
Overview
Background
Prof Lipman is Executive Director of the Burns Trauma & Critical Care Research Centre; Professor of Anesthesiology & Critical Care, The University of Queensland and until recently (for 23 years) was Director of Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital; He holds Honorary Professorial appointments at Chinese University of Hong Kong, Unversity of Witwatersrand (South Africa) and Qeensland University of Technology.
He has qualifications in anesthesia and intensive care and has set up and been in charge of a number of Intensive Care and Trauma Units in South Africa before coming to Australia in 1997. he currently manages a large multidisciplinary research team with an output of over 120 peer-reviewed articles per annum. He has supervised dozens of PhD students to completion and is currently supervising 6 PhD, 1 MPhil and 1 MBBS/Hons students. Prof Lipman has been instrumental in developing the anaesthesiology and critical care component of a graduate medical program for Queensland and continues to lecture to medical and postgraduate students.
Prof Lipman is the author of over 550 peer reviewed publications, 30 book chapters and has been invited to deliver over 120 lectures at national and international conferences in many countries across the world. His research interests include all aspects of infection management in intensive care and he has a special interest in the pharmacokinetics of antibiotic dosage, an area in which he received his MD in 2006. His research into antibiotic usage in acute situations has received international recognition and he is regarded as an expert in the field. As such, he and his research team have conducted and presently conduct a number of clinical trials in Australia, New Zealand, Hong Kong, Europe and the UK.
Prof Lipman is an Editorial Board member for 10 International Journals, is Section Editor on four Antibiotic related Journals, reviews for 23 journals and is an external reviewer for NHMRC project grants (Local) as well as equivalent for a number overseas countries.
He is Chief Investigator on a 7000 patient International Randomised Controlled Trial comparing bolus dosing versus continuous infusions of meropenem and piperacillin-tazobactam
Availability
- Professor Jeffrey Lipman is:
- Not available for supervision
- Media expert
Fields of research
Research interests
-
Antibiotic dosing in critically ill patients
Severe sepsis is defined as failure of one or more organ systems, most commonly cardiovascular (including shock), respiratory and renal failure, caused by infection. Bacteria, either alone or in combination with other pathogens, are the most common cause of severe sepsis, and Gram-positive and Gram-negative organism account for up to 87% of culture positive episodes. Severe sepsis is a major cause of mortality worldwide. The ANZICS CTG reported that the Australian and New Zealand adult annual incidence of severe sepsis is 77 cases per 100,000,4 which is equivalent to over 17,000 patient episodes per year at an estimated cost per episode of AUD 42,300. Similar population incidence rates have been reported elsewhere. Importantly, 11.8% of all admissions to Australian and New Zealand ICUs are associated with severe sepsis and in-hospital mortality is 37.5%. In patients with septic shock, mortality approaches 60%. The burden of death is almost four times the annual national road toll. The death rate also exceeds other diseases that impact significantly on the Australian community, such as breast and colorectal cancer. In short, severe sepsis is a major public health concern in Australia and improved therapies are needed urgently. My research group is conducting national and international clinical trials investigating the effect of various dosing regimes on health outcomes in critically ill patients.
Research impacts
My research has been instrumental in changing antibiotic prescribing habits worldwide for critically ill patients, first with aminoglycosides (I did the first and still largest clinical trial to show single daily dosing to be effective) and more recently with beta-lactam antibiotics. Due to critically ill patients having altered pharmacokinetics, using standard antibiotic dosing for these patients is fraught with problems. This has led to the use of Therapeutic Drug Monitoring (TDM) for beta-lactams.
TDM of aminoglycosides and glycopeptides is performed to decrease side-effects of these drugs. Beta-lactams have a large therapeutic ratio and hence measurement of them is infrequent. I helped set up routine TDM of beta-lactam antibiotics at RBWH. I have changed how we dose patients particularly in ICU but also within the wards of RBWH. By means of TDM we have shown we need dose adjustments in 74% of patients to which we administer β-lactam antibiotics in the ICU (Roberts JA et al. Int J Antimicrob Agents 2010;36:332-39). Although scarcely performed world-wide, TDM of beta-lactams is now becoming more commonly performed. We are currently collating data from 5 International centres that also use TDM in an attempt to show outcome benefits of TDM and are starting to publish accordingly (Wong G et al. An international, multi-centre survey of beta-lactam antibiotics TDM practice in intensive care units. J Antimicrob Chemother 2014;69: 1416–1423).
Works
Search Professor Jeffrey Lipman’s works on UQ eSpace
2009
Journal Article
Respiratory Complications in Burns: An Evolving Spectrum of Injury
Boots, RJ, Dulhunty, JM, Paratz, JD and Lipman, J (2009). Respiratory Complications in Burns: An Evolving Spectrum of Injury. Clinical Pulmonary Medicine, 16 (3), 132-138. doi: 10.1097/CPM.0b013e3181a39032
2009
Journal Article
Management of meningitis due to antibiotic-resistant Acinetobacter species
Baek-Nam, Kim, Peleg, Anton Y., Lodise, Thomas P., Lipman, Jeffrey, Li, Jian, Nation, Roger and Paterson, David L. (2009). Management of meningitis due to antibiotic-resistant Acinetobacter species. Lancet Infectious Diseases, 9 (4), 245-255. doi: 10.1016/S1473-3099(09)70055-6
2009
Journal Article
Point of care measurement of plasma creatinine in critically ill patients with acute kidney injury
Udy, A., O'Donoghue, S., D'Intini, V., Healy, H. and Lipman, J. (2009). Point of care measurement of plasma creatinine in critically ill patients with acute kidney injury. Anaesthesia, 64 (4), 403-407. doi: 10.1111/j.1365-2044.2008.05818.x
2009
Journal Article
Pharmacokinetic issues for antibiotics in the critically ill patient
Roberts, Jason A. and Lipman, Jeffrey (2009). Pharmacokinetic issues for antibiotics in the critically ill patient. Critical Care Medicine, 37 (3), 840-851. doi: 10.1097/CCM.0b013e3181961bff
2009
Journal Article
An update on C-reactive protein for intensivists.
Ho, KM and Lipman, J (2009). An update on C-reactive protein for intensivists.. Anaesthesia and Intensive Care, 37 (2), 234-241. doi: 10.1177/0310057x0903700217
2009
Journal Article
Airway obstruction due to a pre-vertebral haematoma following difficult central line insertion - implications for ultrasound guidance and review of the literature
Udy, A., Senthuran, S. and Lipman, J. (2009). Airway obstruction due to a pre-vertebral haematoma following difficult central line insertion - implications for ultrasound guidance and review of the literature. Anaesthesia and Intensive Care, 37 (2), 309-313. doi: 10.1177/0310057x0903700219
2009
Journal Article
Piperacillin penetration into tissue of critically ill patients with sepsis - Bolus versus continuous administration?
Roberts, Jason A., Roberts, Michael S., Robertson, Thomas A., Dalley, Andrew J. and Lipman, Jeffrey (2009). Piperacillin penetration into tissue of critically ill patients with sepsis - Bolus versus continuous administration?. Critical Care Medicine, 37 (3), 926-933. doi: 10.1097/CCM.0b013e3181968e44
2009
Journal Article
Measurement of tissue cortisol levels in patients with severe burns: a preliminary investigation
Cohen, Jeremy, Deans, Renae, Dalley, Andrew, Lipman, Jeff, Roberts, Michael S. and Venkatesh, Bala (2009). Measurement of tissue cortisol levels in patients with severe burns: a preliminary investigation. Critical Care, 13 (6) R189, xx-xx. doi: 10.1186/cc8184
2009
Book Chapter
Avoiding toxicity of antibiotics
Varghese, Julie M., Roberts, Jason A. and Lipman, Jeffrey (2009). Avoiding toxicity of antibiotics. Patient safety and quality of care in intensive care medicine. (pp. 291-304) edited by Jean-Daniel Chiche and Leanne M. Aitken. Berlin, Germany: Medizinisch Wissenschaftliche Verlagsgesellschaft.
2009
Journal Article
You only find what you look for: The importance of high creatinine clearance in the critically ill
Udy, A., Roberts, J. A., Boots, R. J. and Lipman, J. (2009). You only find what you look for: The importance of high creatinine clearance in the critically ill. Anaesthesia and Intensive Care, 37 (1), 11-13. doi: 10.1177/0310057x0903700123
2009
Conference Publication
Using Population Pharmacokinetics To Determine Gentamicin Dosing during Extended Daily Diafiltration in Critically Ill Patients with Acute Kidney Injury
Roberts, J. A., Field, J., Visser, A., Whitbread, R., Lipman, J. and Kirkpatrick, C. (2009). Using Population Pharmacokinetics To Determine Gentamicin Dosing during Extended Daily Diafiltration in Critically Ill Patients with Acute Kidney Injury. 22nd Annual Congress of the European Society of Intensive Care Medicine, Vienna, Austria, 11-14 October 2009. NEW YORK: SPRINGER.
2009
Journal Article
Unbound Cephalothin Pharmacokinetics in Adult Burn Patients Are Related to the Elapsed Time after Injury
Dalley, Andrew J., Deans, Renae, Lipman, Jeffrey, Venkatesh, Bala, Rudd, Michael, Roberts, Michael S. and Cross, Sheree E. (2009). Unbound Cephalothin Pharmacokinetics in Adult Burn Patients Are Related to the Elapsed Time after Injury. Antimicrobial Agents and Chemotherapy, 53 (12), 5303-5305. doi: 10.1128/AAC.01600-08
2009
Journal Article
Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution
Roberts, Jason A., Kirkpatrick, Carl M. J., Roberts, Michael S., Robertson, Thomas A., Dalley, Andrew J. and Lipman, Jeffrey (2009). Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution. Journal of Antimicrobial Chemotherapy, 64 (1), 142-150. doi: 10.1093/jac/dkp139
2008
Journal Article
Increased fluid resuscitation can lead to adverse outcomes in major-burn injured patients, but low mortality is achievable
Joel M. Dulhunty, Robert J. Boots, Michael J. Rudd, Michael J. Muller and Jeffrey Lipman (2008). Increased fluid resuscitation can lead to adverse outcomes in major-burn injured patients, but low mortality is achievable. Burns, 34 (8), 1090-1097. doi: 10.1016/j.burns.2008.01.011
2008
Book Chapter
Prehospital Care
Brown, Anthony F.T. and Lipman, Jeffrey (2008). Prehospital Care. Mechanical Ventilation: Clinical Applications and Pathophysiology. (pp. 307-319) Elsevier Inc.. doi: 10.1016/B978-0-7216-0186-1.50032-6
2008
Journal Article
A comparison of epinephrine and norepinephrine in critically ill patients
John A Myburgh, Alisa Higgins, Alina Jovanovska, Lipman, Jeffrey, Naresh Ramakrishnan and John Santamaria (2008). A comparison of epinephrine and norepinephrine in critically ill patients. Intensive Care Medicine, 34 (12), 2226-2234. doi: 10.1007/s00134-008-1219-0
2008
Journal Article
Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study
Dulhunty, Joel M., Lipman, Jeffrey and Finfer, Simon (2008). Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study. Intensive Care Medicine, 34 (9), 1654-1661. doi: 10.1007/s00134-008-1160-2
2008
Journal Article
Better outcomes through continuous infusion of time-dependent antibiotics to critically ill patients?
Roberts, Jason A, Lipman, Jeffrey, Blot, Stijn and Rello, Jordi (2008). Better outcomes through continuous infusion of time-dependent antibiotics to critically ill patients?. Current Opinion in Critical Care, 14 (4), 390-396. doi: 10.1097/MCC.0b013e3283021b3a
2008
Journal Article
Antibiotic resistance - what's dosing got to do with it?
Roberts, Jason A., Kruger, Peter, Paterson, David L. and Lipman, Jeffrey (2008). Antibiotic resistance - what's dosing got to do with it?. Critical Care Medicine, 36 (8), 2433-2440. doi: 10.1097/CCM.0b013e318180fe62
2008
Journal Article
Lessons learnt in the pharmacokinetic analysis of the effect of haemoperfusion for acute overdose with sustained-release diltiazem
D. M. Roberts, J. A. Roberts, R. J. Boots, R. Mason and J. Lipman (2008). Lessons learnt in the pharmacokinetic analysis of the effect of haemoperfusion for acute overdose with sustained-release diltiazem. Anaesthesia, 63 (7), 714-718. doi: 10.1111/j.1365-2044.2008.05477.x
Funding
Current funding
Past funding
Supervision
Availability
- Professor Jeffrey Lipman is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
Optimising antibiotic dosing for the treatment and prevention of central nervous system infections
Principal Advisor
Other advisors: Professor Jason Roberts
-
Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Principal Advisor
Other advisors: Professor Kiran Shekar
-
Doctor Philosophy
Local and International epidemiology of Hospital Acquired Blood Stream Infections in the Critically Ill
Principal Advisor
-
Doctor Philosophy
Critical care management of burns patients
Associate Advisor
Other advisors: Associate Professor Jeremy Cohen, Professor Michael Reade
-
Doctor Philosophy
Studies of the Microcirculatory Responses to Hemorrhagic Shock and Resuscitation
Associate Advisor
Other advisors: Professor Ben Ahern, Dr Wendy Goodwin, Professor Mark Midwinter
-
Doctor Philosophy
The Adaptation of Motor Learning Theory in Medical Procedural Tasks
Associate Advisor
Other advisors: Professor Andre Van Zundert
-
Doctor Philosophy
Perioperative pharmacokinetics of surgical antibiotic prophylaxis
Associate Advisor
Other advisors: Professor Andre Van Zundert, Professor Jason Roberts
-
Doctor Philosophy
Perioperative pharmacokinetics of surgical antibiotic prophylaxis
Associate Advisor
Other advisors: Professor Andre Van Zundert, Professor Jason Roberts
-
Doctor Philosophy
Studies of the Microcirculatory Responses to Hemorrhagic Shock and Resuscitation
Associate Advisor
Other advisors: Professor Ben Ahern, Dr Wendy Goodwin, Professor Mark Midwinter
-
Doctor Philosophy
How to use antibiotics better in Paediatric Intensive Care using pharmacokinetic principles
Associate Advisor
Other advisors: Dr Mark Coulthard, Dr Xin Liu, Dr Patty Mitre, Professor Jason Roberts
Completed supervision
-
2024
Doctor Philosophy
Optimising Antibiotic Dosing for Treatment of Nosocomial Central Nervous System Infections in Neurocritical Care Patients
Principal Advisor
Other advisors: Professor Jason Roberts
-
2020
Doctor Philosophy
Early predictors of Health-Related Quality of Life outcomes post-burns for hospitalised adults in Australia.
Principal Advisor
-
2019
Doctor Philosophy
Emergency department patients with sepsis: risk stratification and clinical prediction rules
Principal Advisor
-
2014
Doctor Philosophy
Augmented Renal Clearance in the Critically Ill: Prevalence, Risk Factors, and Implications for Beta-lactam Therapy
Principal Advisor
Other advisors: Associate Professor Robert Boots
-
2014
Doctor Philosophy
Dose optimisation of antibiotics during different forms of renal replacement therapy: focus on tissue and target site antibiotic concentrations
Principal Advisor
Other advisors: Professor Jason Roberts, Associate Professor Robert Boots
-
2009
Doctor Philosophy
Beta-lactam antibiotic dosing in critical care units: Bolus vs continuous dosing
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts
-
2024
Doctor Philosophy
The Adaptation of Motor Learning Theory in Medical Procedural Tasks
Associate Advisor
Other advisors: Professor Andre Van Zundert
-
2023
Doctor Philosophy
Strategies to improve the use of antimicrobials in hospitalised Indonesian patients
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
-
2023
Doctor Philosophy
Translating Microsampling Techniques into Improved Antimicrobial Dosing for Critically Ill Children
Associate Advisor
Other advisors: Professor Jason Roberts
-
2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Associate Advisor
Other advisors: Professor Dan Chambers
-
2019
Doctor Philosophy
A pharmacokinetic/pharmacodynamic and clinical outcome evaluation of beta-lactam antibiotic therapeutic drug monitoring in critically ill patients
Associate Advisor
Other advisors: Professor Jason Roberts
-
2017
Doctor Philosophy
Improving antibiotic dosing in critically ill Australian Indigenous patients with severe sepsis
Associate Advisor
Other advisors: Professor Jason Roberts
-
2017
Doctor Philosophy
Clinical Guidelines relating to the Anaesthetic Management of Obese Parturients: An Evaluation of the Evidence Supporting the Recommendations and their Utility in Clinical Practice
Associate Advisor
Other advisors: Professor Leonie Callaway, Professor Andre Van Zundert
-
2016
Doctor Philosophy
Translating Innovative Pharmacokinetic Sampling Techniques into Improved Antibiotic Dosing Regimens in Critically Ill Patients
Associate Advisor
Other advisors: Professor Jason Roberts
-
2016
Doctor Philosophy
Optimizing beta-lactam antibiotic dosing in critically ill patients: Prolonged infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Dr Christine Staatz, Professor Jason Roberts
-
2016
Doctor Philosophy
An Investigation of the Pharmacokinetics of Piperacillin, Meropenem and Fluconazole in Critically Ill Obese Patients
Associate Advisor
Other advisors: Professor Jason Roberts, Emeritus Professor Michael Roberts
-
2015
Master Philosophy
Vancomycin-associated nephrotoxicity in the Critically-Ill
Associate Advisor
Other advisors: Professor Jason Roberts
-
2015
Doctor Philosophy
ß-lactam antibiotic pharmacokinetics during continuous venovenous haemofiltration in critically ill patients: Continuous infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Professor Jason Roberts
-
2014
Doctor Philosophy
Improving Antimicrobial Use In Critically Ill Patients
Associate Advisor
Other advisors: Professor Jason Roberts
-
2012
Master Philosophy
Challenges in management of infections on a burn injury unit.
Associate Advisor
Other advisors: Professor Jason Roberts
-
2012
Doctor Philosophy
"Phantom Skin Pain" - Neuropathic Pain Following Burn Injury: An Examination of Incidence and Treatment
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
-
2007
Doctor Philosophy
EXAMINATION OF THE ROLE OF POSTURAL CHANGE IN VENTILATED INTENSIVE CARE PATIENTS. CURRENT PRACTICE, INVESTIGATION AND GUIDELINES
Associate Advisor
Media
Enquiries
Contact Professor Jeffrey Lipman directly for media enquiries about:
- Antibiotics
- Intensive care
- pharmacokinetics
Need help?
For help with finding experts, story ideas and media enquiries, contact our Media team: