Overview
Background
Professor Kris Thurecht has appointments at AIBN and UQ’s Centre for Advanced Imaging where he is the Deputy Director of Imaging Technologies. Professor Thurecht has been recognised for scientific excellence with a 2012 Queensland Young Tall Poppy Science Award and a 2010 UQ Foundation Research Excellence Award for his work in developing polymer ‘theranostics’. In 2015 he was recognised by the Royal Australian Chemical Institute Polymer Division through award of the David Sangster Polymer Science and Technology Award for scientific excellence for a mid-career researcher. Since obtaining his PhD in 2005, he has been the recipient of five competitive national and international fellowships, the latest being an NHMRC CDF, and prior to that award an ARC Future Fellowship. He has contributed scientific and review articles to various leading journals in his field, including invited articles in the Emerging Young Investigator issue of Chemical Communications and a Young Talent article in Macromolecular Chemistry and Physics. Professor Thurecht has been chief investigator on grants from various funding bodies, including ARC Discovery grants; ARC Linkage Grants, with both national and international companies; National Health and Medical Research Council (NHMRC) grants; and funding from various cancer foundations. He is co-inventor on 8 patents. He is CI on the ARC Training Centre for Innovation in BioMedical Imaging Technology in which he is theme leader, and is Director of the ARC Research Hub for Advanced Manufacture of Targeted Radiopharmaceuticals.
Availability
- Professor Kristofer Thurecht is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Science, The University of Queensland
- Doctor of Philosophy, The University of Queensland
Research impacts
Research
Design and synthesis of architectural polymers applied to molecular imaging and drug delivery in nanomedicine. In collaboration with industry, Prof Thurecht's research has contributed to development and translation of new agents for detection and treatment of cancer.
Works
Search Professor Kristofer Thurecht’s works on UQ eSpace
2017
Journal Article
Localised delivery of doxorubicin to prostate cancer cells through a PSMA-targeted hyperbranched polymer theranostic
Pearce, Amanda K., Simpson, Joshua D., Fletcher, Nicholas L., Houston, Zachary H., Fuchs, Adrian V., Russell, Pamela J., Whittaker, Andrew K. and Thurecht, Kristofer J. (2017). Localised delivery of doxorubicin to prostate cancer cells through a PSMA-targeted hyperbranched polymer theranostic. Biomaterials, 141, 330-339. doi: 10.1016/j.biomaterials.2017.07.004
2017
Journal Article
Bridging Bio-Nano Science and Cancer Nanomedicine
Björnmalm, Mattias, Thurecht, Kristofer J., Michael, Michael, Scott, Andrew M. and Caruso, Frank (2017). Bridging Bio-Nano Science and Cancer Nanomedicine. Acs Nano, 11 (10), 9594-9613. doi: 10.1021/acsnano.7b04855
2017
Journal Article
Using peptide aptamer targeted polymers as a model nanomedicine for investigating drug distribution in cancer nanotheranostics
Zhao, Yongmei, Houston, Zachary H., Simpson, Joshua D., Chen, Liyu, Fletcher, Nicholas L., Fuchs, Adrian V., Blakey, Idriss and Thurecht, Kristofer J. (2017). Using peptide aptamer targeted polymers as a model nanomedicine for investigating drug distribution in cancer nanotheranostics. Molecular Pharmaceutics, 14 (10), 3539-3549. doi: 10.1021/acs.molpharmaceut.7b00560
2017
Journal Article
Switchable 19F MRI polymer theranostics: towards in situ quantifiable drug release
Fuchs, A. V., Bapat, A. P., Cowin, G. J. and Thurecht, K. J. (2017). Switchable 19F MRI polymer theranostics: towards in situ quantifiable drug release. Polymer Chemistry, 8 (34), 5157-5166. doi: 10.1039/c7py00345e
2017
Journal Article
Charge has a marked influence on hyperbranched polymer nanoparticle association in whole human blood
Glass, Joshua J., Chen, Liyu, Alcantara, Sheilajen, Crampin, Edmund J., Thurecht, Kristofer J., De Rose, Robert and Kent, Stephen J. (2017). Charge has a marked influence on hyperbranched polymer nanoparticle association in whole human blood. ACS Macro Letters, 6 (6), 586-592. doi: 10.1021/acsmacrolett.7b00229
2017
Journal Article
Synthesis and post-polymerisation ligations of PEG-based hyperbranched polymers for RNA conjugation via reversible disulfide linkage
Ardana, Aditya, Whittaker, Andrew K. and Thurecht, Kristofer J. (2017). Synthesis and post-polymerisation ligations of PEG-based hyperbranched polymers for RNA conjugation via reversible disulfide linkage. Macromolecular Research, 25 (6), 599-614. doi: 10.1007/s13233-017-5111-z
2017
Journal Article
In vivo fate of carbon nanotubes with different physicochemical properties for gene delivery applications
Cifuentes-Rius, Anna, Boase, Nathan R. B., Font, Ines, Coronas, Nuria, Ramos-Perez, Victor, Thurecht, Kristofer J. and Borros, Salvador (2017). In vivo fate of carbon nanotubes with different physicochemical properties for gene delivery applications. ACS Applied Materials and Interfaces, 9 (13), 11461-11471. doi: 10.1021/acsami.7b00677
2017
Journal Article
Stability of trithiocarbonate RAFT agents containing both a cyano and a carboxylic acid functional group
Fuchs, Adrian V. and Thurecht, Kristofer J. (2017). Stability of trithiocarbonate RAFT agents containing both a cyano and a carboxylic acid functional group. ACS Macro Letters, 6 (3), 287-291. doi: 10.1021/acsmacrolett.7b00100
2017
Conference Publication
Harnessing shape and bi-specific antibodies for improved cell-targeting efficiency of poly(ethylene glycol) capsules
Song, Danzi, Cui, Jiwei, Ju, Yi, Sun, Huanli, Thurecht, Kristofer and Caruso, Frank (2017). Harnessing shape and bi-specific antibodies for improved cell-targeting efficiency of poly(ethylene glycol) capsules. 253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes, San Francisco, CA USA, 2-6 April 2017. Washington, DC USA: American Chemical Society.
2016
Journal Article
Nano-bio interactions: guiding the development of nanoparticle therapeutics, diagnostics, and imaging agents
Corrie, Simon R. and Thurecht, Kristofer J. (2016). Nano-bio interactions: guiding the development of nanoparticle therapeutics, diagnostics, and imaging agents. Pharmaceutical Research, 33 (10), 2311-2313. doi: 10.1007/s11095-016-2009-y
2016
Journal Article
Preclinical imaging of siRNA delivery
Fletcher, Nicholas, Ardana, Aditya and Thurecht, Kristofer J. (2016). Preclinical imaging of siRNA delivery. Australian Journal of Chemistry, 69 (10), 1073-1077. doi: 10.1071/CH16079
2016
Journal Article
Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date
Bobo, Daniel, Robinson, Kye J., Islam, Jiaul, Thurecht, Kristofer J. and Corrie, Simon R. (2016). Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharmaceutical Research, 33 (10), 2373-2387. doi: 10.1007/s11095-016-1958-5
2016
Journal Article
Targeted nanomaterials: overcoming instability of antibody-nanomaterial conjugates: next generation targeted nanomedicines using bispecific antibodies (Adv. Healthcare Mater. 16/2016)
Howard, Christopher B., Fletcher, Nicholas, Houston, Zachary H., Fuchs, Adrian V., Boase, Nathan R. B., Simpson, Joshua D., Raftery, Lyndon J., Ruder, Tim, Jones, Martina L., de Bakker, Christopher J., Mahler, Stephen M. and Thurecht, Kristofer J. (2016). Targeted nanomaterials: overcoming instability of antibody-nanomaterial conjugates: next generation targeted nanomedicines using bispecific antibodies (Adv. Healthcare Mater. 16/2016). Advanced Healthcare Materials, 5 (16), 1994-1994. doi: 10.1002/adhm.201670084
2016
Journal Article
Bioerodable PLGA-based microparticles for producing sustained-release drug formulations and strategies for improving drug loading
Han, Felicity Y., Thurecht, Kristofer J., Whittaker, Andrew K. and Smith, Maree T. (2016). Bioerodable PLGA-based microparticles for producing sustained-release drug formulations and strategies for improving drug loading. Frontiers in Pharmacology, 7 (JUN) 185, 1-11. doi: 10.3389/fphar.2016.00185
2016
Journal Article
Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies
Howard, Christopher B., Fletcher, Nicholas, Houston, Zachary H., Fuchs, Adrian V., Boase, Nathan R. B., Simpson, Joshua D., Raftery, Lyndon J., Ruder, Tim, Jones, Martina L., de Bakker, Christopher J., Mahler, Stephen M. and Thurecht, Kristofer J. (2016). Overcoming Instability of Antibody-Nanomaterial Conjugates: Next Generation Targeted Nanomedicines Using Bispecific Antibodies. Advanced Healthcare Materials, 5 (16), 2055-2068. doi: 10.1002/adhm.201600263
2016
Journal Article
Targeting Nanomedicines to Prostate Cancer: Evaluation of Specificity of Ligands to Two Different Receptors In Vivo
Pearce, Amanda K., Fuchs, Adrian V., Fletcher, Nicholas L. and Thurecht, Kristofer J. (2016). Targeting Nanomedicines to Prostate Cancer: Evaluation of Specificity of Ligands to Two Different Receptors In Vivo. Pharmaceutical Research, 33 (10), 1-12. doi: 10.1007/s11095-016-1945-x
2016
Journal Article
Fluorinated POSS-star polymers for 19F MRI
Wang, Kewei, Peng, Hui, Thurecht, Kristofer J. and Whittaker, Andrew K. (2016). Fluorinated POSS-star polymers for 19F MRI. Macromolecular Chemistry and Physics, 217 (20), 2262-2274. doi: 10.1002/macp.201600084
2016
Journal Article
Biosensing made easy with PEG-targeted bi-specific antibodies
Raftery, Lyndon J., Grewal, Yadveer S., Howard, Christopher B., Jones, Martina L., Shiddiky, Muhammad J. A., Carrascosa, Laura G., Thurecht, Kristofer J., Mahler, Stephen M. and Trau, Matt (2016). Biosensing made easy with PEG-targeted bi-specific antibodies. Chemical Communications, 52 (33), 5730-5733. doi: 10.1039/C6CC01916A
2016
Journal Article
Synthesis, characterization and biological activities of semicarbazones and their copper complexes
Venkatachalam, Taracad K., Bernhardt, Paul V., Noble, Chris J., Fletcher, Nicholas, Pierens, Gregory K., Thurecht, Kris J. and Reutens, David C. (2016). Synthesis, characterization and biological activities of semicarbazones and their copper complexes. Journal of Inorganic Biochemistry, 162, 295-308. doi: 10.1016/j.jinorgbio.2016.04.006
2016
Journal Article
Synthesis of 19F nucleic acid-polymer conjugates as real-time MRI probes of biorecognition
Sicilia, Giovanna, Davis, Adrienne L., Spain, Sebastian G., Magnusson, Johannes P., Boase, Nathan R. B., Thurecht, Kristofer J. and Alexander, Cameron (2016). Synthesis of 19F nucleic acid-polymer conjugates as real-time MRI probes of biorecognition. Polymer Chemistry, 7 (12), 2180-2191. doi: 10.1039/c5py01883h
Funding
Current funding
Past funding
Supervision
Availability
- Professor Kristofer Thurecht is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Development of novel polymer-protein conjugates
Principal Advisor
Other advisors: Dr Craig Bell, Associate Professor Idriss Blakey
-
Doctor Philosophy
Utilising Molecular Imaging to Understand Nanomedicine Behaviours
Principal Advisor
Other advisors: Associate Professor Idriss Blakey
-
Doctor Philosophy
Design of a complex in vitro microfluidic device for the evaluation of polymeric nanoparticles
Principal Advisor
Other advisors: Dr Nick Fletcher
-
Doctor Philosophy
Development of novel nanoparticles for enhanced radiotherapeutic efficacy
Principal Advisor
Other advisors: Dr Nick Fletcher
-
Doctor Philosophy
Aqueous one-pot photoinitiated polymerization-induced self-assembly (photo-PISA) to synthesize therapeutic protein loaded nanocarriers
Principal Advisor
Other advisors: Dr Craig Bell, Dr Gayathri Ediriweera
-
Doctor Philosophy
Targeted multifunctional nanoparticles for radiation-enhanced cancer therapy
Principal Advisor
Other advisors: Dr Gayathri Ediriweera
-
Doctor Philosophy
Targeted polymeric radiopharmaceutical as cancer theranostics
Principal Advisor
Other advisors: Dr Nick Fletcher
-
Doctor Philosophy
Molecular alpha radiotherapy using nanomaterials mediated via pre-targeting strategy
Principal Advisor
Other advisors: Dr Nick Fletcher, Dr James Wood
-
Doctor Philosophy
Nanoparticle therapy to improve brain outcomes in growth restricted newborns
Principal Advisor
-
Doctor Philosophy
Novel complementary diagnostics for improved therapeutics/theranostics
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher, Dr Rhia Stone
-
Doctor Philosophy
Development of novel polymer-protein conjugates
Principal Advisor
Other advisors: Dr Craig Bell, Associate Professor Idriss Blakey
-
Doctor Philosophy
Novel complementary diagnostics for improved therapeutics/theranostics
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher, Dr Rhia Stone
-
Master Philosophy
Development and characterization of bispecific and bivalent nanobodies for targeting ErBb receptors
Principal Advisor
Other advisors: Dr Jodi Saunus, Dr Nick Fletcher, Dr Pie Huda
-
Doctor Philosophy
Development of site-specific radiopharmaceuticals using nanotechnology
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher, Dr James Humphries
-
Doctor Philosophy
Development of polymeric nanoparticles for monitoring cytokine release in vivo via FRET
Principal Advisor
Other advisors: Dr Craig Bell, Associate Professor Idriss Blakey
-
Doctor Philosophy
Development of novel gene therapy strategies for treating brain cancer
Principal Advisor
Other advisors: Dr James Humphries
-
Doctor Philosophy
The effect of avidity on nanobody-based formats for theranostic applications
Principal Advisor
Other advisors: Dr Jodi Saunus, Dr Nick Fletcher, Dr Pie Huda
-
Doctor Philosophy
Development of polymeric nanoparticles for monitoring cytokine release in vivo via FRET
Principal Advisor
Other advisors: Dr Craig Bell, Associate Professor Idriss Blakey
-
Master Philosophy
High Activity Automated Synthesis of [68Ga]Ga-DOTA-TATE for Improved Clinical Workflow
Associate Advisor
-
Doctor Philosophy
Roles of image fusion and 3D technology in urology: exploration and clinical integration for personalised devices
Associate Advisor
Other advisors: Dr Matthew Roberts, Dr Nick Rukin
-
Doctor Philosophy
Development of Novel Agents for PFAS Monitoring and Removal from Contaminated Sources
Associate Advisor
Other advisors: Dr Cheng Zhang
-
Doctor Philosophy
Understanding the function of CDCP1 and its potential as a theranostic target for cholangiocarcinoma
Associate Advisor
-
Doctor Philosophy
Modulating the Mononuclear Phagocyte System for Improved Nanomaterial Delivery
Associate Advisor
Other advisors: Associate Professor Barbara Rolfe, Dr Nick Fletcher
-
Doctor Philosophy
Seeing the Unseen: Imaging Bacterial Infections
Associate Advisor
Other advisors: Professor Mark Blaskovich, Dr Rhia Stone
-
Doctor Philosophy
Targeted Alpha Therapies and Biological Responses: Improving Prognostic Power and Regimen Design
Associate Advisor
Other advisors: Dr Nick Fletcher
-
Doctor Philosophy
Inhalable nanoparticle-based gene delivery system for cystic fibrosis
Associate Advisor
Other advisors: Dr Neville Butcher, Associate Professor Lisa Kaminskas
-
Doctor Philosophy
Seeing the Unseen: Imaging Bacterial Infections
Associate Advisor
Other advisors: Professor Mark Blaskovich, Dr Rhia Stone
Completed supervision
-
2024
Doctor Philosophy
Design of a complex in vitro microfluidic device for the evaluation of polymeric nanoparticles
Principal Advisor
Other advisors: Dr Nick Fletcher
-
2024
Doctor Philosophy
Biologics as Peptide Delivery Vehicles for Immunotherapy
Principal Advisor
Other advisors: Associate Professor Idriss Blakey, Dr Pie Huda
-
2023
Doctor Philosophy
Design of pH-sensitive, polymeric nanoparticles, and their application in chemotherapeutic drug delivery
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher
-
2023
Doctor Philosophy
Understanding Immunogenicity in Nanomedicine
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher, Dr Pie Huda
-
2023
Doctor Philosophy
Targeted delivery of novel immune-boosting peptides to the tumour microenvironment using polymeric nanoparticles to manage lung cancer
Principal Advisor
Other advisors: Associate Professor Idriss Blakey
-
2023
Doctor Philosophy
Developing nanomedicines for cancer theranostics
Principal Advisor
Other advisors: Dr Nick Fletcher
-
2023
Doctor Philosophy
Novel antibody theranostics for oncology
Principal Advisor
Other advisors: Dr Christopher Howard, Dr Pie Huda
-
2023
Doctor Philosophy
Photoacoustic Molecular Imaging in Nanomedicine: Development of a Polymeric Probe to Assess Tumour Penetration and Reassessment of the Contrast Enhancement Mechanism
Principal Advisor
Other advisors: Dr Craig Bell
-
2023
Doctor Philosophy
Investigation of novel therapeutic ligands against CXCR4
Principal Advisor
Other advisors: Associate Professor Idriss Blakey
-
2021
Doctor Philosophy
Self-assembled polymeric theranostics for hepatic fibrosis - An approach to non-invasive staging and targeted drug delivery
Principal Advisor
Other advisors: Dr Craig Bell
-
2021
Doctor Philosophy
Biological Interactions of Polymeric Nanomedicines & Molecular Imaging Agents
Principal Advisor
Other advisors: Dr Craig Bell, Dr Nick Fletcher
-
2021
Doctor Philosophy
Investigating the delivery and mechanisms of novel dementia and glioblastoma therapeutics
Principal Advisor
Other advisors: Dr Nick Fletcher
-
2020
Doctor Philosophy
Polymeric micelle nanomedicines for monitoring therapeutic efficacy
Principal Advisor
-
2020
Doctor Philosophy
Development of polymeric theranostics using bioorthogonal chemistry
Principal Advisor
Other advisors: Dr Craig Bell
-
2020
Doctor Philosophy
Design and synthesis of nanomaterials as combination therapeutics
Principal Advisor
Other advisors: Dr Craig Bell
-
2019
Master Philosophy
Radiosensitization of Prostate Cancer by Nanoparticle Mediated RNA Interference
Principal Advisor
Other advisors: Honorary Professor Kum Kum Khanna, Dr Nick Fletcher, Dr Christopher Howard
-
2018
Doctor Philosophy
Development of novel polymeric theranostic for the treatment of colorectal cancer
Principal Advisor
Other advisors: Dr Craig Bell
-
2018
Doctor Philosophy
Investigation of polymeric drug delivery systems to improve therapeutic efficiency for breast cancer
Principal Advisor
Other advisors: Associate Professor Idriss Blakey
-
2016
Doctor Philosophy
Physiological Response to Polymeric Materials in Nanomedicine
Principal Advisor
Other advisors: Associate Professor Barbara Rolfe
-
2016
Doctor Philosophy
Development of a Hyperbranched Polymer Theranostic for Prostate Cancer
Principal Advisor
Other advisors: Professor Andrew Whittaker
-
2016
Doctor Philosophy
Design of functional hyperbranched polymers for gene delivery
Principal Advisor
Other advisors: Professor Andrew Whittaker
-
2015
Doctor Philosophy
Hyperbranched Polymers for In Vivo Multimodal Molecular Imaging
Principal Advisor
Other advisors: Associate Professor Idriss Blakey
-
2015
Doctor Philosophy
Controlled delivery of nanoparticles to the colon for tumour targeting
Principal Advisor
Other advisors: Associate Professor Barbara Rolfe
-
2024
Master Philosophy
High Activity Automated Synthesis of [68Ga]Ga-DOTA-TATE for Improved Clinical Workflow
Associate Advisor
-
2023
Doctor Philosophy
Nanomaterials for the Detection of a Small-Molecule Disease Marker
Associate Advisor
Other advisors: Associate Professor Idriss Blakey
-
2022
Doctor Philosophy
Re-examining catalytic chain transfer for the synthesis of specialty polymers
Associate Advisor
Other advisors: Associate Professor Idriss Blakey, Professor Jack Clegg, Professor Andrew Whittaker
-
2016
Doctor Philosophy
Polymer-Ionic Liquid Composites for Advanced Material and Solid Polymer Electrolyte Applications
Associate Advisor
Other advisors: Associate Professor Idriss Blakey
-
2015
Doctor Philosophy
Delivery of therapeutic peptides from thermoplastic polyurethane films
Associate Advisor
Other advisors: Professor Darren Martin
-
2015
Doctor Philosophy
Cancer Chemotherapy Induced Peripheral Neuropathy (CIPN): Preclinical Studies
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Andrew Whittaker
-
2015
Doctor Philosophy
Design, Assembly and Characterisation of a Multifunctional, Self-Assembled Nanoparticle incorporating Antibody Fragments
Associate Advisor
Other advisors: Emeritus Professor Stephen Mahler, Dr Martina Jones
-
2014
Doctor Philosophy
Multifunctional Nanostructured Polymers for Improved 19F MRI
Associate Advisor
Other advisors: Professor Andrew Whittaker, Dr Hui Peng
Media
Enquiries
Contact Professor Kristofer Thurecht directly for media enquiries about:
- Nanomedicine polymer therapeutics
- physical chemistry
- Polymer
- Polymer chemistry
- Polymeric imaging agents
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