Overview
Background
Professor Kris Thurecht has appointments at AIBN and UQ’s Centre for Advanced Imaging where he is the Deputy Director of Imaging Technologies. Professor Thurecht has been recognised for scientific excellence with a 2012 Queensland Young Tall Poppy Science Award and a 2010 UQ Foundation Research Excellence Award for his work in developing polymer ‘theranostics’. In 2015 he was recognised by the Royal Australian Chemical Institute Polymer Division through award of the David Sangster Polymer Science and Technology Award for scientific excellence for a mid-career researcher. Since obtaining his PhD in 2005, he has been the recipient of five competitive national and international fellowships, the latest being an NHMRC CDF, and prior to that award an ARC Future Fellowship. He has contributed scientific and review articles to various leading journals in his field, including invited articles in the Emerging Young Investigator issue of Chemical Communications and a Young Talent article in Macromolecular Chemistry and Physics. Professor Thurecht has been chief investigator on grants from various funding bodies, including ARC Discovery grants; ARC Linkage Grants, with both national and international companies; National Health and Medical Research Council (NHMRC) grants; and funding from various cancer foundations. He is co-inventor on 8 patents. He is CI on the ARC Training Centre for Innovation in BioMedical Imaging Technology in which he is theme leader, and is Director of the ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals.
Availability
- Professor Kristofer Thurecht is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research impacts
Research
Design and synthesis of architectural polymers applied to molecular imaging and drug delivery in nanomedicine. In collaboration with industry, Prof Thurecht's research has contributed to development and translation of new agents for detection and treatment of cancer.
Works
Search Professor Kristofer Thurecht’s works on UQ eSpace
2018
Journal Article
EphA3 pay-loaded antibody therapeutics for the treatment of glioblastoma
Offenhäuser, Carolin, Al-Ejeh, Fares, Puttick, Simon, Ensbey, Kathleen, Bruce, Zara, Jamieson, Paul, Smith, Fiona, Stringer, Brett, Carrington, Benjamin, Fuchs, Adrian, Bell, Craig, Jeffree, Rosalind, Rose, Stephen, Thurecht, Kristofer, Boyd, Andrew and Day, Bryan (2018). EphA3 pay-loaded antibody therapeutics for the treatment of glioblastoma. Cancers, 10 (12) 519, 519. doi: 10.3390/cancers10120519
2018
Journal Article
Dependence of block copolymer domain spacing and morphology on the cation structure of ionic liquid additives
Bennett, Thomas M., Chambers, Lewis C., Thurecht, Kristofer J., Jack, Kevin S. and Blakey, Idriss (2018). Dependence of block copolymer domain spacing and morphology on the cation structure of ionic liquid additives. Macromolecules, 51 (21) acs.macromol.8b01953, 8979-8986. doi: 10.1021/acs.macromol.8b01953
2018
Journal Article
Minimum information reporting in bio–nano experimental literature
Faria, Matthew, Björnmalm, Mattias, Thurecht, Kristofer J., Kent, Stephen J., Parton, Robert G., Kavallaris, Maria, Johnston, Angus P. R., Gooding, J. Justin, Corrie, Simon R., Boyd, Ben J., Thordarson, Pall, Whittaker, Andrew K., Stevens, Molly M., Prestidge, Clive A., Porter, Christopher J. H., Parak, Wolfgang J., Davis, Thomas P., Crampin, Edmund J. and Caruso, Frank (2018). Minimum information reporting in bio–nano experimental literature. Nature Nanotechnology, 13 (9), 777-785. doi: 10.1038/s41565-018-0246-4
2018
Journal Article
Influence of Charge on Hemocompatibility and Immunoreactivity of Polymeric Nanoparticles
Chen, Liyu, Glass, Joshua J., De Rose, Robert, Sperling, Claudia, Kent, Stephen J., Houston, Zachary H., Fletcher, Nicholas L., Rolfe, Barbara E. and Thurecht, Kristofer J. (2018). Influence of Charge on Hemocompatibility and Immunoreactivity of Polymeric Nanoparticles. ACS Applied Bio Materials, 1 (3) acsabm.8b00220, 756-767. doi: 10.1021/acsabm.8b00220
2018
Journal Article
In vivo therapeutic evaluation of polymeric nanomedicines: effect of different targeting peptides on therapeutic efficacy against breast cancer
Zhao, Yongmei, Fletcher, Nicholas L., Liu, Tianqing, Gemmell, Anna C., Houston, Zachary H., Blakey, Idriss and Thurecht, Kristofer J. (2018). In vivo therapeutic evaluation of polymeric nanomedicines: effect of different targeting peptides on therapeutic efficacy against breast cancer. Nanotheranostics, 2 (4), 360-370. doi: 10.7150/ntno.27142
2018
Conference Publication
Targeted beta therapy of human prostate cancer in vivo with Lu-177 labelled MIL-38 antibody against glypican-1 (GPC-1)
Yeh, Mei-Chun, Tse, Brian W. C., Fletcher, Nicholas L., Huston, Zachary H., Stewart, Chelsea, Sokolowski, Kamil, Jeet, Varinder, Wissmueller, Sandra, Thurecht, Kristofer J., Campbell, Douglas H., Walsh, Bradley J., Nelson, Colleen C. and Russell, Pamela J. (2018). Targeted beta therapy of human prostate cancer in vivo with Lu-177 labelled MIL-38 antibody against glypican-1 (GPC-1). 19th Asia-Pacific Prostate Cancer Conference, Brisbane Australia, Aug 22-25, 2018. HOBOKEN: WILEY.
2018
Conference Publication
EPHA3 a novel tumour specific therapeutic target for medulloblastoma
Offenhauser, Carolin, Carrington, Benjamin, Thurecht, Kris, Ensbey, Kathleen, Bruce, Zara, Jamieson, Paul, Lim, Yi Chieh, Akgul, Seckin, Li, Michelle, Stringer, Brett, Puttick, Simon, Fuchs, Adrian, Picard, Daniel, Ingram, Wendy, Hallahan, Andrew, Moore, Andrew, Johns, Terrance, Gottardo, Nicholas, Remke, Marc, Boyd, Andrew and Day, Bryan (2018). EPHA3 a novel tumour specific therapeutic target for medulloblastoma. 18th International Symposium on Pediatric Neuro-Oncology (ISPNO), Denver, CO USA, 30 June-3 July 2018. Cary, NC USA: Oxford University Press.
2018
Journal Article
Confinement of therapeutic enzymes in selectively permeable polymer vesicles by Polymerization-Induced Self-Assembly (PISA) reduces antibody binding and proteolytic susceptibility
Blackman, Lewis D., Varlas, Spyridon, Arno, Maria C., Houston, Zachary H., Fletcher, Nicholas L., Thurecht, Kristofer J., Hasan, Muhammad, Gibson, Matthew I. and O’Reilly, Rachel K. (2018). Confinement of therapeutic enzymes in selectively permeable polymer vesicles by Polymerization-Induced Self-Assembly (PISA) reduces antibody binding and proteolytic susceptibility. ACS Central Science, 4 (6), 718-723. doi: 10.1021/acscentsci.8b00168
2018
Journal Article
Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: challenges and opportunities
Belfiore, Lisa, Saunders, Darren N., Ranson, Marie, Thurecht, Kristofer J., Storm, Gert and Vine, Kara L. (2018). Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: challenges and opportunities. Journal of Controlled Release, 277, 1-13. doi: 10.1016/j.jconrel.2018.02.040
2018
Journal Article
Modified organosilica core-shell nanoparticles for stable pH sensing in biological solutions
Robinson, Kye J., Huynh, Gabriel T., Kouskousis, Betty P., Fletcher, Nicholas L., Houston, Zachary H., Thurecht, Kristofer J. and Corrie, Simon R. (2018). Modified organosilica core-shell nanoparticles for stable pH sensing in biological solutions. ACS Sensors, 3 (5), 967-975. doi: 10.1021/acssensors.8b00034
2018
Journal Article
Enhanced delivery of siRNA to triple negative breast cancer cells in vitro and in vivo through functionalizing lipid-coated calcium phosphate nanoparticles with dual target ligands
Tang, Jie, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Huang, Leaf and Xu, Zhi Ping (2018). Enhanced delivery of siRNA to triple negative breast cancer cells in vitro and in vivo through functionalizing lipid-coated calcium phosphate nanoparticles with dual target ligands. Nanoscale, 10 (9), 4258-4266. doi: 10.1039/c7nr08644j
2018
Journal Article
Bispecific antibody-functionalized upconversion nanoprobe
He, Hao, Howard, Christopher B., Chen, Yinghui, Wen, Shihui, Lin, Gungun, Zhou, Jiajia, Thurecht, Kristofer J. and Jin, Dayong (2018). Bispecific antibody-functionalized upconversion nanoprobe. Analytical Chemistry, 90 (5), 3024-3029. doi: 10.1021/acs.analchem.7b05341
2018
Conference Publication
Development of polymeric MRI agents as theranostics
Thurecht, Kristofer, Fuchs, Adrian, Bapat, Abhijeet and Houston, Zachary (2018). Development of polymeric MRI agents as theranostics. 255th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nexus of Food, Energy, and Water, New Orleans, LA United States, 18-22 March 2018. Washington, DC United States: American Chemical Society.
2018
Conference Publication
Design-led 3D visualization of nanomedicines in virtual reality
Lilja, Andrew R., Strong, Campbell W., Bailey, Benjamin J., Thurecht, Kristofer J., Houston, Zachary H., Fletcher, Nicholas L. and McGhee, John B. (2018). Design-led 3D visualization of nanomedicines in virtual reality. 24th ACM Symposium on Virtual Reality Software and Technology (ACM VRST), Tokyo, Japan, Nov 28- Dec 01 2018. New York, NY, United States: Association for Computing Machinery. doi: 10.1145/3281505.3281572
2018
Book Chapter
Hyperbranched polymers as nanocarriers
Houston, Zachary H., Bell, Craig A. and Thurecht, Kristofer J. (2018). Hyperbranched polymers as nanocarriers. Encyclopedia of polymer science and technology. (pp. 1-27) Hoboken, NJ USA: John Wiley & Sons. doi: 10.1002/0471440264.pst159.pub2
2018
Conference Publication
Development of polymer theranostics to probe the behaviour of nanomaterials in biology
Thurecht, Kristofer, Zhou, Yongmei, Fletcher, Nicholas and Houston, Zachary (2018). Development of polymer theranostics to probe the behaviour of nanomaterials in biology. 255th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nexus of Food, Energy, and Water, New Orleans, LA United States, 18-22 March 2018. Washington, DC United States: American Chemical Society.
2018
Journal Article
Recent advances in the generation of antibody-nanomaterial conjugates
Sivaram, Amal J, Wardiana, Andri, Howard, Christopher B, Mahler, Stephen M and Thurecht, Kristofer J (2018). Recent advances in the generation of antibody-nanomaterial conjugates. Advanced Healthcare Materials, 7 (1) 1700607. doi: 10.1002/adhm.201700607
2018
Journal Article
Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials
Fletcher, N. L., Houston, Z. H., Simpson, J. D., Veedu, R. N. and Thurecht, K. J. (2018). Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials. Chemical Communications, 54 (82), 11538-11541. doi: 10.1039/c8cc05831h
2017
Journal Article
Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice
Chen, Liyu, Simpson, Joshua D, Fuchs, Adrian V, Rolfe, Barbara E and Thurecht, Kristofer J (2017). Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice. Molecular pharmaceutics, 14 (12), 4485-4497. doi: 10.1021/acs.molpharmaceut.7b00611
2017
Journal Article
Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation
Cifuentes-Rius, Anna, Ivask, Angela, Das, Shreya, Penya-Auladell, Nuria, Fabregas, Laura, Fletcher, Nicholas L., Houston, Zachary H., Thurecht, Kristofer J. and Voelcker, Nicolas H. (2017). Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation. Acs Applied Materials & Interfaces, 9 (47), 41159-41167. doi: 10.1021/acsami.7b13100
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kristofer Thurecht is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Development of novel polymer-protein conjugates
Principal Advisor
Other advisors: Dr Craig Bell, Associate Professor Idriss Blakey
-
Doctor Philosophy
Utilising Molecular Imaging to Understand Nanomedicine Behaviours
Principal Advisor
Other advisors: Associate Professor Idriss Blakey
-
Doctor Philosophy
Design of a complex in vitro microfluidic device for the evaluation of polymeric nanoparticles
Principal Advisor
Other advisors: Dr Nick Fletcher
-
Doctor Philosophy
Development of novel nanoparticles for enhanced radiotherapeutic efficacy
Principal Advisor
Other advisors: Dr Nick Fletcher
-
Doctor Philosophy
Aqueous one-pot photoinitiated polymerization-induced self-assembly (photo-PISA) to synthesize therapeutic protein loaded nanocarriers
Principal Advisor
Other advisors: Dr Craig Bell, Dr Gayathri Ediriweera
-
Doctor Philosophy
Targeted multifunctional nanoparticles for radiation-enhanced cancer therapy
Principal Advisor
Other advisors: Dr Gayathri Ediriweera
-
Doctor Philosophy
Targeted polymeric radiopharmaceutical as cancer theranostics
Principal Advisor
Other advisors: Dr Nick Fletcher
-
Doctor Philosophy
Molecular alpha radiotherapy using nanomaterials mediated via pre-targeting strategy
Principal Advisor
Other advisors: Dr Nick Fletcher, Dr James Wood
-
Doctor Philosophy
Nanoparticle therapy to improve brain outcomes in growth restricted newborns
Principal Advisor
-
Doctor Philosophy
Novel complementary diagnostics for improved therapeutics/theranostics
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher, Dr Rhia Stone
-
Doctor Philosophy
Development of novel polymer-protein conjugates
Principal Advisor
Other advisors: Dr Craig Bell, Associate Professor Idriss Blakey
-
Doctor Philosophy
Novel complementary diagnostics for improved therapeutics/theranostics
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher, Dr Rhia Stone
-
Master Philosophy
Development and characterization of bispecific and bivalent nanobodies for targeting ErBb receptors
Principal Advisor
Other advisors: Dr Jodi Saunus, Dr Nick Fletcher, Dr Pie Huda
-
Doctor Philosophy
Development of site-specific radiopharmaceuticals using nanotechnology
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher, Dr James Humphries
-
Doctor Philosophy
Development of polymeric nanoparticles for monitoring cytokine release in vivo via FRET
Principal Advisor
Other advisors: Dr Craig Bell, Associate Professor Idriss Blakey
-
Doctor Philosophy
Development of novel gene therapy strategies for treating brain cancer
Principal Advisor
Other advisors: Dr James Humphries
-
Doctor Philosophy
The effect of avidity on nanobody-based formats for theranostic applications
Principal Advisor
Other advisors: Dr Jodi Saunus, Dr Nick Fletcher, Dr Pie Huda
-
Doctor Philosophy
Development of polymeric nanoparticles for monitoring cytokine release in vivo via FRET
Principal Advisor
Other advisors: Dr Craig Bell, Associate Professor Idriss Blakey
-
Master Philosophy
High Activity Automated Synthesis of [68Ga]Ga-DOTA-TATE for Improved Clinical Workflow
Associate Advisor
-
Doctor Philosophy
Roles of image fusion and 3D technology in urology: exploration and clinical integration for personalised devices
Associate Advisor
Other advisors: Dr Matthew Roberts, Dr Nick Rukin
-
Doctor Philosophy
Development of Novel Agents for PFAS Monitoring and Removal from Contaminated Sources
Associate Advisor
Other advisors: Dr Cheng Zhang
-
Doctor Philosophy
Understanding the function of CDCP1 and its potential as a theranostic target for cholangiocarcinoma
Associate Advisor
-
Doctor Philosophy
Modulating the Mononuclear Phagocyte System for Improved Nanomaterial Delivery
Associate Advisor
Other advisors: Associate Professor Barbara Rolfe, Dr Nick Fletcher
-
Doctor Philosophy
Seeing the Unseen: Imaging Bacterial Infections
Associate Advisor
Other advisors: Professor Mark Blaskovich, Dr Rhia Stone
-
Doctor Philosophy
Targeted Alpha Therapies and Biological Responses: Improving Prognostic Power and Regimen Design
Associate Advisor
Other advisors: Dr Nick Fletcher
-
Doctor Philosophy
Inhalable nanoparticle-based gene delivery system for cystic fibrosis
Associate Advisor
Other advisors: Dr Neville Butcher, Associate Professor Lisa Kaminskas
-
Doctor Philosophy
Seeing the Unseen: Imaging Bacterial Infections
Associate Advisor
Other advisors: Professor Mark Blaskovich, Dr Rhia Stone
Completed supervision
-
2024
Doctor Philosophy
Design of a complex in vitro microfluidic device for the evaluation of polymeric nanoparticles
Principal Advisor
Other advisors: Dr Nick Fletcher
-
2024
Doctor Philosophy
Biologics as Peptide Delivery Vehicles for Immunotherapy
Principal Advisor
Other advisors: Associate Professor Idriss Blakey, Dr Pie Huda
-
2023
Doctor Philosophy
Design of pH-sensitive, polymeric nanoparticles, and their application in chemotherapeutic drug delivery
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher
-
2023
Doctor Philosophy
Understanding Immunogenicity in Nanomedicine
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher, Dr Pie Huda
-
2023
Doctor Philosophy
Developing nanomedicines for cancer theranostics
Principal Advisor
Other advisors: Dr Nick Fletcher
-
2023
Doctor Philosophy
Targeted delivery of novel immune-boosting peptides to the tumour microenvironment using polymeric nanoparticles to manage lung cancer
Principal Advisor
Other advisors: Associate Professor Idriss Blakey
-
2023
Doctor Philosophy
Novel antibody theranostics for oncology
Principal Advisor
Other advisors: Dr Christopher Howard, Dr Pie Huda
-
2023
Doctor Philosophy
Investigation of novel therapeutic ligands against CXCR4
Principal Advisor
Other advisors: Associate Professor Idriss Blakey
-
2023
Doctor Philosophy
Photoacoustic Molecular Imaging in Nanomedicine: Development of a Polymeric Probe to Assess Tumour Penetration and Reassessment of the Contrast Enhancement Mechanism
Principal Advisor
Other advisors: Dr Craig Bell
-
2021
Doctor Philosophy
Self-assembled polymeric theranostics for hepatic fibrosis - An approach to non-invasive staging and targeted drug delivery
Principal Advisor
Other advisors: Dr Craig Bell
-
2021
Doctor Philosophy
Investigating the delivery and mechanisms of novel dementia and glioblastoma therapeutics
Principal Advisor
Other advisors: Dr Nick Fletcher
-
2021
Doctor Philosophy
Biological Interactions of Polymeric Nanomedicines & Molecular Imaging Agents
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher
-
2020
Doctor Philosophy
Polymeric micelle nanomedicines for monitoring therapeutic efficacy
Principal Advisor
-
2020
Doctor Philosophy
Development of polymeric theranostics using bioorthogonal chemistry
Principal Advisor
Other advisors: Dr Craig Bell
-
2020
Doctor Philosophy
Design and synthesis of nanomaterials as combination therapeutics
Principal Advisor
Other advisors: Dr Craig Bell
-
2019
Master Philosophy
Radiosensitization of Prostate Cancer by Nanoparticle Mediated RNA Interference
Principal Advisor
Other advisors: Honorary Professor Kum Kum Khanna, Dr Nick Fletcher, Dr Christopher Howard
-
2018
Doctor Philosophy
Development of novel polymeric theranostic for the treatment of colorectal cancer
Principal Advisor
Other advisors: Dr Craig Bell
-
2018
Doctor Philosophy
Investigation of polymeric drug delivery systems to improve therapeutic efficiency for breast cancer
Principal Advisor
Other advisors: Associate Professor Idriss Blakey
-
2016
Doctor Philosophy
Physiological Response to Polymeric Materials in Nanomedicine
Principal Advisor
Other advisors: Associate Professor Barbara Rolfe
-
2016
Doctor Philosophy
Development of a Hyperbranched Polymer Theranostic for Prostate Cancer
Principal Advisor
Other advisors: Professor Andrew Whittaker
-
2016
Doctor Philosophy
Design of functional hyperbranched polymers for gene delivery
Principal Advisor
Other advisors: Professor Andrew Whittaker
-
2015
Doctor Philosophy
Hyperbranched Polymers for In Vivo Multimodal Molecular Imaging
Principal Advisor
Other advisors: Associate Professor Idriss Blakey
-
2015
Doctor Philosophy
Controlled delivery of nanoparticles to the colon for tumour targeting
Principal Advisor
Other advisors: Associate Professor Barbara Rolfe
-
2024
Master Philosophy
High Activity Automated Synthesis of [68Ga]Ga-DOTA-TATE for Improved Clinical Workflow
Associate Advisor
-
2023
Doctor Philosophy
Nanomaterials for the Detection of a Small-Molecule Disease Marker
Associate Advisor
Other advisors: Associate Professor Idriss Blakey
-
2022
Doctor Philosophy
Re-examining catalytic chain transfer for the synthesis of specialty polymers
Associate Advisor
Other advisors: Associate Professor Idriss Blakey, Professor Jack Clegg, Professor Andrew Whittaker
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2016
Doctor Philosophy
Polymer-Ionic Liquid Composites for Advanced Material and Solid Polymer Electrolyte Applications
Associate Advisor
Other advisors: Associate Professor Idriss Blakey
-
2015
Doctor Philosophy
Delivery of therapeutic peptides from thermoplastic polyurethane films
Associate Advisor
Other advisors: Professor Darren Martin
-
2015
Doctor Philosophy
Cancer Chemotherapy Induced Peripheral Neuropathy (CIPN): Preclinical Studies
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Andrew Whittaker
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2015
Doctor Philosophy
Design, Assembly and Characterisation of a Multifunctional, Self-Assembled Nanoparticle incorporating Antibody Fragments
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
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2014
Doctor Philosophy
Multifunctional Nanostructured Polymers for Improved 19F MRI
Associate Advisor
Other advisors: Professor Andrew Whittaker, Dr Hui Peng
Media
Enquiries
Contact Professor Kristofer Thurecht directly for media enquiries about:
- Nanomedicine polymer therapeutics
- physical chemistry
- Polymer
- Polymer chemistry
- Polymeric imaging agents
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