Overview
Background
Critical Care Medicine focuses on supporting patients, often with one or multiple organ failures. Based at the largest Australian cardiac hospital, our research investigates better ways to support patients with heart and/or lung failure. We explore technological, pharmacological and engineering advances that could help our patients to live longer and better. Our group is world-renowned for clinically relevant large animal models, including heart failure, respiratory failure (ARDS), heart transplantation, sepsis, cardiogenic shock, and more. All our studies use hospital-grade equipment and follow the same clinical guideline to maximise translation. We actively take on honours, MPhil and PhD students from multi-disciplinary backgrounds (science, engineering, medicine, allied health), with a successful track record in supporting our students to secure their own grants and funding. Students are expected to contribute to other studies of the group. For more information about the group, please visit ccrg.org.au, and email if you are interested to join us.
Availability
- Dr Jacky Suen is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Pharmacology, The University of Queensland
- Member, Extracorporeal Life Support Organization, Extracorporeal Life Support Organization
Works
Search Professor Jacky Suen’s works on UQ eSpace
2020
Conference Publication
Donor brain stem death and cardiac transplantation causes mitochondrial dyscoupling and oxidative stress
Wells, Matthew, Seehoe, Louise, Zechovic, Olivia, Nchafatso, Obonyo, Bouquet, Mahe, Hyslop, Keiran, Black, Deborah, McDonald, Charles, Pedersen, Sanne, Suen, Jacky, Peart, Jason, McGiffin, David, Fraser, John and Lye, India (2020). Donor brain stem death and cardiac transplantation causes mitochondrial dyscoupling and oxidative stress. World Congress of Intensive Care, Melbourne, VIC Australia, 14-18 October 2019. Philadelphia, PA USA: Elsevier. doi: 10.1016/j.aucc.2020.04.098
2020
Conference Publication
Hypothermic ex vivo perfusion of brain dead donor hearts improves survival, systemic inflammation and cardiac function following heart transplantation
See Hoe, L., McGiffin, D., Wildi, K., Obonyo, N., Bouquet, M., Wells, M., Skeggs, K., McDonald, C., Engkilde-Pedersen, S., Bartnikowski, N., Colombo, S., Ainola, C., Passmore, M., Hyslop, K., Wood, E., Shuker, T., Sato, K., Jung, J., Heinser, S., James, L., Reid, J., O'Neill, H., Livingstone, S., Abbate, G., He, P., Sato, N., Boon, C., Black, D., Haymet, A. ... Fraser, J. (2020). Hypothermic ex vivo perfusion of brain dead donor hearts improves survival, systemic inflammation and cardiac function following heart transplantation. 8th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 14th Annual Australia and New Zealand Endovascular Therapies Meeting, Online, 11-13 December 2020. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2020.09.127
2020
Conference Publication
Hypothermic ex vivo perfusion preserves post-transplant donor cardiac function
Sato, K., See Hoe, L., Obonyo, N., Wildi, K., Colombo, S., Bouquet, M., Passmore, M., Bartnikowski, N., Wells, M., Skeggs, K., McDonald, C., Hyslop, K., Wood, E., Heinser, S., Ainola, C., Jung, J., James, L., Abbate, G., Haymet, A., Engkilde-Pedersen, S., Reid, J., O'Neill, H., Shuker, T., He, P., Sato, N., Diab, S., Mullins, D., Livingstone, S., Wang, X. ... Fraser, J. (2020). Hypothermic ex vivo perfusion preserves post-transplant donor cardiac function. 8th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 14th Annual Australia and New Zealand Endovascular Therapies Meeting, Virtual, 11-13 December 2020. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2020.09.128
2019
Journal Article
Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney
Ma, Frank Y., Han, Yingjie, Ozols, Elyce, Chew, Phyllis, Vesey, David A., Gobe, Glenda C., Morais, Christudas, Lohman, Rink-Jan, Suen, Jacky Y., Johnson, David W., Fairlie, David P. and Nikolic-Paterson, David J. (2019). Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney. Nephrology, 24 (9) nep.13635, 983-991. doi: 10.1111/nep.13635
2019
Journal Article
Hurdles to cardioprotection in the critically ill
Hoe, Louise E. See, Bartnikowski, Nicole, Wells, Matthew A., Suen, Jacky Y. and Fraser, John F. (2019). Hurdles to cardioprotection in the critically ill. International Journal of Molecular Sciences, 20 (15) 3823, 3823. doi: 10.3390/ijms20153823
2019
Other Outputs
Modulators of protease activated receptors
Fairlie, David, Liu, Ligong, Yau, Mei Kwan and Suen, Jacky (2019). Modulators of protease activated receptors. US9701711B2.
2019
Journal Article
Viability of Mesenchymal Stem Cells in an Ex Vivo Circulation System
Cho, Hwa Jin, Hong, Hyun, Kim, Do Wan, Lee, Kyo Seon, Han, Hwa Seon, Kim, Geum Hee, Choi, Kyung Soon, Kim, Yong Sook, Qayumov, Muhamadjon, Ki, Katrina K, Suen, Jacky, Fraser, John and Jeong, In Seok (2019). Viability of Mesenchymal Stem Cells in an Ex Vivo Circulation System. ASAIO journal (American Society for Artificial Internal Organs : 1992), 66 (4), 1-440. doi: 10.1097/mat.0000000000001025
2019
Journal Article
Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis
Han, Yingjie, Tian, Lifang, Ma, Frank, Tesch, Greg, Vesey, David A., Gobe, Glenda C., Lohman, Rink-Jan, Morais, Christudas, Suen, Jacky Y., Fairlie, David P. and Nikolic-Paterson, David J. (2019). Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis. Clinical and Experimental Pharmacology and Physiology, 46 (5) 1440-1681.13077, 456-464. doi: 10.1111/1440-1681.13077
2019
Journal Article
Mesenchymal stem cells may ameliorate inflammation in an ex vivo model of extracorporeal membrane oxygenation
von Bahr, Viktor, Millar, Jonathan E., Malfertheiner, Maximillian V., Ki, Katrina K., Passmore, Margaret R., Bartnikowski, Nicole, Redd, Meredith A., Cavaye, Michael, Suen, Jacky Y., McAuley, Danny F. and Fraser, John F. (2019). Mesenchymal stem cells may ameliorate inflammation in an ex vivo model of extracorporeal membrane oxygenation. Perfusion, 34 (1_suppl), 15-21. doi: 10.1177/0267659119830857
2019
Journal Article
Effect of ex vivo extracorporeal membrane oxygenation flow dynamics on immune response
Ki, Katrina K., Passmore, Margaret R., Chan, Chris Hoi Houng, Malfertheiner, Maximillian V, Bouquet, Mahe, Cho, Hwa Jin, Suen, Jacky Y. and Fraser, John F. (2019). Effect of ex vivo extracorporeal membrane oxygenation flow dynamics on immune response. Perfusion, 34 (1_suppl), 5-14. doi: 10.1177/0267659119830012
2019
Journal Article
Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models
Millar, Jonathan E., Bartnikowski, Nicole, von Bahr, Viktor, Malfertheiner, Maximilian V., Obonyo, Nchafatso G., Belliato, Mirko, Suen, Jacky Y., Combes, Alain, McAuley, Daniel F., Lorusso, Roberto and Fraser, John F. (2019). Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models. Intensive Care Medicine Experimental, 7 (1) 18, 18. doi: 10.1186/s40635-019-0232-7
2019
Journal Article
Endothelialized flow models for blood transfusion research
Ng, Monica S. Y., Suen, Jacky Y., Tung, John-Paul and Fraser, John F. (2019). Endothelialized flow models for blood transfusion research. Haematologica, 104 (3), 428-434. doi: 10.3324/haematol.2018.205203
2019
Journal Article
Neuron specific enolase and matrix metalloproteinase 9 signal perioperative silent brain infarction during or after transcatheter aortic valve implantation
Fanning, Jonathon P., Hoe, Louise E. See, Passmore, Margaret R., Barnett, Adrian G., Obonyo, Nchafatso G., Millar, Jonathan E., Wesley, Allan J., Suen, Jacky Y. and Fraser, John F. (2019). Neuron specific enolase and matrix metalloproteinase 9 signal perioperative silent brain infarction during or after transcatheter aortic valve implantation. The American Journal of Cardiology, 123 (3), 434-439. doi: 10.1016/j.amjcard.2018.10.022
2019
Journal Article
Pre-clinical study protocol: Blood transfusion in endotoxaemic shock
Obonyo, Nchafatso G., Byrne, Liam, Tung, John-Paul, Simonova, Gabriela, Diab, Sara D., Dunster, Kimble R., Passmore, Margaret R., Boon, Ai-Ching, See Hoe, Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Fauzi, Mohd H., Pimenta, Leticia P., Millar, Jonathan E., Fanning, Jonathon P., Van Haren, Frank, Anstey, Chris M., Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2019). Pre-clinical study protocol: Blood transfusion in endotoxaemic shock. MethodsX, 6, 1124-1132. doi: 10.1016/j.mex.2019.05.005
2019
Conference Publication
Characterisation of cardiac neurohormonal and inflammatory changes induced by brain death in a novel ovine heart transplant model
Hoe, L. See, Shuker, T., Bartnikowski, N., Passmore, M., Bouquet, M., Obonyo, N., Engkilde-Pedersen, S., McDonald, C., Wells, M., Boon, A., Hyslop, K., James, L., Wildi, K., Cullen, L., Bassi, G. Li, Suen, J., McGiffin, D. and Fraser, J. (2019). Characterisation of cardiac neurohormonal and inflammatory changes induced by brain death in a novel ovine heart transplant model. 67th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 13th Annual Australia and New Zealand Endovascular Therapies Meeting, Adelaide, Australia, 8-11 August 2019. chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2019.06.074
2018
Journal Article
Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock
Passmore, Margaret R., Byrne, Liam, Obonyo, Nchafatso G., See Hoe, Louise E., Boon, Ai-Ching, Diab, Sara D., Dunster, Kimble R., Bisht, Kavita, Tung, John-Paul, Fauzi, Mohd H., Narula, Monica, Pedersen, Sanne E., Esguerra-Lallen, Arlanna, Simonova, Gabriela, Sultana, Annette, Anstey, Chris M., Shekar, Kiran, Maitland, Kathryn, Suen, Jacky Y. and Fraser, John F. (2018). Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock. Respiratory Research, 19 (1) 231, 231. doi: 10.1186/s12931-018-0935-4
2018
Journal Article
Recruitment manoeuvres dislodge mucus towards the distal airways in an experimental model of severe pneumonia
Li Bassi, G., Comaru, T., Martí, D., Xiol, E. A., Chiurazzi, C., Travierso, C., Carbonara, M., Ranzani, O. T., Amaro, R., Frigola, G., Fuster, C., Saco, M. A., Zanella, A., De Rosa, F., Rigol, M., Fernandez, L., Luque, N., Ramirez, J., Blasi, F., Suen, J., Fraser, J. and Torres, A. (2018). Recruitment manoeuvres dislodge mucus towards the distal airways in an experimental model of severe pneumonia. British Journal of Anaesthesia, 122 (2), 269-276. doi: 10.1016/j.bja.2018.07.039
2018
Conference Publication
Packed Red Cell Age Associated With Adverse Cardiovascular Changes in an Ovine Model of Septic Shock Resuscitation
Fanning, Jonathon P., Obonyo, Nchafatso G., Tung, John-Paul, Byrne, Liam, Simonova, Gabriela, Diab, Sara, Dunster, Kimble, Passmore, Margaret, Boon, Ai-Ching, See Hoe, Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Hashairi Fauzi, Mohd, Pretti Pimenta, Leticia, Millar, Jonathan, Anstey, Christopher, van Haren, Frank, Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John (2018). Packed Red Cell Age Associated With Adverse Cardiovascular Changes in an Ovine Model of Septic Shock Resuscitation. American Heart Association's 2018 Scientific Sessions, Chicago, IL United States, 10-12 November 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1161/circ.138.suppl_1.17116
2018
Journal Article
Transfusion of packed red blood cells at the end of shelf life is associated with increased risk of mortality - a pooled patient data analysis of 16 observational trials
Ng, Monica S. Y., David, Michael, Middelburg, Rutger A., Ng, Angela S. Y., Suen, Jacky Y., Tung, John-Paul and Fraser, John F. (2018). Transfusion of packed red blood cells at the end of shelf life is associated with increased risk of mortality - a pooled patient data analysis of 16 observational trials. Haematologica, 103 (9), haematol.2018.191932-1548. doi: 10.3324/haematol.2018.191932
2018
Journal Article
Administration of mesenchymal stem cells during ECMO results in a rapid decline in oxygenator performance
Millar, Jonathan Edward, von Bahr, Viktor, Malfertheiner, Maximillian V., Ki, Katrina K., Redd, Meredith A., Bartnikowski, Nicole, Suen, Jacky Y., McAuley, Danny Francis and Fraser, John F. (2018). Administration of mesenchymal stem cells during ECMO results in a rapid decline in oxygenator performance. Thorax, 74 (2), 1-3. doi: 10.1136/thoraxjnl-2017-211439
Funding
Current funding
Supervision
Availability
- Dr Jacky Suen is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
An investigation of Veno-Arterial Extracorporeal Membrane Oxygenation (V-A ECMO) and its interaction with Continuous Renal Replacement Therapy (CRRT)
Principal Advisor
-
Doctor Philosophy
The importance of blood flow pattern on ECMO and cardiogenic shock
Associate Advisor
-
Doctor Philosophy
Vascular Endothelial Injury, Repair and Preconditioning in the Artificial Circulation
Associate Advisor
-
Doctor Philosophy
Load-Independent Right Ventricular Assessment by Echocardiography
Associate Advisor
Completed supervision
-
2023
Doctor Philosophy
The differences in coagulation disturbances of the Acute Respiratory Distress Syndrome subphenotypes
Principal Advisor
-
2024
Doctor Philosophy
Development of Speckle-Tracking Echocardiographic strain accounting for cardiac loading conditions
Associate Advisor
-
2023
Doctor Philosophy
A Comprehensive Pre-Clinical Evaluation of Pulsatile Flow Veno-arterial Extracorporeal Membrane Oxygenation
Associate Advisor
-
2023
Doctor Philosophy
The Significance of Different Phenotypes in Acute Respiratory Distress Syndrome (ARDS) for Effective Treatment
Associate Advisor
-
2022
Master Philosophy
Pre-clinical model development of electrical impedance tomography in the assessment of the pulmonary distribution of nebulized solutions
Associate Advisor
Other advisors: Associate Professor Jayesh Dhanani, Dr Gianluigi Li Bassi
-
2019
Doctor Philosophy
A Translational Approach to Potential Toxicity of Stored Blood Components
Associate Advisor
Other advisors: Dr John-Paul Tung
-
2018
Doctor Philosophy
Modulating Protease-Activated Receptor 2
Associate Advisor
Other advisors: Dr Junxian Lim, Professor David Fairlie
-
2014
Doctor Philosophy
Properties of C5a Receptor on Human Macrophages
Associate Advisor
Other advisors: Professor David Fairlie
Media
Enquiries
Contact Dr Jacky Suen directly for media enquiries about:
- Critical Care Medicine
- ECMO
- Extracorporeal Membrane Oxygenation
- Heart Failure
- Heart transplant
- Respiratory Failure
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