Overview
Background
Critical Care Medicine focuses on supporting patients, often with one or multiple organ failures. Based at the largest Australian cardiac hospital, our research investigates better ways to support patients with heart and/or lung failure. We explore technological, pharmacological and engineering advances that could help our patients to live longer and better. Our group is world-renowned for clinically relevant large animal models, including heart failure, respiratory failure (ARDS), heart transplantation, sepsis, cardiogenic shock, and more. All our studies use hospital-grade equipment and follow the same clinical guideline to maximise translation. We actively take on honours, MPhil and PhD students from multi-disciplinary backgrounds (science, engineering, medicine, allied health), with a successful track record in supporting our students to secure their own grants and funding. Students are expected to contribute to other studies of the group. For more information about the group, please visit ccrg.org.au, and email if you are interested to join us.
Availability
- Dr Jacky Suen is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Pharmacology, The University of Queensland
- Member, Extracorporeal Life Support Organization, Extracorporeal Life Support Organization
Works
Search Professor Jacky Suen’s works on UQ eSpace
2022
Journal Article
Prone position during venovenous extracorporeal membrane oxygenation: survival analysis needed for a time-dependent intervention
Zaaqoq, Akram M., Barnett, Adrian G., Heinsar, Silver, Griffee, Matthew J., MacLaren, Graeme, Jacobs, Jeffrey P., Suen, Jacky Y., Li Bassi, Gianluigi, Fraser, John F., Dalton, Heidi J., Peek, Giles J. and the COVID-19 Critical Care Consortium (COVID Critical) (2022). Prone position during venovenous extracorporeal membrane oxygenation: survival analysis needed for a time-dependent intervention. Critical Care, 26 (1) 39, 39. doi: 10.1186/s13054-022-03923-3
2022
Journal Article
Beneficial effect of prone positioning during venovenous extracorporeal membrane oxygenation for Coronavirus Disease 2019
Zaaqoq, Akram M., Barnett, Adrian G., Griffee, Matthew J., MacLaren, Graeme, Jacobs, Jeffrey P., Heinsar, Silver, Suen, Jacky Y., Li Bassi, Gianluigi, Fraser, John F., Dalton, Heidi J., Peek, Giles J. and COVID-19 Critical Care Consortium (COVID Critical) (2022). Beneficial effect of prone positioning during venovenous extracorporeal membrane oxygenation for Coronavirus Disease 2019. Critical Care Medicine, 50 (2), 275-285. doi: 10.1097/CCM.0000000000005296
2022
Journal Article
Mobile extracorporeal membrane oxygenation for Covid-19 does not pose extra risk to transport team
Javidfar, Jeffrey, Labib, Ahmed, Ragazzo, Gabrielle, Kurtzman, Ethan, Callahan, Maria, Heinsar, Silver, Gudzenko, Vadim, Barrett, Peter, Binongo, José, Wei, Jane Wenjing, Fraser, John, Suen, Jacky Y., Li Bassi, Gianluigi and Peek, Giles (2022). Mobile extracorporeal membrane oxygenation for Covid-19 does not pose extra risk to transport team. ASAIO Journal , 68 (2), 163-167. doi: 10.1097/MAT.0000000000001602
2022
Journal Article
Extracorporeal membrane oxygenation cannulae-related infection: diagnostic difficulties and potential prevention
Pearse, India, Corley, Amanda, Suen, Jacky and Fraser, John F. (2022). Extracorporeal membrane oxygenation cannulae-related infection: diagnostic difficulties and potential prevention. ASAIO Journal, 68 (2), e34-e35. doi: 10.1097/MAT.0000000000001589
2022
Conference Publication
Post-transplant cardiac contractility and mitochondrial function is preserved following 8 hours hypothermic ex vivo perfusion in sheep
See Hoe, L., Bouquet, M., Hyslop, K., Passmore, M., Wells, M., Sato, K., Wilson, E., Wildi, K., Skeggs, K., Palmeri, C., Reid, J., O'Neill, H., Bartnikowski, N., Jung, J., Ainola, C., Abbate, G., Colombo, S., Obonyo, N., McDonald, C., Shuker, T., Heinsar, S., Haymet, A., Engkilde-Pedersen, S., Peart, J., Molenaar, P., Li Bassi, G., Suen, J., McGiffin, D. and Fraser, J. (2022). Post-transplant cardiac contractility and mitochondrial function is preserved following 8 hours hypothermic ex vivo perfusion in sheep. 70th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Gold Coast, QLD, Australia, 11-14 August 2022. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2022.06.547
2021
Journal Article
A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death
See Hoe, Louise E., Wildi, Karin, Obonyo, Nchafatso G., Bartnikowski, Nicole, McDonald, Charles, Sato, Kei, Heinsar, Silver, Engkilde-Pedersen, Sanne, Diab, Sara, Passmore, Margaret R., Wells, Matthew A., Boon, Ai-Ching, Esguerra, Arlanna, Platts, David G., James, Lynnette, Bouquet, Mahe, Hyslop, Kieran, Shuker, Tristan, Ainola, Carmen, Colombo, Sebastiano M., Wilson, Emily S., Millar, Jonathan E., Malfertheiner, Maximillian V., Reid, Janice D., O’Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Sato, Noriko, He, Ting ... Fraser, John F. (2021). A clinically relevant sheep model of orthotopic heart transplantation 24 h after donor brainstem death. Intensive Care Medicine Experimental, 9 (1) 60, 1-24. doi: 10.1186/s40635-021-00425-4
2021
Journal Article
An ovine model of haemorrhagic shock and resuscitation, to assess recovery of tissue oxygen delivery and oxygen debt, and inform patient blood management
Dyer, Wayne B., Tung, John-Paul, Li Bassi, Gianluigi, Wildi, Karin, Jung, Jae-Seung, Colombo, Sebastiano Maria, Rozencwajg, Sacha, Simonova, Gabriela, Chiaretti, Sara, Temple, Fergal T., Ainola, Carmen, Shuker, Tristan, Palmieri, Chiara, Shander, Aryeh, Suen, Jacky Y., Irving, David O. and Fraser, John F. (2021). An ovine model of haemorrhagic shock and resuscitation, to assess recovery of tissue oxygen delivery and oxygen debt, and inform patient blood management. Shock, 56 (6), 1080-1091. doi: 10.1097/SHK.0000000000001805
2021
Journal Article
The value of open-source clinical science in pandemic response: lessons from ISARIC
Abbas, Ali, Abdukahil, Sheryl Ann, Abdulkadir, Nurul Najmee, Abe, Ryuzo, Abel, Laurent, Absil, Lara, Acharya, Subhash, Acker, Andrew, Adachi, Shingo, Adam, Elisabeth, Adrião, Diana, Ageel, Saleh Al, Ahmed, Shakeel, Ain, Quratul, Ainscough, Kate, Aisa, Tharwat, Ait Hssain, Ali, Ait Tamlihat, Younes, Akimoto, Takako, Akmal, Ernita, Al Qasim, Eman, Alalqam, Razi, Alam, Tanvir, Al-dabbous, Tala, Alegesan, Senthilkumar, Alegre, Cynthia, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin ... ISARIC Clinical Characterisation Group (2021). The value of open-source clinical science in pandemic response: lessons from ISARIC. The Lancet Infectious Diseases, 21 (12), 1623-1624. doi: 10.1016/S1473-3099(21)00565-X
2021
Journal Article
Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort
ISARIC Clinical Characterisation Group, Hall, Matthew D., Baruch, Joaquín, Carson, Gail, Citarella, Barbara Wanjiru, Dagens, Andrew, Dankwa, Emmanuelle A., Donnelly, Christl A., Dunning, Jake, Escher, Martina, Kartsonaki, Christiana, Merson, Laura, Pritchard, Mark, Wei, Jia, Horby, Peter W., Rojek, Amanda, Olliaro, Piero L., Li Bassi, Gianluigi, Shrapnel, Sally, Suen, Jacky and Forsyth, Simon J. (2021). Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort. eLife, 10 e70970, 1-30. doi: 10.7554/elife.70970
2021
Journal Article
Assessment of 28-day in-hospital mortality in mechanically ventilated patients with coronavirus disease 2019: an international cohort study
Li Bassi, Gianluigi, Suen, Jacky Y., White, Nicole, Dalton, Heidi J., Fanning, Jonathon, Corley, Amanda, Shrapnel, Sally, Hinton, Samuel, Forsyth, Simon, Parsons, Rex, Laffey, John G., Fan, Eddy, Bartlett, Robert, Brodie, Daniel, Burrell, Aidan, Chiumello, Davide, Elhazmi, Alyaa, Grasselli, Giacomo, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Marwali, Eva, Merson, Laura, Murthy, Srinivas, Nichol, Alistair, Panigada, Mauro, Pelosi, Paolo, Torres, Antoni, Ng, Pauline Yeung ... Obonyo, Nchafatso (2021). Assessment of 28-day in-hospital mortality in mechanically ventilated patients with coronavirus disease 2019: an international cohort study. Critical Care Explorations, 3 (11) e0567, e0567. doi: 10.1097/cce.0000000000000567
2021
Journal Article
Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model
Walweel, K., Boon, A. C., See Hoe, L. E., Obonyo, N. G., Pedersen, S. E., Diab, S. D., Passmore, M. R., Hyslop, K., Colombo, S. M., Bartnikowski, N. J., Bouquet, M., Wells, M. A., Black, D. M., Pimenta, L. P., Stevenson, A. K., Bisht, K., Skeggs, K., Marshall, L., Prabhu, A., James, L. N., Platts, D. G., Macdonald, P. S., McGiffin, D. C., Suen, J. Y. and Fraser, J. F. (2021). Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model. Biomedical Journal, 45 (5), 776-787. doi: 10.1016/j.bj.2021.10.007
2021
Journal Article
An innovative ovine model of severe cardiopulmonary failure supported by veno-arterial extracorporeal membrane oxygenation
Heinsar, Silver, Jung, Jae-Seung, Colombo, Sebastiano Maria, Rozencwajg, Sacha, Wildi, Karin, Sato, Kei, Ainola, Carmen, Wang, Xiaomeng, Abbate, Gabriella, Sato, Noriko, Dyer, Wayne Bruce, Livingstone, Samantha Annie, Pimenta, Leticia Pretti, Bartnikowski, Nicole, Bouquet, Mahe Jeannine Patricia, Passmore, Margaret, Vidal, Bruno, Palmieri, Chiara, Reid, Janice D., Haqqani, Haris M., McGuire, Daniel, Wilson, Emily Susan, Rätsep, Indrek, Lorusso, Roberto, Suen, Jacky Y., Li Bassi, Gianluigi and Fraser, John F. (2021). An innovative ovine model of severe cardiopulmonary failure supported by veno-arterial extracorporeal membrane oxygenation. Scientific Reports, 11 (1) 20458, 1-11. doi: 10.1038/s41598-021-00087-y
2021
Journal Article
Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: an experimental ovine study
Millar, Jonathan E., Wildi, Karin, Bartnikowski, Nicole, Bouquet, Mahe, Hyslop, Kieran, Passmore, Margaret R., Ki, Katrina K., See Hoe, Louise E., Obonyo, Nchafatso G., Neyton, Lucile, Pedersen, Sanne, Rozencwajg, Sacha, Baillie, J. Kenneth, Li Bassi, Gianluigi, Suen, Jacky Y., McAuley, Daniel F. and Fraser, John F. (2021). Characterizing preclinical sub-phenotypic models of acute respiratory distress syndrome: an experimental ovine study. Physiological Reports, 9 (19) e15048, e15048. doi: 10.14814/phy2.15048
2021
Journal Article
Design and rationale of a prospective international follow-up study on intensive care survivors of COVID-19: The long-term impact in intensive care survivors of coronavirus disease-19-AFTERCOR
Wildi, Karin, Li Bassi, Gianluigi, Barnett, Adrian, Panigada, Mauro, Colombo, Sebastiano M., Bandera, Alessandra, Muscatello, Antonio, McNicholas, Bairbre, Laffey, John G., Battaglini, Denise, Robba, Chiara, Torres, Antoni, Motos, Ana, Luna, Carlos M., Rainieri, Fernando, Hodgson, Carol, Burrell, Aidan J. C., Buscher, Hergen, Dalton, Heidi, Cho, Sung-Min, Choi, Huimahn Alex, Thomson, David, Suen, Jacky and Fraser, John F. (2021). Design and rationale of a prospective international follow-up study on intensive care survivors of COVID-19: The long-term impact in intensive care survivors of coronavirus disease-19-AFTERCOR. Frontiers in Medicine, 8 738086, 738086. doi: 10.3389/fmed.2021.738086
2021
Conference Publication
An appraisal of respiratory system compliance in mechanically ventilated COVID-19 patients
Li Bassi, Gianluigi, Suen, Jacky, Dalton, Heidi J., White, Nicole, Sato, Kei, Shrapnel, Sally, Fanning, Jonathon P., Liquet, Benoit, Hinton, Samuel, Vuorinem, Aapeli, Booth, Gareth, Millar, Jonathan E., Forsyth, Simon, Panigada, Mauro, Laffey, John, Brodie, Daniel, Fan, Eddy, Torres, Antoni, Chiumello, Davide, Corley, Amanda, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Yeung, Pauline, Ogino, Mark, Pesenti, Antonio ... Fraser, John F. (2021). An appraisal of respiratory system compliance in mechanically ventilated COVID-19 patients. European-Respiratory-Society (ERS) International Congress, Thessaloniki Greece, Sep 26-30, 2021. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2021.PA3318
2021
Conference Publication
Use of neuromuscular blocking agents in mechanically ventilated patients with COVID-19: A propensity score analysis
Bassi, Gianluigi Li, Gibbons, Kristen, Suen, Jacky, Dalton, Heidi, White, Nicole, Corley, Amanda, Hinton, Samuel, Forsyth, Simon, Laffey, John, Brodie, Daniel, Burrell, Aidan, Fan, Eddy, Bartlett, Robert, Torres, Antoni, Chiumello, Davide, Elhazmi, Alyaa, Hodgson, Carol, Ichiba, Shingo, Luna, Carlos, Murthy, Srinivas, Nichol, Alistair, Ng, Pauline Yeung, Panigada, Mauro and Fraser, John (2021). Use of neuromuscular blocking agents in mechanically ventilated patients with COVID-19: A propensity score analysis. European-Respiratory-Society (ERS) International Congress, Thessaloniki Greece, Sep 26-30, 2021. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2021.OA1259
2021
Journal Article
Anti-thrombogenic surface coatings for extracorporeal membrane oxygenation: a narrative review
Zhang, Meili, Pauls, Jo P., Bartnikowski, Nicole, Haymet, Andrew B., Chan, Chris H. H., Suen, Jacky Y., Schneider, Bailey, Ki, Katrina K., Whittaker, Andrew K., Dargusch, Matthew S. and Fraser, John F. (2021). Anti-thrombogenic surface coatings for extracorporeal membrane oxygenation: a narrative review. ACS Biomaterials Science and Engineering, 7 (9), 4402-4419. doi: 10.1021/acsbiomaterials.1c00758
2021
Journal Article
Coagulation dysfunction in acute respiratory distress syndrome and its potential impact in inflammatory subphenotypes
Livingstone, Samantha A., Wildi, Karin S., Dalton, Heidi J., Usman, Asad, Ki, Katrina K., Passmore, Margaret R., Li Bassi, Gianluigi, Suen, Jacky Y. and Fraser, John F. (2021). Coagulation dysfunction in acute respiratory distress syndrome and its potential impact in inflammatory subphenotypes. Frontiers in Medicine, 8 723217, 723217. doi: 10.3389/fmed.2021.723217
2021
Journal Article
Neurological manifestations of coronavirus disease 2019: a comprehensive review and meta-analysis of the first 6 months of pandemic reporting
Huth, Samuel F., Cho, Sung-Min, Robba, Chiara, Highton, David, Battaglini, Denise, Bellapart, Judith, Suen, Jacky Y., Li Bassi, Gianluigi, Taccone, Fabio Silvio, Arora, Rakesh C., Whitman, Glenn, Fraser, John F. and Fanning, Jonathon P. (2021). Neurological manifestations of coronavirus disease 2019: a comprehensive review and meta-analysis of the first 6 months of pandemic reporting. Frontiers in Neurology, 12 664599, 664599. doi: 10.3389/fneur.2021.664599
2021
Conference Publication
Neurological manifestations of coronavirus disease 2019: a comprehensive review
Fanning, Jonathon, Huth, Samuel, Cho, Sung-Min, Robba, Chiara, Highton, David, Battaglini, Denise, Bellapart-Rubio, Judith, Suen, Jacky, Bassi, Gianluigi Li, Taccone, Fabio, Arora, Rakesh, Whitman, Glenn and Fraser, John (2021). Neurological manifestations of coronavirus disease 2019: a comprehensive review. ANZAN Annual Scientific Meeting 2021, February 2021, 20-21 November 2021. London, United Kingdom: BMJ Group. doi: 10.1136/bmjno-2021-anzan.1
Funding
Current funding
Past funding
Supervision
Availability
- Dr Jacky Suen is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Honours students for cardio-respiratory failure
We are looking for honours students to be involved in our range of studies on cardiac/respiratory failure. Projects include heart transplantation, acute respiratory failure, sepsis and advanced life support. Students will be expected and supported for grant application, as most of our previous honours students were awarded with $10,000 New Investigator Grant.
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Mitochondrial dysfunction and repair during circulatory death and heart transplantation
We are looking for Honours and RHD students to be involved in our NHMRC-funded heart transplantation program. Previously, we have successfully translated our research on extended organ preservation to clinical practice in Australia/New Zealand. As we explore on a new donor source, we are looking for talented students to join the team to study mitochondrial dysfunction, as a key parameter in determining post-transplant cardiac function.
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Systematic examination of ECMO parameters
Extra-Corporeal Membrane Oxygenation (ECMO) is an artificial heart/lung machine that is use to support patients with severe cardiac/respiratory failure. It has been invented for more than 30 years. To date, there is a lack of systematic examination of various parameters and settings for ECMO. Many of the current clinical practise are based on convention and tradition. This project aims to research and provide empirical evidences in order to optimise ECMO usage for patients, leading to improved patient outcome and reduced length of hospital stay. The project could involve bench-top ex vivo experiments, large animal in vivo study, and, perspective and retrospective analysis of clinical studies.
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Impact of blood flow for lung function
We are looking for Honours or RHD students to be involved in a project examining the impact of blood flow to support patients with respiratory failure. The student will be using human primary lung cells to model the condition of respiratory failure and advanced life support. The project will be in partnership with a leading biomed tech industry partner.
Supervision history
Current supervision
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Doctor Philosophy
Load-Independent Right Ventricular Assessment by Echocardiography
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Vascular Endothelial Injury, Repair and Preconditioning in the Artificial Circulation
Associate Advisor
Other advisors: Professor John Fraser
Completed supervision
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2023
Doctor Philosophy
The differences in coagulation disturbances of the Acute Respiratory Distress Syndrome subphenotypes
Principal Advisor
Other advisors: Professor John Fraser
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2024
Doctor Philosophy
Development of Speckle-Tracking Echocardiographic strain accounting for cardiac loading conditions
Associate Advisor
Other advisors: Professor John Fraser
-
2023
Doctor Philosophy
A Comprehensive Pre-Clinical Evaluation of Pulsatile Flow Veno-arterial Extracorporeal Membrane Oxygenation
Associate Advisor
Other advisors: Professor John Fraser
-
2023
Doctor Philosophy
The Significance of Different Phenotypes in Acute Respiratory Distress Syndrome (ARDS) for Effective Treatment
Associate Advisor
Other advisors: Professor John Fraser
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2022
Master Philosophy
Pre-clinical model development of electrical impedance tomography in the assessment of the pulmonary distribution of nebulized solutions
Associate Advisor
Other advisors: Associate Professor Jayesh Dhanani, Dr Gianluigi Li Bassi, Professor John Fraser
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2021
Doctor Philosophy
Combining Extracorporeal Life Support and Cell Therapy in Critical Illness: Mesenchymal stem cell therapy and extracorporeal membrane oxygenation in the Acute Respiratory Distress Syndrome
Associate Advisor
Other advisors: Professor John Fraser
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2019
Doctor Philosophy
A Translational Approach to Potential Toxicity of Stored Blood Components
Associate Advisor
Other advisors: Dr John-Paul Tung, Professor John Fraser
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2018
Doctor Philosophy
Modulating Protease-Activated Receptor 2
Associate Advisor
Other advisors: Dr Junxian Lim, Professor David Fairlie
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2014
Doctor Philosophy
Properties of C5a Receptor on Human Macrophages
Associate Advisor
Other advisors: Professor David Fairlie
Media
Enquiries
Contact Dr Jacky Suen directly for media enquiries about:
- Critical Care Medicine
- ECMO
- Extracorporeal Membrane Oxygenation
- Heart Failure
- Heart transplant
- Respiratory Failure
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