
Overview
Background
Prof Lipman is Executive Director of the Burns Trauma & Critical Care Research Centre; Professor of Anesthesiology & Critical Care, The University of Queensland and until recently (for 23 years) was Director of Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital; He holds Honorary Professorial appointments at Chinese University of Hong Kong, Unversity of Witwatersrand (South Africa) and Qeensland University of Technology.
He has qualifications in anesthesia and intensive care and has set up and been in charge of a number of Intensive Care and Trauma Units in South Africa before coming to Australia in 1997. he currently manages a large multidisciplinary research team with an output of over 120 peer-reviewed articles per annum. He has supervised dozens of PhD students to completion and is currently supervising 6 PhD, 1 MPhil and 1 MBBS/Hons students. Prof Lipman has been instrumental in developing the anaesthesiology and critical care component of a graduate medical program for Queensland and continues to lecture to medical and postgraduate students.
Prof Lipman is the author of over 550 peer reviewed publications, 30 book chapters and has been invited to deliver over 120 lectures at national and international conferences in many countries across the world. His research interests include all aspects of infection management in intensive care and he has a special interest in the pharmacokinetics of antibiotic dosage, an area in which he received his MD in 2006. His research into antibiotic usage in acute situations has received international recognition and he is regarded as an expert in the field. As such, he and his research team have conducted and presently conduct a number of clinical trials in Australia, New Zealand, Hong Kong, Europe and the UK.
Prof Lipman is an Editorial Board member for 10 International Journals, is Section Editor on four Antibiotic related Journals, reviews for 23 journals and is an external reviewer for NHMRC project grants (Local) as well as equivalent for a number overseas countries.
He is Chief Investigator on a 7000 patient International Randomised Controlled Trial comparing bolus dosing versus continuous infusions of meropenem and piperacillin-tazobactam
Availability
- Professor Jeffrey Lipman is:
- Not available for supervision
- Media expert
Fields of research
Research interests
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Antibiotic dosing in critically ill patients
Severe sepsis is defined as failure of one or more organ systems, most commonly cardiovascular (including shock), respiratory and renal failure, caused by infection. Bacteria, either alone or in combination with other pathogens, are the most common cause of severe sepsis, and Gram-positive and Gram-negative organism account for up to 87% of culture positive episodes. Severe sepsis is a major cause of mortality worldwide. The ANZICS CTG reported that the Australian and New Zealand adult annual incidence of severe sepsis is 77 cases per 100,000,4 which is equivalent to over 17,000 patient episodes per year at an estimated cost per episode of AUD 42,300. Similar population incidence rates have been reported elsewhere. Importantly, 11.8% of all admissions to Australian and New Zealand ICUs are associated with severe sepsis and in-hospital mortality is 37.5%. In patients with septic shock, mortality approaches 60%. The burden of death is almost four times the annual national road toll. The death rate also exceeds other diseases that impact significantly on the Australian community, such as breast and colorectal cancer. In short, severe sepsis is a major public health concern in Australia and improved therapies are needed urgently. My research group is conducting national and international clinical trials investigating the effect of various dosing regimes on health outcomes in critically ill patients.
Research impacts
My research has been instrumental in changing antibiotic prescribing habits worldwide for critically ill patients, first with aminoglycosides (I did the first and still largest clinical trial to show single daily dosing to be effective) and more recently with beta-lactam antibiotics. Due to critically ill patients having altered pharmacokinetics, using standard antibiotic dosing for these patients is fraught with problems. This has led to the use of Therapeutic Drug Monitoring (TDM) for beta-lactams.
TDM of aminoglycosides and glycopeptides is performed to decrease side-effects of these drugs. Beta-lactams have a large therapeutic ratio and hence measurement of them is infrequent. I helped set up routine TDM of beta-lactam antibiotics at RBWH. I have changed how we dose patients particularly in ICU but also within the wards of RBWH. By means of TDM we have shown we need dose adjustments in 74% of patients to which we administer β-lactam antibiotics in the ICU (Roberts JA et al. Int J Antimicrob Agents 2010;36:332-39). Although scarcely performed world-wide, TDM of beta-lactams is now becoming more commonly performed. We are currently collating data from 5 International centres that also use TDM in an attempt to show outcome benefits of TDM and are starting to publish accordingly (Wong G et al. An international, multi-centre survey of beta-lactam antibiotics TDM practice in intensive care units. J Antimicrob Chemother 2014;69: 1416–1423).
Works
Search Professor Jeffrey Lipman’s works on UQ eSpace
2020
Other Outputs
Genomic surveillance, characterisation and intervention of a carbapenem-resistant Acinetobacter baumannii outbreak in critical care
Roberts, Leah W., Forde, Brian M., Hurst, Trish, Ling, Weiping, Nimmo, Graeme R., Bergh, Haakon, George, Narelle, Hajkowicz, Krispin, McNamara, John F, Lipman, Jeffrey, Permana, Budi, Schembri, Mark A., Paterson, David, Beatson, Scott A. and Harris, Patrick N. A. (2020). Genomic surveillance, characterisation and intervention of a carbapenem-resistant Acinetobacter baumannii outbreak in critical care. doi: 10.1101/2020.08.10.20166652
2020
Journal Article
Quality of evidence supporting surviving sepsis campaign recommendations
Rello, Jordi, Tejada, Sofia, Xu, Elena, Solé-Lleonart, Candela, Campogiani, Laura, Koulenti, Despoina, Ferreira-Coimbra, João and Lipman, Jeff (2020). Quality of evidence supporting surviving sepsis campaign recommendations. Anaesthesia Critical Care and Pain Medicine, 39 (4), 497-502. doi: 10.1016/j.accpm.2020.06.015
2020
Journal Article
International facilitators and barriers to family engagement in the ICU: Results of a qualitative analysis
Hamilton, Rebekah, Kleinpell, Ruth, Lipman, Jeffrey and Davidson, Judy E. (2020). International facilitators and barriers to family engagement in the ICU: Results of a qualitative analysis. Journal of Critical Care, 58, 72-77. doi: 10.1016/j.jcrc.2020.04.011
2020
Journal Article
Mineralocorticoid dysfunction during critical illness: a review of the evidence
Nethathe, Gladness Dakalo, Cohen, Jeremy, Lipman, Jeffrey, Anderson, Ronald and Feldman, Charles (2020). Mineralocorticoid dysfunction during critical illness: a review of the evidence. Anesthesiology, 133 (2), 439-457. doi: 10.1097/ALN.0000000000003365
2020
Journal Article
Prolonged versus intermittent infusion of β-Lactam antibiotics: a systematic review and meta-regression of bacterial killing in preclinical infection models
Dhaese, Sofie, Heffernan, Aaron, Liu, David, Abdul-Aziz, Mohd Hafiz, Stove, Veronique, Tam, Vincent H., Lipman, Jeffrey, Roberts, Jason A. and De Waele, Jan J. (2020). Prolonged versus intermittent infusion of β-Lactam antibiotics: a systematic review and meta-regression of bacterial killing in preclinical infection models. Clinical Pharmacokinetics, 59 (10), 1237-1250. doi: 10.1007/s40262-020-00919-6
2020
Journal Article
Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model
Heffernan, Aaron J., Sime, Fekade B., Sarovich, Derek S., Neely, Michael, Guerra-Valero, Yarmarly, Naicker, Saiyuri, Cottrell, Kyra, Harris, Patrick, Andrews, Katherine T., Ellwood, David, Wallis, Steven C., Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason A. (2020). Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model. Antimicrobial Agents and Chemotherapy, 64 (9) e00879-20. doi: 10.1128/aac.00879-20
2020
Journal Article
Comparative plasma pharmacokinetics of ceftriaxone and ertapenem between normoalbuminemia, hypoalbuminemia and with albumin replacement in a sheep model
Dhanani, Jayesh A., Ahern, Benjamin, Lupinsky, Liad, Jackson, Karen, Wallis, Steven C., Abdul-Aziz, Mohd H., Lipman, Jeffrey and Roberts, Jason A. (2020). Comparative plasma pharmacokinetics of ceftriaxone and ertapenem between normoalbuminemia, hypoalbuminemia and with albumin replacement in a sheep model. Antimicrobial Agents and Chemotherapy, 64 (7) e02584-19. doi: 10.1128/aac.02584-19
2020
Journal Article
Conventional pig as animal model for human renal drug excretion processes: unravelling the porcine renal function by use of a cocktail of exogenous markers
Dhondt, Laura, Croubels, Siska, De Paepe, Peter, Wallis, Steven C., Pandey, Saurabh, Roberts, Jason A., Lipman, Jeffrey, De Cock, Pieter and Devreese, Mathias (2020). Conventional pig as animal model for human renal drug excretion processes: unravelling the porcine renal function by use of a cocktail of exogenous markers. Frontiers in Pharmacology, 11 883, 883. doi: 10.3389/fphar.2020.00883
2020
Journal Article
Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study
De Bus, Liesbet, Depuydt, Pieter, Steen, Johan, Dhaese, Sofie, De Smet, Ken, Tabah, Alexis, Akova, Murat, Cotta, Menino Osbert, De Pascale, Gennaro, Dimopoulos, George, Fujitani, Shigeki, Garnacho-Montero, Jose, Leone, Marc, Lipman, Jeffrey, Ostermann, Marlies, Paiva, José-Artur, Schouten, Jeroen, Sjövall, Fredrik, Timsit, Jean-François, Roberts, Jason A., Zahar, Jean-Ralph, Zand, Farid, Zirpe, Kapil, De Waele, Jan J. and DIANA study group (2020). Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study. Intensive Care Medicine, 46 (7), 1404-1417. doi: 10.1007/s00134-020-06111-5
2020
Journal Article
Optimization of flucloxacillin dosing regimens in critically ill patients using population pharmacokinetic modelling of total and unbound concentrations
Jager, Nynke G. L., van Hest, Reinier M., Xie, Jiao, Wong, Gloria, Ulldemolins, Marta, Brüggemann, Roger J. M., Lipman, Jeffrey and Roberts, Jason A. (2020). Optimization of flucloxacillin dosing regimens in critically ill patients using population pharmacokinetic modelling of total and unbound concentrations. Journal of Antimicrobial Chemotherapy, 75 (9), 2641-2649. doi: 10.1093/jac/dkaa187
2020
Journal Article
An Integrated Dialysis Pharmacometric (IDP) model to evaluate the pharmacokinetics in patients undergoing renal replacement therapy
Broeker, Astrid, Vossen, Matthias G., Thalhammer, Florian, Wallis, Steven C., Lipman, Jeffrey, Roberts, Jason A. and Wicha, Sebastian G. (2020). An Integrated Dialysis Pharmacometric (IDP) model to evaluate the pharmacokinetics in patients undergoing renal replacement therapy. Pharmaceutical Research, 37 (6) 96, 96. doi: 10.1007/s11095-020-02832-w
2020
Journal Article
Pharmacokinetics of sulfamethoxazole and trimethoprim during veno-venous extracorporeal membrane oxygenation: a case report
Dhanani, Jayesh A., Lipman, Jeffrey, Pincus, Jason, Townsend, Shane, Livermore, Amelia, Wallis, Steven C., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2020). Pharmacokinetics of sulfamethoxazole and trimethoprim during veno-venous extracorporeal membrane oxygenation: a case report. Pharmacotherapy, 40 (7) phar.2413, 713-717. doi: 10.1002/phar.2413
2020
Journal Article
The clinical relevance of oliguria in the critically ill patient: Analysis of a large observational database
Vincent, Jean-Louis, Ferguson, Andrew, Pickkers, Peter, Jakob, Stephan M., Jaschinski, Ulrich, Almekhlafi, Ghaleb A., Leone, Marc, Mokhtari, Majid, Fontes, Luis E., Bauer, Philippe R., Sakr, Yasser, Tomas, Esmael, Bibonge, Eric Amisi, Charra, Boubaker, Faroudy, Mamoun, Doedens, Linda, Farina, Zane, Adler, David, Balkema, Cecile, Kok, Adri, Alaya, Sami, Gharsallah, Hedi, Muzha, Dritan, Temelkov, Atanas, Georgiev, Georgi, Simeonov, Georgi, Tsaryanski, Georgi, Georgiev, Silvi, Seliman, Ali ... for the ICON Investigators (2020). The clinical relevance of oliguria in the critically ill patient: Analysis of a large observational database. Critical Care, 24 (1) 171. doi: 10.1186/s13054-020-02858-x
2020
Journal Article
There is no fire without smoke! Pathophysiology and treatment of inhalational injury in burns: a narrative review
Holley, Anthony D., Reade, Michael C., Lipman, Jeffrey and Cohen, Jeremy (2020). There is no fire without smoke! Pathophysiology and treatment of inhalational injury in burns: a narrative review. Anaesthesia and Intensive Care, 48 (2), 0310057X2091328-122. doi: 10.1177/0310057x20913282
2020
Journal Article
On-site therapeutic drug monitoring
Ates, H. Ceren, Roberts, Jason A., Lipman, Jeffrey, Cass, Anthony E.G., Urban, Gerald A. and Dincer, Can (2020). On-site therapeutic drug monitoring. Trends in Biotechnology, 38 (11), 1262-1277. doi: 10.1016/j.tibtech.2020.03.001
2020
Journal Article
Corrigendum to “Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients: a prospective observational study” [Journal of Critical Care 52 (2019) 75–79]
Dhaese, Sofie A. M., Thooft, Alexander D. J., Farkas, Andras, Lipman, Jeffrey, Verstraete, Alain G., Stove, Veronique, Roberts, Jason A. and De Waele, Jan J. (2020). Corrigendum to “Early target attainment of continuous infusion piperacillin/tazobactam and meropenem in critically ill patients: a prospective observational study” [Journal of Critical Care 52 (2019) 75–79]. Journal of Critical Care, 56, 325-325. doi: 10.1016/j.jcrc.2019.09.020
2020
Journal Article
COVID-19: A critical care perspective informed by lessons learnt from other viral epidemics
Ling, Lowell, Joynt, Gavin M., Lipman, Jeff, Constantin, Jean-Michel and Joannes-Boyau, Olivier (2020). COVID-19: A critical care perspective informed by lessons learnt from other viral epidemics. Anaesthesia Critical Care & Pain Medicine, 39 (2), 163-166. doi: 10.1016/j.accpm.2020.02.002
2020
Journal Article
Prophylactic cefazolin dosing in women with body mass index >35 kg·m−2 undergoing cesarean delivery : a pharmacokinetic study of plasma and interstitial fluid
Eley, Victoria A., Christensen, Rebecca, Ryan, Rochelle, Jackson, Dwane, Parker, Suzanne L., Smith, Matthew, van Zundert, Andre A., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2020). Prophylactic cefazolin dosing in women with body mass index >35 kg·m−2 undergoing cesarean delivery : a pharmacokinetic study of plasma and interstitial fluid. Anesthesia and Analgesia, 131 (1), 1-207. doi: 10.1213/ane.0000000000004766
2020
Journal Article
New guidelines for the management of severe thermal burns in the acute phase in adults and children: Is it time for a global surviving burn injury campaign (SBIC)?
Holley, Anthony, Cohen, Jeremy, Reade, Michael, Laupland, Kevin B. and Lipman, Jeffrey (2020). New guidelines for the management of severe thermal burns in the acute phase in adults and children: Is it time for a global surviving burn injury campaign (SBIC)?. Anaesthesia Critical Care and Pain Medicine, 39 (2), 195-196. doi: 10.1016/j.accpm.2020.03.009
2020
Journal Article
Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime
Liu, Jiajun, Neely, Michael, Lipman, Jeffrey, Sime, Fekade, Roberts, Jason A., Kiel, Patrick J., Avedissian, Sean N., Rhodes, Nathaniel J. and Scheetz, Marc H. (2020). Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime. Clinical Pharmacokinetics, 59 (8), 1027-1036. doi: 10.1007/s40262-020-00873-3
Funding
Current funding
Past funding
Supervision
Availability
- Professor Jeffrey Lipman is:
- Not available for supervision
Supervision history
Current supervision
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Doctor Philosophy
Optimising antibiotic dosing for the treatment and prevention of central nervous system infections
Principal Advisor
Other advisors: Professor Jason Roberts
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Doctor Philosophy
Local and International epidemiology of Hospital Acquired Blood Stream Infections in the Critically Ill
Principal Advisor
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Doctor Philosophy
Single Hand Used inTubaTing Laryngoscope Evaluation (SHUTTLE) Project
Principal Advisor
Other advisors: Professor Kiran Shekar
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Doctor Philosophy
How to use antibiotics better in Paediatric Intensive Care using pharmacokinetic principles
Associate Advisor
Other advisors: Dr Mark Coulthard, Dr Xin Liu, Dr Patty Mitre, Professor Jason Roberts
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Doctor Philosophy
Critical care management of burns patients
Associate Advisor
Other advisors: Associate Professor Jeremy Cohen, Professor Michael Reade
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Doctor Philosophy
Studies of the Microcirculatory Responses to Hemorrhagic Shock and Resuscitation
Associate Advisor
Other advisors: Professor Ben Ahern, Dr Wendy Goodwin, Professor Mark Midwinter
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Doctor Philosophy
The Adaptation of Motor Learning Theory in Medical Procedural Tasks
Associate Advisor
Other advisors: Professor Andre Van Zundert
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Doctor Philosophy
Perioperative pharmacokinetics of surgical antibiotic prophylaxis
Associate Advisor
Other advisors: Professor Andre Van Zundert, Professor Jason Roberts
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Doctor Philosophy
Perioperative pharmacokinetics of surgical antibiotic prophylaxis
Associate Advisor
Other advisors: Professor Andre Van Zundert, Professor Jason Roberts
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Doctor Philosophy
Studies of the Microcirculatory Responses to Hemorrhagic Shock and Resuscitation
Associate Advisor
Other advisors: Professor Ben Ahern, Dr Wendy Goodwin, Professor Mark Midwinter
Completed supervision
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2024
Doctor Philosophy
Optimising Antibiotic Dosing for Treatment of Nosocomial Central Nervous System Infections in Neurocritical Care Patients
Principal Advisor
Other advisors: Professor Jason Roberts
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2020
Doctor Philosophy
Early predictors of Health-Related Quality of Life outcomes post-burns for hospitalised adults in Australia.
Principal Advisor
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2019
Doctor Philosophy
Emergency department patients with sepsis: risk stratification and clinical prediction rules
Principal Advisor
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2014
Doctor Philosophy
Augmented Renal Clearance in the Critically Ill: Prevalence, Risk Factors, and Implications for Beta-lactam Therapy
Principal Advisor
Other advisors: Associate Professor Robert Boots
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2014
Doctor Philosophy
Dose optimisation of antibiotics during different forms of renal replacement therapy: focus on tissue and target site antibiotic concentrations
Principal Advisor
Other advisors: Professor Jason Roberts, Associate Professor Robert Boots
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2009
Doctor Philosophy
Beta-lactam antibiotic dosing in critical care units: Bolus vs continuous dosing
Principal Advisor
Other advisors: Emeritus Professor Michael Roberts
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2024
Doctor Philosophy
The Adaptation of Motor Learning Theory in Medical Procedural Tasks
Associate Advisor
Other advisors: Professor Andre Van Zundert
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2023
Doctor Philosophy
Strategies to improve the use of antimicrobials in hospitalised Indonesian patients
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
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2023
Doctor Philosophy
Translating Microsampling Techniques into Improved Antimicrobial Dosing for Critically Ill Children
Associate Advisor
Other advisors: Professor Jason Roberts
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2021
Doctor Philosophy
Investigations into The Endothelial Glycocalyx in Lung Transplantation: Valuable Biomarker and Therapeutic Target
Associate Advisor
Other advisors: Professor Dan Chambers
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2019
Doctor Philosophy
A pharmacokinetic/pharmacodynamic and clinical outcome evaluation of beta-lactam antibiotic therapeutic drug monitoring in critically ill patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2017
Doctor Philosophy
Improving antibiotic dosing in critically ill Australian Indigenous patients with severe sepsis
Associate Advisor
Other advisors: Professor Jason Roberts
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2017
Doctor Philosophy
Clinical Guidelines relating to the Anaesthetic Management of Obese Parturients: An Evaluation of the Evidence Supporting the Recommendations and their Utility in Clinical Practice
Associate Advisor
Other advisors: Professor Leonie Callaway, Professor Andre Van Zundert
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2016
Doctor Philosophy
Translating Innovative Pharmacokinetic Sampling Techniques into Improved Antibiotic Dosing Regimens in Critically Ill Patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2016
Doctor Philosophy
Optimizing beta-lactam antibiotic dosing in critically ill patients: Prolonged infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Dr Christine Staatz, Professor Jason Roberts
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2016
Doctor Philosophy
An Investigation of the Pharmacokinetics of Piperacillin, Meropenem and Fluconazole in Critically Ill Obese Patients
Associate Advisor
Other advisors: Professor Jason Roberts, Emeritus Professor Michael Roberts
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2015
Doctor Philosophy
ß-lactam antibiotic pharmacokinetics during continuous venovenous haemofiltration in critically ill patients: Continuous infusion versus intermittent bolus administration
Associate Advisor
Other advisors: Professor Jason Roberts
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2015
Master Philosophy
Vancomycin-associated nephrotoxicity in the Critically-Ill
Associate Advisor
Other advisors: Professor Jason Roberts
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2014
Doctor Philosophy
Improving Antimicrobial Use In Critically Ill Patients
Associate Advisor
Other advisors: Professor Jason Roberts
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2012
Master Philosophy
Challenges in management of infections on a burn injury unit.
Associate Advisor
Other advisors: Professor Jason Roberts
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2012
Doctor Philosophy
"Phantom Skin Pain" - Neuropathic Pain Following Burn Injury: An Examination of Incidence and Treatment
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2007
Doctor Philosophy
EXAMINATION OF THE ROLE OF POSTURAL CHANGE IN VENTILATED INTENSIVE CARE PATIENTS. CURRENT PRACTICE, INVESTIGATION AND GUIDELINES
Associate Advisor
Media
Enquiries
Contact Professor Jeffrey Lipman directly for media enquiries about:
- Antibiotics
- Intensive care
- pharmacokinetics
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