repair and Preconditioning in the Artificial Circulation
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Load-Independent Right Ventricular Assessment by Echocardiography
Associate Advisor
Other advisors: Professor John Fraser
Completed supervision
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2023
Doctor Philosophy
The differences in coagulation disturbances of the Acute Respiratory Distress Syndrome subphenotypes
Principal Advisor
Other advisors: Professor John Fraser
-
2024
Doctor Philosophy
Development of Speckle-Tracking Echocardiographic strain accounting for cardiac loading conditions
Associate Advisor
Other advisors: Professor John Fraser
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2023
Doctor Philosophy
A Comprehensive Pre-Clinical Evaluation of Pulsatile Flow Veno-arterial Extracorporeal Membrane Oxygenation
Associate Advisor
Other advisors: Professor John Fraser
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2023
Doctor Philosophy
The Significance of Different Phenotypes in Acute Respiratory Distress Syndrome (ARDS) for Effective Treatment
Associate Advisor
Other advisors: Professor John Fraser
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2022
Master Philosophy
Pre-clinical model development of electrical impedance tomography in the assessment of the pulmonary distribution of nebulized solutions
Associate Advisor
Other advisors: Associate Professor Jayesh Dhanani, Dr Gianluigi Li Bassi, Professor John Fraser
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2021
Doctor Philosophy
Combining Extracorporeal Life Support and Cell Therapy in Critical Illness: Mesenchymal stem cell therapy and extracorporeal membrane oxygenation in the Acute Respiratory Distress Syndrome
Associate Advisor
Other advisors: Professor John Fraser
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2019
Doctor Philosophy
A Translational Approach to Potential Toxicity of Stored Blood Components
Associate Advisor
Other advisors: Dr John-Paul Tung, Professor John Fraser
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2018
Doctor Philosophy
Modulating Protease-Activated Receptor 2
Associate Advisor
Other advisors: Dr Junxian Lim, Professor David Fairlie
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2014
Doctor Philosophy
Properties of C5a Receptor on Human Macrophages
Associate Advisor
Other advisors: Professor David Fairlie
Media
Enquiries
Contact Dr Jacky Suen directly for media enquiries about:
- Critical Care Medicine
- ECMO
- Extracorporeal Membrane Oxygenation
- Heart Failure
- Heart transplant
- Respiratory Failure
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