Professor Glenn King
Professor

Glenn King

Email: 
Phone: 
+61 7 334 62025

Availability

Professor Glenn King is:
Available for supervision
Media expert

Fields of research

Biological Sciences Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Science, University of Sydney
  • Doctor of Philosophy, University of Sydney

Research interests

  • Bugs and drugs

    Our research harnesses the chemistry of venoms from arthropod predators, such as spiders, scorpions and centipedes, to develop novel pharmaceuticals to treat chronic pain, epilepsy and stroke. Stroke is the second-leading cause of death worldwide. In addition, it causes an extremely high incidence of disability in surviving victims due to the brain damage suffered during stroke. Likewise, chronic pain is a huge medical problem that affects one in five adults. There are few drugs available for treating chronic pain, and many of these have limited efficacy and dose-limiting side effects. Animal venoms are a rich source of stable natural peptides that potently modulate the activity of a wide range of neuronal ion channels and receptors. We have the largest collection of arthropod venoms in the world, a high-throughput pipeline for venoms-based drug discovery, protocols for rapid protein expression and structure determination, and links to key laboratories for testing the efficacy of lead molecules in rodent models of pain, epilepsy and stroke. We are using these world-class resources to move us closer to achieving our aim of developing novel analgesics for pain relief, novel drugs for treating severe paediatric epilepsies, and novel neuroprotective agents for treating stroke victims. An equally important focus of our research is on helping to safeguard Australia’s agricultural crops and reduce the spread of disease from insect pests by discovering new environmentally friendly insecticides. Currently, arthropod pests destroy approximately 15 per cent of the world’s food supply and spread pernicious diseases such as dengue and malaria. Our work is finding better, safer ways to control disease-spreading pests and protect crops.

Search Professor Glenn King’s works on UQ eSpace

431 works between 1983 and 2024
All (431) Journal Article (354) Book Chapter (19) Conference Publication (54) Book (2) Other Outputs (2)

421 - 431 of 431 works

1986

Journal Article

Application of Progress Curve Analysis to Insitu Enzyme-Kinetics Using H-1-Nmr Spectroscopy

Vandenberg, JI, Kuchel, PW and King, GF (1986). Application of Progress Curve Analysis to Insitu Enzyme-Kinetics Using H-1-Nmr Spectroscopy. Analytical Biochemistry, 155 (1), 38-44. doi: 10.1016/0003-2697(86)90221-6

Application of Progress Curve Analysis to Insitu Enzyme-Kinetics Using H-1-Nmr Spectroscopy

1986

Journal Article

Direct Nmr Evidence That Prolidase Is Specific for the Trans Isomer of Imidodipeptide Substrates

King, GF, Middlehurst, CR and Kuchel, PW (1986). Direct Nmr Evidence That Prolidase Is Specific for the Trans Isomer of Imidodipeptide Substrates. Biochemistry, 25 (5), 1054-1062. doi: 10.1021/bi00353a016

Direct Nmr Evidence That Prolidase Is Specific for the Trans Isomer of Imidodipeptide Substrates

1985

Journal Article

Enkephalin Degradation by Human-Erythrocytes and Hemolysates Studied Using H-1-Nmr Spectroscopy

Vandenberg, JI, King, GF and Kuchel, PW (1985). Enkephalin Degradation by Human-Erythrocytes and Hemolysates Studied Using H-1-Nmr Spectroscopy. Archives of Biochemistry and Biophysics, 242 (2), 515-522. doi: 10.1016/0003-9861(85)90238-3

Enkephalin Degradation by Human-Erythrocytes and Hemolysates Studied Using H-1-Nmr Spectroscopy

1985

Journal Article

Assimilation of Alpha-Glutamyl-Peptides by Human-Erythrocytes - a Possible Means of Glutamate Supply for Glutathione Synthesis

King, GF and Kuchel, PW (1985). Assimilation of Alpha-Glutamyl-Peptides by Human-Erythrocytes - a Possible Means of Glutamate Supply for Glutathione Synthesis. Biochemical Journal, 227 (3), 833-842. doi: 10.1042/bj2270833

Assimilation of Alpha-Glutamyl-Peptides by Human-Erythrocytes - a Possible Means of Glutamate Supply for Glutathione Synthesis

1985

Journal Article

The Assimilation of Tripeptides and Tetrapeptides by Human-Erythrocytes

Vandenberg, JI, King, GF and Kuchel, PW (1985). The Assimilation of Tripeptides and Tetrapeptides by Human-Erythrocytes. Biochimica Et Biophysica Acta, 846 (1), 127-134. doi: 10.1016/0167-4889(85)90118-1

The Assimilation of Tripeptides and Tetrapeptides by Human-Erythrocytes

1984

Journal Article

Monitoring Metabolic Reactions in Erythrocytes Using Nmr-Spectroscopy

Kuchel, PW, Chapman, BE, Endre, ZH, King, GF, Thorburn, DR and York, MJ (1984). Monitoring Metabolic Reactions in Erythrocytes Using Nmr-Spectroscopy. Biomedica Biochimica Acta, 43 (6), 719-726.

Monitoring Metabolic Reactions in Erythrocytes Using Nmr-Spectroscopy

1984

Journal Article

A Proton Nmr-Study of Iminodipeptide Transport and Hydrolysis in the Human-Erythrocyte - Possible Physiological Roles for the Coupled System

King, GF and Kuchel, PW (1984). A Proton Nmr-Study of Iminodipeptide Transport and Hydrolysis in the Human-Erythrocyte - Possible Physiological Roles for the Coupled System. Biochemical Journal, 220 (2), 553-560. doi: 10.1042/bj2200553

A Proton Nmr-Study of Iminodipeptide Transport and Hydrolysis in the Human-Erythrocyte - Possible Physiological Roles for the Coupled System

1984

Journal Article

NMR-STUDIES OF MYELIN BASIC-PROTEIN .11. CONFORMATION OF A NONAPEPTIDE FROM A SEGMENT ENCEPHALITOGENIC IN RHESUS-MONKEY

MENDZ, GL, MOORE, WJ, KING, G and WRIGHT, PE (1984). NMR-STUDIES OF MYELIN BASIC-PROTEIN .11. CONFORMATION OF A NONAPEPTIDE FROM A SEGMENT ENCEPHALITOGENIC IN RHESUS-MONKEY. International Journal of Peptide and Protein Research, 24 (3), 208-217.

NMR-STUDIES OF MYELIN BASIC-PROTEIN .11. CONFORMATION OF A NONAPEPTIDE FROM A SEGMENT ENCEPHALITOGENIC IN RHESUS-MONKEY

1984

Journal Article

Studies of Rat-Brain Metabolism Using Proton Nuclear Magnetic-Resonance - Spectral Assignments and Monitoring of Prolidase, Acetylcholinesterase, and Glutaminase

Middlehurst, CR, King, GF, Beilharz, GR, Hunt, GE, Johnson, Gfs and Kuchel, PW (1984). Studies of Rat-Brain Metabolism Using Proton Nuclear Magnetic-Resonance - Spectral Assignments and Monitoring of Prolidase, Acetylcholinesterase, and Glutaminase. Journal of Neurochemistry, 43 (6), 1561-1567. doi: 10.1111/j.1471-4159.1984.tb06079.x

Studies of Rat-Brain Metabolism Using Proton Nuclear Magnetic-Resonance - Spectral Assignments and Monitoring of Prolidase, Acetylcholinesterase, and Glutaminase

1984

Journal Article

Monitoring metabolic reactions in erythrocytes using NMR spectroscopy

Kuchel, P W, Chapman, B E, Endre, Z H, King, G F, Thorburn, D R and York, M J (1984). Monitoring metabolic reactions in erythrocytes using NMR spectroscopy. Biomedica biochimica acta, 43 (6), 719-26.

Monitoring metabolic reactions in erythrocytes using NMR spectroscopy

1983

Journal Article

Proton Nmr Spectroscopic Studies of Dipeptidase in Human-Erythrocytes

King, GF, York, MJ, Chapman, BE and Kuchel, PW (1983). Proton Nmr Spectroscopic Studies of Dipeptidase in Human-Erythrocytes. Biochemical and Biophysical Research Communications, 110 (1), 305-312. doi: 10.1016/0006-291X(83)91296-2

Proton Nmr Spectroscopic Studies of Dipeptidase in Human-Erythrocytes

Current funding

  • 2025 - 2029
    Venoms to drugs: translating venom peptides into human therapeutics
    NHMRC Investigator Grants
    Open grant
  • 2024 - 2028
    Spider venom peptides: precision therapy for genetic epilepsies
    NHMRC MRFF Stem Cells Therapies Mission
    Open grant
  • 2024 - 2028
    The HEART REHAB Clinical Trials: Therapeutics to Protect the Human Heart
    MRFF Frontier Health and Medical Research Program administered by AusIndustry
    Open grant
  • 2024 - 2026
    Glycaemic variability: A culprit cause of heart disease in diabetes
    MRFF Targeted Translation Research Accelerator
    Open grant
  • 2023 - 2025
    Therapies for pain relief
    Golden Casket Lottery Corporation Ltd
    Open grant
  • 2023 - 2026
    Peptide Inhibitors Targeting Sodium Channels to Treat Amyotrophic Lateral Sclerosis
    United States Congressionally Directed Medical Research Programs - Amyotrophic Lateral Sclerosis Research Program
    Open grant
  • 2022 - 2024
    Developing a first-in-class therapeutic for chronic visceral pain using venom derived peptides (NHMRC Development Grant administered by SAHMRI)
    South Australian Health and Medical Research Institute Limited
    Open grant
  • 2021 - 2025
    Development of drugs to prevent ischemic injuries of the heart and brain
    NHMRC MRFF - Cardiovascular Health Mission
    Open grant
  • 2021 - 2028
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    ARC Centres of Excellence
    Open grant
  • 2021 - 2024
    ASIC1a, a new therapeutic drug target for cardiac ischemia
    NHMRC IDEAS Grants
    Open grant
  • 2021 - 2024
    Development of a first-in-class therapeutic for protecting the ischemic heart
    NHMRC Development Grant
    Open grant

Past funding

  • 2023 - 2024
    Studying the basis of and developing new therapies to treat heart disease
    IPF Healthy - Medical Research
    Open grant
  • 2022
    Australian Peptide Display Facility (ARC LIEF administered by University of Sydney)
    University of Sydney
    Open grant
  • 2021 - 2023
    Donation for stroke research
    Golden Casket Lottery Corporation Ltd
    Open grant
  • 2020
    Electrophysiology Platform for Ion-channel Characterisation
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2020 - 2023
    A novel platform for large-scale production of a first-in-class biologic drug for stroke
    NHMRC Development Grant
    Open grant
  • 2019 - 2022
    Gain from pain: new tools from venomous animals for exploring pain pathways
    ARC Discovery Projects
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2021
    Development of a first-in-class neuroprotective drug for protecting the brain after stroke
    NHMRC Development Grant
    Open grant
  • 2019
    Imaging Mass Spectrometry at Higher Mass Resolution
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    Vevo 3100 Imaging System for ultrahigh resolution and frame rate echocardiographic assessment of small animals.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019 - 2022
    Virtuous cycles: a novel cyclic peptide approach to develop neuroprotective and cardioprotective drugs
    NHMRC Project Grant
    Open grant
  • 2018 - 2019
    Development of dual Nav1.1/1.7 inhibitors for the treatment of IBS-related pain
    UniQuest Pty Ltd
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2023
    Venoms to drugs: translating venom peptides into human therapeutics
    NHMRC Research Fellowship
    Open grant
  • 2017 - 2018
    Evaluation of the stability of Nav1.1 activating peptides for treatment of Dravet Syndrome
    UniQuest Pty Ltd
    Open grant
  • 2017
    Deep Protein Sequencing, Structure and Quantification Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2017 - 2018
    Australian high field EPR facility (ARC LIEF project administered by the Australian National University)
    Australian National University
    Open grant
  • 2016
    4D Mass Spectrometer
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Novel Pain therapeutics discovery: Probing molecular mechanisms
    NHMRC Equipment Grant
    Open grant
  • 2016
    Patch-clamp electrophysiology platform for drug and insecticide discovery
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2018
    Unravelling the molecular diversity and evolution of centipede venoms
    ARC Discovery Projects
    Open grant
  • 2016 - 2018
    Voltage-dependent structural changes in voltage-gated sodium channels
    ARC Discovery Projects
    Open grant
  • 2015 - 2017
    A novel therapeutic intervention for Dravet syndrome
    Citizens United for Research in Epilepsy (CURE)
    Open grant
  • 2015 - 2020
    Evaluation of insecticidal spider peptides
    UniQuest Pty Ltd
    Open grant
  • 2015 - 2017
    Tailoring plant protease inhibitors for control of the crop pest Helicoverpa armigera
    Australia-India Strategic Research Fund
    Open grant
  • 2015 - 2019
    Ion channel modulators of pain pathways
    NHMRC Program Grant
    Open grant
  • 2015
    Murine behavioural phenotyping facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Protein Analysis Facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2017
    Imaging the world of miniature venomous arthropods
    ARC Linkage Projects
    Open grant
  • 2014 - 2017
    Discovery and characterisation of novel spider-venom peptides targeting the human Nav1.7 channel
    ARC Linkage Projects
    Open grant
  • 2014 - 2017
    Developing subtype-selective blockers of acid-sensing ion channels for treating peripheral pain
    NHMRC Project Grant
    Open grant
  • 2014 - 2016
    Development of selective blockers of acid sensing ion channel 1a for the treatment of stroke
    NHMRC Project Grant
    Open grant
  • 2014 - 2017
    Endosomal sorting of amyloid precursor protein in Alzheimer's disease
    NHMRC Project Grant
    Open grant
  • 2013 - 2016
    Understanding how membrane trafficking controls the levels of Alzheimer's disease causing Aß peptides
    NHMRC Project Grant
    Open grant
  • 2013 - 2018
    Efficacy Profiling Innovation in Novel Pain Therapeutics Discovery
    ARC Linkage Projects
    Open grant
  • 2013 - 2017
    NHMRC Research Fellowship: Venoms to drugs: translating venom peptides into therapeutics
    NHMRC Research Fellowship
    Open grant
  • 2012 - 2013
    High-resolution and high-throughput Nuclear Magnetic Resonance (NMR) Facility (ARC LIEF Grant administered by JCU)
    ARC LIEF Collaborating/Partner Organisation Contributions
    Open grant
  • 2012 - 2013
    Endosomal protein sorting and APP processing in Alzheimer's disease
    NHMRC Project Grant
    Open grant
  • 2012
    High- throughput Fourier Transform Infrared (FTIR) spectrometer.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2012 - 2014
    Rational development of novel analgesics for the treatment of chronic pain
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Development of novel analgesics for the treatment of chronic pain
    UQ FirstLink Scheme
    Open grant
  • 2011 - 2014
    Development of environmentally-friendly bioinsecticides for control of Australian crop pests
    ARC Linkage Projects
    Open grant
  • 2011 - 2012
    High-throughput, high resolution protein-peptide sequencing and quantification facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2011
    Auto-iTC200 microcalorimeter for high-throughput molecular interaction analyses
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Developing inhibitors of an essential histidine kinase in Staphylococcus aureus
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    Development of potent and selective blockers of acid sensing ion channels for the treatment of pain
    NHMRC Project Grant
    Open grant
  • 2011 - 2014
    Development of potent and specific modulators of the human sodium channel Nav1.7
    ARC Discovery Projects
    Open grant
  • 2011 - 2012
    Discovery of New P2X7 Blockers from Spider Venoms as Potential Analgesics
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2011
    Freedom Evo 150 robotic worktable: Automated high throughput and long-time course spectrophotometric multiwell plate assay system
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2011
    Advanced molecular discovery and characterisation facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2010
    Automated liquid handling platform
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Infrared imaging system for quantitative protein analysis
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2012
    Peptidic spider toxins: a novel paradigm for control of insect pests
    ARC Discovery Projects
    Open grant
  • 2010
    The development of peptides (mini-proteins) as drugs: improved purification capability
    UQ Major Equipment and Infrastructure
    Open grant
  • 2008 - 2011
    Development of novel antibacterial compounds from subtilosin A
    NHMRC Project Grant
    Open grant
  • 2008 - 2010
    Dissecting the divisome: development of antibacterial agents that inhibit bacterial cytokinesis
    NHMRC Project Grant
    Open grant
  • 2008 - 2010
    Examining the role ASIC channels in pain through the development of subtype-specific ASIC channel modulators
    NHMRC Project Grant
    Open grant
  • 2008 - 2010
    Inhibition of histidine kinase signal sensing: a novel paradigm for antimicrobial development
    NHMRC Project Grant
    Open grant
  • 2008 - 2010
    Orally active spider toxins: a novel paradigm for control of insect pests
    ARC Discovery Projects
    Open grant
  • 2007 - 2009
    Safeguarding Australia against invasive arthropod pests
    ARC Discovery Projects
    Open grant

Availability

Professor Glenn King is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Venom-derived drugs for targeting ion channels involved in genetic epilepsies

    Principal Advisor

    Other advisors: Associate Professor Lata Vadlamudi

  • Doctor Philosophy

    Development of a first-in-class biologic drug for stroke

    Principal Advisor

    Other advisors: Dr Natalie Saez

  • Doctor Philosophy

    Identifying the structure, function, and mechanism of action of cardiotoxic components in the venoms of box (Chironex fleckeri) and Irukandji (Carukia barnesi) jellyfish

    Principal Advisor

    Other advisors: Associate Professor Nathan Palpant, Dr Andrew Walker

  • Doctor Philosophy

    Utilising invertebrates to identify novel coagulotoxins

    Associate Advisor

    Other advisors: Professor Bryan Fry, Dr Andrew Walker

  • Doctor Philosophy

    Characterising the Structure and Function of Caterpillar Venom Toxins

    Associate Advisor

    Other advisors: Dr Andrew Walker

  • Master Philosophy

    Pharmacological screening of Columbian scorpion venoms

    Associate Advisor

    Other advisors: Dr Andrew Walker

  • Doctor Philosophy

    Evaluation of Phylogenetic Patterns of Scorpion Pathophysiological Effects and Effectiveness of Next-Generation Antivenoms

    Associate Advisor

    Other advisors: Dr Sam Robinson, Professor Bryan Fry

  • Doctor Philosophy

    Selective inhibition of voltage gated sodium channels using ProTx-III spider venom peptide to treat motor neuron disease

    Associate Advisor

    Other advisors: Dr Fernanda Cardoso

Completed supervision

Enquiries

Contact Professor Glenn King directly for media enquiries about:

  • Chronic pain
  • Dravet syndrome
  • drug discovery
  • epilepsy
  • Insecticides
  • Ion channel drugs
  • NMR spectroscopy
  • pain drugs
  • painkillers
  • peptide drugs
  • Protein structure
  • Stroke
  • Venomous animals

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