
Overview
Background
Craig M. Williams was born in Adelaide, Australia. He received his B.Sc. (Hons) degree in chemistry in 1994 from Flinders University. In 1997, he was awarded his Ph.D. in organic chemistry from the same institution under the supervision of Professor Rolf H. Prager. He undertook post-doctoral studies as an Alexander von Humboldt Fellow working with Professor Armin de Meijere at the Georg-August-Universität, Göttingen, Germany, from 1997 to 1999. In early 1999, he accepted a second post-doctoral fellowship at the Australian National University with Professor Lewis N. Mander.
Professor Williams has held an academic position at the University of Queensland since 2000, and during this time has won a number of awards including a Thieme Chemistry Journals Award in 2007, an Australian Research Council Future Fellowship award in 2011, and the Award for Outstanding Contribution to Research (SCMB, UQ, 2019). The Williams research group explores numerous interests within the discipline of organic chemistry (e.g. medicinal chemistry, fundamental molecules, natural productisolation, microelectronics, drug and agrichemical development, impact sensitive molecules) enabled by organic synthesis refined through the construction of biologically active complex natural products (diterpenes, polyketides, alkaloids), and designs synthetic methodology to assist in this endeavour (synthetic transformations and reagents). Professor Williams especially enjoys teaching whole molecule retrosynthesis to undergraduate and post-graduate students.
Availability
- Professor Craig Williams is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Flinders University
Research impacts
He has published more than 170 scientific papers, patents, review articles and book chapters that have been cited over 2700 times. Since starting his independent career in mid 2000 CMW has attracted substantial research funding as a sole investigator through fundamental and applied research and associated industry engagement (UQ, ARC, NHMRC, DPIF, CSIRO, DAAD, BioTech). Professor Williams has supervised over 120 young researchers to date. H-Index=28.
Works
Search Professor Craig Williams’s works on UQ eSpace
2019
Journal Article
Hydrogen-bonding interactions in the Ley-Griffith oxidation: practical considerations for the synthetic chemist
Moore, Peter W., Zerk, Timothy J., Burns, Jed M., Bernhardt, Paul V. and Williams, Craig M. (2019). Hydrogen-bonding interactions in the Ley-Griffith oxidation: practical considerations for the synthetic chemist. European Journal of Organic Chemistry, 2019 (2-3), 303-308. doi: 10.1002/ejoc.201800860
2019
Journal Article
A protocol for an iodine-metal exchange reaction on cubane using lithium organozincates
Kato, Yumi, Williams, Craig M., Uchiyama, Masanobu and Matsubara, Seijiro (2019). A protocol for an iodine-metal exchange reaction on cubane using lithium organozincates. Organic Letters, 21 (2), 473-475. doi: 10.1021/acs.orglett.8b03721
2019
Journal Article
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
McAlpine, James B., Chen, Shao-Nong, Kutateladze, Andrei, MacMillan, John B., Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A., Biavatti, Maique W., Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S., Capon, Robert J., Choi, Young H., Coppage, David, Crews, Phillip, Crimmins, Michael T., Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M., Garson, Mary J., Genta-Jouve, Grégory, Gerwick, William H., Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M., Hunter, Luke, Jeannerat, Damien, Ji, Nai-Yun ... Pauli, Guido F. (2019). Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36 (1), 248-249. doi: 10.1039/c8np90041h
2019
Conference Publication
Chemistry, mode of action and clinical efficacy of the anticancer diterpenoid tigilanol tigliate (EBC-46)
Appendino, G., Pagani, A., Williams, C., Cullen, J., Boyle, G., Parsons, P., Campbell, J., Gordon,, Schmidt, P. and Reddell, P. (2019). Chemistry, mode of action and clinical efficacy of the anticancer diterpenoid tigilanol tigliate (EBC-46). 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Innsbruck, Austria, 1-5 September, 2019. Stuttgart, Germany: Georg Thieme Verlag. doi: 10.1055/s-0039-3399676
2018
Journal Article
Cover Feature: Hydrogen-Bonding Interactions in the Ley-Griffith Oxidation: Practical Considerations for the Synthetic Chemist (Eur. J. Org. Chem. 2-3/2019)
Moore, Peter W., Zerk, Timothy J., Burns, Jed M., Bernhardt, Paul V. and Williams, Craig M. (2018). Cover Feature: Hydrogen-Bonding Interactions in the Ley-Griffith Oxidation: Practical Considerations for the Synthetic Chemist (Eur. J. Org. Chem. 2-3/2019). European Journal of Organic Chemistry, 2019 (2-3), 230-230. doi: 10.1002/ejoc.201801822
2018
Journal Article
Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A. and Guddat, Luke W. (2018). Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proceedings of the National Academy of Sciences of the United States of America, 115 (41), E9649-E9658. doi: 10.1073/pnas.1809422115
2018
Journal Article
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
McAlpine, James B., Chen, Shao-Nong, Kutateladze, Andrei, MacMillan, John B., Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A., Biavatti, Maique W., Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S., Capon, Robert J., Choi, Young H., Coppage, David, Crews, Phillip, Crimmins, Michael T., Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M., Garson, Mary J., Genta-Jouve, Grégory, Gerwick, William H., Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M., Hunter, Luke, Jeannerat, Damien, Ji, Nai-Yun ... Pauli, Guido F. (2018). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36 (1), 35-107. doi: 10.1039/c7np00064b
2018
Journal Article
Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675)
Chalmers, Benjamin A., Xing, Hui, Houston, Sevan, Clark, Charlotte, Ghassabian, Sussan, Kuo, Andy, Cao, Benjamin, Reitsma, Andrea, Murray, Cody-Ellen P., Stok, Jeanette E., Boyle, Glen M., Pierce, Carly J., Littler, Stuart W., Winkler, David A., Bernhardt, Paul V., Pasay, Cielo, De Voss, James J., McCarthy, James, Parsons, Peter G., Walter, Gimme H., Smith, Maree T., Cooper, Helen M., Nilsson, Susan K., Tsanaktsidis, John, Savage, G. Paul and Williams, Craig M. (2018). Corrigendum to: Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere (Angewandte Chemie International Edition, (2016), 55, 11, (3580-3585), 10.1002/anie.201510675). Angewandte Chemie - International Edition, 57 (28), 8359-8359. doi: 10.1002/anie.201711161
2018
Journal Article
Developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer
Xie, Sida, Savchenko, Andrei I., Krenske, Elizabeth H., Grange, Rebecca L., Gahan, Lawrence R. and Williams, Craig M. (2018). Developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer. European Journal of Organic Chemistry, 2018 (25), 3265-3270. doi: 10.1002/ejoc.201800449
2018
Journal Article
Front cover: developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer (Eur. J. Org. Chem. /2018)
Xie, Sida, Savchenko, Andrei I., Krenske, Elizabeth H., Grange, Rebecca L., Gahan, Lawrence R. and Williams, Craig M. (2018). Front cover: developing cyclic peptide heteroatom interchange: synthesis and DFT modelling of a HI-ascidiacyclamide isomer (Eur. J. Org. Chem. /2018). European Journal of Organic Chemistry, 2018 (25), 3246-3246. doi: 10.1002/ejoc.201800902
2018
Journal Article
Heteroatom-Interchanged Isomers of Lissoclinamide 5: Copper(II) Complexation, Halide Binding, and Biological Activity
Xie, Sida, Savchenko, Andrei I., Kerscher, Marion, Grange, Rebecca L., Krenske, Elizabeth H., Harmer, Jeffrey R., Bauer, Michelle J., Broit, Natasa, Watters, Dianne J., Boyle, Glen M., Bernhardt, Paul V., Parsons, Peter G., Comba, Peter, Gahan, Lawrence R. and Williams, Craig M. (2018). Heteroatom-Interchanged Isomers of Lissoclinamide 5: Copper(II) Complexation, Halide Binding, and Biological Activity. European Journal of Organic Chemistry, 2018 (12), 1465-1476. doi: 10.1002/ejoc.201701659
2018
Journal Article
ATP3 and MTP3: easily prepared stable perruthenate salts for oxidation applications in synthesis
Moore, Peter W., Read, Christopher D. G., Bernhardt, Paul V. and Williams, Craig M. (2018). ATP3 and MTP3: easily prepared stable perruthenate salts for oxidation applications in synthesis. Chemistry: A European Journal, 24 (18), 4556-4561. doi: 10.1002/chem.201800531
2018
Conference Publication
Mass spectrometric analysis of volatile organic compounds produced by duodenal microbiota
Bahr, Constance, Moore, Peter, Shanahan, Erin R., Burn, Paul, Williams, Craig, Holtmann, Gerald J., deVoss, James and Morrison, Mark (2018). Mass spectrometric analysis of volatile organic compounds produced by duodenal microbiota. Annual Meeting of the American Society for Gastrointestinal Endoscopy / Digestive Disease Week, Washington, DC, United States, 2-5 June, 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/s0016-5085(18)32307-2
2017
Journal Article
High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism
Lonhienne, Thierry, Garcia, Mario D., Noble, Chris, Harmer, Jeffrey, Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017). High resolution crystal structures of the acetohydroxyacid synthase-pyruvate complex provide new insights into its catalytic mechanism. Chemistryselect, 2 (36), 11981-11988. doi: 10.1002/slct.201702128
2017
Journal Article
Elucidating the mechanism of the Ley-Griffith (TPAP) alcohol oxidation
Zerk, Timothy J., Moore, Peter W., Harbort, Joshua S., Chow, Sharon, Byrne, Lindsay, Koutsantonis, George A., Harmer, Jeffrey R., Martinez, Manuel, Williams, Craig M. and Bernhardt, Paul V. (2017). Elucidating the mechanism of the Ley-Griffith (TPAP) alcohol oxidation. Chemical Science, 8 (12), 8435-8442. doi: 10.1039/c7sc04260d
2017
Journal Article
Dialkyl carbonate synthesis via in situ generated carbonyl dibromide on porous glass
Vuong, Khuong Q. , Effenberger, Reinhard, Zilberman, Joseph, Smart, Simon, Williams, Craig M. and McFarland, Eric W. (2017). Dialkyl carbonate synthesis via in situ generated carbonyl dibromide on porous glass. ACS Sustainable Chemistry & Engineering, 5 (9), 7492-7495. doi: 10.1021/acssuschemeng.7b01487
2017
Journal Article
7-Step total synthesis of (+)-EBC-329: Photoisomerisation reveals new seco-casbane family member
Vanden Berg, Timothy J., Pinkerton, David M. and Williams, Craig M. (2017). 7-Step total synthesis of (+)-EBC-329: Photoisomerisation reveals new seco-casbane family member. Organic & Biomolecular Chemistry, 15 (34), 7102-7105. doi: 10.1039/c7ob01400g
2017
Journal Article
An improved preparation of phorbol from croton oil
Pagani, Alberto, Gaeta, Simone, Savchenko, Andrei I., Williams, Craig M. and Appendino, Giovanni (2017). An improved preparation of phorbol from croton oil. Beilstein Journal of Organic Chemistry, 13 (1), 1361-1367. doi: 10.3762/bjoc.13.133
2017
Journal Article
Furofuran lignans from the Simpson Desert species Eremophila macdonnellii
Tan, Y. P., Savchenko, A. I., Broit, N., Boyle, G. M., Parsons, P. G. and Williams, C. M. (2017). Furofuran lignans from the Simpson Desert species Eremophila macdonnellii. Fitoterapia, 126, 93-97. doi: 10.1016/j.fitote.2017.06.004
2017
Journal Article
Asymmetric sequential Cu-catalyzed 1,6/1,4-conjugate additions of hard nucleophiles to cyclic dienones: determination of absolute configurations and origins of enantioselectivity
Blons, Charlie, Morin, Marie S. T., Schmid, Thibault E., Vives, Thomas, Colombel-Rouen, Sophie, Basle, Olivier, Reynaldo, Thibault, Covington, Cody L., Halbert, Stephanie, Cuskelly, Sean N., Bernhardt, Paul V., Williams, Craig M., Crassous, Jeanne, Polavarapu, Prasad L., Crevisy, Christophe, Gerard, Helene and Mauduit, Marc (2017). Asymmetric sequential Cu-catalyzed 1,6/1,4-conjugate additions of hard nucleophiles to cyclic dienones: determination of absolute configurations and origins of enantioselectivity. Chemistry-A European Journal, 23 (31), 7515-7525. doi: 10.1002/chem.201606034
Funding
Current funding
Past funding
Supervision
Availability
- Professor Craig Williams is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
The synthesis of strained chemical building blocks as technology enablers
Principal Advisor
-
Doctor Philosophy
Discovery of New Herbicides
Principal Advisor
Other advisors: Professor Luke Guddat
-
Doctor Philosophy
Development of innovative synthetic methodologies: electrochemical Atom Transfer Radical Addition (eATRA) and strained nitrogen ring synthesis paradigms
Principal Advisor
Other advisors: Professor Paul Bernhardt
-
Doctor Philosophy
Pioneering stable copper carbanions for new C-C bond forming paradigms
Principal Advisor
Other advisors: Professor Paul Bernhardt
-
Doctor Philosophy
Developing novel copper catalysts for carbon-carbon bond forming reactions using electrosynthesis.
Associate Advisor
Other advisors: Dr Masnun Naher, Professor Paul Bernhardt
-
Doctor Philosophy
Synthesis of inhibitors and probes for heparan sulfate degrading enzymes
Associate Advisor
Other advisors: Professor Vito Ferro
-
Doctor Philosophy
Developing next generation green herbicides
Associate Advisor
Other advisors: Professor Luke Guddat
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Associate Advisor
Other advisors: Professor Gary Schenk, Professor Luke Guddat
-
Doctor Philosophy
Synthesis and applications of glycosaminoglycan mimetics
Associate Advisor
Other advisors: Professor Vito Ferro
-
Doctor Philosophy
Microbial manufacturing of plant saponin-inspired vaccine adjuvants
Associate Advisor
Other advisors: Professor James De Voss
-
Doctor Philosophy
Cryo-EM inspired antifungal drug discovery
Associate Advisor
Other advisors: Professor Gary Schenk, Professor Luke Guddat
-
Doctor Philosophy
Development of new chemical tools for probing glycosaminoglycan-dependent cellular processes
Associate Advisor
Other advisors: Professor Vito Ferro
Completed supervision
-
2024
Doctor Philosophy
Developing Chemical Building Blocks for Medicinal Chemistry and Microelectronic Applications
Principal Advisor
Other advisors: Professor James De Voss
-
2023
Doctor Philosophy
Analgesic Drug Discovery
Principal Advisor
Other advisors: Emeritus Professor Maree Smith
-
2022
Doctor Philosophy
Sensitiveness of Oxidants and Cage Compounds and Synthesis of [n]-Azacubane Precursors
Principal Advisor
-
2022
Doctor Philosophy
The Use and Development of Catalytic Systems in Organic Synthesis
Principal Advisor
Other advisors: Professor Vito Ferro
-
2022
Doctor Philosophy
Investigations into Cubane and Related Strained N-Heterocyclic Compounds
Principal Advisor
-
2022
Doctor Philosophy
Cage Hydrocarbon Scaffolds for Viral Inhibition and Microlithography
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2019
Doctor Philosophy
Discovery of novel natural products from the Australian arid and semi-arid zones
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2019
Doctor Philosophy
Acetohydroxyacid synthase AHAS: A new drug target for human fungal pathogens
Principal Advisor
Other advisors: Professor Luke Guddat
-
2018
Doctor Philosophy
Exploration of the Ley-Griffith Oxidation and Subsequent Efforts Towards Epipyrone A
Principal Advisor
Other advisors: Professor Vito Ferro
-
2017
Doctor Philosophy
Cubane in Drug Discovery and Development
Principal Advisor
Other advisors: Professor Elizabeth Krenske
-
2017
Doctor Philosophy
Explorations in Novel Caged Hydrocarbon Chemistry
Principal Advisor
Other advisors: Professor Elizabeth Krenske
-
2017
Doctor Philosophy
Modifications and a Mechanistic Study of the Ley-Griffith Oxidation, and Generation of Hydroxyl Radicals in the Gas Phase
Principal Advisor
Other advisors: Professor Paul Bernhardt
-
2015
Doctor Philosophy
Synthesis and evaluation of novel heteroatom interchanged thiazole containing cyclic peptides
Principal Advisor
-
2014
Doctor Philosophy
Towards the Total Synthesis of (-)-Phorbol for Novel Anti-Cancer Studies
Principal Advisor
Other advisors: Professor Vito Ferro
-
2014
Master Philosophy
Development of Novel Heat Shock Protein 90 (Hsp90) Inhibitors by Chemically Re-Engineering Gedunin using Fragment-Based Drug Design
Principal Advisor
-
2012
Doctor Philosophy
Investigations into Cubane Based Analogues of Current Pharmaceuticals
Principal Advisor
-
2012
Doctor Philosophy
Enantioselective Total Synthesis of the Tetranortriterpenoids
Principal Advisor
Other advisors: Associate Professor Shih-Chun Lo
-
2012
Doctor Philosophy
Total synthesis of (-)-neovibsanin G and (-)-14-epi-neovibsanin G and synthetic studies towards other related caged neovibsanins
Principal Advisor
Other advisors: Professor James De Voss
-
2011
Doctor Philosophy
Towards the Total Synthesis of 5ß-Hydroxy-Cis-Dehydrocrotonin And Development of Novel Methodology in the Synthesis of Cis-Vinylstannanes and Cis-Vinylpinacolboronates.
Principal Advisor
Other advisors: Professor James De Voss
-
2010
Doctor Philosophy
Biomimetic orientated total synthesis of neovibsane natural products and comparison of synthetic neovibsanes on neurite outgrowth promotion in PC12 cells
Principal Advisor
-
2008
Doctor Philosophy
Direct alkynylation of bridgehead halides with silver acetylides and Towards the Total Synthesis of trans-Crotonin
Principal Advisor
Other advisors: Professor Joanne Blanchfield
-
2008
Doctor Philosophy
2-Iodoxybenzoic acid: Acidity investigations and the total synthesis of 5,14-bis-epi-spirovibsanin A
Principal Advisor
Other advisors: Professor James De Voss
-
2007
Doctor Philosophy
NUCLEOPHILIC HETEROAROMATIC THIAZOLE SUBSTITUTION AND TOWARDS THE TOTAL SYNTHESIS OF AZEDARALIDE, ODORATIN AND MEXICANOLIDE
Principal Advisor
-
2024
Doctor Philosophy
INVESTIGATING THE POTENTIAL OF MANUKA OIL AS A NOVEL TOPICAL SCABICIDE
Associate Advisor
Other advisors: Professor Malcolm Jones
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2023
Doctor Philosophy
Synthesis for the exploration and exploitation of Cytochrome P450 enzymes
Associate Advisor
Other advisors: Professor James De Voss
-
2023
Doctor Philosophy
Electrocatalysis at the Atypical Cu(II)-C bond: Electrochemical and Spectroscopic Studies
Associate Advisor
Other advisors: Professor Paul Bernhardt
-
2017
Doctor Philosophy
Synthesis of potential inhibitors of iduronate-2-sulfatase as pharmacological chaperones for MPS II and development of chemical tools for quantification of heparan sulfate in urine from MPS patients
Associate Advisor
Other advisors: Professor Vito Ferro
-
2006
Doctor Philosophy
SYNTHESES AND REACTIONS OF IMINOPROPADIENONES, SYDNONES AND OXAZINONES
Associate Advisor
Other advisors: Emeritus Professor Curt Wentrup
-
Doctor Philosophy
NITRENES REARRANGEMENTS: FORMATION OF REACTIVE INTERMEDIATES AND UNUSUAL MOLECULES
Associate Advisor
Other advisors: Emeritus Professor Curt Wentrup
Media
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