Overview
Background
Neurologist
Dr McCombe graduated in Medicine from UQ and completed a Science degree for medical students. She then trained as a neurologist in Sydney, at Prince Henry and Prince of Wales Hospitals. She obtained a PhD from the University of Sydney. She obtained experience in Neurophysiology in Cleveland and then returned to UQ as a post-doctoral fellow. She worked for some years as a research fellow in Neuroimmunology and was an NHMRc SRF. Later she resumed clinical practice as a neurologist, and contimued her research as an NHMRC Practitioner Fellow. She is currentlyProfessor and Head of the Royal Brisbane Clinical school in the School of Medicine and Co-head of the Brain and Mental Health Theme at the UQ Centre for Clinical Research.
Availability
- Professor Pamela McCombe is:
- Available for supervision
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Bachelor of Medicine and Surgery and Medical Science, The University of Queensland
- Doctor of Philosophy, University of Sydney
- Royal Australasian College of Physicians, Royal Australasian College of Physicians
Research interests
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Biomarkers and heterogeneity in ALS
One of the challenges of ALS is understanding disease heterogeneity. Our work studies the variability of patients by detailed clinical, laboratory and genetic studies, and by identifying biomarkers that are associated with disease. We use a range of techniques including neurophysiology, MRI, metabolic studies, genetic studies, immune markers and biochemical studies including proteomics. We are using this information to analyse whether patients can be assigned into subgroups and to correlated with survival.
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Inflammatory neuropathy studies
This is an ongoing study of the immunological basis and genetic basis of acute and chronic inflammatory neuropathy
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Pregnancy and MS
This study is exploring the short and long term effects of pregnancy in multiple sclerosis. This includes the clinical effects of pregnancy and the effects on gene expression and methylation
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Immunology of stroke
This study involves documenting the immune responses after human stroke and determining the significance of these responses.
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Neuromuscular disease
This work is based at the Neuromuscular clinic at Royal Brisbane and Women's Hospital, and involves correlation of genotype and phenotype of inherited neuromuscular disease
Works
Search Professor Pamela McCombe’s works on UQ eSpace
1986
Journal Article
Class II antigen expression and T lymphocyte subsets in chronic inflammatory demyelinating polyneuropathy
Pollard, J. D., McCombe, P. A., Baverstock, J., Gatenby, P. A. and McLeod, J. G. (1986). Class II antigen expression and T lymphocyte subsets in chronic inflammatory demyelinating polyneuropathy. Journal of Neuroimmunology, 13 (2), 123-134. doi: 10.1016/0165-5728(86)90059-7
1985
Conference Publication
Immunogenetics of human demyelinating diseases
Feeney, D. J., Pollard, J. D., Stewart, G. J., Clark, P., McCombe, P., Kirk, R. L. and McLeod, J. G. (1985). Immunogenetics of human demyelinating diseases. -, -, -. Ottawa, Canada: Canadian Medical Association.
1985
Journal Article
Alpha-1 antitrypsin phenotypes in demyelinating disease: an association between demyelinating disease and the allele PiM3
McCombe, P. A., Clark, P., Frith, J. A., Hammond, S. R., Stewart, G. J., Pollard, J. D. and McLeod , J. G. (1985). Alpha-1 antitrypsin phenotypes in demyelinating disease: an association between demyelinating disease and the allele PiM3. Annals of Neurology, 18 (4), 514-516. doi: 10.1002/ana.410180417
1984
Journal Article
The peripheral neuropathy vitamin B12 deficiency
McCombe, P. A. and McLeod, J. G. (1984). The peripheral neuropathy vitamin B12 deficiency. Journal of the Neurological Sciences, 66 (1), 117-126. doi: 10.1016/0022-510X(84)90147-3
1984
Conference Publication
ALPHA-1 Antitrypsin Phenotypes in Guillain-Barre Syndrome, Chronic Inflammatory Demyelinating Polyneuropathy, and Multiple Sclerosis
McCombe, P. A., Clark, P., Pollard, J. D., Hammond, S. R. and McLeod, J. G. (1984). ALPHA-1 Antitrypsin Phenotypes in Guillain-Barre Syndrome, Chronic Inflammatory Demyelinating Polyneuropathy, and Multiple Sclerosis. You have full text access to this content 109th Annual Meeting of the American Neurological Association, Baltimore MD, 7-10 October 1984. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/ana.410160128
1978
Journal Article
Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses
Spector, Deborah H., Smith, Karen, Padgett, Thomas, McCombe, Pamela and et al. (1978). Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses. Cell, 13 (2), 371-379. doi: 10.1016/0092-8674(78)90205-2
1976
Journal Article
Control of DNA repair linked to neuroblastoma differentiation
McCombe, Pam, Lavin, Martin and Kidson, Chev (1976). Control of DNA repair linked to neuroblastoma differentiation. International Journal of Radiation Biology, 29 (6), 523-531. doi: 10.1080/09553007614550621
1976
Journal Article
DNA replication and post-replication repair in U.V.-sensitive mouse neuroblastoma cells
Lavin, Martin F., McCombe, Pam and Kidson, Chev (1976). DNA replication and post-replication repair in U.V.-sensitive mouse neuroblastoma cells. International Journal of Radiation Biology, 30 (1), 31-40. doi: 10.1080/09553007614550781
1975
Journal Article
A repressible DNA-repair system in mouse neuroblastoma cells
McCombe, P. and Kidson, C. (1975). A repressible DNA-repair system in mouse neuroblastoma cells. Basic life sciences, 5 B, 813-815.
1975
Conference Publication
Repair of ultraviolet irradiation damage in mouse neuroblastoma cells: a model for post mitotic cell repair
McCombe, P., Lavin, M. F., Campbell, B., Mansbridge, J. N. and Kidson, C. (1975). Repair of ultraviolet irradiation damage in mouse neuroblastoma cells: a model for post mitotic cell repair. Australian Biochemical Society Annual General Meeting, -, -. Kent Town, SA, Australia: Australian Society for Biochemistry and Molecular Biology.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Pamela McCombe is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Survival and heterogeneity in Motor Neurone Disease
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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Doctor Philosophy
Survival and heterogeneity in Motor Neurone Disease
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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Doctor Philosophy
Studies of neurophysiology of motor neurone disease
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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Master Philosophy
Neurophysiology of Motor Neurone disease
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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Doctor Philosophy
The potential role of CXCR2 activation in motor neuron disease
Associate Advisor
Other advisors: Professor Trent Woodruff, Dr Jenny Fung, Dr John Lee
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Doctor Philosophy
The Role of Neutrophils in Motor Neuron Disease
Associate Advisor
Other advisors: Professor Trent Woodruff, Dr Jenny Fung, Dr John Lee, Dr Cedric Cui
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Doctor Philosophy
Studies of myasthenia gravis using MGBase.
Associate Advisor
Other advisors: Associate Professor Stefan Blum
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Doctor Philosophy
The potential role of CXCR2 activation in motor neuron disease
Associate Advisor
Other advisors: Professor Trent Woodruff, Dr Jenny Fung, Dr John Lee
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Doctor Philosophy
The role of Epstein-Barr virus infection in multiple sclerosis
Associate Advisor
Other advisors: Associate Professor Judith Greer
Completed supervision
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2024
Doctor Philosophy
Defining the Clinical Phenotype of Autoantibody Associated Epilepsy
Principal Advisor
Other advisors: Honorary Professor Kristen Radford
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2022
Master Philosophy
Studies of Amyotrophic Lateral Sclerosis
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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2018
Doctor Philosophy
Clinical and laboratory features of ALS
Principal Advisor
Other advisors: Associate Professor Robert Henderson, Dr Aven Lee
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2017
Master Philosophy
Energy metabolism in amyotrophic lateral sclerosis: Assessment of body composition and energy expenditure
Principal Advisor
Other advisors: Associate Professor Robert Henderson, Associate Professor Shyuan Ngo, Associate Professor Frederik Steyn
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2017
Doctor Philosophy
Measuring the progression of upper motor neuron disease using diffusion MRI and its correlation with Clinical phenotype
Principal Advisor
Other advisors: Associate Professor Robert Henderson, Dr Nyoman Kurniawan, Dr Kerstin Pannek
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2014
Doctor Philosophy
Pathogenesis of Guillain-Barre syndrome and chronic inflammatory polyradiculoneuropathy
Principal Advisor
Other advisors: Associate Professor Judith Greer
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2012
Doctor Philosophy
Biomarkers of Motor Neurone Disease : Neurophysiological studies of lower motor degeneration
Principal Advisor
Other advisors: Associate Professor Robert Henderson
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2007
Doctor Philosophy
EXAMINATION OF SURFACE-RECORDED MOTOR UNITS AND A NEW APPROACH TO MOTOR UNIT NUMBER ESTIMATES
Principal Advisor
Other advisors: Associate Professor Judith Greer
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2003
Doctor Philosophy
IMMUNOSUPPRESSION IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Principal Advisor
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2023
Doctor Philosophy
Multimodal evaluation of autoimmune encephalitis in Queensland
Associate Advisor
Other advisors: Associate Professor Stefan Blum
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2019
Doctor Philosophy
Asymmetry and Vulnerability in Amyotrophic Lateral Sclerosis
Associate Advisor
Other advisors: Associate Professor Robert Henderson
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2013
Doctor Philosophy
Molecular analysis of the motor neuron disease-associated protein, TDP-43
Associate Advisor
Media
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