Overview
Background
Critical Care Medicine focuses on supporting patients, often with one or multiple organ failures. Based at the largest Australian cardiac hospital, our research investigates better ways to support patients with heart and/or lung failure. We explore technological, pharmacological and engineering advances that could help our patients to live longer and better. Our group is world-renowned for clinically relevant large animal models, including heart failure, respiratory failure (ARDS), heart transplantation, sepsis, cardiogenic shock, and more. All our studies use hospital-grade equipment and follow the same clinical guideline to maximise translation. We actively take on honours, MPhil and PhD students from multi-disciplinary backgrounds (science, engineering, medicine, allied health), with a successful track record in supporting our students to secure their own grants and funding. Students are expected to contribute to other studies of the group. For more information about the group, please visit ccrg.org.au, and email if you are interested to join us.
Availability
- Dr Jacky Suen is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Pharmacology, The University of Queensland
- Member, Extracorporeal Life Support Organization, Extracorporeal Life Support Organization
Works
Search Professor Jacky Suen’s works on UQ eSpace
2023
Journal Article
The effects of nitric oxide on coagulation and inflammation in ex‐vivo models of extracorporeal membrane oxygenation and cardiopulmonary bypass
Malfertheiner, Maximilian V., Ashlen, Garrett, Margaret, Passmore, Haymet, Andrew B., Richard, Webb I., von Bahr, Viktor, Millar, Jonathan E., Schneider, Bailey A., Obonyo, Nchafatso G., Debra, Black, Mahe, Bouquet, Nicole, Bartnikowski, Suen, Jacky Y. and Fraser, John F. (2023). The effects of nitric oxide on coagulation and inflammation in ex‐vivo models of extracorporeal membrane oxygenation and cardiopulmonary bypass. Artificial Organs, 47 (10), 1581-1591. doi: 10.1111/aor.14608
2023
Journal Article
Application of anti-inflammatory treatment in two different ovine Acute Respiratory Distress Syndrome injury models: a preclinical randomized intervention study
Wildi, Karin, Livingstone, Samantha, Ainola, Carmen, Colombo, Sebastiano Maria, Heinsar, Silver, Sato, Noriko, Sato, Kei, Bouquet, Mahé, Wilson, Emily, Abbate, Gabriella, Passmore, Margaret, Hyslop, Kieran, Liu, Keibun, Wang, Xiaomeng, Palmieri, Chiara, See Hoe, Louise E., Jung, Jae-Seung, Ki, Katrina, Mueller, Christian, Laffey, John, Pelosi, Paolo, Li Bassi, Gianluigi, Suen, Jacky and Fraser, John (2023). Application of anti-inflammatory treatment in two different ovine Acute Respiratory Distress Syndrome injury models: a preclinical randomized intervention study. Scientific Reports, 13 (1) 17986, 1-15. doi: 10.1038/s41598-023-45081-8
2023
Journal Article
Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: a prospective, multinational, observational study
Reyes, Luis Felipe, Garcia-Gallo, Esteban, Murthy, Srinivas, Fuentes, Yuli V., Serrano, Cristian C., Ibáñez-Prada, Elsa D., Lee, James, Rojek, Amanda, Citarella, Barbara Wanjiru, Gonçalves, Bronner P., Dunning, Jake, Rätsep, Indrek, Viñan-Garces, Andre Emilio, Kartsonaki, Christiana, Rello, Jordi, Martin-Loeches, Ignacio, Shankar-Hari, Manu, Olliaro, Piero L., Merson, Laura, Abbas, Ali, Abdukahil, Sheryl Ann, Abdulkadir, Nurul Najmee, Abe, Ryuzo, Abebrese, Franklina Korkor, Abel, Laurent, Abrous, Amal, Absil, Lara, Acharya, Subhash, Acker, Andrew ... Zucman, David (2023). Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: a prospective, multinational, observational study. Journal of Critical Care, 77 154318, 1-13. doi: 10.1016/j.jcrc.2023.154318
2023
Journal Article
The use of noninvasive multimodal neuromonitoring in adult critically ill patients with COVID-19 infection
Battaglini, Denise, Premraj, Lavienraj, Huth, Samuel, Fanning, Jonathon, Whitman, Glenn, Arora, Rakesh C, Bellapart, Judith, Bastos Porto, Diego, Taccone, Fabio S, Suen, Jacky Y, Li Bassi, Gianluigi, Fraser, John F, Cho, Sung-Min and Robba, Chiara (2023). The use of noninvasive multimodal neuromonitoring in adult critically ill patients with COVID-19 infection. Journal of Neurosurgical Anesthesiology, 35 (4), 423-428. doi: 10.1097/ANA.0000000000000859
2023
Journal Article
Characteristics and outcomes of patients with severe COVID-19 in Indonesia: Lessons from the first wave
Burhan, Erlina, Liu, Keibun, Marwali, Eva M., Huth, Samuel, Wulung, Navy G H M L, Juzar, Dafsah A., Taufik, Muhammad A., Wijaya, Surya O., Wati, Dyah K., Kusumastuti, Neurinda P., Yuliarto, Saptadi, Pratomo, Bhirowo Y., Pradian, Erwin, Somasetia, Dadang H., Rusmawatiningtyas, Desy, Fatoni, Arie Z., Mandei, Jose M., Lantang, Eka Y., Perdhana, Fajar, Semedi, Bambang P., Rayhan, Muhammad, Tarigan, Tiffany R S, White, Nicole, Bassi, Gianluigi L., Suen, Jacky Y. and Fraser, John F. (2023). Characteristics and outcomes of patients with severe COVID-19 in Indonesia: Lessons from the first wave. PLoS One, 18 (9) e0290964, 1-18. doi: 10.1371/journal.pone.0290964
2023
Journal Article
Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort
Shah, Neel, Xue, Bing, Xu, Ziqi, Yang, Hanqing, Marwali, Eva, Dalton, Heidi, Payne, Philip P. R., Lu, Chenyang, Said, Ahmed S., Abdukahil, Sheryl Ann, Abdulkadir, Nurul Najmee, Absil, Lara, Acker, Andrew, Adrião, Diana, Hssain, Ali Ait, Akwani, Chika, Al Qasim, Eman, Alalqam, Razi, Al-dabbous, Tala, Alex, Beatrice, Al-Fares, Abdulrahman, Alfoudri, Huda, Aliudin, Jeffrey, Alves, João, Alves, Rita, Alves, João Melo, Cabrita, Joana Alves, Amaral, Maria, Amira, Nur ... ISARIC Clinical Characterisation Group (2023). Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort. Artificial Organs, 47 (9), 1490-1502. doi: 10.1111/aor.14542
2023
Journal Article
Current animal models of extracorporeal cardiopulmonary resuscitation: a scoping review
Ijuin, Shinichi, Liu, Keibun, Gill, Denzil, Kyun Ro, Sun, Vukovic, Jana, Ishihara, Satoshi, Belohlavek, Jan, Li Bassi, Gianluigi, Suen, Jacky Y. and Fraser, John F. (2023). Current animal models of extracorporeal cardiopulmonary resuscitation: a scoping review. Resuscitation Plus, 15 100426, 1-9. doi: 10.1016/j.resplu.2023.100426
2023
Journal Article
Erratum: Hemorrhage, disseminated intravascular coagulopathy, and thrombosis complications among critically ill patients with COVID-19: An International COVID-19 Critical Care Consortium Study (Critical Care Medicine (2023) 51 (619-631) DOI: 10.1097/CCM.0000000000005798)
Motos, Anna, Torres, Antoni, Barbé, Ferran, Grasselli, Giacomo, Zanella, Alberto, Etchill, Eric, Ali Usman, Asad, Feth, Maximilian, White, Nicole M., Suen, Jacky Y., Bassi, Gianluigi Li, Peek, Giles J., Fraser, John F. and Dalton, Heidi (2023). Erratum: Hemorrhage, disseminated intravascular coagulopathy, and thrombosis complications among critically ill patients with COVID-19: An International COVID-19 Critical Care Consortium Study (Critical Care Medicine (2023) 51 (619-631) DOI: 10.1097/CCM.0000000000005798). Critical Care Medicine, 51 (8), E177-E177. doi: 10.1097/CCM.0000000000005961
2023
Journal Article
Donor heart ischemic time can be extended to 8 hours using hypothermic machine perfusion in sheep
See Hoe, Louise E., Bassi, Gianluigi Li, Wildi, Karin, Passmore, Margaret R., Bouquet, Mahe, Sato, Kei, Heinsar, Silver, Ainola, Carmen, Bartnikowski, Nicole, Wilson, Emily S., Hyslop, Kieran, Skeggs, Kris, Obonyo, Nchafatso G., Shuker, Tristan, Bradbury, Lucy, Palmieri, Chiara, Pedersen, Sanne-Engkilde, McDonald, Charles, Colombo, Sebastiano M., Wells, Matthew A., Reid, Janice D., O'Neill, Hollier, Livingstone, Samantha, Abbate, Gabriella, Haymet, Andrew, Jung, Jae-Seung, Sato, Noriko, James, Lynnette, He, Ting ... Fraser, John F. (2023). Donor heart ischemic time can be extended to 8 hours using hypothermic machine perfusion in sheep. The Journal of Heart and Lung Transplantation, 42 (8), 1015-1029. doi: 10.1016/j.healun.2023.03.020
2023
Journal Article
Effects of transfusing older red blood cells and platelets on obstetric patient outcomes: a retrospective cohort study
Obonyo, Nchafatso G., Lu, Lawrence Y., White, Nicole M., Sela, Declan P., Rachakonda, Reema H., Teo, Derek, Tunbridge, Matthew, Sim, Beatrice, See Hoe, Louise E., Fanning, Jonathon P., Tung, John‐Paul, McKnoulty, Matthew, Bassi, Gianluigi Li, Suen, Jacky Y. and Fraser, John F. (2023). Effects of transfusing older red blood cells and platelets on obstetric patient outcomes: a retrospective cohort study. International Journal of Gynecology and Obstetrics, 164 (1), 184-191. doi: 10.1002/ijgo.14997
2023
Conference Publication
A novel speckle-tracking echocardiographic parameter assessing left ventricular loading during VA ECMO in a pre-clinical model of cardiogenic shock
Sato, K., Heinsar, S., Obonyo, N., Wildi, K., Liu, K., Farah, S., Ainola, C., Sato, N., Ijuin, S., Ro, S. Kyun, Fior, G., Gandini, L., Bouquet, M., Wilson, E., Passmore, M., Hyslop, K., Chan, J., Platts, D., Scalia, G., Suen, J., Bassi, G. Li and Fraser, J. (2023). A novel speckle-tracking echocardiographic parameter assessing left ventricular loading during VA ECMO in a pre-clinical model of cardiogenic shock. 71st Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Adelaide, SA Australia, 3-6 August 2023. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2023.06.562
2023
Conference Publication
Effects of Red Blood Cell Transfusion on Patients Undergoing Cardiac Surgery in Queensland—A Retrospective Cohort Study
Dhanapathy, V., Obonyo, N., White, N., Sela, D., Rachakonda, R., Tunbridge, M., Sim, B., Teo, D., Hoe, L. See, Fanning, J., Tung, J., Suen, J. and Fraser, J. (2023). Effects of Red Blood Cell Transfusion on Patients Undergoing Cardiac Surgery in Queensland—A Retrospective Cohort Study. 71st Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Adelaide, SA Australia, 3-6 August 2023. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2023.06.458
2023
Journal Article
Assessment and diagnosis of right ventricular failure—retrospection and future directions
Ro, Sun Kyun, Sato, Kei, Ijuin, Shinichi, Sela, Declan, Fior, Gabriele, Heinsar, Silver, Kim, Ji Young, Chan, Jonathan, Nonaka, Hideaki, Lin, Aaron C. W., Bassi, Gianluigi Li, Platts, David G., Obonyo, Nchafatso G., Suen, Jacky Y. and Fraser, John F. (2023). Assessment and diagnosis of right ventricular failure—retrospection and future directions. Frontiers in Cardiovascular Medicine, 10 1030864, 1-17. doi: 10.3389/fcvm.2023.1030864
2023
Journal Article
Correction : Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies
McNicholas, Bairbre A, Rezoagli, Emanuele, Simpkin, Andrew J, Khanna, Sankalp, Suen, Jacky Y, Yeung, Pauline, Brodie, Daniel, Bassi, Gianluigi Li, Pham, Tai, Bellani, Giacomo, Fraser, John F, Laffey, John and CCCC Consortium (2023). Correction : Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies. Critical Care, 27 (1) 202, 1-2. doi: 10.1186/s13054-023-04487-6
2023
Journal Article
Ethical Withdrawal of ECMO Support Over the Objections of Competent Patients
Wilkinson, Dominic, Fraser, John, Suen, Jacky, Suzuki, Mioko Kasagi and Savulescu, Julian (2023). Ethical Withdrawal of ECMO Support Over the Objections of Competent Patients. The American Journal of Bioethics, 23 (6), 27-30. doi: 10.1080/15265161.2023.2201194
2023
Journal Article
Preclinical studies on pulsatile veno-arterial extracorporeal membrane oxygenation: a systematic review
Kanagarajan, Dhayananth, Heinsar, Silver, Gandini, Lucia, Suen, Jacky Y., Dau, Van Thanh, Pauls, Jo and Fraser, John F. (2023). Preclinical studies on pulsatile veno-arterial extracorporeal membrane oxygenation: a systematic review. ASAIO Journal, 69 (5), e167-e180. doi: 10.1097/mat.0000000000001922
2023
Conference Publication
Proposal of a reliable scoring system for the histological assessment of multiorgan injury in large animal models of ischaemia and shock
Palmieri, C., See Hoe, L., Dyer, W., Heinsar, S., Rozencwaig, S., Tung, J.P., Bartnikowski, N., Passmore, M., Bouquet, M., Hislop, K., Wilson, E., Li Bassi, g., Mcgiffin, D., Suen, J. and Fraser, J. (2023). Proposal of a reliable scoring system for the histological assessment of multiorgan injury in large animal models of ischaemia and shock. 2022 Annual Congress of the European Society of Veterinary Pathology and European College of Veterinary Pathologists, Athens, Greece, 7 - 10 September 2022. London, United Kingdom: Elsevier. doi: 10.1016/j.jcpa.2023.03.059
2023
Journal Article
Cerebrovascular complications of COVID-19 on venovenous extracorporeal membrane oxygenation
Zaaqoq, Akram M., Griffee, Matthew J., Kelly, Thu-Lan, Fanning, Jonathon P., Heinsar, Silver, Suen, Jacky Y., Mariani, Silvia, Li Bassi, Gianluigi, Jacobs, Jeffrey P., White, Nicole, Fraser, John F., Lorusso, Roberto, Peek, Giles J., Cho, Sung-Min and COVID-19 Critical Care Consortium (COVID Critical) (2023). Cerebrovascular complications of COVID-19 on venovenous extracorporeal membrane oxygenation. Critical Care Medicine, 51 (8), 1043-1053. doi: 10.1097/ccm.0000000000005861
2023
Journal Article
Iliopsoas haematoma during extracorporeal membrane oxygenation: A registry report from the COVID-19 critical care consortium across 30 countries
Taniguchi, Hayato, Rätsep, Indrek, Heinsar, Silver, Liu, Keibun, Cespedes, Marcela, Suen, Jacky Y., Li Bassi, Gianluigi, Fraser, John F., Jacobs, Jeffrey P. and Peek, Giles J. (2023). Iliopsoas haematoma during extracorporeal membrane oxygenation: A registry report from the COVID-19 critical care consortium across 30 countries. Perfusion, 39 (5), 1-5. doi: 10.1177/02676591231168285
2023
Journal Article
Interleukin-6 inhibitors in non-COVID-19 ARDS: analyzing the past to step into the post-COVID-19 era
Gandini, Lucia, Fior, Gabriele, Schibler, Andreas, Obonyo, Nchafatso G., Li Bassi, Gianluigi, Suen, Jacky Y. and Fraser, John F. (2023). Interleukin-6 inhibitors in non-COVID-19 ARDS: analyzing the past to step into the post-COVID-19 era. Critical Care, 27 (1) 124, 124. doi: 10.1186/s13054-023-04394-w
Funding
Current funding
Past funding
Supervision
Availability
- Dr Jacky Suen is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Honours students for cardio-respiratory failure
We are looking for honours students to be involved in our range of studies on cardiac/respiratory failure. Projects include heart transplantation, acute respiratory failure, sepsis and advanced life support. Students will be expected and supported for grant application, as most of our previous honours students were awarded with $10,000 New Investigator Grant.
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Mitochondrial dysfunction and repair during circulatory death and heart transplantation
We are looking for Honours and RHD students to be involved in our NHMRC-funded heart transplantation program. Previously, we have successfully translated our research on extended organ preservation to clinical practice in Australia/New Zealand. As we explore on a new donor source, we are looking for talented students to join the team to study mitochondrial dysfunction, as a key parameter in determining post-transplant cardiac function.
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Systematic examination of ECMO parameters
Extra-Corporeal Membrane Oxygenation (ECMO) is an artificial heart/lung machine that is use to support patients with severe cardiac/respiratory failure. It has been invented for more than 30 years. To date, there is a lack of systematic examination of various parameters and settings for ECMO. Many of the current clinical practise are based on convention and tradition. This project aims to research and provide empirical evidences in order to optimise ECMO usage for patients, leading to improved patient outcome and reduced length of hospital stay. The project could involve bench-top ex vivo experiments, large animal in vivo study, and, perspective and retrospective analysis of clinical studies.
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Impact of blood flow for lung function
We are looking for Honours or RHD students to be involved in a project examining the impact of blood flow to support patients with respiratory failure. The student will be using human primary lung cells to model the condition of respiratory failure and advanced life support. The project will be in partnership with a leading biomed tech industry partner.
Supervision history
Current supervision
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Doctor Philosophy
Vascular Endothelial Injury, Repair and Preconditioning in the Artificial Circulation
Associate Advisor
Other advisors: Professor John Fraser
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Doctor Philosophy
Vascular Endothelial Injury, Repair and Preconditioning in the Artificial Circulation
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Novel Right Heart Assessment by Speckle Tracking Echocardiography
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Development of Speckle-Tracking Echocardiographic strain accounting for cardiac loading conditions
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Load-Independent Right Ventricular Assessment by Echocardiography
Associate Advisor
Other advisors: Professor John Fraser
Completed supervision
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2023
Doctor Philosophy
The differences in coagulation disturbances of the Acute Respiratory Distress Syndrome subphenotypes
Principal Advisor
Other advisors: Professor John Fraser
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2024
Doctor Philosophy
Development of Speckle-Tracking Echocardiographic strain accounting for cardiac loading conditions
Associate Advisor
Other advisors: Professor John Fraser
-
2023
Doctor Philosophy
A Comprehensive Pre-Clinical Evaluation of Pulsatile Flow Veno-arterial Extracorporeal Membrane Oxygenation
Associate Advisor
Other advisors: Professor John Fraser
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2023
Doctor Philosophy
The Significance of Different Phenotypes in Acute Respiratory Distress Syndrome (ARDS) for Effective Treatment
Associate Advisor
Other advisors: Professor John Fraser
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2022
Master Philosophy
Pre-clinical model development of electrical impedance tomography in the assessment of the pulmonary distribution of nebulized solutions
Associate Advisor
Other advisors: Associate Professor Jayesh Dhanani, Dr Gianluigi Li Bassi, Professor John Fraser
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2021
Doctor Philosophy
Combining Extracorporeal Life Support and Cell Therapy in Critical Illness: Mesenchymal stem cell therapy and extracorporeal membrane oxygenation in the Acute Respiratory Distress Syndrome
Associate Advisor
Other advisors: Professor John Fraser
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2019
Doctor Philosophy
A Translational Approach to Potential Toxicity of Stored Blood Components
Associate Advisor
Other advisors: Professor John Fraser
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2018
Doctor Philosophy
Modulating Protease-Activated Receptor 2
Associate Advisor
Other advisors: Dr Junxian Lim, Professor David Fairlie
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2014
Doctor Philosophy
Properties of C5a Receptor on Human Macrophages
Associate Advisor
Other advisors: Professor David Fairlie
Media
Enquiries
Contact Dr Jacky Suen directly for media enquiries about:
- Critical Care Medicine
- ECMO
- Extracorporeal Membrane Oxygenation
- Heart Failure
- Heart transplant
- Respiratory Failure
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