
Overview
Background
Prof Lipman is Executive Director of the Burns Trauma & Critical Care Research Centre; Professor of Anesthesiology & Critical Care, The University of Queensland and until recently (for 23 years) was Director of Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital; He holds Honorary Professorial appointments at Chinese University of Hong Kong, Unversity of Witwatersrand (South Africa) and Qeensland University of Technology.
He has qualifications in anesthesia and intensive care and has set up and been in charge of a number of Intensive Care and Trauma Units in South Africa before coming to Australia in 1997. he currently manages a large multidisciplinary research team with an output of over 120 peer-reviewed articles per annum. He has supervised dozens of PhD students to completion and is currently supervising 6 PhD, 1 MPhil and 1 MBBS/Hons students. Prof Lipman has been instrumental in developing the anaesthesiology and critical care component of a graduate medical program for Queensland and continues to lecture to medical and postgraduate students.
Prof Lipman is the author of over 550 peer reviewed publications, 30 book chapters and has been invited to deliver over 120 lectures at national and international conferences in many countries across the world. His research interests include all aspects of infection management in intensive care and he has a special interest in the pharmacokinetics of antibiotic dosage, an area in which he received his MD in 2006. His research into antibiotic usage in acute situations has received international recognition and he is regarded as an expert in the field. As such, he and his research team have conducted and presently conduct a number of clinical trials in Australia, New Zealand, Hong Kong, Europe and the UK.
Prof Lipman is an Editorial Board member for 10 International Journals, is Section Editor on four Antibiotic related Journals, reviews for 23 journals and is an external reviewer for NHMRC project grants (Local) as well as equivalent for a number overseas countries.
He is Chief Investigator on a 7000 patient International Randomised Controlled Trial comparing bolus dosing versus continuous infusions of meropenem and piperacillin-tazobactam
Availability
- Professor Jeffrey Lipman is:
- Not available for supervision
- Media expert
Fields of research
Research interests
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Antibiotic dosing in critically ill patients
Severe sepsis is defined as failure of one or more organ systems, most commonly cardiovascular (including shock), respiratory and renal failure, caused by infection. Bacteria, either alone or in combination with other pathogens, are the most common cause of severe sepsis, and Gram-positive and Gram-negative organism account for up to 87% of culture positive episodes. Severe sepsis is a major cause of mortality worldwide. The ANZICS CTG reported that the Australian and New Zealand adult annual incidence of severe sepsis is 77 cases per 100,000,4 which is equivalent to over 17,000 patient episodes per year at an estimated cost per episode of AUD 42,300. Similar population incidence rates have been reported elsewhere. Importantly, 11.8% of all admissions to Australian and New Zealand ICUs are associated with severe sepsis and in-hospital mortality is 37.5%. In patients with septic shock, mortality approaches 60%. The burden of death is almost four times the annual national road toll. The death rate also exceeds other diseases that impact significantly on the Australian community, such as breast and colorectal cancer. In short, severe sepsis is a major public health concern in Australia and improved therapies are needed urgently. My research group is conducting national and international clinical trials investigating the effect of various dosing regimes on health outcomes in critically ill patients.
Research impacts
My research has been instrumental in changing antibiotic prescribing habits worldwide for critically ill patients, first with aminoglycosides (I did the first and still largest clinical trial to show single daily dosing to be effective) and more recently with beta-lactam antibiotics. Due to critically ill patients having altered pharmacokinetics, using standard antibiotic dosing for these patients is fraught with problems. This has led to the use of Therapeutic Drug Monitoring (TDM) for beta-lactams.
TDM of aminoglycosides and glycopeptides is performed to decrease side-effects of these drugs. Beta-lactams have a large therapeutic ratio and hence measurement of them is infrequent. I helped set up routine TDM of beta-lactam antibiotics at RBWH. I have changed how we dose patients particularly in ICU but also within the wards of RBWH. By means of TDM we have shown we need dose adjustments in 74% of patients to which we administer β-lactam antibiotics in the ICU (Roberts JA et al. Int J Antimicrob Agents 2010;36:332-39). Although scarcely performed world-wide, TDM of beta-lactams is now becoming more commonly performed. We are currently collating data from 5 International centres that also use TDM in an attempt to show outcome benefits of TDM and are starting to publish accordingly (Wong G et al. An international, multi-centre survey of beta-lactam antibiotics TDM practice in intensive care units. J Antimicrob Chemother 2014;69: 1416–1423).
Works
Search Professor Jeffrey Lipman’s works on UQ eSpace
2010
Journal Article
Augmented renal clearance: Implications for antibacterial dosing in the critically Ill
Udy, Andrew A., Roberts, Jason A., Boots, Robert J., Paterson, David L. and Lipman, Jeffrey (2010). Augmented renal clearance: Implications for antibacterial dosing in the critically Ill. Clinical Pharmacokinetics, 49 (1), 1-16. doi: 10.2165/11318140-000000000-00000
2010
Conference Publication
Assessment of adequacy of loading dose of phenytoin (PTN) in adult intensive care patients using population pharmacokinetics
Putt, M. T., Roberts, J. A., Udy, A. A., Martin, J. H., Jarrett, P., Salmon, N. and Lipman, J. (2010). Assessment of adequacy of loading dose of phenytoin (PTN) in adult intensive care patients using population pharmacokinetics. 23rd Annual Meeting of the European Society of Intensive Care Medicine, Barcelona, Spain, 9-13 October 2010. Heidelberg, Germany: Springer. doi: 10.1007/s00134-010-2001-7
2010
Book Chapter
Antibiotic dosing in critically ill patients
Ulldemolins, Marta, Roberts, Jason, Varghese, Julie and Lipman, Jeffrey (2010). Antibiotic dosing in critically ill patients. Critical Care Update 2009. (pp. 128-142) edited by Vineet Nayar, J. V. Peter, Roop Kishen and S. Srinivas. Daryaganj, New Delhi, India: Jaypee Brothers Medical Publishers.
2009
Journal Article
A new paradigm for treating infections: "go hard and go home"
Lipman, Jeffrey and Boots, Rob (2009). A new paradigm for treating infections: "go hard and go home". Critical Care and Resuscitation, 11 (4), 276-281.
2009
Journal Article
Optimising intraperitoneal gentamicin dosing in peritoneal dialysis patients with peritonitis (GIPD) study
Ranganathan, Dwarakanathan, Varghese, Julie M., Fassett, Robert G., Lipman, Jeffrey, D'Intini, Vincent, Healy, Helen and Roberts, Jason A. (2009). Optimising intraperitoneal gentamicin dosing in peritoneal dialysis patients with peritonitis (GIPD) study. BMC Nephrology, 10 (1) 42, 1-6. doi: 10.1186/1471-2369-10-42
2009
Journal Article
International Study of the Prevalence and Outcomes of Infection in Intensive Care Units
Vincent, Jean-Louis, Rello, Jordi, Marshall, John, Silva, Eliezer, Anzueto, Antonio, Martin, Claude D., Moreno, Rui, Lipman, Jeffrey, Gomersall, Charles, Sakr, Yasser and Reinhart, Konrad (2009). International Study of the Prevalence and Outcomes of Infection in Intensive Care Units. Journal of the American Medical Association, 302 (21), 2323-2329. doi: 10.1001/jama.2009.1754
2009
Journal Article
Emphysematous pyelonephritis: an unusual complication of blunt abdominal trauma
McNeill, G, Holley, A and Lipman, J (2009). Emphysematous pyelonephritis: an unusual complication of blunt abdominal trauma. Critical Care and Resuscitation, 11 (4), 269-271.
2009
Journal Article
Assessment of clinical risk predictive rules for invasive candidiasis in a prospective multicentre cohort of ICU patients
Playford, E. G., Lipman, J., Kabir, M., McBryde, E. S., Nimmo, Graeme R., Lau, A. and Sorrell, T. C. (2009). Assessment of clinical risk predictive rules for invasive candidiasis in a prospective multicentre cohort of ICU patients. Intensive Care Medicine, 35 (12), 2141-2145. doi: 10.1007/s00134-009-1619-9
2009
Journal Article
A systematic review of antibiotic dosing regimens for septic patients receiving continuous renal replacement therapy: do current studies supply sufficient data?
Li, A. M. M. Y., Gomersall, C. D., Choi, G., Tian, Q., Joynt, G. M. and Lipman, J. (2009). A systematic review of antibiotic dosing regimens for septic patients receiving continuous renal replacement therapy: do current studies supply sufficient data?. Journal of Antimicrobial Chemotherapy, 64 (5) dkp302, 929-937. doi: 10.1093/jac/dkp302
2009
Journal Article
Predictors and outcome associated with an Enterococcus positive isolate during intensive care unit admission
Chatterjee, I., Dulhunty, J.M., Iredell, J., Gallagher, J.E., Sud, A., Woods, M. and Lipman, J. (2009). Predictors and outcome associated with an Enterococcus positive isolate during intensive care unit admission. Anaesthesia and Intensive Care, 37 (6), 976-982. doi: 10.1177/0310057x0903700610
2009
Journal Article
The microcirculation, regional blood flow and tissue oxygenation: Will new technologies drive new resuscitation goals?
Thirlwell, J., Holley, A., Udy, A., Lipman, J. and Paratz, J. (2009). The microcirculation, regional blood flow and tissue oxygenation: Will new technologies drive new resuscitation goals?. Anaesthesia and Intensive Care, 37 (6), 891-891.
2009
Journal Article
Tissue accumulation of cephalothin in burns: A comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers
Dalley, A.J., Lipman, J., Deans, R., Venkatesh, B., Rudd, M., Roberts, M.S. and Cross, S.E. (2009). Tissue accumulation of cephalothin in burns: A comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers. Antimicrobial Agents and Chemotherapy, 53 (1), 210-215. doi: 10.1128/AAC.00718-08
2009
Journal Article
Clearance of intravenous 5-fluorocytosine during continuous venovenous haemodiafiltration in a patient with hepatosplenic candidiasis
Roberts, Jason A., Udy, Andrew A., O'Donoghue, Stephen, Briscoe, Scott, Paterson, David L. and Lipman, Jeffrey (2009). Clearance of intravenous 5-fluorocytosine during continuous venovenous haemodiafiltration in a patient with hepatosplenic candidiasis. International Journal of Antimicrobial Agents, 34 (4), 383-384. doi: 10.1016/j.ijantimicag.2009.05.005
2009
Journal Article
The microcirculation, regional blood flow and tissue oxygenation: will new technologies drive new resuscitation goals?
Holley, A, Udy, A and Lipman, J (2009). The microcirculation, regional blood flow and tissue oxygenation: will new technologies drive new resuscitation goals?. Anaesthesia and Intensive Care, 37 (5), 700-702. doi: 10.1177/0310057X0903700524
2009
Journal Article
Midazolam metabolism: Implications for individualised dosing?
Roberts, Jason A., Coulthard, Mark G., Addison, Russell S., Foot, Carole and Lipman, Jeffrey (2009). Midazolam metabolism: Implications for individualised dosing?. Journal of Pharmacy Practice and Research, 39 (3), 198-201. doi: 10.1002/j.2055-2335.2009.tb00452.x
2009
Journal Article
Tissue Distribution of Beta-Lactam Antibiotics: Continuous versus Bolus Dosing
Roberts, JA and Lipman, J (2009). Tissue Distribution of Beta-Lactam Antibiotics: Continuous versus Bolus Dosing. Journal of Pharmacy Practice and Research, 39 (3), 219-222. doi: 10.1002/j.2055-2335.2009.tb00457.x
2009
Journal Article
Dose matters: Dose of antibiotics in the critically ill patient depends on the dose of renal replacement therapy
Roberts, Jason A. and Lipman, Jeffrey (2009). Dose matters: Dose of antibiotics in the critically ill patient depends on the dose of renal replacement therapy. Critical Care Medicine, 37 (8), 2491-2492. doi: 10.1097/CCM.0b013e3181aee840
2009
Journal Article
Principles of antibacterial dosing in continuous renal replacement therapy
Choi, Gordon, Gomersall, Charles D., Tian, Qi, Joynt, Gavin M., Freebairn, Ross and Lipman, Jeffrey (2009). Principles of antibacterial dosing in continuous renal replacement therapy. Critical Care Medicine, 37 (7), 2268-2282. doi: 10.1097/CCM.0b013e3181aab3d0
2009
Journal Article
Temporal trends, risk factors and outcomes in albicans and non-albicans candidaemia: an international epidemiological study in four multidisciplinary intensive care units
Holley, Anthony, Dulhunty, Joel, Blot, Stijn, Lipman, Jeffrey, Lobo, Suzana, Dancer, Craig, Rello, Jordi and Dimopoulos, George (2009). Temporal trends, risk factors and outcomes in albicans and non-albicans candidaemia: an international epidemiological study in four multidisciplinary intensive care units. International Journal of Antimicrobial Agents, 33 (6), 554.e1-554.e7. doi: 10.1016/j.ijantimicag.2008.10.035
2009
Journal Article
A systematic review on clinical benefits of continuous administration of [beta]-lactam antibiotics
Roberts, Jason A., Webb, Steven, Paterson, David, Ho, Kwok M. and Lipman, Jeffrey (2009). A systematic review on clinical benefits of continuous administration of [beta]-lactam antibiotics. Critical Care Medicine, 37 (6), 2071-2078. doi: 10.1097/CCM.0b013e3181a0054d
Funding
Current funding
Past funding
Supervision
Availability
- Professor Jeffrey Lipman is:
- Not available for supervision
Supervision history
Current supervision
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Doctor Philosophy
Optimising antibiotic dosing for the treatment and prevention of central nervous system infections
Principal Advisor
Other advisors: Professor Jason Roberts
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Doctor Philosophy
Local and International epidemiology of Hospital Acquired Blood Stream Infections in the Critically Ill
Principal Advisor
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Principal Advisor
Other advisors: Professor Kiran Shekar
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Doctor Philosophy
How to use antibiotics better in Paediatric Intensive Care using pharmacokinetic principles
Associate Advisor
Other advisors: Dr Mark Coulthard, Dr Xin Liu, Dr Patty Mitre, Professor Jason Roberts
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Doctor Philosophy
Critical care management of burns patients
Associate Advisor
Other advisors: Associate Professor Jeremy Cohen, Professor Michael Reade
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Doctor Philosophy
Studies of the Microcirculatory Responses to Hemorrhagic Shock and Resuscitation
Associate Advisor
Other advisors: Professor Ben Ahern, Dr Wendy Goodwin, Professor Mark Midwinter
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Doctor Philosophy
The Adaptation of Motor Learning Theory in Medical Procedural Tasks
Associate Advisor
Other advisors: Professor Andre Van Zundert
-
Doctor Philosophy
Perioperative pharmacokinetics of surgical antibiotic prophylaxis
Associate Advisor
Other advisors: Professor Andre Van Zundert, Professor Jason Roberts
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Doctor Philosophy
Perioperative pharmacokinetics of surgical antibiotic prophylaxis
Associate Advisor
Other advisors: Professor Andre Van Zundert, Professor Jason Roberts
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Doctor Philosophy
Studies of the Microcirculatory Responses to Hemorrhagic Shock and Resuscitation
Associate Advisor
Other advisors: Professor Ben Ahern, Dr Wendy Goodwin, Professor Mark Midwinter
Completed supervision
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2024
Doctor Philosophy
Optimising Antibiotic Dosing for Treatment of Nosocomial Central Nervous System Infections in Neurocritical Care Patients
Principal Advisor
Other advisors: Professor Jason Roberts
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2020
Doctor Philosophy
Early predictors of Health-Related Quality of Life outcomes post-burns for hospitalised adults in Australia.
Principal Advisor
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2019
Doctor Philosophy
Emergency department patients with sepsis: risk stratification and clinical prediction rules
Principal Advisor
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2014
Doctor Philosophy
Augmented Renal Clearance in the Critically Ill: Prevalence, Risk Factors, and Implications for Beta-lactam Therapy
Principal Advisor
Other advisors: Associate Professor Robert Boots
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2014
Doctor Philosophy
Dose optimisation of antibiotics during different forms of renal replacement therapy: focus on tissue and target site antibiotic concentrations
Principal Advisor
Other advisors: Professor Jason Roberts, Associate Professor Robert Boots
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2009
Doctor Philosophy
Beta-lactam antibiotic dosing in critical care units: Bolus vs continuous dosing
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts
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2024
Doctor Philosophy
The Adaptation of Motor Learning Theory in Medical Procedural Tasks
Associate Advisor
Other advisors: Professor Andre Van Zundert
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2023
Doctor Philosophy
Strategies to improve the use of antimicrobials in hospitalised Indonesian patients
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2023
Doctor Philosophy
Translating Microsampling Techniques into Improved Antimicrobial Dosing for Critically Ill Children
Associate Advisor
Other advisors: Professor Jason Roberts
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Associate Advisor
Other advisors: Professor Dan Chambers
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2019
Doctor Philosophy
A pharmacokinetic/pharmacodynamic and clinical outcome evaluation of beta-lactam antibiotic therapeutic drug monitoring in critically ill patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2017
Doctor Philosophy
Improving antibiotic dosing in critically ill Australian Indigenous patients with severe sepsis
Associate Advisor
Other advisors: Professor Jason Roberts
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2017
Doctor Philosophy
Clinical Guidelines relating to the Anaesthetic Management of Obese Parturients: An Evaluation of the Evidence Supporting the Recommendations and their Utility in Clinical Practice
Associate Advisor
Other advisors: Professor Leonie Callaway, Professor Andre Van Zundert
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2016
Doctor Philosophy
Translating Innovative Pharmacokinetic Sampling Techniques into Improved Antibiotic Dosing Regimens in Critically Ill Patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2016
Doctor Philosophy
Optimizing beta-lactam antibiotic dosing in critically ill patients: Prolonged infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Dr Christine Staatz, Professor Jason Roberts
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2016
Doctor Philosophy
An Investigation of the Pharmacokinetics of Piperacillin, Meropenem and Fluconazole in Critically Ill Obese Patients
Associate Advisor
Other advisors: Professor Jason Roberts, Emeritus Professor Michael Roberts
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2015
Doctor Philosophy
ß-lactam antibiotic pharmacokinetics during continuous venovenous haemofiltration in critically ill patients: Continuous infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Professor Jason Roberts
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2015
Master Philosophy
Vancomycin-associated nephrotoxicity in the Critically-Ill
Associate Advisor
Other advisors: Professor Jason Roberts
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2014
Doctor Philosophy
Improving Antimicrobial Use In Critically Ill Patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2012
Master Philosophy
Challenges in management of infections on a burn injury unit.
Associate Advisor
Other advisors: Professor Jason Roberts
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2012
Doctor Philosophy
"Phantom Skin Pain" - Neuropathic Pain Following Burn Injury: An Examination of Incidence and Treatment
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2007
Doctor Philosophy
EXAMINATION OF THE ROLE OF POSTURAL CHANGE IN VENTILATED INTENSIVE CARE PATIENTS. CURRENT PRACTICE, INVESTIGATION AND GUIDELINES
Associate Advisor
Media
Enquiries
Contact Professor Jeffrey Lipman directly for media enquiries about:
- Antibiotics
- Intensive care
- pharmacokinetics
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