Overview
Background
Critical Care Medicine focuses on supporting patients, often with one or multiple organ failures. Based at the largest Australian cardiac hospital, our research investigates better ways to support patients with heart and/or lung failure. We explore technological, pharmacological and engineering advances that could help our patients to live longer and better. Our group is world-renowned for clinically relevant large animal models, including heart failure, respiratory failure (ARDS), heart transplantation, sepsis, cardiogenic shock, and more. All our studies use hospital-grade equipment and follow the same clinical guideline to maximise translation. We actively take on honours, MPhil and PhD students from multi-disciplinary backgrounds (science, engineering, medicine, allied health), with a successful track record in supporting our students to secure their own grants and funding. Students are expected to contribute to other studies of the group. For more information about the group, please visit ccrg.org.au, and email if you are interested to join us.
Availability
- Dr Jacky Suen is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Pharmacology, The University of Queensland
- Member, Extracorporeal Life Support Organization, Extracorporeal Life Support Organization
Works
Search Professor Jacky Suen’s works on UQ eSpace
2016
Journal Article
Potent small agonists of protease activated receptor 2
Yau, Mei-Kwan, Suen, Jacky Y., Xu, Weijun, Lim, Junxian, Liu, Ligong, Adams, Mark N., He, Yaowu, Hooper, John D., Reid, Robert C. and Fairlie, David P. (2016). Potent small agonists of protease activated receptor 2. ACS Medicinal Chemistry Letters, 7 (1), 105-110. doi: 10.1021/acsmedchemlett.5b00429
2016
Journal Article
PAR2 modulators derived from GB88
Yau, Mei-Kwan, Liu, Ligong, Suen, Jacky Y., Lim, Junxian, Lohman, Rink-Jan, Jiang, Yuhong, Cotterell, Adam J., Barry, Grant D., Mak, Jeffrey Y. W., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). PAR2 modulators derived from GB88. ACS Medicinal Chemistry Letters, 7 (12), 1179-1184. doi: 10.1021/acsmedchemlett.6b00306
2016
Conference Publication
Protease activated-receptor-2 induced inflammation and fibrosis is mediated in part through activation of transforming growth factor-beta signalling
Owens, E., Iyer, A., Morais, C., Lohman, R., Suen, J., Johnson, D., Nikolic-Paterson, D., Gobe, G., Fairlie, D. and Vesey, D. (2016). Protease activated-receptor-2 induced inflammation and fibrosis is mediated in part through activation of transforming growth factor-beta signalling. The 15th Asian Pacific Congress of Nephrology (APCN) and 52nd ANZSN ASM, Perth Western Australia, 17–21 September 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12887
2015
Journal Article
Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships
Singh, Ranee, Reed, Anthony N., Chu, Peifei, Scully, Conor C. G., Yau, Mei-Kwan, Suen, Jacky Y., Durek, Thomas, Reid, Robert C. and Fairlie, David P. (2015). Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships. Bioorganic and Medicinal Chemistry Letters, 25 (23), 5604-5608. doi: 10.1016/j.bmcl.2015.10.038
2015
Journal Article
Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2
Xu, Weijun, Lim, Junxian, Goh, Chai-Yeen, Suen, Jacky Y., Jiang, Yuhong, Yau, Mei-Kwan, Wu, Kai-Chen, Liu, Ligong and Fairlie, David P. (2015). Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2. Journal of Chemical Information and Modeling, 55 (10), 2079-2084. doi: 10.1021/acs.jcim.5b00500
2015
Conference Publication
Potent small agonists of protease activated receptor 2
Yau, Mei Kwan, Suen, Jacky, Xu, Weijun, Lim, Junxian, Liu, Ligong, Adams, Mark, He, Yaowu, Hooper, John, Reid, Robert and Fairlie, David (2015). Potent small agonists of protease activated receptor 2. WASHINGTON: AMER CHEMICAL SOC.
2015
Journal Article
Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists
Hoang, Huy N., Song, Kun, Hill, Timothy A., Derksen, David R., Edmonds, David J., Kok, W. Mei, Limberakis, Chris, Liras, Spiros, Loria, Paula M., Mascitti, Vincent, Mathiowetz, Alan M., Mitchell, Justin M., Piotrowski, David W., Price, David A., Stanton, Robert V., Suen, Jacky Y., Withka, Jane M., Griffith, David A. and Fairlie, David P. (2015). Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists. Journal of Medicinal Chemistry, 58 (9), 4080-4085. doi: 10.1021/acs.jmedchem.5b00166
2015
Conference Publication
Downsizing Proteins Without Losing Potency or Function
Fairlie, David P. , Yau, Mei-Kwan , Hamidon, Johan K. , Singh, Ranee , Lim, Junxian , Suen, Jacky Y. , Rowley, Jessica A. , Lohman, Rink-Jan , Stoermer, Martin J. , Iyer, Abishek and Reid, Robert C. (2015). Downsizing Proteins Without Losing Potency or Function. American Peptide Symposium 2015, Orlando , Florida, United States, 20-25 June 2015. American Peptide Society. doi: 10.17952/24APS.2015.016
2014
Journal Article
Pathway-selective antagonism of proteinase activated receptor 2
Suen, J. Y., Cotterell, A., Lohman, R. J., Lim, J., Han, A., Yau, M. K., Liu, L., Cooper, M. A., Vesey, D. A. and Fairlie, D. P. (2014). Pathway-selective antagonism of proteinase activated receptor 2. British Journal of Pharmacology, 171 (17), 4112-4124. doi: 10.1111/bph.12757
2014
Journal Article
Biased signalling and proteinase-activated receptors (PARs): Targeting inflammatory disease
Hollenberg, M. D., Mihara, K., Polley, D., Suen, J. Y., Han, A., Fairlie, D. P. and Ramachandran, R. (2014). Biased signalling and proteinase-activated receptors (PARs): Targeting inflammatory disease. British Journal of Pharmacology, 171 (5), 1180-1194. doi: 10.1111/bph.12544
2013
Journal Article
Downsizing a human inflammatory protein to a small molecule with equal potency and functionality
Reid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Reed, Anthony N., Chu, Peifei, Suen, Jacky Y., Stoermer, Martin J., Blakeney, Jade S., Lim, Junxian, Faber, Jonathan M. and David P. Fairlie, (2013). Downsizing a human inflammatory protein to a small molecule with equal potency and functionality. Nature Communications, 4 (2802) 2802, 1-9. doi: 10.1038/ncomms3802
2013
Journal Article
Inflammatory Responses Induced by Lipopolysaccharide Are Amplified in Primary Human Monocytes but Suppressed in Macrophages by Complement Protein C5a
Seow, Vernon, Lim, Junxian, Iyer, Abishek, Suen, Jacky Y., Ariffin, Juliana K., Hohenhaus, Daniel M., Sweet, Matthew J. and Fairlie, David P. (2013). Inflammatory Responses Induced by Lipopolysaccharide Are Amplified in Primary Human Monocytes but Suppressed in Macrophages by Complement Protein C5a. Journal of Immunology, 191 (8), 4308-4316. doi: 10.4049/jimmunol.1301355
2013
Journal Article
Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism
Lim, Junxian, Iyer, Abishek, Liu, Ligong, Suen, Jacky Y., Lohman, Rink-Jan, Seow, Vernon, Yau, Mei-Kwan, Brown, Lindsay and Fairlie, David P. (2013). Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism. The FASEB Journal, 27 (12), 4757-4767. doi: 10.1096/fj.13-232702
2013
Journal Article
PAR2-induced inflammatory responses in human kidney tubular epithelial cells
Vesey, David A., Suen, Jacky Y., Seow, Vernon, Lohman, Rink-Jan, Liu, Ligong, Gobe, Glenda C., Johnson, David W. and Fairlie, David P. (2013). PAR2-induced inflammatory responses in human kidney tubular epithelial cells. American Journal of Physiology - Renal Physiology, 304 (6), F737-F750. doi: 10.1152/ajprenal.00540.2012
2013
Journal Article
C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling
Liu, Junxian, Iyer, Abishek, Suen, Jacky Y., Seow, Vernon, Reid, Robert C., Brown, Lindsay and Fairlie, David P. (2013). C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling. The FASEB Journal, 27 (2), 822-831. doi: 10.1096/fj.12-220582
2012
Journal Article
An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats
Iyer, Abishek, Lim, Junxian, Poudyal, Hemant, Reid, Robert C., Suen, Jacky Y., Webster, Julie, Prins, Johannes B., Whitehead, Jonathan P., Fairlie, David P. and Brown, Lindsay (2012). An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats. Diabetes, 61 (9), 2320-2329. doi: 10.2337/db11-1179
2012
Journal Article
A comparative study of impedance versus optical label-free systems relative to labelled assays in a predominantly Gi coupled GPCR (C5aR) signalling
Halai, Reena, Croker, Daniel E., Suen, Jacky Y., Fairlie, David P. and Cooper, Matthew A. (2012). A comparative study of impedance versus optical label-free systems relative to labelled assays in a predominantly Gi coupled GPCR (C5aR) signalling. Biosensors, 2 (3), 273-290. doi: 10.3390/bios2030273
2012
Journal Article
An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats
Lohman, Rink-Jan, Cotterell, Adam J., Barry, Grant D., Liu, Ligong, Suen, Jacky Y., Vesey, David A. and Fairlie, David P. (2012). An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. The FASEB Journal, 26 (7), 2877-2887. doi: 10.1096/fj.11-201004
2012
Journal Article
Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)
Suen, J. Y., Barry, G. D., Lohman, R. J., Halili, M. A., Cotterell, A. J., Le, G. T. and Fairlie, D. P. (2012). Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). British Journal of Pharmacology, 165 (5), 1413-1423. doi: 10.1111/j.1476-5381.2011.01610.x
2012
Journal Article
Antagonism of protease-activated receptor 2 protects against experimental colitis.
Lohman, Rink-Jan, Cotterell, Adam J., Suen, Jacky, Liu, Ligong, Do, Anh T., Vesey, David A. and Fairlie, David P. (2012). Antagonism of protease-activated receptor 2 protects against experimental colitis.. Journal of Pharmacology and Experimental Therapeutics, 340 (2), 256-265. doi: 10.1124/jpet.111.187062
Funding
Current funding
Past funding
Supervision
Availability
- Dr Jacky Suen is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Honours students for cardio-respiratory failure
We are looking for honours students to be involved in our range of studies on cardiac/respiratory failure. Projects include heart transplantation, acute respiratory failure, sepsis and advanced life support. Students will be expected and supported for grant application, as most of our previous honours students were awarded with $10,000 New Investigator Grant.
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Mitochondrial dysfunction and repair during circulatory death and heart transplantation
We are looking for Honours and RHD students to be involved in our NHMRC-funded heart transplantation program. Previously, we have successfully translated our research on extended organ preservation to clinical practice in Australia/New Zealand. As we explore on a new donor source, we are looking for talented students to join the team to study mitochondrial dysfunction, as a key parameter in determining post-transplant cardiac function.
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Systematic examination of ECMO parameters
Extra-Corporeal Membrane Oxygenation (ECMO) is an artificial heart/lung machine that is use to support patients with severe cardiac/respiratory failure. It has been invented for more than 30 years. To date, there is a lack of systematic examination of various parameters and settings for ECMO. Many of the current clinical practise are based on convention and tradition. This project aims to research and provide empirical evidences in order to optimise ECMO usage for patients, leading to improved patient outcome and reduced length of hospital stay. The project could involve bench-top ex vivo experiments, large animal in vivo study, and, perspective and retrospective analysis of clinical studies.
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Impact of blood flow for lung function
We are looking for Honours or RHD students to be involved in a project examining the impact of blood flow to support patients with respiratory failure. The student will be using human primary lung cells to model the condition of respiratory failure and advanced life support. The project will be in partnership with a leading biomed tech industry partner.
Supervision history
Current supervision
-
Doctor Philosophy
Novel Right Heart Assessment by Speckle Tracking Echocardiography
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Load-Independent Right Ventricular Assessment by Echocardiography
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Vascular Endothelial Injury, Repair and Preconditioning in the Artificial Circulation
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Vascular Endothelial Injury, Repair and Preconditioning in the Artificial Circulation
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Development of Speckle-Tracking Echocardiographic strain accounting for cardiac loading conditions
Associate Advisor
Other advisors: Professor John Fraser
Completed supervision
-
2023
Doctor Philosophy
The differences in coagulation disturbances of the Acute Respiratory Distress Syndrome subphenotypes
Principal Advisor
Other advisors: Professor John Fraser
-
2024
Doctor Philosophy
Development of Speckle-Tracking Echocardiographic strain accounting for cardiac loading conditions
Associate Advisor
Other advisors: Professor John Fraser
-
2023
Doctor Philosophy
A Comprehensive Pre-Clinical Evaluation of Pulsatile Flow Veno-arterial Extracorporeal Membrane Oxygenation
Associate Advisor
Other advisors: Professor John Fraser
-
2023
Doctor Philosophy
The Significance of Different Phenotypes in Acute Respiratory Distress Syndrome (ARDS) for Effective Treatment
Associate Advisor
Other advisors: Professor John Fraser
-
2022
Master Philosophy
Pre-clinical model development of electrical impedance tomography in the assessment of the pulmonary distribution of nebulized solutions
Associate Advisor
Other advisors: Associate Professor Jayesh Dhanani, Dr Gianluigi Li Bassi, Professor John Fraser
-
2021
Doctor Philosophy
Combining Extracorporeal Life Support and Cell Therapy in Critical Illness: Mesenchymal stem cell therapy and extracorporeal membrane oxygenation in the Acute Respiratory Distress Syndrome
Associate Advisor
Other advisors: Professor John Fraser
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2019
Doctor Philosophy
A Translational Approach to Potential Toxicity of Stored Blood Components
Associate Advisor
Other advisors: Professor John Fraser
-
2018
Doctor Philosophy
Modulating Protease-Activated Receptor 2
Associate Advisor
Other advisors: Dr Junxian Lim, Professor David Fairlie
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2014
Doctor Philosophy
Properties of C5a Receptor on Human Macrophages
Associate Advisor
Other advisors: Professor David Fairlie
Media
Enquiries
Contact Dr Jacky Suen directly for media enquiries about:
- Critical Care Medicine
- ECMO
- Extracorporeal Membrane Oxygenation
- Heart Failure
- Heart transplant
- Respiratory Failure
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