
Overview
Background
Neurologist
Dr McCombe graduated in Medicine from UQ and completed a Science degree for medical students. She then trained as a neurologist in Sydney, at Prince Henry and Prince of Wales Hospitals. She obtained a PhD from the University of Sydney. She obtained experience in Neurophysiology in Cleveland and then returned to UQ as a post-doctoral fellow. She worked for some years as a research fellow in Neuroimmunology and was an NHMRc SRF. Later she resumed clinical practice as a neurologist, and contimued her research as an NHMRC Practitioner Fellow. She is currentlyProfessor and Head of the Royal Brisbane Clinical school in the School of Medicine and Co-head of the Brain and Mental Health Theme at the UQ Centre for Clinical Research.
Availability
- Professor Pamela McCombe is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Doctor of Philosophy, University of Sydney
- Royal Australasian College of Physicians, Royal Australasian College of Physicians
Research interests
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Biomarkers and heterogeneity in ALS
One of the challenges of ALS is understanding disease heterogeneity. Our work studies the variability of patients by detailed clinical, laboratory and genetic studies, and by identifying biomarkers that are associated with disease. We use a range of techniques including neurophysiology, MRI, metabolic studies, genetic studies, immune markers and biochemical studies including proteomics. We are using this information to analyse whether patients can be assigned into subgroups and to correlated with survival.
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Inflammatory neuropathy studies
This is an ongoing study of the immunological basis and genetic basis of acute and chronic inflammatory neuropathy
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Pregnancy and MS
This study is exploring the short and long term effects of pregnancy in multiple sclerosis. This includes the clinical effects of pregnancy and the effects on gene expression and methylation
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Immunology of stroke
This study involves documenting the immune responses after human stroke and determining the significance of these responses.
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Neuromuscular disease
This work is based at the Neuromuscular clinic at Royal Brisbane and Women's Hospital, and involves correlation of genotype and phenotype of inherited neuromuscular disease
Works
Search Professor Pamela McCombe’s works on UQ eSpace
2010
Conference Publication
Immune response in acute ischaemic stroke
Badve, Monica S., Yan, J., Hull, R., Henderson, Robert, O’Sullivan, John D., Read, Stephen J., Wong, Andrew A. and McCombe, Pamela (2010). Immune response in acute ischaemic stroke. ANZAN Annual Scientific Meeting 2010, -, 2010. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jocn.2010.07.064
2009
Journal Article
Sexual dimorphism in autoimmune disease
McCombe, P.A., Greer, J.M. and Mackay, I.R. (2009). Sexual dimorphism in autoimmune disease. Current Molecular Medicine, 9 (9), 1058-1079. doi: 10.2174/156652409789839116
2009
Journal Article
Chapter 5 Results of Bayesian statistical analysis in normal and ALS subjects
Henderson, R. D., Ridall, P. G., Pettitt, A. N. and McCombe, P. A. (2009). Chapter 5 Results of Bayesian statistical analysis in normal and ALS subjects. Supplements to Clinical Neurophysiology, 60 (C), 57-63. doi: 10.1016/S1567-424X(08)00005-6
2009
Journal Article
Chapter 4 Bayesian analysis of the stimulus-response curve
Ridall, P. G., Pettitt, A. N., McCombe, P. A. and Henderson, R. D. (2009). Chapter 4 Bayesian analysis of the stimulus-response curve. Supplements to Clinical Neurophysiology, 60 (C), 47-56. doi: 10.1016/S1567-424X(08)00004-4
2009
Journal Article
CMAP decrement in ALS
Henderson, Robert, Baumann, Fusun, Hutchinson, Nicole and McCombe, Pamela A. (2009). CMAP decrement in ALS. Muscle and Nerve, 39 (4), 555-556. doi: 10.1002/mus.21105
2009
Journal Article
Bladder dysfunction in multiple sclerosis.
McCombe, Pamela A., Gordon TP and Jackson MW (2009). Bladder dysfunction in multiple sclerosis.. Expert Rev Neurother., 9 (3), 331-340. doi: 10.1586/14737175.9.3.331
2009
Conference Publication
Results of Bayesian statistical analysis in normal and ALS subjects
Henderson, R. D., Ridall, P. G., Pettitt, A. N. and McCombe, P. A. (2009). Results of Bayesian statistical analysis in normal and ALS subjects. 2nd International Symposium on MUNE and QEMG, Utah, United States, 18-20 August 2006. Amsterdam, The Netherlands: Elsevier BV. doi: 10.1016/S1567-424X(08)00005-6
2009
Journal Article
Immune activation in the peripheral blood of patients with acute ischemic stroke
Yan, Jun, Greer, Judith M., Etherington, Kellie, Cadigan, Greg P., Cavanagh, Helen, Henderson, Robert D., O'Sullivan, John D., Pandian, Jeyaraj D., Read, Stephen J. and McCombe, Pamela A. (2009). Immune activation in the peripheral blood of patients with acute ischemic stroke. Journal of Neuroimmunology, 206 (1-2), 112-117. doi: 10.1016/j.jneuroim.2008.11.001
2009
Book
Autoimmune neurological disease
Pender, Michael P. and McCombe, Pamela A. Autoimmune neurological disease. Cambridge, United Kingdom: Cambridge University Press, 2009. doi:10.1017/cbo9780511526916
2009
Conference Publication
Bayesian analysis of the stimulus-response curve
Ridall, P. G., Pettitt, A. N., McCombe, P. A. and Henderson, R. D. (2009). Bayesian analysis of the stimulus-response curve. 2nd International Symposium on MUNE and QEMG, Utah, United States, 18-20 August 2006. Amsterdam, The Netherlands: Elsevier BV. doi: 10.1016/S1567-424X(08)00004-4
2009
Conference Publication
Biological basis for motor unit number estimation through Bayesian statistical analysis of the stimulus-response curve
McCombe, P. A., Henderson, R. D., Ridall, P. G. and Pettitt, A. N. (2009). Biological basis for motor unit number estimation through Bayesian statistical analysis of the stimulus-response curve. 2nd International Symposium on MUNE and QEMG, Utah, United States, 18-20 August 2006. Amsterdam, The Netherlands: Elsevier BV. doi: 10.1016/S1567-424X(08)00003-2
2008
Journal Article
Recombinant EPF/chaperonin 10 promotes the survival of O4-positive pro-oligodendrocytes prepared from neonatal rat brain
McCombe, P. A. (2008). Recombinant EPF/chaperonin 10 promotes the survival of O4-positive pro-oligodendrocytes prepared from neonatal rat brain. Cell Stress & Chaperones, 13 (4), 467-474. doi: 10.1007/s12192-008-0045-1
2008
Journal Article
Immune and inflammatory responses to stroke: Good or bad?
McCombe, Pamela A. and Read, Stephen J. (2008). Immune and inflammatory responses to stroke: Good or bad?. International Journal of Stroke, 3 (4), 254-265. doi: 10.1111/j.1747-4949.2008.00222.x
2008
Journal Article
Autoantibody-mediated bowel and bladder dysfunction in a patient with chronic, nondiabetic neuropathy
Jackson, Michael W., Gordon, Thomas P. and McCombe, Pamela A. (2008). Autoantibody-mediated bowel and bladder dysfunction in a patient with chronic, nondiabetic neuropathy. Muscle and Nerve, 37 (4), 537-543. doi: 10.1002/mus.20946
2008
Journal Article
Symptom management and patient issues
McCombe, Pamela A. (2008). Symptom management and patient issues. Focus on Multiple Sclerosis, 3 (1), 4-6.
2008
Journal Article
The Lockhart Committee: Developing policy through commitment to moral values, community and democratic processes
Skene, L., Kerridge, I., Marshall, B. and McCombe, Pamela A. (2008). The Lockhart Committee: Developing policy through commitment to moral values, community and democratic processes. Journal of Law & Medicine, 16 (1), 132-138.
2008
Journal Article
Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barre syndrome patients compared to controls
Harness, J. and McCombe, Pamela A. (2008). Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barre syndrome patients compared to controls. Journal of Clinical Neuroscience, 15 (9), 1031--1035. doi: 10.1016/j.jocn.2007.09.016
2007
Journal Article
Bayesian statistical MUNE method
Henderson, R. D., Ridall, P. G., Hutchinson, N. M., Pettitt, A. N. and McCombe, P. A. (2007). Bayesian statistical MUNE method. Muscle & Nerve, 36 (2), 206-213. doi: 10.1002/mus.20805
2007
Journal Article
Motor unit number estimation using reversible jump Markov chain Monte Carlo methods
Ridall, P. G., Pettitt, A. N., Friel, N., McCombe, P. A. and Henderson, R. D. (2007). Motor unit number estimation using reversible jump Markov chain Monte Carlo methods. Journal of the Royal Statistical Society, 56 (3), 235-269. doi: 10.1111/j.1467-9876.2007.00576.x
2007
Journal Article
Antibody responses to peptides of peripheral nerve myelin proteins P0 and P2 in patients with inflammatory demyelinating neuropathy
Inglis, H. R., Csurhes, P. A. and McCombe, P. A. (2007). Antibody responses to peptides of peripheral nerve myelin proteins P0 and P2 in patients with inflammatory demyelinating neuropathy. Journal of Neurology, Neurosurgery & Psychiatry, 78 (4), 419-422. doi: 10.1136/jnnp.2006.106617
Funding
Current funding
Past funding
Supervision
Availability
- Professor Pamela McCombe is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Neurophysiology of Motor Neurone disease
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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Doctor Philosophy
Survival and heterogeneity in Motor Neurone Disease
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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Doctor Philosophy
Survival and heterogeneity in Motor Neurone Disease
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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Doctor Philosophy
Studies of neurophysiology of motor neurone disease
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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Doctor Philosophy
The Role of Neutrophils in Motor Neuron Disease
Associate Advisor
Other advisors: Professor Trent Woodruff, Dr Jenny Fung, Dr John Lee, Dr Cedric Cui
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Doctor Philosophy
Studies of myasthenia gravis using MGBase.
Associate Advisor
Other advisors: Associate Professor Stefan Blum
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Doctor Philosophy
The potential role of CXCR2 activation in motor neuron disease
Associate Advisor
Other advisors: Professor Trent Woodruff, Dr Jenny Fung, Dr John Lee
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Doctor Philosophy
The role of Epstein-Barr virus infection in multiple sclerosis
Associate Advisor
Other advisors: Associate Professor Judith Greer
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Doctor Philosophy
The potential role of CXCR2 activation in motor neuron disease
Associate Advisor
Other advisors: Professor Trent Woodruff, Dr Jenny Fung, Dr John Lee
Completed supervision
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2024
Doctor Philosophy
Defining the Clinical Phenotype of Autoantibody Associated Epilepsy
Principal Advisor
Other advisors: Honorary Professor Kristen Radford
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2022
Master Philosophy
Studies of Amyotrophic Lateral Sclerosis
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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2018
Doctor Philosophy
Clinical and laboratory features of ALS
Principal Advisor
Other advisors: Associate Professor Robert Henderson, Dr Aven Lee
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2017
Master Philosophy
Energy metabolism in amyotrophic lateral sclerosis: Assessment of body composition and energy expenditure
Principal Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo, Associate Professor Frederik Steyn
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2017
Doctor Philosophy
Measuring the progression of upper motor neuron disease using diffusion MRI and its correlation with Clinical phenotype
Principal Advisor
Other advisors: Associate Professor Robert Henderson, Dr Nyoman Kurniawan, Dr Kerstin Pannek
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2014
Doctor Philosophy
Pathogenesis of Guillain-Barre syndrome and chronic inflammatory polyradiculoneuropathy
Principal Advisor
Other advisors: Associate Professor Judith Greer
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2012
Doctor Philosophy
Biomarkers of Motor Neurone Disease : Neurophysiological studies of lower motor degeneration
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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2007
Doctor Philosophy
EXAMINATION OF SURFACE-RECORDED MOTOR UNITS AND A NEW APPROACH TO MOTOR UNIT NUMBER ESTIMATES
Principal Advisor
Other advisors: Associate Professor Judith Greer
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2003
Doctor Philosophy
IMMUNOSUPPRESSION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Principal Advisor
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2023
Doctor Philosophy
Multimodal evaluation of autoimmune encephalitis in Queensland
Associate Advisor
Other advisors: Associate Professor Stefan Blum
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2019
Doctor Philosophy
Asymmetry and Vulnerability in Amyotrophic Lateral Sclerosis
Associate Advisor
Other advisors: Associate Professor Robert Henderson
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2013
Doctor Philosophy
Molecular analysis of the motor neuron disease-associated protein, TDP-43
Associate Advisor
Media
Enquiries
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