Overview
Background
Critical Care Medicine focuses on supporting patients, often with one or multiple organ failures. Based at the largest Australian cardiac hospital, our research investigates better ways to support patients with heart and/or lung failure. We explore technological, pharmacological and engineering advances that could help our patients to live longer and better. Our group is world-renowned for clinically relevant large animal models, including heart failure, respiratory failure (ARDS), heart transplantation, sepsis, cardiogenic shock, and more. All our studies use hospital-grade equipment and follow the same clinical guideline to maximise translation. We actively take on honours, MPhil and PhD students from multi-disciplinary backgrounds (science, engineering, medicine, allied health), with a successful track record in supporting our students to secure their own grants and funding. Students are expected to contribute to other studies of the group. For more information about the group, please visit ccrg.org.au, and email if you are interested to join us.
Availability
- Dr Jacky Suen is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor (Honours) of Science (Advanced), The University of Queensland
- Doctor of Philosophy of Pharmacology, The University of Queensland
- Member, Extracorporeal Life Support Organization, Extracorporeal Life Support Organization
Works
Search Professor Jacky Suen’s works on UQ eSpace
2023
Journal Article
A comprehensive evaluation of hemodynamic energy production and circuit loss using four different ECMO arterial cannulae
Heinsar, Silver, Bartnikowski, Nicole, Hartel, Gunter, Farah, Samia M., Seah, E‐Peng, Wu, Eric, Colombo, Sebastiano Maria, Semenzin, Clayton, Haymet, Andrew, Rätsep, Indrek, Pauls, Jo, Fraser, John F. and Suen, Jacky Y. (2023). A comprehensive evaluation of hemodynamic energy production and circuit loss using four different ECMO arterial cannulae. Artificial Organs, 47 (7), 1122-1132. doi: 10.1111/aor.14523
2023
Journal Article
Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation
Rozencwajg, Sacha, Heinsar, Silver, Wildi, Karin, Jung, Jae‐Seung, Colombo, Sebastiano Maria, Palmieri, Chiara, Sato, Kei, Ainola, Carmen, Wang, Xiaomeng, Abbate, Gabriella, Sato, Noriko, Dyer, Wayne B., Livingstone, Samantha, Helms, Leticia, Bartnikowski, Nicole, Bouquet, Mahe, Passmore, Margaret R., Hyslop, Kieran, Vidal, Bruno, Reid, Janice D., McGuire, Daniel, Wilson, Emily S., Rätsep, Indrek, Lorusso, Roberto, Schmidt, Matthieu, Suen, Jacky Y., Bassi, Gianluigi Li and Fraser, John F. (2023). Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation. Scientific Reports, 13 (1) 4002, 1-11. doi: 10.1038/s41598-023-30226-6
2023
Conference Publication
A novel speckle-tracking echocardiographic parameter considering left ventricular loading condition in cardiogenic shock during VA ECMO
Sato, Kei, Heinsar, Silver, Wildi, Karin Susanne, Obonyo, Nchafatso, Liu, Keibun, Farah, Samia, Ainola, Carmen, Sato, Noriko, Fior, Gabriele, Ro, Sun Kyun, Gandini, Lucia, Ijuin, Shinichi, Bouquet, Mahe, Wilson, Emily, Passmore, Margaret, Hyslop, Kieran, Chan, Jonathan H., Platts, David, Suen, Jacky, Li Bassi, Gianluigi and Fraser, John (2023). A novel speckle-tracking echocardiographic parameter considering left ventricular loading condition in cardiogenic shock during VA ECMO. 72nd Annual Scientific Session (ACC), New Orleans, LA, United States, 4-6 March 2023. San Diego, CA, United States: Elsevier.
2023
Journal Article
A novel speckle-tracking echocardiographic parameter considering left ventricular loading condition in cardiogenic shock during VA ECMO
Sato, Kei, Heinsar, Silver, Wildi, Karin Susanne, Obonyo, Nchafatso, LIU, KEIBUN, Farah, Samia, Ainola, Carmen, Sato, Noriko, Fior, Gabriele, Ro, Sun Kyun, Gandini, Lucia, Ijuin, Shinichi, Bouquet, Mahe, Wilson, Emily, Passmore, Margaret, Hyslop, Kieran, Chan, Jonathan H., Platts, David, Suen, Jacky, Bassi, Gianluigi Li and Fraser, John (2023). A novel speckle-tracking echocardiographic parameter considering left ventricular loading condition in cardiogenic shock during VA ECMO. Journal of the American College of Cardiology, 81 (8) 1396, 1-1. doi: 10.1016/s0735-1097(23)01840-5
2023
Journal Article
Hemorrhage, disseminated intravascular coagulopathy, and thrombosis complications among critically ill patients with COVID-19: an international COVID-19 critical care consortium study
Fanning, Jonathon P., Weaver, Natasha, Fanning, Robert B., Griffee, Matthew J., Cho, Sung-Min, Panigada, Mauro, Obonyo, Nchafatso G., Zaaqoq, Akram M., Rando, Hannah, Chia, Yew Woon, Fan, Bingwen Eugene, Sela, Declan, Chiumello, Davide, Coppola, Silvia, Labib, Ahmed, Whitman, Glenn J. R., Arora, Rakesh C., Kim, Bo S., Motos, Anna, Torres, Antoni, Barbé, Ferran, Grasselli, Giacomo, Zanella, Alberto, Etchill, Eric, Usman, Asad Ali, Feth, Maximilian, White, Nicole M., Suen, Jacky Y., Li Bassi, Gianluigi ... on behalf of the COVID-19 Critical Care Consortium (2023). Hemorrhage, disseminated intravascular coagulopathy, and thrombosis complications among critically ill patients with COVID-19: an international COVID-19 critical care consortium study. Critical Care Medicine, 51 (5), 619-631. doi: 10.1097/ccm.0000000000005798
2023
Journal Article
Morbid obesity’s impact on COVID-19 patients requiring venovenous extracorporeal membrane oxygenation: the covid-19 critical care consortium database review
Javidfar, Jeffrey, Zaaqoq, Akram M, Labib, Ahmed, Barnett, Adrian G, Hayanga, JW Awori, Eschun, Greg, Yamashita, Michael H, Jacobs, Jeffrey P, Heinsar, Silver, Suen, Jacky Y, Fraser, John F, Bassi, Gianluigi Li, Arora, Rakesh C, Peek, Giles J and on behalf of the Covid-19 Critical Care Consortium (COVID Critical) (2023). Morbid obesity’s impact on COVID-19 patients requiring venovenous extracorporeal membrane oxygenation: the covid-19 critical care consortium database review. Perfusion, 39 (4), 2676591231156487-712. doi: 10.1177/02676591231156487
2023
Journal Article
Resuscitation Associated Endotheliopathy (PubMed)
Obonyo, Nchafatso G., Sela, Declan P., Raman, Sainath, Rachakonda, Reema, Schneider, Bailey, Hoe, Louise E. See, Fanning, Jonathon P., Bassi, Gianluigi Li, Maitland, Kathryn, Suen, Jacky Y. and Fraser, John F. (2023). Resuscitation Associated Endotheliopathy (PubMed). searchRxiv, 2023. doi: 10.1079/searchrxiv.2023.00206
2023
Conference Publication
LENGTH OF PRE-ECMO MECHANICAL VENTILATION IS NOT ASSOCIATED WITH MORTALITY IN PATIENTS WITH COVID-19
Zhang, Chengda, Zakhary, Bishoy, White, Nicole, Heinsar, Silver, Burrell, Aidan, Zaaqoq, Akram, Jacobs, Jeffrey, Dalton, Heidi, Labib, Ahmed, Suen, Jacky, Mariani, Silvia, Bassi, Gianluigi Li, Fraser, John and Peek, Giles (2023). LENGTH OF PRE-ECMO MECHANICAL VENTILATION IS NOT ASSOCIATED WITH MORTALITY IN PATIENTS WITH COVID-19. 52nd Critical Care Congress of the Society-of-Critical-Care-Medicine (SCCM), San Francisco Ca, Jan 21-24, 2023. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
2022
Conference Publication
Length Of Pre-ecmo Mechanical Ventilation Is Not Associated With Mortality In Patients With COVID-19
Zhang, Chengda, Zakhary, Bishoy, White, Nicole, Heinsar, Silver, Burrell, Aidan, Zaaqoq, Akram, Jacobs, Jeffrey, Dalton, Heidi, Labib, Ahmed, Suen, Jacky, Mariani, Silvia, Li Bassi, Gianluigi, Fraser, John and Peek, Giles (2022). Length Of Pre-ecmo Mechanical Ventilation Is Not Associated With Mortality In Patients With COVID-19. 52nd Critical Care Congress, San Francisco, CA United States, 21-24 January 2023. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.ccm.0000906076.27255.5d
2022
Journal Article
Tracheostomy outcomes in critically ill COVID-19 patients: a systematic review, meta-analysis, and meta-regression
Battaglini, Denise, Premraj, Lavienraj, White, Nicole, Sutt, Anna-Liisa, Robba, Chiara, Cho, Sung-Min, Di Giacinto, Ida, Bressan, Filippo, Sorbello, Massimiliano, Cuthbertson, Brian, Bassi, Gianluigi Li, Suen, Jacky, Fraser, John and Pelosi, Paolo (2022). Tracheostomy outcomes in critically ill COVID-19 patients: a systematic review, meta-analysis, and meta-regression. British Journal of Anaesthesia, 129 (5), 679-692. doi: 10.1016/j.bja.2022.07.032
2022
Journal Article
Design, development and preliminary assessment in a porcine model of a novel peripheral intravenous catheter aimed at reducing early failure rates
Doyle, Barry J., Kelsey, Lachlan J., Shelverton, Caroline, Abbate, Gabriella, Ainola, Carmen, Sato, Noriko, Livingstone, Samantha, Bouquet, Mahe, Passmore, Margaret R, Wilson, Emily S., Colombo, Sebastiano, Sato, Kei, Liu, Keibun, Heinsar, Silver, Wildi, Karin, Carr, Peter J., Suen, Jacky, Fraser, John, Li Bassi, Gianluigi and Keogh, Samantha (2022). Design, development and preliminary assessment in a porcine model of a novel peripheral intravenous catheter aimed at reducing early failure rates. The Journal of Vascular Access, 25 (3), 11297298221127760-799. doi: 10.1177/11297298221127760
2022
Journal Article
An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
Gonçalves, Bronner P, Hall, Matthew, Jassat, Waasila, Balan, Valeria, Murthy, Srinivas, Kartsonaki, Christiana, Semple, Malcolm G, Rojek, Amanda, Baruch, Joaquín, Reyes, Luis Felipe, Dasgupta, Abhishek, Dunning, Jake, Citarella, Barbara Wanjiru, Pritchard, Mark, Martín-Quiros, Alejandro, Sili, Uluhan, Baillie, J Kenneth, Aryal, Diptesh, Arabi, Yaseen, Rashan, Aasiyah, Angheben, Andrea, Caoili, Janice, Carrier, François Martin, Harrison, Ewen M, Gómez-Junyent, Joan, Figueiredo-Mello, Claudia, Douglas, James Joshua, Mat Nor, Mohd Basri, Chow, Yock Ping ... Suen, Jacky Y. (2022). An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients. eLife, 11 e80556. doi: 10.7554/eLife.80556
2022
Journal Article
Transcriptomic profiling of cardiac tissues from SARS‐CoV ‐2 patients identifies DNA damage
Kulasinghe, Arutha, Liu, Ning, Tan, Chin Wee, Monkman, James, Sinclair, Jane E., Bhuva, Dharmesh D., Godbolt, David, Pan, Liuliu, Nam, Andy, Sadeghirad, Habib, Sato, Kei, Bassi, Gianluigi Li, O'Byrne, Ken, Hartmann, Camila, Miggiolaro, Anna Flavia Ribeiro dos Santos, Marques, Gustavo Lenci, Moura, Lidia Zytynski, Richard, Derek, Adams, Mark, Noronha, Lucia de, Baena, Cristina Pellegrino, Suen, Jacky Y., Arora, Rakesh, Belz, Gabrielle T., Short, Kirsty R., Davis, Melissa J., Souza‐Fonseca Guimaraes, Fernando and Fraser, John F. (2022). Transcriptomic profiling of cardiac tissues from SARS‐CoV ‐2 patients identifies DNA damage. Immunology, 168 (3), 403-419. doi: 10.1111/imm.13577
2022
Journal Article
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
Reyes, Luis Felipe, Murthy, Srinivas, Garcia-Gallo, Esteban, Merson, Laura, Ibáñez-Prada, Elsa D., Rello, Jordi, Fuentes, Yuli V., Martin-Loeches, Ignacio, Bozza, Fernando, Duque, Sara, Taccone, Fabio S., Fowler, Robert A., Kartsonaki, Christiana, Gonçalves, Bronner P., Citarella, Barbara Wanjiru, Aryal, Diptesh, Burhan, Erlina, Cummings, Matthew J., Delmas, Christelle, Diaz, Rodrigo, Figueiredo-Mello, Claudia, Hashmi, Madiha, Panda, Prasan Kumar, Jiménez, Miguel Pedrera, Rincon, Diego Fernando Bautista, Thomson, David, Nichol, Alistair, Marshall, John C., Olliaro, Piero L. ... Suen, Jacky Y. (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Critical Care, 26 (1) 276. doi: 10.1186/s13054-022-04155-1
2022
Journal Article
Neurological manifestations of COVID-19 in adults and children
Cho, Sung Min, White, Nicole, Premraj, Lavienraj, Battaglini, Denise, Fanning, Jonathon, Suen, Jacky, Bassi, Gianluigi Li, Fraser, John, Robba, Chiara, Griffee, Matthew, Singh, Bhagteshwar, Citarella, Barbara Wanjiru, Merson, Laura, Solomon, Tom, Thomson, David, ISARIC Clinical Characterisation Group, Forsyth, Simon and Shrapnel, Sally (2022). Neurological manifestations of COVID-19 in adults and children. Brain, 146 (4), 1648-1661. doi: 10.1093/brain/awac332
2022
Journal Article
Current intraoperative storage and handling practices of autologous bypass conduit: A survey of the royal australasian college of surgeons
Haymet, A. B., Pinto, N., Peden, S., Cohen, T., Vallely, M. P., McGiffin, D., Naidoo, R., Jenkins, J., Suen, J. Y. and Fraser, J. F. (2022). Current intraoperative storage and handling practices of autologous bypass conduit: A survey of the royal australasian college of surgeons. Frontiers in Surgery, 9 956177, 1-7. doi: 10.3389/fsurg.2022.956177
2022
Journal Article
Modifying a hydroxyl patch in glucagon-like peptide 1 produces biased agonists with unique signaling profiles
Wang, Peiqi, Hill, Timothy A., Mitchell, Justin, Fitzsimmons, Rebecca L., Xu, Weijun, Loh, Zhixuan, Suen, Jacky Y., Lim, Junxian, Iyer, Abishek and Fairlie, David P. (2022). Modifying a hydroxyl patch in glucagon-like peptide 1 produces biased agonists with unique signaling profiles. Journal of Medicinal Chemistry, 65 (17), 11759-11775. doi: 10.1021/acs.jmedchem.2c00653
2022
Journal Article
ISARIC-COVID-19 dataset: A prospective, standardized, global dataset of patients hospitalized with COVID-19
ISARIC Clinical Characterization Group, Garcia-Gallo, Esteban, Merson, Laura, Kennon, Kalynn, Kelly, Sadie, Wanjiru Citarella, Barbara, Vidali Fryer, Daniel, Shrapnel, Sally, Lee, James, Duque, Sara, Fuentes, Yuli V., Balan,Valeria, Smith, Sue, Wei, Jia, Gonçalves, Bronner P., Russell, Clark D., Sigfrid, Louise, Dagens, Andrew, Olliaro, Piero L., Baruch, Joaquin, Kartsonaki, Christiana, Dunning, Jake, Rojek, Amanda, Rashan, Aasiyah, Beane, Abi, Murthy, Srinivas, Reyes, Luis Felipe, Forsyth, Simon J. and Suen, Jacky Y. (2022). ISARIC-COVID-19 dataset: A prospective, standardized, global dataset of patients hospitalized with COVID-19. Scientific Data, 9 (1) 454, 454. doi: 10.1038/s41597-022-01534-9
2022
Journal Article
Neurological manifestations of SARS-CoV-2 infection: Protocol for a sub-analysis of the COVID-19 critical care consortium observational study
Battaglini, Denise, Premraj, Lavienraj, Griffee, Matthew, Huth, Samuel, Fanning, Jonathon, Whitman, Glenn, Bastos Porto, Diego, Arora, Rakesh, Durham, Lucian, Gnall, Eric, Amato, Marcelo, Williams, Virginie, Noel, Alexandre, De Franca, Sabrina Araujo, Samoukovic, Gordan, Pujo, Bambang, Kent, David, Marwali, Eva, Al-Fares, Abdulrahman, Stecher, Stephanie-Susanne, Panigada, Mauro, Giani, Marco, Foti, Giuseppe, Pelosi, Paolo, Pesenti, Antonio, White, Nicole Marie, Li Bassi, Gianluigi, Suen, Jacky, Fraser, John F. ... Cho, Sung-Min (2022). Neurological manifestations of SARS-CoV-2 infection: Protocol for a sub-analysis of the COVID-19 critical care consortium observational study. Frontiers in Medicine, 9 930217, 1-12. doi: 10.3389/fmed.2022.930217
2022
Journal Article
Differential protein expression among two different ovine ARDS phenotypes—A preclinical randomized study
Wildi, Karin, Bouquet, Mahe, Ainola, Carmen, Livingstone, Samantha, Colombo, Sebastiano Maria, Heinsar, Silver, Sato, Noriko, Sato, Kei, Wilson, Emily, Abbate, Gabriella, Passmore, Margaret R., Hyslop, Kieran, Liu, Keibun, Li Bassi, Gianluigi, Suen, Jacky Y. and Fraser, John F. (2022). Differential protein expression among two different ovine ARDS phenotypes—A preclinical randomized study. Metabolites, 12 (7) 655, 1-17. doi: 10.3390/metabo12070655
Funding
Current funding
Past funding
Supervision
Availability
- Dr Jacky Suen is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Honours students for cardio-respiratory failure
We are looking for honours students to be involved in our range of studies on cardiac/respiratory failure. Projects include heart transplantation, acute respiratory failure, sepsis and advanced life support. Students will be expected and supported for grant application, as most of our previous honours students were awarded with $10,000 New Investigator Grant.
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Mitochondrial dysfunction and repair during circulatory death and heart transplantation
We are looking for Honours and RHD students to be involved in our NHMRC-funded heart transplantation program. Previously, we have successfully translated our research on extended organ preservation to clinical practice in Australia/New Zealand. As we explore on a new donor source, we are looking for talented students to join the team to study mitochondrial dysfunction, as a key parameter in determining post-transplant cardiac function.
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Systematic examination of ECMO parameters
Extra-Corporeal Membrane Oxygenation (ECMO) is an artificial heart/lung machine that is use to support patients with severe cardiac/respiratory failure. It has been invented for more than 30 years. To date, there is a lack of systematic examination of various parameters and settings for ECMO. Many of the current clinical practise are based on convention and tradition. This project aims to research and provide empirical evidences in order to optimise ECMO usage for patients, leading to improved patient outcome and reduced length of hospital stay. The project could involve bench-top ex vivo experiments, large animal in vivo study, and, perspective and retrospective analysis of clinical studies.
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Impact of blood flow for lung function
We are looking for Honours or RHD students to be involved in a project examining the impact of blood flow to support patients with respiratory failure. The student will be using human primary lung cells to model the condition of respiratory failure and advanced life support. The project will be in partnership with a leading biomed tech industry partner.
Supervision history
Current supervision
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Doctor Philosophy
Novel Right Heart Assessment by Speckle Tracking Echocardiography
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Load-Independent Right Ventricular Assessment by Echocardiography
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Vascular Endothelial Injury, Repair and Preconditioning in the Artificial Circulation
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Vascular Endothelial Injury, Repair and Preconditioning in the Artificial Circulation
Associate Advisor
Other advisors: Professor John Fraser
-
Doctor Philosophy
Development of Speckle-Tracking Echocardiographic strain accounting for cardiac loading conditions
Associate Advisor
Other advisors: Professor John Fraser
Completed supervision
-
2023
Doctor Philosophy
The differences in coagulation disturbances of the Acute Respiratory Distress Syndrome subphenotypes
Principal Advisor
Other advisors: Professor John Fraser
-
2024
Doctor Philosophy
Development of Speckle-Tracking Echocardiographic strain accounting for cardiac loading conditions
Associate Advisor
Other advisors: Professor John Fraser
-
2023
Doctor Philosophy
A Comprehensive Pre-Clinical Evaluation of Pulsatile Flow Veno-arterial Extracorporeal Membrane Oxygenation
Associate Advisor
Other advisors: Professor John Fraser
-
2023
Doctor Philosophy
The Significance of Different Phenotypes in Acute Respiratory Distress Syndrome (ARDS) for Effective Treatment
Associate Advisor
Other advisors: Professor John Fraser
-
2022
Master Philosophy
Pre-clinical model development of electrical impedance tomography in the assessment of the pulmonary distribution of nebulized solutions
Associate Advisor
Other advisors: Associate Professor Jayesh Dhanani, Dr Gianluigi Li Bassi, Professor John Fraser
-
2021
Doctor Philosophy
Combining Extracorporeal Life Support and Cell Therapy in Critical Illness: Mesenchymal stem cell therapy and extracorporeal membrane oxygenation in the Acute Respiratory Distress Syndrome
Associate Advisor
Other advisors: Professor John Fraser
-
2019
Doctor Philosophy
A Translational Approach to Potential Toxicity of Stored Blood Components
Associate Advisor
Other advisors: Professor John Fraser
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2018
Doctor Philosophy
Modulating Protease-Activated Receptor 2
Associate Advisor
Other advisors: Dr Junxian Lim, Professor David Fairlie
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2014
Doctor Philosophy
Properties of C5a Receptor on Human Macrophages
Associate Advisor
Other advisors: Professor David Fairlie
Media
Enquiries
Contact Dr Jacky Suen directly for media enquiries about:
- Critical Care Medicine
- ECMO
- Extracorporeal Membrane Oxygenation
- Heart Failure
- Heart transplant
- Respiratory Failure
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